Best TWAS P=4.97e-22 · Best GWAS P=1.16e-26 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | CAMK1D | 0.28 | 0.24 | enet | 25 | 0.24 | 2.3e-18 | -7.8 | -7.8 | 5.7e-15 | 0.51 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Whole Blood | CAMK1D | 0.14 | 0.01 | enet | 26 | 0.04 | 2.5e-04 | -7.8 | -8.0 | 1.7e-15 | 0.63 | 0.24 | 0.68 | TRUE |
| 3 | METSIM | Adipose | SEC61A2 | 0.07 | 0.02 | bslmm | 546 | 0.02 | 4.4e-04 | -5.1 | 5.2 | 1.6e-07 | -0.15 | 0.74 | 0.01 | TRUE |
| 4 | NTR | Blood | CAMK1D | 0.10 | 0.09 | bslmm | 900 | 0.08 | 4.4e-25 | -7.8 | -8.3 | 9.4e-17 | 0.59 | 1.00 | 0.00 | FALSE |
| 5 | NTR | Blood | CDC123 | 0.06 | 0.04 | bslmm | 537 | 0.04 | 4.7e-14 | -10.7 | -9.6 | 5.0e-22 | 0.91 | 0.00 | 1.00 | TRUE |
| 6 | YFS | Blood | CAMK1D | 0.27 | 0.23 | bslmm | 875 | 0.26 | 7.7e-86 | -7.8 | -8.4 | 3.2e-17 | 0.63 | 1.00 | 0.00 | TRUE |
| 7 | YFS | Blood | CDC123 | 0.08 | 0.03 | enet | 35 | 0.06 | 9.6e-19 | -7.8 | -7.4 | 1.2e-13 | 0.65 | 0.52 | 0.48 | TRUE |
| 8 | YFS | Blood | NUDT5 | 0.13 | 0.12 | enet | 40 | 0.13 | 1.1e-41 | -7.8 | -9.6 | 6.1e-22 | 0.71 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SEC61A2 | 0.03 | 0.02 | blup | 59 | 0.03 | 5.2e-04 | -5.0 | 5.3 | 1.1e-07 | -0.23 | 0.23 | 0.02 | FALSE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CDC123 | 0.26 | 0.07 | lasso | 4 | 0.07 | 1.4e-03 | -7.4 | 8.7 | 3.0e-18 | -0.65 | 0.11 | 0.12 | TRUE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NUDT5 | 0.13 | -0.01 | blup | 55 | 0.01 | 1.1e-01 | -5.0 | -8.4 | 4.1e-17 | 0.53 | 0.02 | 0.14 | FALSE |
| 12 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CDC123 | 0.08 | 0.00 | blup | 64 | 0.03 | 4.0e-03 | -1.9 | -8.7 | 3.0e-18 | 0.64 | 0.01 | 0.15 | FALSE |
| 13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NUDT5 | 0.08 | 0.07 | enet | 8 | 0.07 | 8.2e-05 | -3.9 | -8.3 | 1.3e-16 | 0.51 | 0.83 | 0.05 | FALSE |