Best TWAS P=4.56e-08 · Best GWAS P=5.41e-09 conditioned to 0.00579
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | WAC-AS1 | 0.28 | 0.19 | lasso | 4 | 0.14 | 7.2e-06 | 5.0 | 5.1 | 2.9e-07 | 0.63 | 0.10 | 0.88 | FALSE |
| 2 | GTEx | Artery Coronary | WAC-AS1 | 0.41 | 0.21 | lasso | 6 | 0.19 | 4.0e-07 | 5.0 | 5.4 | 7.2e-08 | 0.67 | 0.11 | 0.89 | FALSE |
| 3 | GTEx | Brain Hippocampus | WAC-AS1 | 0.29 | 0.01 | enet | 10 | -0.01 | 8.5e-01 | 5.8 | 5.4 | 8.1e-08 | 0.85 | 0.03 | 0.67 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | WAC | 0.21 | 0.29 | lasso | 5 | 0.29 | 5.9e-37 | 5.3 | 5.5 | 4.6e-08 | 0.71 | 0.04 | 0.96 | TRUE |
| 5 | YFS | Blood | WAC | 0.06 | 0.08 | bslmm | 649 | 0.08 | 2.2e-24 | 5.0 | -5.1 | 3.0e-07 | -0.68 | 0.05 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | WAC | 0.06 | 0.04 | lasso | 3 | 0.03 | 4.2e-04 | 5.3 | 5.4 | 5.6e-08 | 0.68 | 0.02 | 0.93 | FALSE |