TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr5:77,052,232-78,753,539
Best TWAS P=9.56e-12 · Best GWAS P=3.17e-14 conditioned to 0.000672
77M
77.2M
77.4M
77.6M
77.8M
78M
78.2M
78.4M
78.6M
78.8M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
AP3B1
0.02
0.00
blup
126
0.01
0.0182
-7.2
-6.8
9.6e-12
0.86
0.02
0.86
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
AP3B1
0.05
0.02
blup
126
0.03
0.0005
3.0
-6.0
1.9e-09
0.80
0.02
0.92
FALSE
1
GTEx
Pituitary
LHFPL2
0.38
0.02
lasso
9
0.04
0.0402
2.1
-5.7
1.4e-08
0.52
0.04
0.46
FALSE