Best TWAS P=1.93e-13 · Best GWAS P=9.41e-14 conditioned to 0.0636
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | -6.1 | 6.8 | 8.0e-12 | 0.95 | 0.08 | 0.92 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | 7.1 | 7.4 | 1.9e-13 | 0.91 | 0.15 | 0.82 | TRUE |
3 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | 6.8 | 7.2 | 6.6e-13 | 0.98 | 0.05 | 0.94 | FALSE |
4 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | 6.0 | 6.7 | 1.7e-11 | 0.93 | 0.08 | 0.88 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | CCDC171 | 0.27 | 0.18 | enet | 10 | 0.19 | 8.3e-06 | -6.4 | 5.8 | 7.0e-09 | 0.85 | 0.09 | 0.84 | FALSE |
6 | GTEx | Brain Hypothalamus | CCDC171 | 0.32 | 0.17 | enet | 6 | 0.09 | 4.0e-03 | 7.1 | 5.7 | 1.5e-08 | 0.91 | 0.08 | 0.74 | FALSE |
7 | GTEx | Lung | CCDC171 | 0.13 | 0.03 | enet | 9 | 0.01 | 5.0e-02 | -3.6 | 5.2 | 2.2e-07 | 0.72 | 0.36 | 0.44 | FALSE |
8 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | 7.1 | 7.0 | 2.0e-12 | 0.99 | 0.05 | 0.95 | FALSE |
9 | GTEx | Ovary | CCDC171 | 0.21 | 0.19 | lasso | 4 | 0.16 | 7.7e-05 | -6.0 | -6.2 | 4.5e-10 | -0.86 | 0.14 | 0.58 | FALSE |
10 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | -6.2 | 6.3 | 2.2e-10 | 0.92 | 0.18 | 0.76 | FALSE |
11 | METSIM | Adipose | CCDC171 | 0.03 | 0.00 | blup | 828 | 0.01 | 4.0e-02 | -6.4 | 6.0 | 2.0e-09 | 0.81 | 0.17 | 0.65 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | -6.3 | 6.1 | 8.6e-10 | 0.83 | 0.76 | 0.24 | FALSE |