Hub : Genes

ZDHHC24

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0890	0.0410	2.5e-03	0.090	NA	0.050	NA	0.064	1.1e-05	NA	9.1e-04	NA	2.0e-04
2	GTEx	Brain Cerebellar Hemisphere	0.2160	0.0990	4.1e-03	0.113	NA	0.156	NA	0.103	7.8e-04	NA	8.2e-05	NA	1.3e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.0574	0.0230	5.5e-05	0.028	0.023	0.040	0.029	0.053	1.4e-04	4.7e-04	6.1e-06	1.2e-04	2.1e-07
4	YFS	Blood	0.2228	0.0487	2.5e-14	0.070	0.047	0.075	0.078	0.080	8.7e-22	4.1e-15	2.8e-23	2.5e-24	7.6e-25
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0318	0.0190	7.2e-05	0.025	0.032	0.026	NA	0.013	6.9e-04	1.5e-04	5.5e-04	NA	1.0e-02
6	TCGA	Lung Adenocarcinoma	0.0344	0.0220	9.8e-05	0.040	0.039	0.043	NA	0.044	1.5e-05	1.9e-05	8.2e-06	NA	6.4e-06
7	TCGA	Uterine Corpus Endometrial Carcinoma	0.4200	0.1520	2.9e-05	0.018	0.093	0.093	NA	0.074	9.9e-02	1.5e-03	1.5e-03	NA	4.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	4.9	7.8	13.7	-2.9	1.7	3.0	0.3	-3.7	-2.9	-3.5
Bipolar Disorder or Schizophrenia	5.4	13.3	23.1	-3.7	2.9	3.1	-1.5	-4.8	-3.6	-4.8
Depressed Affect (Nagel 2018)	0.6	1.3	3.0	-1.0	1.7	1.1	-0.8	-1.1	-0.8	-1.1
Depression (Nagel 2018)	0.4	0.6	1.4	1.0	-0.0	-0.7	-0.8	0.6	1.2	0.5
Intelligence (Savage-Jansen 2018)	2.1	6.5	8.7	2.9	-2.5	-2.6	0.4	2.9	2.7	2.8
Neuroticism (Nagel 2018)	0.2	0.5	1.5	-0.3	1.2	1.0	0.0	-0.9	0.1	-0.3
Schizophrenia (2018)	3.0	6.2	11.5	-2.4	2.3	2.2	-1.0	-3.2	-2.3	-3.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	0.5	0.1	-0.4	-0.3	0.9	0.5	1.0
Worry (Nagel 2018)	0.5	1.0	2.8	1.3	-0.3	-0.9	0.5	0.7	1.7	1.1
Alzheimer’s Disease (in mother)	1.5	1.7	3.4	1.3	-1.1	-1.8	-1.8	0.8	1.4	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.0	-0.1	0.8	0.5	1.0	0.5	-0.0	0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.5	-0.3	-0.9	-0.8	0.5	0.6	0.4
Crohns Disease (2017)	0.2	0.5	1.0	1.0	-0.1	-0.4	0.6	0.8	1.0	0.6
Irritable Bowel Disease (IBD)	0.5	1.2	1.8	-0.7	0.8	1.2	1.3	-1.2	-0.7	-1.3
Ulcerative Colitis (UC)	2.6	4.9	6.7	-2.0	1.8	2.6	1.8	-2.6	-2.0	-2.6
Major Depression (MDD)	0.2	0.2	1.0	-0.1	1.0	-0.0	-0.6	-0.2	-0.1	0.4
Reaction Time	0.2	0.3	1.0	-0.7	-0.2	0.5	0.1	-0.5	-1.0	-0.4
Verbal and Numeric Reasoning (VNR)	1.3	3.1	4.7	2.2	-1.2	-2.1	-0.8	1.8	1.6	2.1
Breast Cancer	3.3	8.1	13.4	3.6	-3.2	-3.2	0.1	2.6	3.7	1.8
Ovarian Cancer	0.8	1.0	2.6	-0.9	0.0	1.0	-0.1	-1.2	-1.1	-1.6
Prostate Cancer	0.1	0.1	0.3	0.2	0.3	-0.1	0.3	-0.1	0.5	-0.4
Age at First Birth	0.2	0.3	0.8	-0.5	0.1	0.5	0.9	0.4	-0.1	0.7
Bipolar Disorder (2011)	2.3	2.2	6.5	-1.2	0.3	1.8	0.0	-2.0	-0.6	-2.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.3	-0.1	0.6	0.4	-0.2	-0.3	0.0
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.6	-0.4	0.9	0.0	0.3	0.4	0.0
Crohns Disease (2012)	0.4	0.6	1.6	1.0	-0.5	-0.2	1.3	0.4	1.1	0.3
Mean Putamen Volume	0.2	0.2	0.6	0.2	0.1	-0.5	-0.8	0.5	0.2	0.5
Fasting Glucose	0.5	0.6	1.1	0.7	-0.5	-1.0	0.9	0.7	0.4	0.8
HbA1C	0.9	1.0	1.7	1.2	-0.9	-0.9	-1.3	0.9	1.1	0.7
HDL Cholesterol	0.3	0.5	1.2	0.4	-0.9	-1.1	-0.7	0.5	0.6	0.3
LDL Cholesterol	5.0	7.9	12.0	-3.4	2.8	3.5	0.7	-3.1	-3.1	-2.2
Lupus	1.1	1.7	3.0	1.7	-1.0	-1.4	-0.2	1.5	1.7	0.9
Neuroticism (2016)	0.8	1.2	3.6	0.6	0.7	0.7	1.9	0.4	1.1	1.3
Primary Biliary Cirrhosis	3.2	4.6	7.9	-2.6	1.7	2.4	0.3	-2.3	-2.8	-1.9
