Best TWAS P=4.6e-17 · Best GWAS P=6.53e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RAD9A | 0.43 | 0.22 | lasso | 6 | 0.23 | 7.1e-19 | -8.1 | -7.8 | 5.7e-15 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | RAD9A | 0.39 | 0.26 | lasso | 2 | 0.24 | 3.5e-19 | -8.1 | -8.1 | 6.8e-16 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | ZDHHC24 | 0.22 | 0.11 | enet | 15 | 0.16 | 8.2e-05 | 4.2 | -5.2 | 1.9e-07 | 0.08 | 0.08 | 0.50 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RAD9A | 0.24 | 0.16 | lasso | 3 | 0.16 | 3.6e-12 | -8.1 | -7.1 | 1.4e-12 | 0.92 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Colon Transverse | RAD9A | 0.40 | 0.16 | lasso | 8 | 0.16 | 7.2e-08 | -8.1 | -7.0 | 3.2e-12 | 0.88 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RAD9A | 0.25 | 0.26 | lasso | 2 | 0.26 | 6.2e-16 | -8.1 | -8.4 | 4.6e-17 | 0.99 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Muscle Skeletal | RAD9A | 0.12 | 0.02 | lasso | 4 | 0.03 | 4.2e-04 | -8.1 | -6.7 | 2.4e-11 | 0.83 | 0.00 | 0.99 | FALSE |
| 8 | GTEx | Nerve Tibial | RAD9A | 0.53 | 0.24 | lasso | 10 | 0.23 | 5.6e-16 | -8.1 | -7.7 | 1.7e-14 | 0.99 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Testis | RAD9A | 0.72 | 0.50 | lasso | 4 | 0.49 | 1.1e-24 | -8.1 | -8.0 | 9.0e-16 | 1.00 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Thyroid | RAD9A | 0.27 | 0.07 | lasso | 6 | 0.20 | 1.8e-15 | -8.1 | -5.2 | 1.7e-07 | 0.70 | 0.00 | 1.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | RAD9A | 0.34 | 0.17 | enet | 21 | 0.20 | 1.1e-25 | -8.1 | -7.7 | 1.4e-14 | 0.89 | 0.00 | 1.00 | FALSE |
| 12 | YFS | Blood | RAD9A | 0.08 | 0.02 | lasso | 7 | 0.04 | 5.4e-12 | -8.1 | -5.6 | 2.8e-08 | 0.78 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC87 | 0.03 | 0.02 | blup | 34 | 0.02 | 2.0e-03 | 4.7 | 5.8 | 8.0e-09 | -0.13 | 0.01 | 0.66 | TRUE |