TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced expiratory volume in 1-second (FEV1)
:
←
→
chr7:22,946,782-24,382,726
Best TWAS P=1.85e-09 · Best GWAS P=1.97e-16 conditioned to 1.05e-06
23M
23.2M
23.4M
23.6M
23.8M
24M
24.2M
24.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells EBV-transformed lymphocytes
CCDC126
0.52
0.39
enet
26
0.40
3.0e-14
-6.0
-6.0
1.9e-09
0.40
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Esophageal Carcinoma
TRA2A
0.18
0.02
blup
40
0.05
1.2e-02
-6.9
-5.7
1.4e-08
0.74
0.01
0.48
TRUE
2
GTEx
Esophagus Mucosa
CCDC126
0.12
0.03
lasso
7
0.01
4.3e-02
-5.7
5.9
4.3e-09
-0.79
0.01
0.96
FALSE
3
YFS
Blood
CCDC126
0.05
0.04
enet
10
0.05
1.6e-15
-6.2
-5.7
1.6e-08
0.51
1.00
0.00
FALSE