Rheumatoid Arthritis	0.2	0.3	0.7	0.5	-0.2	-0.6	-0.3	0.8	0.5	0.5
Schizophrenia (2014)	2.9	6.4	9.3	-2.5	2.6	2.7	0.2	-3.0	-2.4	-3.1
Triglycerides	0.7	1.2	3.2	-1.3	1.8	1.3	0.3	-0.7	-1.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.0	-0.9	0.4	1.4	0.0	-0.6	-0.7	-0.2
Ulcerative Colitis	4.4	6.4	9.4	-2.4	2.2	2.8	1.3	-3.1	-2.4	-3.0
Blood Eosinophil Count	0.2	1.6	3.4	0.9	1.0	-1.2	-0.1	1.4	1.7	1.9
Blood Platelet Count	0.1	1.0	2.4	1.1	-0.7	-1.5	-0.6	0.2	1.6	0.2
Blood Red Count	3.5	33.4	70.2	-6.0	3.1	4.8	-2.0	-7.7	-5.7	-8.4
Blood White Count	0.1	0.8	2.4	1.1	0.5	-1.0	-0.4	0.5	1.6	0.5
Heel T-Score	0.8	6.6	17.4	2.5	1.4	-1.4	2.3	3.1	1.9	4.2
BMI	1.8	10.7	19.4	-3.7	2.6	3.3	-1.1	-4.4	-3.3	-3.5
Height	2.7	51.4	88.5	8.0	-4.8	-6.0	2.5	9.4	7.7	9.1
Waist Hip Ratio (WHR)	0.2	0.9	2.2	-0.8	1.2	0.6	-0.7	-1.5	-0.5	-0.9
Systolic Blood Pressure	0.1	0.4	1.3	0.1	-1.1	0.2	1.1	-0.0	-0.4	0.4
Smoking Status	0.6	1.4	4.9	-0.8	0.7	0.1	-2.2	-1.0	-0.5	-1.6
Allergy or Eczema	0.7	1.8	4.1	-0.7	-0.3	1.6	2.0	-1.6	-0.4	-1.6
Cardiovascular Disease	0.8	2.5	5.7	-1.7	1.8	1.5	-0.1	-2.4	-1.5	-1.3
Hypothyroidism (self reported)	0.4	1.0	3.6	-0.9	0.8	-0.2	-1.9	-0.7	-1.1	-0.4
Respiratory disease	5.4	11.9	18.6	-4.0	2.2	3.8	1.1	-4.3	-3.8	-3.8
Type 2 Diabetes (T2D) (2018)	0.8	1.6	2.5	-1.4	1.0	1.5	0.2	-1.6	-1.4	-1.1
Lung FEV1/FVC ratio	0.2	1.1	2.9	-0.0	-1.5	-0.9	-1.7	1.1	-0.0	0.9
Lung FVC	3.2	16.2	41.0	4.7	-6.4	-3.6	-0.9	3.6	4.9	-0.1
Neuroticism	0.3	0.7	1.4	-0.7	1.2	1.0	0.6	-1.0	-0.3	-0.4
Chronotype (morning person)	1.0	2.4	4.9	1.3	-1.0	-1.1	1.5	2.2	1.1	2.2
Hair Pigment	0.2	6.0	10.7	3.0	-3.1	-2.8	-0.3	2.1	3.3	0.5
Tanning	0.1	1.3	2.8	-1.4	1.2	1.1	-0.1	-1.0	-1.7	-0.9
Hand grip strength (left)	3.6	9.6	18.8	3.5	-2.8	-2.7	0.8	4.3	3.4	3.0
Number of treatments/medications taken	4.0	7.2	13.0	-2.8	2.5	3.0	1.2	-3.6	-2.7	-2.3
Average weekly spirits intake	0.5	0.6	1.8	0.7	-0.6	-0.0	1.4	0.7	0.7	0.7
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.2	0.9	0.3	0.3	-0.2	0.1	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.3	0.9	0.8	0.8	-0.3	-0.1	-0.4
Hearing difficulty/problems: Yes	1.5	2.2	5.5	-1.4	1.0	1.6	0.3	-2.3	-1.0	-1.9
Relative age of first facial hair	0.8	1.6	3.8	-1.3	0.9	1.2	0.4	-1.9	-1.5	-1.0
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	6.1	-1.8	1.9	2.0	-0.1	-2.5	-1.6	-2.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	-1.2	0.4	1.0	-0.4	-0.9	-1.2	-1.0
Ever had hysterectomy (womb removed)	0.9	1.1	4.0	-0.8	-0.1	0.1	-2.0	-0.9	-1.0	-1.0
Systolic blood pressure, automated reading	0.0	0.1	0.3	-0.0	-0.5	-0.0	0.2	-0.4	-0.6	0.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.7	-0.7	-0.4	0.0	0.4	0.9	0.4
Angina	1.0	1.3	2.1	1.4	-0.6	-1.5	-0.8	1.0	1.4	1.0
Medication for hormone replacement therapy	0.3	0.3	1.4	0.2	-0.5	0.2	1.2	0.2	0.3	-0.3
Vitamin and mineral supplements	1.6	2.2	3.6	-1.9	1.4	1.8	0.5	-1.4	-1.8	-1.1
Supplements: Zinc	0.0	0.0	0.1	0.1	0.1	0.1	0.1	0.0	-0.3	-0.0
Medication: Co-codamol	4.5	5.2	7.6	-2.5	2.8	2.0	-1.2	-2.6	-2.7	-1.8
Medication: Metformin	0.2	0.3	0.7	-0.5	0.9	0.7	0.3	-0.5	-0.3	0.3
Diabetes (father)	0.7	0.9	2.0	0.9	-1.4	-1.0	-0.7	0.6	0.9	1.0
Diabetes (mother)	0.5	0.6	1.8	0.7	-1.3	-0.2	0.6	0.6	0.8	0.9
Severe depression (siblings)	0.1	0.1	0.3	0.2	-0.1	-0.3	0.5	-0.1	0.3	-0.0
