TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced vital capacity (FVC)
:
←
→
chr7:91,380,845-93,160,671
Best TWAS P=3.76e-13 · Best GWAS P=3.81e-12 conditioned to 0.241
91.4M
91.6M
91.8M
92M
92.2M
92.4M
92.6M
92.8M
93M
93.2M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
GTEx
Testis
CDK6
0.10
0.10
lasso
3
0.09
8.0e-05
6.9
-7.3
3.8e-13
-0.88
0.01
0.98
TRUE
1
CommonMind
Brain Pre-frontal Cortex
CDK6
0.12
0.10
lasso
2
0.10
1.9e-12
6.5
6.5
6.5e-11
0.80
0.08
0.92
FALSE
2
GTEx
Cells Transformed fibroblasts
GATAD1
0.23
0.20
lasso
4
0.22
1.4e-16
4.8
-5.9
3.9e-09
-0.73
0.88
0.12
FALSE
3
GTEx
Esophagus Muscularis
FAM133B
0.07
0.01
enet
2
0.01
1.2e-01
-4.9
-5.3
9.3e-08
-0.67
0.08
0.29
FALSE