[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr9:96,326,127-100,114,913

Best TWAS P=4.99e-22 · Best GWAS P=1.66e-28 conditioned to 0.00114

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Tibial	RP11-435O5.5	0.09	0.04	lasso	2	0.02	7.3e-03	9.91	-9.6	5.0e-22	-0.44	0.25	0.06	TRUE
15	NTR	Blood	PTCH1	0.04	0.02	blup	433	0.02	4.1e-08	10.00	7.5	5.9e-14	0.64	0.02	0.98	TRUE
11	GTEx	Spleen	PTCH1	0.33	0.08	lasso	8	0.18	1.9e-05	-0.42	7.0	3.3e-12	0.64	0.05	0.75	TRUE
7	GTEx	Heart Atrial Appendage	RP11-435O5.4	0.18	0.00	lasso	5	0.00	6.2e-01	4.28	-6.7	2.6e-11	0.07	0.07	0.06	TRUE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	HABP4	0.05	0.08	lasso	5	0.08	6.9e-09	6.07	-6.1	8.8e-10	-0.04	0.03	0.97	TRUE
3	GTEx	Breast Mammary Tissue	ERCC6L2	0.17	0.02	lasso	4	0.03	1.2e-02	4.61	5.6	1.8e-08	-0.03	0.28	0.03	TRUE
13	GTEx	Testis	C9orf3	0.15	0.00	enet	18	0.00	2.4e-01	-1.56	-5.4	8.3e-08	-0.10	0.06	0.11	TRUE
16	NTR	Blood	ZNF169	0.02	0.00	lasso	6	0.00	1.1e-02	-6.91	-5.2	1.9e-07	0.08	0.08	0.12	TRUE
8	GTEx	Liver	PTCH1	0.25	0.06	enet	11	0.03	4.9e-02	10.94	9.6	6.7e-22	0.91	0.01	0.94	FALSE
18	YFS	Blood	PTCH1	0.09	0.05	lasso	8	0.05	1.2e-15	9.98	9.4	3.8e-21	0.95	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	PTCH1	0.02	0.01	blup	54	0.02	1.1e-03	9.58	-7.5	4.6e-14	-0.19	0.06	0.04	FALSE
9	GTEx	Nerve Tibial	HSD17B3	0.14	0.00	enet	20	0.00	2.4e-01	5.75	6.1	1.2e-09	0.04	0.03	0.77	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HABP4	0.02	0.02	blup	44	0.02	7.1e-03	6.08	6.0	2.6e-09	0.02	0.02	0.79	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC14B	0.03	0.02	blup	42	0.02	2.1e-03	6.08	-5.9	2.8e-09	-0.03	0.02	0.85	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	HABP4	0.08	0.06	blup	44	0.05	1.6e-02	5.69	-5.9	2.9e-09	-0.05	0.02	0.57	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC14B	0.02	0.01	lasso	1	0.01	3.0e-03	5.91	-5.9	3.5e-09	-0.03	0.02	0.74	FALSE
12	GTEx	Testis	HABP4	0.19	0.22	lasso	9	0.21	1.1e-09	5.84	5.9	3.7e-09	0.02	0.04	0.96	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC14B	0.05	0.06	lasso	5	0.06	6.5e-07	6.08	-5.9	3.7e-09	-0.01	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	CDC14B	0.05	0.07	blup	42	0.08	4.8e-08	6.06	-5.9	4.8e-09	-0.02	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	CDC14B	0.16	0.17	blup	41	0.19	2.6e-06	6.08	-5.8	6.6e-09	0.00	0.02	0.97	FALSE
2	GTEx	Breast Mammary Tissue	CDC14B	0.16	0.02	enet	21	0.02	3.7e-02	6.11	-5.8	6.9e-09	-0.01	0.02	0.95	FALSE
5	GTEx	Cells Transformed fibroblasts	ERCC6L2	0.19	0.02	enet	34	0.16	4.1e-12	4.54	5.7	9.7e-09	0.02	0.98	0.00	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	AAED1	0.17	0.02	lasso	3	0.04	2.4e-02	6.08	5.7	1.3e-08	0.00	0.03	0.68	FALSE
6	GTEx	Esophagus Muscularis	ERCC6L2	0.15	0.10	lasso	6	0.08	8.8e-06	4.73	5.5	3.0e-08	-0.01	0.87	0.01	FALSE
10	GTEx	Nerve Tibial	ZNF367	0.10	0.05	lasso	3	0.02	7.9e-03	5.83	5.5	3.1e-08	0.04	0.06	0.90	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDC14B	0.08	0.02	blup	41	0.04	1.0e-03	4.41	-5.5	4.6e-08	-0.05	0.02	0.70	FALSE
14	GTEx	Thyroid	CDC14B	0.15	0.10	lasso	5	0.08	5.3e-07	5.67	-5.4	8.4e-08	-0.03	0.09	0.91	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PTCH1	0.04	0.00	blup	56	0.02	1.6e-03	9.98	5.3	1.2e-07	0.72	0.02	0.28	FALSE
17	YFS	Blood	HABP4	0.08	0.09	enet	24	0.11	5.9e-34	4.95	-5.2	2.2e-07	-0.04	0.90	0.10	FALSE