Pack years adult smoking proportion	1.4	2.1	4.5	-1.6	0.2	1.8	0.9	-1.4	-1.3	-2.1
Impedance of leg (right)	2.0	9.9	25.1	3.0	-0.8	-3.2	-0.2	5.0	2.6	4.2
Leg fat-free mass (left)	0.1	0.4	1.2	-0.4	0.1	0.9	0.5	-1.1	-0.3	-0.4
Trunk fat percentage	1.0	4.2	9.4	-2.0	3.1	2.3	1.0	-2.2	-2.1	-0.4
Hand grip strength (right)	2.2	6.1	12.3	2.6	-2.0	-2.0	0.5	3.5	2.4	3.0
Townsend deprivation index at recruitment	0.6	0.8	1.5	-0.8	0.9	1.2	0.4	-1.1	-0.7	-0.9
Current tobacco smoking	2.1	3.5	5.2	-2.3	1.1	2.1	-0.5	-1.8	-2.2	-2.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.3	0.1	0.0	0.5	-0.1	0.4	0.4
Maternal smoking around birth	0.3	0.4	1.8	-0.4	0.2	0.7	0.4	-0.6	-0.5	-1.3
Fed-up feelings	2.1	3.8	10.1	-2.2	3.2	1.8	-0.4	-1.7	-1.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.3	-0.9	2.1	0.7	-0.4	-0.9	-0.7	-0.8
Relative age voice broke	0.0	0.0	0.1	-0.1	-0.0	0.1	0.4	-0.2	-0.1	0.3
Taking other prescription medications	4.3	6.7	11.6	-2.7	2.4	3.0	1.2	-3.4	-2.5	-2.3
Age when periods started (menarche)	0.9	2.2	4.7	-1.6	2.2	1.0	-1.0	-1.5	-1.9	-0.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	2.9	-1.7	0.6	1.2	-1.1	-1.5	-1.7	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.5	4.4	1.0	0.4	-0.3	2.1	1.0	0.8	1.8
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.6	-1.6	-0.3	1.1	-1.0	-1.6	-1.1	-2.1
Qualifications: CSEs or equivalent	1.5	2.0	3.1	0.8	-1.2	-1.7	-1.8	1.6	0.9	1.6
Serious illness, injury or assault to yourself	3.6	4.4	10.0	-2.0	3.2	2.7	1.4	-1.7	-1.5	-1.5
High blood pressure	0.3	1.0	2.4	-0.6	1.1	1.1	1.6	-1.1	-0.5	0.0
Hayfever, allergic rhinitis or eczema	1.5	3.3	6.4	-1.4	-0.0	2.5	2.5	-1.7	-1.1	-2.0
Multivitamins +/- minerals	1.4	1.8	3.8	1.6	-0.8	-1.9	-1.1	1.2	1.2	1.2
Stomach or abdominal pain in last month	0.4	0.5	1.1	-0.5	0.8	0.9	0.8	-1.1	-0.3	-0.1
Supplements: Glucosamine	3.6	4.7	7.8	2.7	-2.2	-2.8	-0.8	2.0	2.6	1.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.9	1.3	-0.5	-0.9	0.7	0.7	1.4	0.9
Medication: Atenolol	1.5	1.9	2.9	1.7	-0.7	-1.6	-0.5	1.4	1.6	1.7
Medication: Levothyroxine sodium	0.6	1.0	5.5	-0.3	0.8	-0.9	-2.3	-0.2	-0.2	0.2
Sitting height	0.8	5.8	9.4	2.8	-1.9	-2.4	-0.2	3.1	2.6	2.7
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	0.3	1.1	-0.1	0.6	0.0	0.2	1.2
High blood pressure (mother)	2.2	3.1	6.7	2.1	-1.2	-1.8	0.3	1.6	1.8	2.6
Body mass index (BMI)	2.9	12.4	22.0	-3.9	3.2	3.7	-0.4	-4.7	-3.6	-3.5
Impedance of leg (left)	2.3	11.0	26.7	3.2	-1.2	-3.3	-0.1	5.2	3.0	4.4
Leg predicted mass (left)	0.1	0.4	1.1	-0.4	0.1	0.9	0.6	-1.1	-0.2	-0.4
Trunk fat mass	0.7	2.9	6.2	-1.7	2.5	2.0	0.8	-1.9	-1.6	-0.3
Waist circumference	1.1	4.2	7.3	-2.1	2.3	2.5	0.3	-2.7	-1.8	-1.6
Number of incorrect matches in round	2.0	3.4	5.8	2.2	-1.0	-2.4	-0.9	2.4	2.0	1.2
Past tobacco smoking	0.2	0.3	0.8	-0.1	-0.4	0.4	0.9	0.5	-0.4	0.7
Alcohol usually taken with meals	2.5	4.1	7.9	2.3	-2.8	-1.7	0.7	2.1	2.3	1.5
Nervous feelings	2.3	4.3	8.7	2.1	-1.3	-1.8	0.8	2.6	2.3	2.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	-0.6	1.4	1.0	0.6	-0.7	-0.3	-0.3
Hearing difficulty/problems with background noise	1.6	2.5	4.9	-1.5	1.3	1.7	0.5	-2.2	-0.9	-2.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	-0.8	0.2	0.2	-1.2	-0.4	-0.9	-0.5
Had menopause	0.3	0.4	1.9	0.1	-0.5	-0.7	-1.4	0.0	0.2	0.4
