Best TWAS P=8.91e-09 · Best GWAS P=2.68e-09 conditioned to 0.00414
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | AHI1 | 0.38 | 0.24 | enet | 19 | 0.23 | 5.4e-08 | -5.1 | 5.8 | 8.9e-09 | -0.66 | 0.12 | 0.87 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | RP3-388E23.2 | 0.26 | 0.05 | lasso | 6 | 0.02 | 7.1e-02 | -5.3 | 5.2 | 1.8e-07 | -0.67 | 0.10 | 0.58 | FALSE |
| 3 | NTR | Blood | AHI1 | 0.11 | 0.14 | lasso | 6 | 0.15 | 3.2e-47 | -5.3 | 5.3 | 1.4e-07 | -0.72 | 0.12 | 0.88 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C6orf217 | 0.02 | 0.02 | blup | 80 | 0.02 | 1.2e-05 | -5.0 | 5.7 | 1.5e-08 | -0.87 | 0.06 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AHI1 | 0.03 | 0.02 | enet | 7 | 0.01 | 8.1e-03 | -5.2 | 5.3 | 9.5e-08 | -0.65 | 0.00 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C6orf217 | 0.04 | 0.03 | blup | 81 | 0.01 | 1.7e-02 | -5.1 | 5.4 | 8.3e-08 | -0.85 | 0.06 | 0.74 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C6orf217 | 0.10 | 0.00 | blup | 82 | 0.04 | 6.8e-03 | -5.0 | 5.2 | 2.2e-07 | -0.82 | 0.03 | 0.42 | FALSE |