Hub : Genes

ARPC5L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2140	0.0760	1.3e-05	0.337	NA	0.310	NA	0.319	1.8e-09	NA	1.1e-08	NA	6.1e-09
2	GTEx	Brain Cerebellum	0.3060	0.0860	9.5e-09	0.369	NA	0.269	NA	0.043	7.7e-12	NA	1.5e-08	NA	2.1e-02
3	GTEx	Skin Sun Exposed Lower leg	0.1060	0.0460	4.0e-04	0.024	NA	0.008	NA	0.019	4.1e-03	NA	6.9e-02	NA	8.8e-03
4	GTEx	Thyroid	0.1770	0.0550	2.8e-11	0.123	NA	0.164	NA	0.161	1.2e-09	NA	1.5e-12	NA	2.4e-12
5	METSIM	Adipose	0.0197	0.0111	4.3e-03	0.011	0.016	0.014	NA	0.015	6.8e-03	1.5e-03	3.2e-03	NA	2.0e-03
6	YFS	Blood	0.0526	0.0294	1.7e-02	0.003	-0.001	0.007	NA	0.003	2.0e-02	9.0e-01	1.4e-03	NA	3.2e-02
7	TCGA	Brain Lower Grade Glioma	0.1149	0.0513	1.1e-11	0.078	0.111	0.103	NA	0.100	3.5e-09	1.3e-12	9.7e-12	NA	2.1e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	1.2	-0.9	0.9	0.0	1.0	1.0	-1.1	-0.3
Bipolar Disorder or Schizophrenia	0.7	1.7	2.8	-1.5	1.6	1.7	1.5	1.0	-0.8	0.5
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	-0.1	0.1	0.0	-1.0	0.0	0.5	0.8
Depression (Nagel 2018)	1.6	2.3	4.7	1.6	-1.5	0.0	-2.2	-1.9	1.7	-0.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.1	-1.0	1.1	0.0	1.0	0.9	-1.5	0.9
Neuroticism (Nagel 2018)	0.8	2.0	5.3	0.2	-0.3	0.0	-2.3	-1.3	2.0	1.6
Schizophrenia (2018)	0.4	0.8	1.8	-1.2	1.3	0.0	1.1	0.4	-0.0	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	0.5	-0.7	-0.6	-0.8	-1.0	0.9	-0.0
Worry (Nagel 2018)	1.6	3.4	8.4	1.0	-1.3	0.0	-2.4	-2.3	2.9	1.4
Alzheimer’s Disease (in mother)	1.6	1.9	3.7	1.6	-1.7	0.0	-1.7	-1.9	-0.1	-1.3
Alzheimer’s Disease (in father)	1.5	1.6	4.3	-1.4	1.2	0.0	1.9	2.1	-0.0	0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	0.9	-0.9	0.0	-1.0	-0.5	0.5	-0.8
Crohns Disease (2017)	0.1	0.3	0.9	-0.6	0.6	0.1	0.4	0.2	-1.0	0.0
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.8	0.8	0.6	0.8	0.6	-1.5	0.1
Ulcerative Colitis (UC)	0.4	0.8	2.3	-0.7	0.7	0.8	0.9	0.8	-1.5	-0.0
Major Depression (MDD)	4.6	5.6	10.2	2.7	-2.9	0.0	-3.2	-2.9	-0.3	-2.1
Reaction Time	0.0	0.1	0.3	0.2	-0.0	-0.0	0.2	0.4	-0.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	-0.8	0.9	0.7	0.7	0.6	-0.1	1.3
Breast Cancer	0.0	0.1	0.2	-0.3	0.2	0.0	-0.3	0.5	0.2	0.4
Ovarian Cancer	1.9	2.5	3.6	-1.8	1.6	1.9	1.4	1.9	-0.3	1.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.8	4.1	5.6	-2.0	2.2	2.3	2.4	2.2	-0.3	2.0
Bipolar Disorder (2011)	1.1	1.0	2.1	-1.4	1.4	0.0	1.4	1.0	0.0	0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.2	0.2	0.0	0.6	0.3	0.1	0.2
Coronary Artery Disease (CAD)	0.3	0.3	0.8	-0.3	0.7	0.0	0.9	-0.5	0.0	0.8
Crohns Disease (2012)	1.1	1.7	2.6	-1.6	1.6	1.4	1.4	1.1	-1.0	0.8
Mean Putamen Volume	2.8	3.3	4.7	2.0	-2.0	-2.0	-1.8	-2.2	0.5	-1.7
Fasting Glucose	1.6	1.9	4.2	1.4	-1.4	-2.0	-0.9	-1.4	0.3	-1.5
HbA1C	1.9	2.1	3.8	1.9	-1.9	0.0	-1.3	-1.6	-0.0	-1.7
HDL Cholesterol	0.1	0.2	1.6	0.2	0.3	0.0	0.1	0.1	-1.3	-0.2
LDL Cholesterol	0.1	0.2	0.4	0.2	-0.3	0.0	-0.6	-0.4	-0.6	-0.2
Lupus	1.1	1.6	4.3	1.1	-1.1	-0.9	-0.9	-1.7	-0.2	-2.1
Neuroticism (2016)	1.7	2.4	7.9	1.5	-1.5	0.0	-2.8	-1.7	1.3	0.1
Primary Biliary Cirrhosis	0.6	0.9	4.7	0.5	-0.3	0.0	-0.1	-0.6	-2.2	-0.9
Rheumatoid Arthritis	0.8	1.1	2.5	-1.3	1.3	0.0	0.9	0.9	-1.6	0.7
Schizophrenia (2014)	0.4	1.0	2.2	-1.4	1.5	0.0	0.9	0.3	-0.8	1.0