Had other major operations	0.2	0.3	1.1	-0.0	-0.4	0.7	1.0	-0.1	0.1	-0.4
Forced vital capacity (FVC)	5.8	22.3	32.6	5.5	-5.7	-4.7	-0.6	5.6	5.5	3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.1	1.4	0.1	-0.8	1.8	1.4	1.1	2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.6	-0.8	0.4	-0.1	-1.6	-0.8	-0.5	-0.3
Qualifications: None of the above	0.6	1.3	2.0	-1.4	1.3	1.0	-0.8	-1.1	-1.3	-0.9
Financial difficulties in last 2 years	2.2	2.9	4.5	-2.0	1.3	1.6	-0.8	-2.1	-1.8	-2.0
Mouth/teeth dental problems	0.1	0.2	0.5	-0.5	0.1	0.4	0.4	0.0	-0.6	-0.7
Heart attack	3.1	4.0	6.2	2.5	-2.0	-2.1	0.1	2.1	2.4	1.9
Allergy	4.7	10.8	17.2	3.2	-1.3	-4.2	-2.6	3.9	2.9	4.0
Pain all over the body in last month	1.3	1.4	2.3	-1.5	0.8	1.3	-0.1	-1.3	-1.1	-1.5
Diabetes (self-reported)	1.8	2.8	6.5	-1.8	2.5	1.5	-0.4	-2.0	-1.8	-0.8
Hayfever/allergic rhinitis (self-reported)	2.4	3.1	4.8	-1.8	1.0	2.0	1.1	-2.0	-1.9	-2.2
Medication: Ramipril	0.4	0.6	1.3	-0.4	0.4	0.7	1.0	-1.2	-0.7	-0.6
Medication: Simvastatin	2.7	4.0	6.0	-2.4	2.4	1.9	-0.2	-2.1	-2.4	-1.5
Fluid intelligence score	2.7	5.5	9.5	2.6	-1.4	-3.1	-1.9	2.2	2.1	2.8
Illnesses of siblings	1.8	2.5	4.7	1.7	-1.2	-0.8	1.4	2.0	2.2	1.5
Neuroticism score	0.1	0.2	0.8	-0.1	0.9	0.3	0.6	-0.3	0.3	-0.0
Weight	0.3	1.6	2.7	-1.3	1.5	1.6	0.4	-1.6	-1.2	-0.6
Impedance of arm (right)	0.3	1.4	2.7	1.2	-0.0	-1.1	1.1	1.5	0.7	1.6
Arm fat percentage (right)	4.4	17.5	29.6	-4.6	4.0	4.4	0.4	-5.4	-4.5	-4.0
Trunk fat-free mass	0.1	0.7	1.6	1.0	-1.3	-0.6	-0.1	0.8	1.2	0.4
Hip circumference	0.0	0.1	0.4	-0.2	0.5	0.7	0.2	-0.4	-0.1	0.1
Time employed in main current job	0.3	0.3	1.0	0.4	0.1	-0.3	0.5	0.6	0.7	1.0
Alcohol intake versus 10 years previously	0.2	0.4	1.8	-0.1	0.4	-0.3	-1.4	0.1	-0.0	0.7
Father’s age at death	0.4	0.6	1.6	0.7	-0.7	-1.3	-1.0	0.4	0.3	0.6
Worrier / anxious feelings	0.2	0.5	2.3	0.1	1.5	0.1	0.5	-0.2	0.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	4.8	7.8	11.7	-2.9	3.4	3.2	1.4	-3.3	-2.8	-2.0
Falls in the last year	1.6	2.2	4.5	-1.4	1.3	1.7	0.0	-2.1	-1.6	-1.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	-0.3	0.8	0.5	0.4	-1.1	-0.4	-0.8
Number of live births	1.0	1.4	4.0	-0.9	-0.6	0.2	-2.0	-1.2	-0.5	-1.6
Forced expiratory volume in 1-second (FEV1)	6.4	21.6	32.9	5.2	-5.7	-4.9	-1.7	5.3	5.2	2.9
Pulse rate	1.6	2.7	5.9	-1.8	0.6	1.5	-0.4	-2.4	-1.7	-2.0
Happiness	0.8	1.0	2.0	-0.7	1.2	0.4	-1.1	-1.4	-0.7	-1.0
Noisy workplace	2.4	3.0	4.8	-1.8	1.2	2.2	2.0	-1.7	-1.6	-1.5
Qualifications: A levels/AS levels or equivalent	2.0	4.4	7.7	2.8	-1.7	-2.5	-0.6	2.1	2.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.7	0.4	0.4	-0.7	-1.3	0.3	0.2	0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.1	-0.1	0.0	-0.5	-0.2	0.2	0.3
Asthma	6.3	12.5	20.1	-4.0	2.2	4.0	1.0	-4.5	-3.7	-4.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	2.8	1.6	-1.3	-1.0	0.9	0.8	1.7	0.8
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.2	0.7	0.4	0.4	-0.4	-0.3	-0.3
Depression (self-reported)	2.4	2.9	5.9	-1.9	2.4	1.9	0.4	-1.9	-1.7	-0.7
Medication: Lansoprazole	0.2	0.3	0.6	-0.6	0.2	0.6	-0.1	-0.6	-0.4	-0.8
Prospective memory result	0.2	0.3	0.9	0.2	-0.9	-0.4	-0.7	0.2	0.2	-0.5
Lung cancer (father)	1.3	1.5	2.4	-1.6	1.0	1.4	-0.1	-1.2	-1.2	-1.4
Illnesses of mother	0.0	0.0	0.1	-0.1	0.1	0.2	0.1	0.3	0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	5.3	16.9	26.3	4.7	-5.1	-4.1	-1.1	4.7	4.7	2.8
