Best TWAS P=8.63e-14 · Best GWAS P=8.93e-13 conditioned to 0.237
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAM19 | 0.09 | 0.08 | lasso | 6 | 0.05 | 5.6e-05 | -7.1 | -7.0 | 2.6e-12 | 0.99 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | ADAM19 | 0.11 | 0.10 | lasso | 1 | 0.06 | 3.6e-04 | -7.1 | -7.1 | 1.4e-12 | 1.00 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | ADAM19 | 0.11 | 0.14 | lasso | 6 | 0.10 | 5.1e-04 | -7.1 | -7.1 | 1.0e-12 | 0.98 | 0.01 | 0.92 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | ADAM19 | 0.16 | 0.02 | enet | 17 | 0.06 | 3.0e-05 | 1.1 | -5.3 | 1.1e-07 | 0.63 | 0.06 | 0.93 | FALSE |
| 5 | GTEx | Esophagus Mucosa | ADAM19 | 0.14 | 0.03 | enet | 19 | 0.09 | 2.4e-06 | 1.5 | -5.5 | 3.6e-08 | 0.57 | 0.06 | 0.90 | FALSE |
| 6 | GTEx | Muscle Skeletal | ADAM19 | 0.06 | 0.02 | lasso | 4 | 0.01 | 1.5e-02 | -7.1 | -7.5 | 8.6e-14 | 0.88 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Nerve Tibial | ADAM19 | 0.34 | 0.16 | enet | 45 | 0.30 | 1.2e-21 | -3.9 | -5.4 | 6.4e-08 | 0.78 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Ovary | ADAM19 | 0.32 | 0.11 | lasso | 9 | 0.08 | 6.5e-03 | -3.7 | -5.5 | 3.3e-08 | 0.65 | 0.04 | 0.74 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | ADAM19 | 0.10 | 0.01 | lasso | 4 | 0.08 | 5.2e-05 | -4.8 | -7.1 | 1.5e-12 | 0.75 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | ADAM19 | 0.07 | 0.04 | lasso | 6 | 0.06 | 1.2e-05 | -4.5 | -6.9 | 5.9e-12 | 0.80 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Testis | ADAM19 | 0.16 | 0.00 | enet | 17 | -0.01 | 6.7e-01 | -3.9 | -6.8 | 9.8e-12 | 0.82 | 0.02 | 0.89 | FALSE |
| 12 | GTEx | Whole Blood | ADAM19 | 0.12 | 0.07 | enet | 20 | 0.07 | 9.8e-07 | -4.8 | -5.7 | 1.0e-08 | 0.57 | 0.91 | 0.09 | FALSE |
| 13 | METSIM | Adipose | ADAM19 | 0.08 | 0.07 | lasso | 9 | 0.07 | 2.5e-10 | -7.1 | -7.1 | 1.3e-12 | 1.00 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAM19 | 0.08 | 0.02 | blup | 159 | 0.03 | 5.3e-04 | -4.4 | -6.2 | 4.6e-10 | 0.70 | 0.03 | 0.83 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADAM19 | 0.09 | 0.03 | lasso | 4 | 0.05 | 2.4e-06 | -7.1 | -7.4 | 1.1e-13 | 0.83 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADAM19 | 0.05 | 0.01 | blup | 159 | 0.03 | 9.5e-04 | 1.2 | -5.2 | 1.6e-07 | 0.57 | 0.06 | 0.22 | FALSE |