Triglycerides	0.5	0.8	1.4	0.9	-1.0	0.0	-1.2	-0.9	0.6	-1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.5	0.5	0.0	0.7	-0.2	-0.6	-0.5
Ulcerative Colitis	0.3	0.4	2.5	-0.1	-0.1	-0.2	0.2	0.1	-1.6	-0.5
Blood Eosinophil Count	0.2	1.7	2.9	-1.1	1.0	1.2	1.7	1.6	-1.5	-0.8
Blood Platelet Count	0.1	1.5	3.3	-1.2	1.2	1.0	1.8	1.6	-0.8	-0.5
Blood Red Count	0.1	1.3	4.4	0.4	-0.9	-0.9	-1.4	0.1	2.1	1.0
Blood White Count	0.1	1.1	3.5	-0.6	0.4	0.4	1.0	1.1	-1.0	-1.9
Heel T-Score	0.4	2.8	4.2	-1.9	2.0	1.6	2.0	1.9	0.3	1.3
BMI	0.2	1.0	3.3	-0.5	0.4	0.2	1.8	0.9	-1.4	-1.0
Height	0.7	12.5	24.0	-3.9	3.9	3.6	4.9	4.2	0.7	1.1
Waist Hip Ratio (WHR)	1.8	8.0	17.3	2.9	-2.7	-2.5	-4.2	-3.6	0.7	-1.7
Systolic Blood Pressure	0.7	3.3	9.5	-0.7	0.4	-0.4	2.4	1.2	-2.4	-3.1
Smoking Status	7.0	16.7	32.7	3.8	-3.8	-4.0	-5.7	-5.3	2.9	-1.4
Allergy or Eczema	0.3	0.7	2.0	0.1	0.1	0.7	1.0	1.4	-0.9	-0.9
Cardiovascular Disease	1.0	3.2	15.1	1.2	-1.0	-1.1	0.2	-0.6	-1.7	-3.9
Hypothyroidism (self reported)	0.7	1.6	2.4	-1.3	1.4	1.4	1.4	1.6	-0.3	1.0
Respiratory disease	0.6	1.3	2.8	1.6	-1.4	-0.7	-0.9	-0.6	-0.3	-1.7
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.1	-2.3	2.2	1.9	2.1	1.3	-0.1	1.5
Lung FEV1/FVC ratio	1.0	5.3	11.2	-2.1	2.2	2.2	2.6	1.2	-3.3	1.8
Lung FVC	1.8	9.1	14.7	-3.2	3.4	2.8	3.4	3.8	-1.2	2.7
Neuroticism	2.7	6.4	14.0	1.9	-2.1	-2.0	-3.7	-2.9	3.2	0.5
Chronotype (morning person)	1.0	2.3	3.7	-1.4	1.5	1.9	1.7	0.8	-1.8	1.1
Hair Pigment	0.0	1.3	3.9	-0.7	0.9	1.0	0.1	0.4	2.0	1.8
Tanning	0.3	3.9	5.9	1.9	-2.1	-2.3	-2.4	-1.7	1.5	-1.8
Hand grip strength (left)	8.7	22.9	31.7	-5.5	5.6	5.2	5.2	5.2	-2.3	3.6
Number of treatments/medications taken	5.6	10.1	16.4	3.3	-3.4	-3.2	-2.7	-3.5	-1.5	-4.0
Average weekly spirits intake	0.5	0.6	1.2	0.9	-0.8	-1.1	-0.8	-0.4	0.8	-0.3
Sensitivity / hurt feelings	1.3	2.2	7.1	1.1	-1.2	-0.8	-2.7	-2.0	0.9	-0.5
Frequency of depressed mood in last 2 weeks	2.5	3.6	5.2	1.9	-1.9	-1.7	-2.3	-2.3	1.9	-1.0
Hearing difficulty/problems: Yes	1.2	1.8	3.1	1.3	-1.4	-1.2	-1.5	-1.8	1.2	-0.9
Relative age of first facial hair	0.6	1.2	3.1	0.8	-1.0	-0.9	-1.8	-1.4	0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	7.5	9.8	14.5	3.8	-3.6	-3.2	-3.4	-3.0	0.0	-3.1
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.8	1.5	-1.4	-1.7	-1.8	-2.2	0.1	-1.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	0.2	-0.1	-0.7	-0.6	-0.3	-0.0	-0.1
Systolic blood pressure, automated reading	0.8	2.3	8.5	-1.2	1.0	0.5	2.9	1.2	-1.5	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	0.3	-0.3	-0.4	0.4	-0.6	-0.9	-1.1
Angina	1.6	2.1	4.0	1.5	-1.5	-1.1	-1.2	-2.0	-1.2	-1.4
Medication for hormone replacement therapy	1.5	1.6	3.5	1.1	-1.3	-1.0	-1.7	-1.9	0.3	-1.0
Vitamin and mineral supplements	0.6	0.8	2.3	0.2	-0.3	-0.5	-0.9	0.2	1.4	1.5
Supplements: Zinc	0.9	1.0	3.5	0.8	-0.8	-1.3	-0.1	-0.9	-0.1	-1.9
Medication: Co-codamol	2.0	2.3	3.6	1.1	-1.5	-1.9	-1.6	-1.9	0.3	-1.8
Medication: Metformin	3.3	4.6	7.3	-2.7	2.7	2.4	2.7	1.7	-0.7	1.3
Diabetes (father)	0.7	0.9	1.4	-1.2	1.1	1.1	0.8	0.3	-0.7	1.0
Diabetes (mother)	0.9	1.2	2.7	-1.6	1.2	0.7	1.4	1.0	-0.1	0.6
Severe depression (siblings)	0.4	0.4	1.3	0.4	-0.2	0.0	-0.2	-0.7	-1.1	-0.9
Pack years adult smoking proportion	3.3	5.0	7.5	2.5	-2.4	-1.8	-2.7	-2.2	2.5	-1.3
Impedance of leg (right)	1.3	6.5	15.4	2.3	-2.4	-2.3	-3.9	-3.4	1.4	0.2