Pulse wave Arterial Stiffness index	1.3	1.5	3.5	-1.3	-0.2	1.1	-0.3	-1.9	-0.9	-1.7
Impedance of arm (left)	0.6	2.9	7.3	1.7	0.2	-1.2	1.6	2.2	1.1	2.7
Arm fat mass (right)	2.4	9.7	16.8	-3.5	3.2	3.2	-0.1	-4.1	-3.4	-2.7
Trunk predicted mass	0.1	0.7	1.6	1.0	-1.3	-0.5	-0.0	0.8	1.2	0.4
Standing height	2.4	23.9	41.3	5.5	-3.4	-4.2	1.6	6.4	5.2	6.1
Length of working week for main job	0.3	0.4	0.9	-0.2	1.0	0.3	0.9	-0.3	-0.2	0.6
Exposure to tobacco smoke at home	1.0	1.1	2.1	-1.5	1.0	1.3	0.1	-0.7	-1.3	-0.8
Breastfed as a baby	0.3	0.4	1.2	0.6	-1.1	-0.6	0.4	0.3	0.6	0.4
Tense / ‘highly strung’	0.6	1.0	2.5	1.2	-0.5	-1.0	-0.1	0.7	1.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	7.0	10.7	20.1	-3.7	3.4	3.2	-0.4	-4.5	-3.2	-3.0
Hair/balding pattern: Pattern 4	0.2	0.6	2.7	0.2	-0.8	0.4	1.6	0.4	0.4	-0.3
Birth weight of first child	3.1	5.6	7.4	2.7	-2.6	-2.3	0.8	2.7	2.7	2.2
Peak expiratory flow (PEF)	6.7	15.6	27.1	4.3	-5.2	-4.3	-1.9	4.4	4.2	2.3
Pulse wave reflection index	0.3	0.3	1.1	0.0	-0.7	0.4	1.1	-0.1	0.3	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.3	0.8	0.2	0.3	-0.4	-0.2	0.6
Loud music exposure frequency	2.4	2.6	11.8	-0.9	1.0	1.9	3.4	-0.6	-0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.2	0.8	-0.5	-0.2	1.1	0.7	0.8	0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.4	-0.1	1.2	0.0	0.0	-0.3	0.0	0.7
Blood clot in the leg (DVT)	2.8	3.6	6.8	-1.8	2.2	2.6	1.8	-1.7	-1.9	-1.0
Medication: Paracetamol	0.2	0.3	0.6	0.5	0.0	-0.1	0.7	0.1	0.8	0.7
Headache pain in last month	0.8	1.4	3.7	-1.0	0.4	1.2	0.7	-1.9	-1.1	-1.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.7	-0.2	-0.3	-0.8	-1.9	0.2	-0.3	-0.4
Glaucoma (self-reported)	0.1	0.2	0.4	0.4	-0.3	-0.5	-0.2	0.3	0.3	0.7
Gout (self-reported)	0.6	0.8	2.1	0.6	0.6	-0.7	-0.4	1.4	0.6	1.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	4.2	-0.7	1.0	-0.4	-2.1	-0.6	-0.7	-0.2
Medication: Amlodipine	0.9	1.3	2.8	1.1	-1.4	-0.4	1.5	0.7	1.7	0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.3	-1.4	0.2	1.3	0.2	-1.3	-1.5	-1.3
Birth weight	2.1	4.6	8.8	-2.5	1.4	2.2	0.4	-3.0	-2.3	-2.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	-0.3	0.1	0.4	0.1	0.1	-0.2	-0.7
High blood pressure (siblings)	0.5	0.7	1.8	-0.5	1.4	0.1	-0.8	-1.1	-0.7	-0.4
Forced vital capacity (FVC), Best measure	5.3	19.2	27.5	5.2	-5.2	-4.1	-0.3	5.2	5.1	3.2
Body fat percentage	1.7	6.8	11.3	-2.9	3.4	2.9	0.5	-3.0	-2.9	-1.4
Leg fat percentage (right)	2.1	7.4	10.3	-3.2	3.2	2.9	-0.4	-3.0	-3.1	-2.1
Arm fat-free mass (right)	0.1	0.4	0.7	0.6	-0.5	-0.4	-0.6	0.7	0.8	0.8
Exposure to tobacco smoke outside home	0.4	0.6	2.7	0.2	0.3	0.1	1.6	1.0	0.3	0.5
Comparative body size at age 10	0.2	0.5	1.1	-0.7	0.5	1.0	1.1	-0.1	-0.5	0.2
Number of full brothers	0.9	1.1	3.3	1.1	-1.8	-1.0	-0.2	0.8	1.3	0.3
Worry too long after embarrassment	2.1	3.5	5.3	-1.9	1.2	2.2	1.3	-2.3	-2.0	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.5	-1.2	1.7	1.6	0.5	-1.9	-0.7	-1.2
Wheeze or whistling in the chest in last year	2.7	4.8	7.9	-2.2	1.5	2.8	1.6	-2.8	-1.9	-2.2
Number of children fathered	0.0	0.0	0.1	-0.2	-0.3	0.1	0.2	0.1	0.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	1.0	-0.3	-1.0	-0.2	0.5	0.9	-0.1
