[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) :

chr9:126,844,856-128,824,378

Best TWAS P=1.49e-09 · Best GWAS P=1.38e-08 conditioned to 0.0181

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SCAI 0.04 0.00 enet 8 0.02 4.2e-03 1.1 -5.4 5.5e-08 -0.58 0.05 0.77 FALSE
2 GTEx Adipose Subcutaneous GOLGA1 0.04 0.05 lasso 1 0.05 8.6e-05 5.1 5.1 3.0e-07 0.96 0.07 0.91 FALSE
3 GTEx Adipose Subcutaneous SCAI 0.07 0.05 lasso 4 0.02 7.4e-03 5.7 -5.4 5.4e-08 -0.96 0.03 0.97 FALSE
4 GTEx Brain Caudate basal ganglia OLFML2A 0.12 0.10 lasso 4 0.03 3.7e-02 5.2 5.1 2.9e-07 0.96 0.06 0.76 FALSE
5 GTEx Brain Cerebellum ARPC5L 0.31 0.37 enet 7 0.27 1.5e-08 5.1 5.1 3.0e-07 0.97 0.09 0.91 FALSE
6 GTEx Brain Cerebellum PRPS1P2 0.09 0.08 enet 16 0.04 2.8e-02 -3.4 5.5 3.8e-08 0.67 0.06 0.72 FALSE
7 GTEx Esophagus Muscularis PPP6C 0.05 0.03 lasso 3 0.01 1.2e-01 5.1 -5.3 1.4e-07 -0.91 0.08 0.50 FALSE
8 GTEx Muscle Skeletal GOLGA1 0.07 0.02 lasso 4 0.02 2.2e-03 5.1 5.2 1.6e-07 0.93 0.06 0.90 FALSE
9 GTEx Nerve Tibial PRPS1P2 0.11 0.11 enet 9 0.10 1.4e-07 5.4 5.2 2.3e-07 0.72 0.05 0.95 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic PPP6C 0.08 0.06 lasso 4 0.05 7.8e-04 5.4 -5.4 8.1e-08 -0.74 0.04 0.92 FALSE
11 GTEx Skin Sun Exposed Lower leg PPP6C 0.11 0.10 lasso 5 0.09 9.1e-08 5.4 -5.2 1.9e-07 -0.69 0.03 0.97 FALSE
12 GTEx Skin Sun Exposed Lower leg RABEPK 0.07 0.05 lasso 4 0.05 6.3e-05 5.2 -5.3 1.5e-07 -0.75 0.04 0.96 FALSE
13 GTEx Skin Sun Exposed Lower leg GAPVD1 0.04 0.01 lasso 4 0.01 3.8e-02 3.7 -5.1 3.0e-07 -0.61 0.13 0.80 FALSE
14 GTEx Spleen PRPS1P2 0.18 0.02 lasso 4 0.04 3.9e-02 5.2 6.0 1.5e-09 0.64 0.07 0.42 TRUE
15 GTEx Testis PPP6C 0.10 0.03 enet 13 0.01 1.1e-01 4.1 -5.5 3.0e-08 -0.76 0.04 0.74 FALSE
16 GTEx Thyroid ARPC5L 0.18 0.12 enet 17 0.16 1.5e-12 5.7 5.7 9.4e-09 0.94 0.02 0.98 FALSE
17 METSIM Adipose ARPC5L 0.02 0.01 blup 270 0.02 1.5e-03 5.2 5.6 2.2e-08 0.90 0.04 0.91 FALSE
18 ROSMAP Brain Pre-frontal Cortex PPP6C 0.11 0.19 lasso 5 0.20 8.6e-26 5.4 -5.4 7.9e-08 -0.75 0.03 0.97 FALSE
19 ROSMAP Brain Pre-frontal Cortex GOLGA1 0.08 0.07 bslmm 281 0.07 2.3e-09 5.0 5.4 7.2e-08 0.91 0.05 0.95 FALSE
20 The Cancer Genome Atlas Breast Invasive Carcinoma PPP6C 0.03 0.03 lasso 5 0.03 7.3e-07 5.6 -5.1 2.8e-07 -0.68 0.01 0.99 FALSE
21 The Cancer Genome Atlas Breast Invasive Carcinoma RABEPK 0.02 0.02 lasso 2 0.02 1.4e-04 5.6 -5.6 2.5e-08 -0.74 0.00 0.99 FALSE
22 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PPP6C 0.05 0.06 lasso 3 0.05 1.1e-03 5.4 -5.3 1.1e-07 -0.70 0.01 0.90 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma SCAI 0.02 0.02 blup 94 0.01 2.1e-02 5.0 -5.5 3.6e-08 -0.94 0.05 0.76 FALSE
24 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PPP6C 0.17 0.06 enet 5 0.09 2.0e-04 5.4 -5.4 5.2e-08 -0.73 0.01 0.80 FALSE