Best TWAS P=1.09e-10 · Best GWAS P=9.36e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NDUFB2 | 0.06 | 0.02 | lasso | 3 | 0.03 | 1.4e-03 | 4.3 | -5.2 | 2.3e-07 | -0.44 | 0.20 | 0.44 | FALSE |
| 2 | GTEx | Esophagus Muscularis | NDUFB2-AS1 | 0.08 | 0.00 | enet | 11 | 0.00 | 3.5e-01 | 4.3 | -5.2 | 2.3e-07 | -0.48 | 0.10 | 0.22 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | NDUFB2 | 0.05 | 0.05 | enet | 9 | 0.04 | 7.4e-06 | 3.9 | -5.5 | 3.6e-08 | -0.39 | 0.96 | 0.03 | TRUE |
| 4 | YFS | Blood | BRAF | 0.01 | 0.02 | enet | 2 | 0.01 | 1.6e-04 | 6.5 | 6.5 | 1.1e-10 | 1.00 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | MRPS33 | 0.09 | 0.04 | blup | 28 | 0.07 | 4.0e-03 | 6.1 | -5.3 | 9.0e-08 | -0.60 | 0.00 | 0.85 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NDUFB2 | 0.07 | 0.03 | blup | 26 | 0.04 | 6.6e-05 | 5.0 | -5.9 | 2.7e-09 | -0.54 | 0.00 | 0.97 | FALSE |