Age at first live birth	0.6	1.1	1.5	1.2	-1.2	-1.2	0.6	1.2	0.9	0.7
Pulse wave peak to peak time	2.0	2.4	5.2	1.7	-0.1	-1.4	0.3	2.3	1.3	2.2
Health satisfaction	8.2	10.6	18.1	-3.5	4.3	2.9	-0.9	-3.9	-3.4	-2.9
Shortness of breath walking on level ground	2.1	2.5	6.1	-1.8	1.1	1.3	-0.4	-2.5	-1.6	-1.5
Qualifications: College or University degree	0.8	2.4	5.3	2.3	-1.3	-2.1	-0.5	1.4	1.8	0.5
Eye problems/disorders: None of the above	0.3	0.3	1.8	-0.2	0.0	-0.5	-1.3	0.1	-0.2	0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.6	-0.8	-0.8	-0.9	0.3	0.7	-0.2
Emphysema/chronic bronchitis	0.5	0.6	2.3	-0.5	-0.7	0.2	-0.6	-0.6	-0.4	-1.5
Medication for pain relief, constipation, heartburn	0.3	0.6	1.4	0.3	-0.0	-0.9	-1.1	1.2	0.0	0.6
Neck or shoulder pain in last month	0.5	0.7	2.2	0.4	0.7	-0.4	-0.6	1.1	0.8	1.5
Medication: Blood pressure	1.4	2.5	11.4	1.3	-0.6	0.3	3.4	0.7	1.5	1.2
Angina (self-reported)	1.1	1.4	2.4	1.5	-0.8	-1.5	-0.7	1.0	1.5	1.0
Migraine (self-reported)	1.7	2.1	4.3	-1.4	1.7	1.5	0.9	-2.1	-1.2	-0.9
Medication: Ibuprofen	0.5	0.6	1.1	1.0	-0.5	-0.7	0.7	0.5	1.0	0.9
Medication: Allopurinol	2.0	2.6	6.3	1.4	-0.2	-1.5	0.2	2.5	1.4	2.4
Medication: Omeprazole	1.9	2.3	4.9	-1.5	0.8	1.5	0.8	-1.8	-1.3	-2.2
Medication: Seretide 50 evohaler	3.7	4.2	8.0	-2.1	2.1	2.8	2.2	-1.5	-2.2	-0.9
Mean time to correctly identify matches	0.6	1.1	2.0	-1.2	0.6	1.4	1.2	-0.7	-1.3	-0.4
Heart disease (mother)	0.0	0.0	0.1	0.0	0.2	-0.1	-0.1	-0.2	-0.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.8	1.3	-1.2	-1.7	-0.5	1.3	1.7	0.7
Whole body fat mass	1.0	4.0	7.2	-2.2	2.7	2.3	0.4	-2.4	-2.1	-1.0
Leg fat mass (right)	1.3	4.9	6.8	-2.6	2.6	2.4	-0.3	-2.6	-2.4	-1.6
Arm predicted mass (right)	0.1	0.6	1.1	0.8	-0.5	-0.6	-0.7	0.8	1.0	1.0
Pulse rate, automated reading	1.8	5.8	7.9	-2.6	2.3	2.7	1.0	-2.8	-2.6	-2.3
Alcohol intake frequency.	0.8	1.8	2.8	-1.7	0.7	1.2	-1.5	-1.6	-1.5	-0.8
Comparative height size at age 10	2.3	12.4	20.6	4.2	-2.8	-2.8	1.2	4.5	4.1	3.8
Number of full sisters	2.4	2.9	6.8	-1.8	0.5	1.5	-1.5	-2.1	-1.2	-2.6
Suffer from ‘nerves’	1.7	2.7	5.4	2.1	-1.2	-1.7	0.5	1.5	2.3	1.5
Overall health rating	8.1	17.4	26.6	-4.6	4.8	4.2	-0.4	-5.2	-4.4	-3.7
Chest pain or discomfort	1.7	2.5	5.3	-1.5	1.1	1.4	-0.3	-2.3	-1.6	-2.0
Had major operations	0.1	0.1	0.3	0.3	-0.1	0.0	-0.2	-0.1	0.6	-0.3
Age at last live birth	0.7	1.1	4.8	0.8	-2.2	-0.6	0.7	0.6	0.9	-0.2
Family relationship satisfaction	0.7	0.8	1.4	-1.0	1.2	1.0	0.5	-1.1	-0.9	-0.5
Leg pain on walking	0.9	1.1	2.4	-1.0	0.4	0.5	-0.5	-1.4	-1.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.2	5.4	-2.2	2.1	1.7	-0.3	-1.8	-2.3	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	4.0	0.8	-2.0	-0.6	0.3	0.9	0.9	1.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	1.2	-1.3	-1.1	0.3	0.9	0.9	0.7
Medication: Aspirin	0.2	0.3	0.9	0.7	0.0	-0.2	0.6	0.2	0.2	1.0
Supplements: Vitamin C	0.5	0.6	1.0	1.0	-0.6	-0.6	0.6	1.0	0.9	0.7
Knee pain experienced in last month	0.5	0.8	1.9	-0.9	0.8	1.2	1.4	-0.7	-0.7	-0.3
Hypertension (Self-reported)	0.4	1.0	3.1	-0.5	1.1	1.1	1.8	-1.2	-0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.3	-0.4	0.0	0.5	0.2	0.2	0.0
Illnesses of father: Heart disease	0.4	0.5	1.3	-0.4	0.0	0.2	-1.1	-1.0	-0.5	-1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-0.9	-0.0	0.6	-0.6	-0.6	-0.8	-1.0
