TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr20:30,060,562-31,870,640
Best TWAS P=6.24e-10 · Best GWAS P=3.26e-10 conditioned to 1
30M
30.5M
31M
31.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Cells Transformed fibroblasts
TSPY26P
0.07
0.05
lasso
5
0.03
1.2e-03
-6.2
6.2
6.2e-10
-0.97
0.02
0.94
TRUE
5
GTEx
Vagina
RSL24D1P6
0.44
-0.01
lasso
13
0.00
2.5e-01
-3.5
5.7
1.3e-08
-0.68
0.03
0.54
FALSE
4
GTEx
Thyroid
C20orf112
0.05
0.00
lasso
5
0.00
1.4e-01
-6.2
5.5
3.4e-08
-0.87
0.04
0.73
FALSE
1
GTEx
Artery Aorta
TSPY26P
0.13
0.00
lasso
7
0.00
5.7e-01
-3.7
5.3
9.9e-08
-0.61
0.04
0.34
FALSE
2
GTEx
Brain Cerebellum
TSPY26P
0.25
0.06
lasso
6
0.15
2.9e-05
-5.7
5.3
1.1e-07
-0.69
0.06
0.50
FALSE
6
METSIM
Adipose
KIF3B
0.03
0.02
bslmm
357
0.01
6.4e-03
-5.7
-5.2
1.7e-07
0.70
0.01
0.94
FALSE