TWAS
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Genes
Traits
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Traits
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Forced vital capacity (FVC)
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chr6:141,924,760-143,855,272
Best TWAS P=8.93e-30 · Best GWAS P=1.49e-31 conditioned to 1
142M
142.5M
143M
143.5M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Subcutaneous
GPR126
0.06
0.04
lasso
4
0.04
0.00061
-11.3
11.3
8.9e-30
-0.98
0.02
0.95
TRUE
2
METSIM
Adipose
GPR126
0.05
0.01
blup
429
0.02
0.00019
-4.0
7.0
1.8e-12
-0.74
0.10
0.89
TRUE
4
The Cancer Genome Atlas
Uterine Corpus Endometrial Carcinoma
NMBR
0.09
0.01
blup
46
0.04
0.03380
2.9
-5.2
2.4e-07
0.12
0.02
0.60
TRUE
3
NTR
Blood
HIVEP2
0.02
0.01
blup
424
0.01
0.00262
-2.3
-6.2
6.9e-10
0.40
0.34
0.06
FALSE