Smoking status: Previous	0.1	0.2	0.7	0.0	0.8	-0.1	-0.4	-0.5	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.8	0.9	-0.5	-0.8	0.4	1.7	0.8	1.7
Whole body fat-free mass	0.1	0.3	0.9	0.7	-1.0	-0.2	0.1	0.2	0.9	0.3
Leg fat-free mass (right)	0.1	0.3	0.9	-0.1	-0.3	0.8	0.8	-0.9	0.1	-0.3
Arm fat percentage (left)	3.8	15.3	25.7	-4.3	4.0	4.1	0.4	-5.1	-4.2	-3.3
Average weekly red wine intake	3.0	4.4	8.4	2.9	-1.7	-2.8	-0.6	1.7	2.8	0.8
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.5	-0.2	-0.6	-0.1	0.4	0.2	-0.1
Mood swings	1.6	2.9	5.2	-1.9	2.3	1.5	-0.7	-1.9	-1.6	-1.6
Loneliness, isolation	0.5	0.7	1.8	-0.4	1.3	0.9	0.8	-0.7	-0.4	-0.8
Long-standing illness, disability or infirmity	5.1	7.7	10.8	-2.9	3.2	3.1	0.9	-3.3	-2.8	-2.6
Ever had bowel cancer screening	0.5	0.5	0.9	-0.9	0.6	0.8	-0.2	-1.0	-0.8	-0.5
Diabetes diagnosed by doctor	2.2	3.7	6.8	-2.1	2.6	2.0	0.0	-2.3	-2.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.5	-1.6	0.4	1.3	-0.2	-2.1	-1.6	-2.1
Friendships satisfaction	0.1	0.1	0.3	0.2	0.6	-0.3	-0.0	-0.2	0.1	0.0
Qualifications: nursing, teaching	2.4	3.7	6.0	2.4	-2.1	-1.7	1.0	1.9	2.4	1.6
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.2	1.0	0.6	1.1	-0.4	-0.2	-0.4
Eye problems/disorders: Cataract	0.2	0.2	1.0	0.4	-0.3	0.5	1.0	0.0	0.2	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.6	1.5	-1.4	-1.4	0.5	1.6	1.4	1.5
Medication for cholesterol	1.1	1.7	2.8	1.5	-1.1	-1.7	-0.9	1.3	1.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	-0.3	-0.2	1.2	0.7	-0.5	0.1	-0.9
Back pain experienced in last month	0.3	0.5	1.8	-0.6	0.8	0.0	-1.4	-0.6	-0.5	0.1
Mineral and other dietary supplements	5.1	6.9	11.5	-3.4	2.5	2.7	-0.9	-2.8	-3.3	-2.0
Breast cancer (self-reported)	0.6	0.8	2.2	-0.7	1.5	1.0	0.7	-0.4	-0.7	-0.5
Asthma (self-reported)	5.9	11.8	19.6	-4.0	2.0	3.8	0.7	-4.4	-3.6	-3.9
Osteoporosis (self-reported)	1.3	1.6	3.0	-1.4	0.5	0.8	-1.0	-1.5	-1.3	-1.7
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.2	0.3	0.0	0.1	0.1	-0.1	-0.3
Medication: Aspirin	0.3	0.4	1.1	0.8	0.1	-0.3	0.7	0.4	0.3	1.1
Medication: Gliclazide	0.1	0.1	0.4	0.2	0.0	-0.3	-0.6	-0.3	-0.0	0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-0.3	-0.4	0.6	1.0	0.7	0.1	0.2
Smoking status: Current	1.6	2.5	4.2	-1.9	0.9	1.7	-0.5	-1.5	-1.8	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	10.9	2.0	-3.3	-1.5	-0.4	1.6	2.2	0.1
Whole body water mass	0.0	0.2	0.8	0.6	-0.9	-0.2	-0.0	0.1	0.7	0.1
Leg predicted mass (right)	0.1	0.4	0.9	-0.2	-0.3	0.8	0.9	-0.9	0.0	-0.3
Arm fat mass (left)	2.0	8.3	14.4	-3.2	3.0	3.1	0.1	-3.8	-3.0	-2.4
Number of self-reported non-cancer illnesses	6.3	11.0	16.6	-3.6	4.1	3.6	0.9	-4.1	-3.3	-2.5
Average weekly champagne plus white wine intake	0.8	1.1	1.5	1.2	-1.2	-0.8	0.9	1.0	1.1	1.0
Miserableness	0.1	0.1	0.6	-0.2	-0.1	0.5	-0.1	-0.2	0.0	-0.7
Guilty feelings	0.4	0.6	1.3	0.9	0.2	-0.4	1.1	0.7	1.0	0.7
Wears glasses or contact lenses	1.2	1.4	2.5	-1.2	1.1	1.6	1.0	-1.4	-1.2	-0.3
Ever taken oral contraceptive pill	1.5	1.6	3.9	1.4	-2.0	-0.9	-0.1	1.2	1.8	0.1
Hearing aid user	1.7	1.9	3.3	-1.6	1.8	1.1	-0.3	-1.5	-1.6	-1.1
Mother’s age at death	0.1	0.1	0.4	-0.2	-0.2	0.2	0.7	-0.4	-0.4	-0.3
Financial situation satisfaction	1.2	1.5	2.6	-1.6	1.4	1.6	0.3	-1.0	-1.4	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.5	-1.2	0.9	0.9	-0.7	-1.6	-1.2	-1.5
