TWAS
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Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr10:28,113,533-29,610,861
Best TWAS P=4.56e-08 · Best GWAS P=5.41e-09 conditioned to 0.00579
28.2M
28.4M
28.6M
28.8M
29M
29.2M
29.4M
29.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
WAC
0.21
0.29
lasso
5
0.29
5.9e-37
5.3
5.5
4.6e-08
0.71
0.04
0.96
TRUE
6
The Cancer Genome Atlas
Thyroid Carcinoma
WAC
0.06
0.04
lasso
3
0.03
4.2e-04
5.3
5.4
5.6e-08
0.68
0.02
0.93
FALSE
2
GTEx
Artery Coronary
WAC-AS1
0.41
0.21
lasso
6
0.19
4.0e-07
5.0
5.4
7.2e-08
0.67
0.11
0.89
FALSE
3
GTEx
Brain Hippocampus
WAC-AS1
0.29
0.01
enet
10
-0.01
8.5e-01
5.8
5.4
8.1e-08
0.85
0.03
0.67
FALSE
1
GTEx
Adrenal Gland
WAC-AS1
0.28
0.19
lasso
4
0.14
7.2e-06
5.0
5.1
2.9e-07
0.63
0.10
0.88
FALSE
5
YFS
Blood
WAC
0.06
0.08
bslmm
649
0.08
2.2e-24
5.0
-5.1
3.0e-07
-0.68
0.05
0.95
FALSE