Leg fat-free mass (left)	1.6	8.4	21.8	-2.9	3.0	2.5	4.7	3.6	-0.8	0.1
Trunk fat percentage	0.1	0.5	1.6	0.5	-0.5	-1.3	-0.2	-0.8	0.1	-0.6
Hand grip strength (right)	7.8	21.3	30.0	-5.2	5.3	4.7	5.5	5.3	-2.2	2.9
Townsend deprivation index at recruitment	6.7	9.4	12.7	3.6	-3.6	-3.0	-3.5	-3.2	0.8	-3.0
Current tobacco smoking	8.5	14.0	26.1	3.7	-3.7	-3.3	-5.1	-4.3	3.4	-1.7
Average weekly fortified wine intake	1.1	1.3	2.0	1.3	-1.3	-1.1	-1.4	-0.9	1.1	-0.6
Maternal smoking around birth	0.5	0.7	3.5	0.0	-0.1	-0.1	-0.7	-0.3	1.9	1.0
Fed-up feelings	0.0	0.0	0.1	-0.0	0.0	-0.0	-0.2	-0.2	0.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	4.9	6.5	8.9	2.7	-2.7	-2.2	-3.0	-2.9	2.1	-1.8
Relative age voice broke	1.5	2.2	3.6	1.5	-1.7	-1.6	-1.7	-1.9	-0.2	-1.3
Taking other prescription medications	2.7	4.1	5.7	2.3	-2.3	-2.4	-2.1	-1.5	-0.1	-2.4
Age when periods started (menarche)	3.4	8.2	10.9	2.9	-3.1	-3.2	-2.9	-3.3	1.3	-3.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.6	0.8	0.8	0.4	1.0	-0.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	0.8	-0.7	-0.9	-0.9	-0.7	1.3	-0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	0.8	-0.9	-0.7	-0.7	-1.0	-0.9	-1.4
Qualifications: CSEs or equivalent	0.9	1.2	2.6	1.1	-1.1	-1.0	-0.8	-0.6	1.2	-1.6
Serious illness, injury or assault to yourself	2.0	2.4	3.6	1.8	-1.7	-1.3	-1.2	-1.9	0.9	-1.9
High blood pressure	0.8	2.3	10.9	0.8	-0.6	-0.3	1.0	-0.2	-1.7	-3.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.1	-0.5	0.7	0.9	1.3	2.3	-0.6	0.1
Multivitamins +/- minerals	1.3	1.7	2.9	-1.2	1.2	1.6	1.7	0.7	-1.7	-0.5
Stomach or abdominal pain in last month	4.4	5.5	8.7	2.4	-2.5	-3.0	-2.3	-2.3	2.1	-1.8
Supplements: Glucosamine	0.3	0.4	0.8	-0.5	0.6	-0.2	0.7	0.2	-0.8	0.9
Diverticular disease/diverticulitis (self-reported)	4.4	5.2	8.3	2.3	-2.5	-2.8	-2.5	-2.9	1.1	-1.3
Medication: Atenolol	1.3	1.7	4.8	1.2	-1.5	-0.9	-1.1	-2.2	-0.3	-0.9
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.5	0.3	0.9	0.5	0.7	0.8	0.4
Sitting height	1.1	7.5	16.1	-2.9	2.9	2.4	4.0	3.5	-1.0	0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	2.8	0.3	-0.3	-0.8	-0.4	-0.0	1.7	0.2
High blood pressure (mother)	1.2	1.7	7.6	1.2	-1.2	-0.8	0.1	-0.7	0.3	-2.8
Body mass index (BMI)	0.1	0.5	2.0	-0.3	0.2	-0.3	1.4	0.7	-0.6	-0.7
Impedance of leg (left)	1.4	6.7	17.5	2.4	-2.4	-2.3	-4.2	-3.4	1.0	0.3
Leg predicted mass (left)	1.6	8.6	22.3	-2.9	3.1	2.5	4.7	3.6	-0.8	0.1
Trunk fat mass	0.1	0.3	1.2	-0.3	0.3	-0.4	1.1	0.2	-0.2	-0.5
Waist circumference	0.1	0.3	1.0	0.4	-0.2	-0.7	0.3	-0.3	-0.4	-1.0
Number of incorrect matches in round	0.2	0.3	1.0	-0.0	-0.1	0.0	-0.8	-1.0	0.1	0.4
Past tobacco smoking	3.0	5.6	11.8	-2.2	2.2	2.3	3.0	3.4	-0.8	1.6
Alcohol usually taken with meals	1.9	3.0	6.9	-1.8	1.9	1.4	2.1	2.6	-0.6	0.8
Nervous feelings	2.6	4.8	11.0	1.5	-1.5	-1.6	-3.2	-2.2	3.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	5.6	2.1	-2.1	-1.8	-2.4	-2.1	1.9	-1.5
Hearing difficulty/problems with background noise	0.7	1.2	3.3	1.1	-1.0	-0.7	-0.8	-1.2	1.8	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.3	-1.1	1.1	1.0	0.9	1.1	-0.6	0.4
Had menopause	0.5	0.6	1.8	0.4	-0.5	-1.4	-1.2	-0.2	0.8	-0.1
Had other major operations	1.5	1.9	2.6	1.6	-1.5	-1.4	-1.4	-1.3	1.0	-1.3