Commuting to job workplace: Public transport	0.5	0.6	2.2	0.7	1.5	-0.2	1.0	0.2	0.5	0.5
Eye problems/disorders: Glaucoma	0.4	0.5	2.4	0.3	-0.2	-0.9	-1.6	0.3	0.3	0.4
Medication: Blood pressure	0.5	0.9	1.5	-1.0	1.2	1.1	0.4	-1.1	-1.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.5	0.1	-0.4	-0.3	0.5	0.4	0.6
Supplements: Fish oil (including cod liver oil)	8.3	10.8	17.5	4.2	-2.7	-3.1	1.3	3.7	4.1	3.1
High cholesterol (Self-reported)	2.9	5.1	6.9	-2.6	2.6	2.1	-0.2	-2.6	-2.5	-2.2
Medication: Bendroflumethiazide	1.4	2.2	4.1	-1.5	0.6	2.0	2.0	-1.6	-1.2	-0.8
Medication: Paracetamol	0.1	0.1	0.4	-0.2	0.6	0.3	0.4	-0.4	-0.0	0.3
Medication: Lisinopril	1.1	1.4	2.1	1.2	-1.1	-0.5	1.3	1.5	1.3	1.1
Medication: Atorvastatin	0.1	0.1	0.9	-0.0	0.9	0.1	-0.1	-0.0	-0.2	0.3
Illnesses of father: High blood pressure	0.5	0.7	1.4	0.9	-1.1	-1.2	-0.5	0.4	0.8	-0.1
Alcohol drinker status: Never	1.0	1.2	2.9	-0.9	0.7	1.5	1.7	-1.1	-0.8	-0.3
Ever smoked	0.2	0.4	1.0	0.1	-0.3	-0.3	-1.0	-0.4	0.4	-1.0
Basal metabolic rate	0.0	0.1	0.1	0.1	-0.3	0.3	0.1	-0.3	0.3	-0.0
Leg fat percentage (left)	1.7	6.3	8.8	-3.0	2.9	2.8	-0.2	-2.8	-2.8	-1.9
Arm fat-free mass (left)	0.0	0.2	0.4	0.4	-0.6	-0.0	0.1	0.4	0.7	0.4
Number of operations (self-reported)	3.0	4.4	6.5	-2.4	2.0	2.3	-0.2	-2.5	-2.3	-2.1
Average weekly beer plus cider intake	1.5	2.1	3.1	-1.8	1.3	1.1	-1.2	-1.6	-1.4	-1.7
Irritability	0.2	0.3	0.7	0.4	0.3	-0.5	-0.7	0.2	0.9	0.3
Risk taking	0.2	0.3	0.6	0.6	0.4	-0.8	-0.4	0.6	0.7	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	-0.6	0.8	0.6	0.6	-0.6	-0.4	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	3.5	0.3	-0.3	-1.0	-1.9	-0.4	0.4	-0.5
Age started oral contraceptive pill	0.7	0.8	2.8	-0.8	0.7	0.1	-1.7	-1.0	-0.6	-0.8
Diastolic blood pressure, automated reading	0.1	0.3	1.6	0.2	-1.2	-0.1	0.2	-0.2	-0.3	-0.6
Ever depressed for a whole week	0.8	1.0	3.2	-0.9	1.0	-0.2	-1.8	-1.0	-0.9	-0.3
Unable to work because of sickness or disability	0.5	0.6	1.2	-1.1	0.6	0.8	0.0	-0.7	-1.0	-0.8
Commuting to job workplace: Cycle	4.1	4.9	8.6	2.7	-2.0	-2.9	-1.6	2.1	2.7	0.6
Myopia	1.0	1.5	2.6	1.6	-1.5	-1.2	0.2	1.1	1.5	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.7	0.5	-0.8	-1.0	-1.3	1.2	0.3	0.2
Cholesterol lowering medication	4.7	7.0	10.6	-3.1	3.1	2.5	-0.6	-2.9	-3.2	-2.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.0	-1.1	0.6	1.2	0.7	-1.5	-0.9	-1.7
Pain experienced in last month	0.7	1.2	2.3	1.4	-1.5	-1.1	0.1	1.3	0.8	0.7
Supplements: Calcium	6.3	6.9	10.8	3.0	-2.9	-2.9	-0.8	2.7	3.3	1.9
Basal cell carcinoma (self-reported)	1.2	1.4	3.0	-1.2	1.7	1.1	-0.2	-1.0	-1.5	-1.0
Heart attack/myocardial infarction (self-reported)	3.5	4.5	6.9	2.6	-2.3	-2.1	0.2	2.2	2.5	1.8
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	6.1	-1.6	2.1	2.5	1.7	-1.5	-1.7	-0.8
Heart disease (siblings)	2.5	3.1	6.2	-2.0	1.5	1.6	-0.3	-2.1	-2.5	-1.5
Alcohol drinker status: Previous	0.3	0.4	0.9	0.8	-0.8	-0.4	-0.3	0.2	0.9	0.5
Pack years of smoking	1.2	1.8	3.9	-1.5	0.0	1.7	0.9	-1.2	-1.2	-2.0
Impedance of whole body	1.2	6.2	14.7	2.4	-0.1	-2.2	1.1	3.7	2.0	3.8
Leg fat mass (left)	1.1	4.4	6.5	-2.5	2.4	2.2	-0.4	-2.5	-2.3	-1.5
Arm predicted mass (left)	0.0	0.1	0.1	0.2	-0.3	0.1	-0.2	0.1	0.4	0.2