Best TWAS P=2.97e-09 · Best GWAS P=2.91e-11 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | LRPAP1 | 0.16 | 0.04 | lasso | 4 | 0.04 | 1.6e-04 | 5.4 | -5.4 | 8.2e-08 | 0.12 | 0.18 | 0.32 | TRUE |
2 | GTEx | Artery Aorta | LRPAP1 | 0.20 | 0.13 | lasso | 3 | 0.13 | 1.7e-07 | 5.1 | -5.8 | 5.4e-09 | 0.30 | 0.83 | 0.16 | TRUE |
3 | GTEx | Artery Coronary | LRPAP1 | 0.24 | 0.13 | lasso | 2 | 0.07 | 2.1e-03 | 5.3 | -5.3 | 1.2e-07 | 0.19 | 0.34 | 0.10 | FALSE |
4 | GTEx | Artery Tibial | LRPAP1 | 0.36 | 0.21 | lasso | 7 | 0.21 | 3.5e-16 | 5.3 | -5.4 | 7.1e-08 | 0.18 | 0.84 | 0.16 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | LRPAP1 | 0.53 | 0.04 | lasso | 11 | 0.17 | 4.1e-05 | -1.7 | -5.2 | 2.4e-07 | 0.31 | 0.07 | 0.36 | FALSE |
6 | GTEx | Esophagus Muscularis | LRPAP1 | 0.22 | 0.03 | lasso | 7 | 0.02 | 1.1e-02 | 5.4 | -5.1 | 2.9e-07 | 0.15 | 0.74 | 0.10 | FALSE |
7 | GTEx | Nerve Tibial | LRPAP1 | 0.29 | 0.11 | enet | 16 | 0.14 | 7.6e-10 | 5.1 | -5.8 | 5.3e-09 | 0.32 | 0.90 | 0.10 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | LRPAP1 | 0.13 | 0.03 | enet | 12 | 0.08 | 3.6e-07 | -1.8 | -5.8 | 5.0e-09 | 0.45 | 0.35 | 0.56 | TRUE |
9 | METSIM | Adipose | MFSD10 | 0.16 | 0.03 | enet | 48 | 0.05 | 2.1e-08 | -4.5 | -5.2 | 1.7e-07 | -0.03 | 0.03 | 0.90 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LRPAP1 | 0.05 | 0.00 | blup | 52 | 0.02 | 2.8e-02 | -1.5 | -5.2 | 2.0e-07 | 0.29 | 0.04 | 0.08 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LRPAP1 | 0.12 | 0.09 | blup | 52 | 0.12 | 1.5e-12 | 5.4 | -5.2 | 1.9e-07 | 0.10 | 0.82 | 0.18 | FALSE |
12 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LRPAP1 | 0.12 | 0.02 | blup | 52 | 0.05 | 6.6e-04 | 1.1 | -5.9 | 3.0e-09 | 0.45 | 0.04 | 0.15 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | DOK7 | 0.22 | 0.10 | lasso | 3 | 0.14 | 9.2e-14 | -5.9 | -5.9 | 4.7e-09 | 0.47 | 0.14 | 0.86 | TRUE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | RGS12 | 0.08 | 0.01 | blup | 108 | 0.01 | 2.4e-02 | -5.2 | -5.6 | 1.7e-08 | 0.32 | 0.02 | 0.27 | FALSE |