Best TWAS P=5.71e-12 · Best GWAS P=3.17e-15 conditioned to 0.000695
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FBXO38 | 0.05 | 0.01 | blup | 489 | 0.02 | 1.5e-03 | 6.0 | -6.1 | 1.1e-09 | -0.72 | 0.02 | 0.98 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | HTR4 | 0.06 | 0.03 | lasso | 4 | 0.03 | 4.3e-05 | 6.9 | 5.4 | 7.4e-08 | 0.79 | 0.01 | 0.98 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | FBXO38 | 0.18 | 0.05 | enet | 35 | 0.10 | 1.1e-07 | 6.0 | -5.7 | 1.0e-08 | -0.60 | 0.61 | 0.36 | FALSE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FBXO38 | 0.04 | 0.04 | blup | 52 | 0.04 | 4.8e-03 | 5.6 | -6.9 | 5.7e-12 | -0.75 | 0.05 | 0.14 | TRUE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | FBXO38 | 0.05 | 0.02 | lasso | 2 | 0.02 | 4.3e-02 | 5.1 | -6.7 | 2.9e-11 | -0.77 | 0.04 | 0.29 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FBXO38 | 0.02 | 0.03 | enet | 2 | 0.03 | 1.9e-04 | -6.0 | -6.7 | 2.0e-11 | -0.76 | 0.04 | 0.58 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FBXO38 | 0.03 | 0.01 | enet | 6 | 0.01 | 5.0e-02 | 5.9 | -6.3 | 3.0e-10 | -0.53 | 0.08 | 0.04 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FBXO38 | 0.11 | 0.02 | blup | 52 | 0.04 | 8.2e-06 | 6.0 | -5.6 | 1.7e-08 | -0.53 | 0.68 | 0.09 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | FBXO38 | 0.03 | 0.02 | blup | 51 | 0.02 | 7.7e-04 | 5.1 | -5.3 | 1.3e-07 | -0.63 | 0.54 | 0.08 | TRUE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FBXO38 | 0.05 | 0.01 | blup | 51 | 0.02 | 7.9e-03 | -1.2 | -5.3 | 1.4e-07 | -0.66 | 0.05 | 0.17 | FALSE |
11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FBXO38 | 0.13 | 0.17 | enet | 16 | 0.15 | 2.3e-04 | 5.9 | -6.1 | 9.8e-10 | -0.65 | 0.12 | 0.31 | FALSE |