[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr6:129,638,583-132,080,991

Best TWAS P=6.32e-26 · Best GWAS P=4.47e-27 conditioned to 7.27e-15

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	10.0	10.5	6.3e-26	-0.34	0.42	0.16	TRUE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC285733	0.22	0.19	enet	9	0.19	3.9e-11	5.6	5.6	2.2e-08	0.02	0.40	0.60	TRUE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	10.0	10.2	1.5e-24	-0.35	0.17	0.07	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	10.0	10.1	3.5e-24	-0.31	0.81	0.19	FALSE
28	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	10.0	10.1	3.9e-24	-0.36	0.81	0.19	FALSE
30	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	10.0	10.1	4.6e-24	-0.33	0.81	0.19	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	10.0	10.1	5.6e-24	-0.32	0.82	0.18	FALSE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	10.0	10.1	8.2e-24	-0.32	0.81	0.19	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	10.0	10.0	1.5e-23	-0.33	0.49	0.07	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	10.0	10.0	1.8e-23	-0.29	0.85	0.15	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	8.5	9.9	3.2e-23	-0.32	0.91	0.09	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	10.0	9.9	3.4e-23	-0.30	0.26	0.07	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	10.0	9.9	3.5e-23	-0.32	0.88	0.08	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	10.0	9.9	3.5e-23	-0.29	0.86	0.14	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	10.0	9.9	5.3e-23	-0.32	0.95	0.05	FALSE
27	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	10.0	9.8	1.3e-22	-0.35	0.80	0.19	FALSE
29	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	8.0	9.8	1.7e-22	-0.32	0.95	0.05	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	8.5	9.7	2.3e-22	-0.32	0.29	0.12	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	10.0	9.7	2.6e-22	-0.35	0.94	0.06	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	7.6	9.7	2.7e-22	-0.28	0.36	0.13	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	10.0	9.7	3.0e-22	-0.27	0.81	0.19	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	10.0	9.7	5.1e-22	-0.36	0.21	0.10	FALSE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	8.5	9.6	5.8e-22	-0.29	0.97	0.01	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	8.5	9.6	6.6e-22	-0.33	0.97	0.02	FALSE
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	10.0	9.6	8.2e-22	-0.32	0.85	0.15	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	7.7	9.6	9.5e-22	-0.34	0.82	0.14	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	10.0	9.5	1.6e-21	-0.33	0.26	0.06	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	10.0	9.5	3.2e-21	-0.30	0.16	0.06	FALSE
25	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	8.2	9.2	4.7e-20	-0.40	0.99	0.01	FALSE
17	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	7.6	8.7	3.7e-18	-0.15	0.84	0.04	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	10.0	8.3	1.3e-16	-0.37	0.83	0.17	FALSE
32	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	8.5	8.2	3.5e-16	-0.20	1.00	0.00	FALSE
18	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	7.6	7.8	6.8e-15	-0.09	0.42	0.04	FALSE
26	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	8.2	7.3	2.2e-13	-0.39	0.27	0.04	FALSE
35	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	8.5	7.3	2.5e-13	-0.22	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	8.5	6.8	7.7e-12	-0.10	0.13	0.04	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	EPB41L2	0.12	0.12	blup	522	0.10	6.5e-13	4.8	5.5	4.3e-08	0.01	0.98	0.02	FALSE