Forced vital capacity (FVC)	4.2	16.1	25.9	-4.4	4.5	3.7	4.8	5.1	-1.0	3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.5	-0.1	-0.0	0.0	-0.1	-0.1	0.7	-0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.2	1.4	-1.3	-1.5	-1.0	-0.9	0.5	-1.3
Qualifications: None of the above	5.8	12.5	18.3	3.9	-4.1	-4.3	-3.9	-3.7	1.5	-2.4
Financial difficulties in last 2 years	3.7	5.0	7.6	2.8	-2.4	-2.2	-2.7	-2.0	1.9	-1.3
Mouth/teeth dental problems	2.4	3.6	5.4	-2.1	2.1	1.0	1.9	2.2	-1.4	2.3
Heart attack	2.1	2.7	4.0	1.9	-1.9	-1.5	-2.0	-1.9	0.9	-1.1
Allergy	0.3	0.8	1.6	-1.3	1.2	0.6	0.5	-0.3	0.2	1.1
Pain all over the body in last month	2.2	2.4	4.5	1.4	-1.6	-1.6	-1.8	-1.4	2.1	-0.2
Diabetes (self-reported)	0.9	1.4	2.8	-1.7	1.5	1.5	1.3	0.4	-0.7	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	0.4	-0.2	0.1	0.8	1.1	-1.0	-1.0
Medication: Ramipril	0.3	0.3	0.8	-0.4	0.3	-0.3	0.6	0.4	-0.9	-0.8
Medication: Simvastatin	2.1	3.0	6.2	1.5	-1.5	-1.7	-1.4	-1.6	-1.8	-2.5
Fluid intelligence score	0.2	0.4	1.2	-0.5	0.6	0.4	0.2	1.0	0.1	1.1
Illnesses of siblings	1.9	2.7	5.0	-1.8	1.8	1.8	1.0	1.7	0.7	2.2
Neuroticism score	2.5	5.2	10.7	2.0	-2.2	-1.8	-3.3	-2.8	2.3	-0.4
Weight	0.6	2.9	9.5	-1.6	1.7	1.1	3.1	2.1	-0.5	-0.1
Impedance of arm (right)	0.5	2.5	6.1	0.1	-0.1	-0.6	-1.9	-1.6	2.5	2.3
Arm fat percentage (right)	0.0	0.2	0.7	-0.1	-0.1	-0.8	0.5	-0.3	0.5	-0.2
Trunk fat-free mass	1.7	9.7	24.8	-3.0	3.2	2.9	5.0	3.8	-1.2	0.1
Hip circumference	0.9	3.7	10.6	-2.0	2.0	1.3	3.3	2.3	-0.6	0.5
Time employed in main current job	0.7	0.8	1.7	-1.2	0.9	0.7	0.4	1.3	-0.3	1.1
Alcohol intake versus 10 years previously	2.2	3.3	6.5	-2.1	1.9	1.9	2.5	1.5	-1.2	0.9
Father’s age at death	0.1	0.1	0.4	0.4	-0.2	-0.1	0.3	-0.0	-0.2	-0.6
Worrier / anxious feelings	0.6	1.2	2.7	0.6	-0.3	-0.4	-1.5	-1.3	1.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	6.1	9.9	13.6	3.6	-3.6	-2.8	-3.4	-3.7	2.8	-1.7
Falls in the last year	2.3	3.1	4.8	1.9	-1.9	-1.3	-2.2	-2.1	1.5	-1.3
Hair/balding pattern: Pattern 3	0.3	0.5	2.5	0.3	-0.1	-0.3	0.2	0.2	-1.6	-0.8
Number of live births	0.1	0.2	0.5	0.6	-0.3	0.0	0.1	-0.7	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	6.6	22.1	33.0	-5.0	5.1	4.6	5.7	5.6	-2.1	3.7
Pulse rate	1.4	2.4	5.3	-1.4	1.4	1.8	2.3	1.4	-1.4	0.0
Happiness	0.8	1.0	1.8	1.4	-1.2	-0.9	-1.3	-0.9	0.1	-0.6
Noisy workplace	2.3	2.8	4.5	1.8	-1.8	-1.7	-1.6	-1.8	-0.3	-2.1
Qualifications: A levels/AS levels or equivalent	2.4	5.4	7.4	-2.6	2.7	2.2	2.7	2.3	-2.3	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.1	0.2	0.7	0.1	0.6	-0.4	-0.6
Mouth/teeth dental problems: Dentures	4.1	6.9	11.1	2.9	-3.0	-2.2	-2.8	-2.7	0.2	-3.3
Asthma	0.5	0.9	2.1	1.4	-1.3	-0.8	-0.8	-0.4	-0.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.5	6.6	2.6	-2.5	-2.0	-2.1	-2.5	-0.5	-2.0
Medication: Cholesterol lowering	3.8	6.0	8.3	2.2	-2.2	-2.1	-1.8	-2.8	-2.8	-2.9
Depression (self-reported)	1.1	1.3	2.0	1.0	-1.2	-0.5	-1.3	-1.4	1.0	-1.3
Medication: Lansoprazole	1.0	1.1	1.8	0.8	-0.9	-1.3	-1.3	-1.0	-0.8	-1.1
Prospective memory result	0.2	0.3	0.6	-0.4	0.6	0.7	0.2	0.2	-0.5	0.8
Lung cancer (father)	0.8	1.0	1.8	1.2	-1.0	-0.7	-1.4	-1.2	-0.1	-0.7
Illnesses of mother	0.2	0.2	0.4	-0.4	0.4	0.1	0.5	0.4	-0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.5	17.8	-3.7	3.9	3.7	4.2	3.7	-2.6	2.6
