TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr3:128,276,332-129,714,372
Best TWAS P=1.48e-12 · Best GWAS P=1.08e-10 conditioned to 0.00922
128.2M
128.4M
128.6M
128.8M
129M
129.2M
129.4M
129.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
H1FX
0.02
0.02
lasso
5
0.03
6.5e-07
5.0
7.1
1.5e-12
-0.62
0.09
0.88
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
H1FX
0.02
0.00
blup
36
0.00
5.1e-01
-6.5
7.0
2.1e-12
-0.65
0.01
0.65
FALSE
2
YFS
Blood
H1FX
0.02
0.01
lasso
3
0.01
1.4e-03
-5.5
5.6
2.3e-08
-0.84
0.07
0.60
FALSE
1
METSIM
Adipose
COPG1
0.04
0.02
bslmm
303
0.03
7.6e-06
4.7
-5.2
1.7e-07
0.33
0.73
0.09
FALSE