Best TWAS P=1.13e-07 · Best GWAS P=1.63e-07 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | ABHD12 | 0.09 | 0.05 | enet | 13 | 0.04 | 2.9e-02 | -5.1 | -5.3 | 1.1e-07 | 0.95 | 0.06 | 0.81 | TRUE |
2 | GTEx | Cells Transformed fibroblasts | ABHD12 | 0.24 | 0.33 | lasso | 4 | 0.35 | 6.3e-27 | -5.2 | -5.2 | 2.5e-07 | 0.97 | 0.05 | 0.95 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | GINS1 | 0.04 | 0.01 | lasso | 3 | 0.01 | 5.2e-02 | -4.3 | -5.3 | 1.4e-07 | 0.81 | 0.10 | 0.82 | FALSE |
4 | GTEx | Colon Sigmoid | ABHD12 | 0.17 | 0.17 | lasso | 15 | 0.17 | 1.0e-06 | -5.0 | -5.1 | 2.9e-07 | 0.88 | 0.07 | 0.93 | FALSE |
5 | GTEx | Liver | ABHD12 | 0.20 | 0.20 | lasso | 19 | 0.15 | 7.3e-05 | -5.0 | -5.3 | 1.5e-07 | 0.96 | 0.09 | 0.90 | FALSE |
6 | GTEx | Ovary | ABHD12 | 0.23 | 0.04 | lasso | 8 | 0.05 | 1.9e-02 | -4.9 | -5.3 | 1.4e-07 | 0.86 | 0.08 | 0.64 | FALSE |
7 | GTEx | Spleen | PYGB | 0.15 | 0.09 | lasso | 6 | 0.04 | 2.6e-02 | -5.0 | -5.3 | 1.2e-07 | 0.93 | 0.09 | 0.80 | FALSE |
8 | GTEx | Thyroid | VN1R108P | 0.05 | 0.01 | lasso | 2 | 0.02 | 1.8e-02 | -4.2 | -5.1 | 3.1e-07 | 0.84 | 0.09 | 0.74 | FALSE |
9 | The Cancer Genome Atlas | Glioblastoma Multiforme | ABHD12 | 0.14 | 0.10 | lasso | 5 | 0.13 | 1.1e-04 | -5.0 | -5.2 | 2.5e-07 | 0.90 | 0.05 | 0.90 | FALSE |
10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NINL | 0.11 | 0.03 | blup | 81 | 0.07 | 2.1e-03 | 4.6 | 5.2 | 1.8e-07 | -0.94 | 0.03 | 0.71 | FALSE |