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	0.8	-0.7	-0.9	-0.0	-0.9	1.1	-1.2
Impedance of arm (left)	0.5	2.2	5.1	0.5	-0.5	-1.0	-2.2	-1.5	2.3	1.5
Arm fat mass (right)	0.2	0.7	3.1	-0.8	0.8	0.0	1.8	0.9	0.1	-0.1
Trunk predicted mass	1.7	9.9	25.3	-3.0	3.2	2.9	5.0	3.8	-1.2	0.1
Standing height	0.9	9.1	17.6	-3.3	3.5	3.2	4.2	3.4	0.0	1.3
Length of working week for main job	0.2	0.3	0.7	-0.5	0.4	0.5	0.2	0.6	-0.8	-0.1
Exposure to tobacco smoke at home	2.5	2.8	4.5	2.1	-1.9	-1.7	-2.1	-1.9	-0.1	-1.1
Breastfed as a baby	0.8	1.0	2.2	-1.4	1.5	0.9	0.9	1.0	-0.4	0.3
Tense / ‘highly strung’	2.6	4.3	6.3	1.9	-2.2	-2.3	-2.5	-2.3	2.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	3.7	1.8	-1.5	-1.5	-1.9	-1.9	1.5	-1.7
Hair/balding pattern: Pattern 4	0.6	1.5	4.3	1.3	-1.2	-1.1	-1.1	-2.1	-0.6	-0.1
Birth weight of first child	0.3	0.6	1.3	-0.6	0.9	1.1	0.9	0.1	-0.8	-0.1
Peak expiratory flow (PEF)	7.4	17.2	26.2	-4.3	4.4	3.9	5.1	5.0	-2.3	3.2
Pulse wave reflection index	1.1	1.4	2.0	1.3	-1.2	-1.4	-1.3	-1.4	0.5	-0.9
Ever highly irritable/argumentative for 2 days	6.9	8.3	11.7	3.4	-3.4	-3.2	-3.0	-2.6	1.7	-2.4
Loud music exposure frequency	4.5	5.0	6.9	2.5	-2.6	-1.8	-2.4	-2.5	-0.7	-2.4
Qualifications: O levels/GCSEs or equivalent	3.8	6.1	9.2	-2.5	2.7	2.7	3.0	2.8	-2.0	0.9
Mouth/teeth dental problems: Bleeding gums	2.6	3.4	6.0	-1.7	1.9	2.5	1.9	2.0	0.3	1.8
Blood clot in the leg (DVT)	0.5	0.6	1.6	0.8	-0.8	-0.6	-0.9	-1.3	0.4	0.3
Medication: Paracetamol	3.4	5.7	9.1	3.0	-2.8	-2.2	-2.6	-2.8	1.3	-1.5
Headache pain in last month	3.7	6.4	11.3	2.7	-2.8	-1.8	-2.6	-3.4	-0.3	-2.8
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	7.0	-1.4	1.4	1.5	0.5	1.5	2.3	2.6
Glaucoma (self-reported)	0.3	0.3	0.8	0.1	-0.4	-0.6	-0.2	-0.9	0.5	-0.7
Gout (self-reported)	0.8	1.1	2.8	1.0	-1.1	-0.8	-1.2	-0.9	0.2	-1.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	-1.0	0.9	1.2	1.2	1.3	0.2	0.7
Medication: Amlodipine	0.3	0.4	1.5	0.0	-0.1	-0.0	0.9	-0.1	-0.7	-1.2
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.0	1.2	-1.0	-1.0	-0.9	-1.1	-0.6	-1.4
Birth weight	0.1	0.2	0.8	-0.3	0.3	-0.4	0.2	-0.1	0.9	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.8	-0.1	0.0	0.0	-0.3	0.1	0.9	0.5
High blood pressure (siblings)	1.5	2.2	6.6	1.5	-1.4	-1.3	-0.5	-1.0	-1.2	-2.6
Forced vital capacity (FVC), Best measure	2.5	9.1	13.2	-3.2	3.4	3.1	3.6	3.4	-1.3	2.3
Body fat percentage	0.2	0.7	2.3	0.7	-0.8	-1.5	-0.4	-0.9	0.1	-0.7
Leg fat percentage (right)	0.5	1.8	3.6	1.4	-1.5	-1.9	-1.0	-1.5	-0.2	-1.1
Arm fat-free mass (right)	1.3	6.4	17.3	-2.3	2.4	2.1	4.2	3.2	-1.4	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	1.0	0.6	-0.2	-0.7	-0.8	-0.5	1.0	-0.4
Comparative body size at age 10	0.6	1.7	4.5	-1.2	1.5	1.1	0.7	1.4	-0.1	2.1
Number of full brothers	2.0	2.5	4.2	1.7	-1.7	-1.8	-1.4	-2.1	0.8	-1.2
Worry too long after embarrassment	1.2	2.0	5.4	-0.3	0.2	0.5	-1.4	-1.2	2.1	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	5.3	6.9	12.3	2.6	-2.6	-2.4	-3.5	-2.6	1.8	-2.4
Wheeze or whistling in the chest in last year	5.7	10.2	14.2	3.6	-3.7	-3.1	-2.8	-3.8	0.3	-3.7
Number of children fathered	0.8	0.9	2.4	0.8	-0.5	-1.0	-0.5	-0.3	-1.5	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	4.6	-0.9	1.2	1.0	0.7	1.6	1.5	2.1
Age at first live birth	3.1	5.5	8.7	-2.2	2.4	2.9	2.4	2.6	1.0	2.4
