[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr9:126,844,856-128,824,378

Best TWAS P=1.49e-09 · Best GWAS P=1.38e-08 conditioned to 0.0181

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Spleen	PRPS1P2	0.18	0.02	lasso	4	0.04	3.9e-02	5.2	6.0	1.5e-09	0.64	0.07	0.42	TRUE
16	GTEx	Thyroid	ARPC5L	0.18	0.12	enet	17	0.16	1.5e-12	5.7	5.7	9.4e-09	0.94	0.02	0.98	FALSE
17	METSIM	Adipose	ARPC5L	0.02	0.01	blup	270	0.02	1.5e-03	5.2	5.6	2.2e-08	0.90	0.04	0.91	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	RABEPK	0.02	0.02	lasso	2	0.02	1.4e-04	5.6	-5.6	2.5e-08	-0.74	0.00	0.99	FALSE
15	GTEx	Testis	PPP6C	0.10	0.03	enet	13	0.01	1.1e-01	4.1	-5.5	3.0e-08	-0.76	0.04	0.74	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAI	0.02	0.02	blup	94	0.01	2.1e-02	5.0	-5.5	3.6e-08	-0.94	0.05	0.76	FALSE
6	GTEx	Brain Cerebellum	PRPS1P2	0.09	0.08	enet	16	0.04	2.8e-02	-3.4	5.5	3.8e-08	0.67	0.06	0.72	FALSE
24	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PPP6C	0.17	0.06	enet	5	0.09	2.0e-04	5.4	-5.4	5.2e-08	-0.73	0.01	0.80	FALSE
3	GTEx	Adipose Subcutaneous	SCAI	0.07	0.05	lasso	4	0.02	7.4e-03	5.7	-5.4	5.4e-08	-0.96	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SCAI	0.04	0.00	enet	8	0.02	4.2e-03	1.1	-5.4	5.5e-08	-0.58	0.05	0.77	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	GOLGA1	0.08	0.07	bslmm	281	0.07	2.3e-09	5.0	5.4	7.2e-08	0.91	0.05	0.95	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	PPP6C	0.11	0.19	lasso	5	0.20	8.6e-26	5.4	-5.4	7.9e-08	-0.75	0.03	0.97	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	PPP6C	0.08	0.06	lasso	4	0.05	7.8e-04	5.4	-5.4	8.1e-08	-0.74	0.04	0.92	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PPP6C	0.05	0.06	lasso	3	0.05	1.1e-03	5.4	-5.3	1.1e-07	-0.70	0.01	0.90	FALSE
7	GTEx	Esophagus Muscularis	PPP6C	0.05	0.03	lasso	3	0.01	1.2e-01	5.1	-5.3	1.4e-07	-0.91	0.08	0.50	FALSE
12	GTEx	Skin Sun Exposed Lower leg	RABEPK	0.07	0.05	lasso	4	0.05	6.3e-05	5.2	-5.3	1.5e-07	-0.75	0.04	0.96	FALSE
8	GTEx	Muscle Skeletal	GOLGA1	0.07	0.02	lasso	4	0.02	2.2e-03	5.1	5.2	1.6e-07	0.93	0.06	0.90	FALSE
11	GTEx	Skin Sun Exposed Lower leg	PPP6C	0.11	0.10	lasso	5	0.09	9.1e-08	5.4	-5.2	1.9e-07	-0.69	0.03	0.97	FALSE
9	GTEx	Nerve Tibial	PRPS1P2	0.11	0.11	enet	9	0.10	1.4e-07	5.4	5.2	2.3e-07	0.72	0.05	0.95	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP6C	0.03	0.03	lasso	5	0.03	7.3e-07	5.6	-5.1	2.8e-07	-0.68	0.01	0.99	FALSE
4	GTEx	Brain Caudate basal ganglia	OLFML2A	0.12	0.10	lasso	4	0.03	3.7e-02	5.2	5.1	2.9e-07	0.96	0.06	0.76	FALSE
2	GTEx	Adipose Subcutaneous	GOLGA1	0.04	0.05	lasso	1	0.05	8.6e-05	5.1	5.1	3.0e-07	0.96	0.07	0.91	FALSE
5	GTEx	Brain Cerebellum	ARPC5L	0.31	0.37	enet	7	0.27	1.5e-08	5.1	5.1	3.0e-07	0.97	0.09	0.91	FALSE
13	GTEx	Skin Sun Exposed Lower leg	GAPVD1	0.04	0.01	lasso	4	0.01	3.8e-02	3.7	-5.1	3.0e-07	-0.61	0.13	0.80	FALSE