Pulse wave peak to peak time	0.8	1.0	2.2	-1.0	0.9	0.9	0.2	1.2	-0.7	1.5
Health satisfaction	2.7	3.5	5.8	2.1	-1.9	-1.8	-2.1	-1.4	-1.1	-2.4
Shortness of breath walking on level ground	1.0	1.1	4.7	0.3	-0.1	-0.1	0.6	0.5	-2.2	-1.6
Qualifications: College or University degree	2.2	7.0	11.3	-2.7	3.0	2.9	3.2	3.4	-1.0	1.3
Eye problems/disorders: None of the above	0.3	0.4	1.4	-0.1	-0.0	0.5	-0.6	0.6	1.2	0.5
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.1	1.4	-1.4	-1.4	-1.7	-1.8	0.4	-1.3
Emphysema/chronic bronchitis	2.0	2.2	3.7	1.3	-1.5	-1.4	-1.9	-1.7	-0.3	-1.7
Medication for pain relief, constipation, heartburn	5.6	9.6	13.6	-3.7	3.6	3.0	3.5	3.5	-0.3	2.6
Neck or shoulder pain in last month	3.7	5.3	7.3	2.7	-2.6	-2.0	-2.5	-2.4	0.1	-2.7
Medication: Blood pressure	0.7	1.3	4.2	0.3	-0.3	-0.2	1.0	-0.4	-2.0	-1.9
Angina (self-reported)	2.0	2.6	4.5	1.7	-1.7	-1.3	-1.2	-2.1	-1.4	-1.8
Migraine (self-reported)	0.9	1.1	3.2	0.8	-0.7	-0.2	-1.3	-0.6	-1.8	-1.3
Medication: Ibuprofen	3.0	3.6	5.8	2.4	-2.1	-1.8	-1.4	-1.7	-1.1	-2.3
Medication: Allopurinol	1.4	1.8	3.3	1.3	-1.5	-1.3	-1.6	-1.1	0.4	-1.8
Medication: Omeprazole	2.5	3.0	6.6	1.9	-1.9	-2.6	-1.6	-1.5	1.3	-0.7
Medication: Seretide 50 evohaler	0.2	0.2	1.0	0.3	0.1	0.2	0.1	1.0	0.2	0.2
Mean time to correctly identify matches	0.0	0.0	0.2	0.0	0.0	0.0	0.3	0.1	0.0	-0.4
Heart disease (mother)	0.1	0.1	0.2	-0.5	0.3	0.2	-0.3	0.2	0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	-0.7	0.6	0.9	0.7	1.1	0.5	0.8
Whole body fat mass	0.1	0.3	1.5	-0.4	0.4	-0.4	1.2	0.3	-0.1	-0.4
Leg fat mass (right)	0.1	0.3	0.6	0.1	-0.2	-0.7	0.8	-0.2	-0.3	-0.8
Arm predicted mass (right)	1.1	5.7	15.5	-2.0	2.1	1.8	3.9	3.0	-1.6	-0.8
Pulse rate, automated reading	1.4	4.6	11.6	-2.3	2.1	2.4	3.4	1.6	-1.8	-0.4
Alcohol intake frequency.	0.3	0.6	2.6	0.1	-0.4	0.2	0.1	-0.2	-1.6	-1.2
Comparative height size at age 10	0.5	2.6	5.2	-1.9	1.9	1.6	2.3	1.6	0.6	0.7
Number of full sisters	1.7	2.1	3.0	1.6	-1.5	-1.7	-1.7	-1.5	1.1	-0.5
Suffer from ‘nerves’	1.9	3.0	10.1	1.0	-1.3	-1.2	-1.9	-1.8	3.2	0.7
Overall health rating	9.6	20.6	29.0	5.0	-5.2	-4.7	-5.4	-4.9	0.8	-4.0
Chest pain or discomfort	6.3	9.1	14.7	3.4	-3.5	-2.8	-3.8	-3.1	1.6	-2.3
Had major operations	1.3	1.5	4.5	1.3	-1.2	-1.4	-0.3	-0.7	0.6	-2.1
Age at last live birth	1.6	2.4	4.3	-1.4	1.6	1.5	2.1	1.4	0.8	1.7
Family relationship satisfaction	1.0	1.2	1.6	-1.1	1.3	0.8	1.2	1.2	-0.7	1.2
Leg pain on walking	0.3	0.3	1.0	0.6	-0.6	-0.2	-0.6	-0.4	1.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.8	0.9	-1.1	-0.9	-1.1	-1.7	-0.1	-1.6
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.2	0.1	0.0	-0.0	0.1	-0.2	-0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	4.0	-0.4	0.4	0.3	0.8	-0.5	-2.0	-0.1
Medication: Aspirin	0.8	1.1	1.8	1.0	-1.0	-0.6	-1.1	-1.3	-1.1	-1.1
Supplements: Vitamin C	0.8	1.0	2.9	0.8	-0.8	-0.7	-0.0	-0.9	-1.1	-1.7
Knee pain experienced in last month	1.6	2.5	4.6	1.7	-1.7	-1.5	-1.8	-1.4	0.1	-2.1
Hypertension (Self-reported)	0.9	2.4	11.0	0.9	-0.7	-0.5	1.1	-0.3	-1.7	-3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	7.5	1.4	-1.7	-2.7	-1.6	-1.5	0.6	-1.1
Illnesses of father: Heart disease	0.8	1.1	2.0	-1.2	1.1	0.9	1.1	0.9	-0.3	1.4
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.3	0.2	-0.6	0.3	-0.1	-0.0	-0.4
Smoking status: Previous	0.4	0.6	2.5	0.4	-0.4	-0.7	-0.8	-1.6	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.6	-0.7	0.7	0.6	0.1	0.3	1.2	0.8
Whole body fat-free mass	1.7	9.5	24.6	-3.0	3.2	2.8	5.0	3.7	-1.1	0.0
Leg fat-free mass (right)	1.9	10.1	23.9	-3.2	3.4	2.9	4.9	3.9	-1.0	0.4
Arm fat percentage (left)	0.1	0.2	0.8	-0.1	-0.1	-0.9	0.6	-0.1	0.3	-0.5
Average weekly red wine intake	1.2	1.7	2.8	-1.6	1.5	1.5	1.7	1.4	0.3	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.7	-0.4	-0.8	-0.8	-0.6	-0.2	-0.6
Mood swings	0.8	1.4	3.7	0.9	-0.8	-1.2	-1.4	-0.9	1.9	-0.5
Loneliness, isolation	0.8	1.1	2.1	1.2	-1.2	-0.4	-0.9	-1.0	-0.6	-1.5
Long-standing illness, disability or infirmity	3.5	5.3	8.1	2.5	-2.6	-2.2	-2.8	-2.9	0.7	-1.7
Ever had bowel cancer screening	3.1	3.6	6.1	2.0	-2.0	-2.0	-1.7	-2.5	1.5	-1.3
Diabetes diagnosed by doctor	0.6	1.0	1.9	-1.4	1.2	1.3	1.0	0.2	-0.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	0.9	-0.8	-0.7	-0.6	-1.0	0.2	-0.9
Friendships satisfaction	0.2	0.2	0.7	0.1	0.0	0.8	-0.3	0.4	-0.2	0.6
Qualifications: nursing, teaching	2.4	3.8	6.3	-2.5	2.4	1.9	2.2	1.8	-0.5	1.5
Commuting to job workplace: Walk	0.8	0.8	2.5	-0.3	0.4	1.3	0.6	0.9	-1.6	0.2
Eye problems/disorders: Cataract	0.3	0.3	1.2	0.0	0.2	-0.2	1.1	-0.4	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.1	1.4	-1.3	-0.8	-0.8	-1.8	1.0	-1.7
Medication for cholesterol	0.2	0.3	1.0	0.4	-0.1	-0.3	-0.0	0.3	1.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	6.0	0.0	-0.2	-0.7	-1.1	-0.2	2.5	1.7
Back pain experienced in last month	4.0	5.8	7.9	2.6	-2.8	-2.0	-2.3	-2.7	0.8	-2.8
Mineral and other dietary supplements	0.9	1.2	3.3	-0.3	0.4	1.2	0.2	0.5	1.8	1.7
Breast cancer (self-reported)	0.8	1.0	5.3	-0.6	0.6	-0.1	0.3	0.6	0.8	2.3
Asthma (self-reported)	0.6	1.3	2.7	1.6	-1.4	-0.9	-0.9	-0.5	-0.3	-1.4
Osteoporosis (self-reported)	1.4	1.8	3.3	1.7	-1.4	-1.1	-1.0	-0.2	-1.4	-1.8
Osteoarthritis (self-reported)	3.3	4.3	6.0	2.4	-2.2	-2.0	-2.5	-2.4	0.6	-1.6
Medication: Aspirin	1.1	1.4	2.6	1.2	-1.1	-0.8	-1.2	-1.6	-0.9	-1.3
Medication: Gliclazide	0.9	1.0	1.6	-1.3	1.1	1.2	1.1	1.0	-0.6	-0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	2.1	0.9	-1.1	-0.7	-1.4	-1.2	-0.4	-0.3
Smoking status: Current	9.4	14.9	26.5	4.0	-4.0	-3.5	-5.1	-4.4	3.0	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	10.9	-2.0	2.1	2.0	2.5	3.3	-2.3	1.5
Whole body water mass	1.7	9.7	24.9	-3.0	3.2	2.8	5.0	3.8	-1.2	0.0
Leg predicted mass (right)	1.8	9.8	23.3	-3.2	3.4	2.9	4.8	3.9	-1.0	0.4
Arm fat mass (left)	0.2	0.7	2.9	-0.7	0.6	-0.1	1.7	0.8	-0.0	-0.4
Number of self-reported non-cancer illnesses	6.1	10.6	17.1	3.6	-3.7	-3.4	-3.0	-3.0	-0.6	-4.1
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.0	0.3	0.5	0.3	0.4	-0.7	0.0
Miserableness	0.7	1.2	3.5	1.0	-0.9	-0.7	-1.9	-0.5	1.5	0.0
Guilty feelings	1.0	1.5	5.4	0.9	-0.9	-0.3	-2.3	-1.7	1.0	0.1
Wears glasses or contact lenses	0.5	0.6	1.6	0.3	-0.8	-1.3	-0.3	-0.9	-0.6	-0.9
Ever taken oral contraceptive pill	0.3	0.4	2.0	-0.3	0.0	0.1	0.2	0.2	0.5	1.4
Hearing aid user	0.4	0.5	2.5	0.1	-0.0	-0.1	0.2	0.5	-1.6	-0.8
Mother’s age at death	0.7	0.8	4.5	0.3	-0.2	-0.3	0.2	0.2	-2.1	-1.0
Financial situation satisfaction	3.3	4.1	6.8	2.6	-2.2	-2.2	-1.8	-1.9	-0.5	-2.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.6	-0.5	-0.5	-0.2	0.1	-0.8	-0.6
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	0.6	0.5	0.6	0.4	0.4	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.3	0.1	-0.3	0.1	-0.6	-0.2	-0.5
Medication: Blood pressure	0.3	0.6	2.9	0.1	-0.2	0.0	0.4	0.3	-1.0	-1.7
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.3	1.4	-1.8	-1.4	-1.6	-1.8	1.8	-0.7
Supplements: Fish oil (including cod liver oil)	2.4	3.2	5.6	1.5	-1.6	-2.2	-1.4	-1.6	-1.6	-2.4
High cholesterol (Self-reported)	0.8	1.4	4.0	0.6	-0.5	-0.9	-0.0	-1.1	-2.0	-1.8
Medication: Bendroflumethiazide	1.4	2.2	10.6	0.3	-0.2	-0.0	0.4	0.3	-3.3	-2.1
Medication: Paracetamol	2.6	4.0	8.0	2.8	-2.5	-2.0	-1.9	-2.0	0.7	-1.4
Medication: Lisinopril	0.9	1.1	4.4	-0.4	0.6	0.4	0.9	1.0	-2.1	-0.9
Medication: Atorvastatin	1.4	1.7	4.3	1.0	-1.1	-1.2	-0.9	-2.1	-0.1	-1.8
Illnesses of father: High blood pressure	1.1	1.4	3.3	1.2	-0.9	-0.9	-0.3	-1.1	-1.4	-1.8
Alcohol drinker status: Never	0.9	1.0	4.0	0.6	-0.7	-0.4	-0.6	-1.0	-2.0	-1.0
Ever smoked	4.4	7.8	13.2	2.8	-2.7	-2.7	-3.5	-3.6	1.3	-2.2
Basal metabolic rate	1.5	8.1	21.4	-2.8	2.9	2.5	4.6	3.5	-1.0	0.1
Leg fat percentage (left)	0.5	1.7	3.5	1.4	-1.5	-1.9	-1.0	-1.4	-0.4	-1.1
Arm fat-free mass (left)	1.0	5.0	15.0	-1.9	2.0	1.7	3.9	2.8	-1.2	-0.7
Number of operations (self-reported)	4.5	6.6	9.4	3.0	-3.0	-2.8	-1.7	-2.8	0.3	-3.1
Average weekly beer plus cider intake	0.1	0.2	0.6	0.2	-0.1	-0.1	-0.3	-0.5	0.7	0.8
Irritability	3.8	6.4	8.2	2.7	-2.8	-2.5	-2.9	-2.7	1.4	-2.5
Risk taking	2.3	3.4	8.4	2.0	-1.9	-2.0	-1.5	-1.2	-0.2	-2.9
Ever had prostate specific antigen (PSA) test	3.4	3.9	6.7	2.1	-2.1	-2.6	-1.6	-1.7	-0.1	-2.5
Fractured/broken bones in last 5 years	0.3	0.3	1.2	0.6	-0.5	-0.4	-0.3	0.1	-0.6	-1.1
Age started oral contraceptive pill	1.1	1.4	2.4	-1.4	1.2	0.6	1.2	1.6	-0.4	1.5
Diastolic blood pressure, automated reading	0.9	2.9	8.2	-2.1	1.8	1.2	2.9	1.4	-0.2	0.9
Ever depressed for a whole week	2.5	3.1	5.5	2.1	-1.9	-2.3	-1.9	-0.9	0.9	-1.7
Unable to work because of sickness or disability	1.8	2.3	4.1	1.4	-1.6	-1.2	-2.0	-1.6	-0.3	-1.8
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.2	0.0	0.3	0.2	0.9	0.4	-0.6
Myopia	3.1	4.6	7.7	-2.5	2.4	1.7	2.5	2.8	-0.5	1.7
Vascular/heart problems diagnosed by doctor	1.1	3.0	12.2	-1.5	1.3	1.0	0.0	1.4	1.4	3.5
Cholesterol lowering medication	0.1	0.1	0.3	-0.2	-0.0	-0.2	0.0	-0.5	-0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	7.3	2.0	-2.1	-2.7	-2.0	-1.7	1.5	-1.0
Pain experienced in last month	8.4	14.0	21.2	-3.9	4.1	3.0	4.1	4.6	-1.4	4.1
Supplements: Calcium	0.2	0.2	1.0	0.1	0.1	-0.2	0.2	0.4	-0.4	-1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.3	0.2	-0.3	0.2	0.5	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	2.1	2.7	3.7	1.9	-1.9	-1.5	-1.9	-1.9	0.8	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.4	-0.5	-0.3	-0.6	-1.0	-0.0	0.5
Heart disease (siblings)	0.8	1.0	3.1	1.0	-1.0	-0.9	-0.9	-1.8	-0.0	-0.6
Alcohol drinker status: Previous	0.1	0.1	0.3	0.2	-0.1	0.4	-0.4	-0.1	-0.5	0.2
Pack years of smoking	2.7	4.0	5.8	2.3	-2.1	-1.6	-2.4	-2.0	1.7	-1.5
Impedance of whole body	1.0	5.0	13.5	1.7	-1.8	-1.9	-3.7	-2.9	1.7	0.9
Leg fat mass (left)	0.1	0.2	0.6	0.1	-0.1	-0.6	0.8	-0.0	-0.3	-0.7
Arm predicted mass (left)	1.2	6.2	17.4	-2.2	2.3	1.9	4.2	3.1	-1.5	-0.3