TWAS hub - RAD9A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.4330	0.0660	3.0e-07	0.215	NA	0.222	NA	0.232	2.0e-17	NA	4.4e-18	NA	7.1e-19
2	GTEx	Adrenal Gland	0.4571	0.1156	1.3e-04	0.079	NA	0.193	NA	0.216	8.8e-04	NA	1.8e-07	NA	2.9e-08
3	GTEx	Artery Tibial	0.3872	0.0840	9.8e-05	0.261	NA	0.231	NA	0.245	1.6e-20	NA	4.6e-18	NA	3.5e-19
4	GTEx	Cells Transformed fibroblasts	0.2430	0.0830	9.4e-05	0.155	NA	0.136	NA	0.162	9.8e-12	NA	2.2e-10	NA	3.6e-12
5	GTEx	Colon Transverse	0.3960	0.1090	2.2e-04	0.163	NA	0.111	NA	0.156	3.3e-08	NA	6.3e-06	NA	7.2e-08
6	GTEx	Esophagus Muscularis	0.2470	0.1130	5.8e-03	0.256	NA	0.255	NA	0.259	1.0e-15	NA	1.2e-15	NA	6.2e-16
7	GTEx	Muscle Skeletal	0.1220	0.0481	1.1e-03	0.019	NA	0.030	NA	0.032	5.1e-03	NA	6.2e-04	NA	4.2e-04
8	GTEx	Nerve Tibial	0.5297	0.0787	1.9e-06	0.245	NA	0.184	NA	0.226	2.0e-17	NA	4.5e-13	NA	5.6e-16
9	GTEx	Skin Sun Exposed Lower leg	0.3330	0.0790	2.0e-06	0.022	NA	0.119	NA	0.097	5.7e-03	NA	4.4e-10	NA	2.0e-08
10	GTEx	Testis	0.7220	0.0650	1.1e-06	0.505	NA	0.453	NA	0.493	1.5e-25	NA	3.6e-22	NA	1.1e-24
11	GTEx	Thyroid	0.2680	0.0670	1.1e-06	0.069	NA	0.192	NA	0.203	6.0e-06	NA	1.2e-14	NA	1.8e-15
12	ROSMAP	Brain Pre-frontal Cortex	0.3435	0.0542	2.5e-13	0.171	0.157	0.204	0.204	0.186	1.8e-21	1.1e-19	1.1e-25	1.2e-25	2.6e-23
13	YFS	Blood	0.0753	0.0305	1.1e-05	0.024	0.019	0.031	0.035	0.036	1.8e-08	6.1e-07	1.4e-10	1.3e-11	5.4e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Height	46.6	898.9	1310.4	-34.7	-15.9	-36.0	-31.7	-30.2	-36.2	-28.8	-35.8	-11.4	-35.7	-23.3	-31.9	-25.1
Standing height	42.7	423.5	630.0	-24.1	-10.5	-25.0	-21.6	-20.9	-25.1	-19.8	-24.7	-6.8	-24.7	-15.5	-21.8	-16.8
Comparative height size at age 10	36.7	202.3	313.3	-16.9	-6.4	-17.4	-14.8	-14.1	-17.7	-13.2	-17.3	-4.5	-17.2	-10.6	-15.4	-11.4
Forced vital capacity (FVC), Best measure	29.9	109.4	161.3	-11.5	-6.0	-12.2	-11.3	-10.7	-12.7	-9.4	-11.9	-5.2	-12.1	-9.3	-11.3	-9.2
Forced vital capacity (FVC)	28.2	108.5	169.0	-11.8	-5.3	-12.4	-11.1	-10.5	-13.0	-9.3	-12.1	-4.5	-12.3	-8.9	-11.3	-8.7
Forced expiratory volume in 1-second (FEV1), predicted	24.8	51.4	71.9	-8.4	-4.3	-8.5	-7.7	-7.4	-8.3	-7.4	-8.2	-3.0	-8.4	-5.9	-6.8	-6.4
Forced expiratory volume in 1-second (FEV1), Best measure	22.2	71.0	104.0	-9.4	-4.7	-9.8	-9.1	-8.6	-10.2	-7.5	-9.5	-4.2	-9.8	-7.4	-9.2	-7.5
Forced expiratory volume in 1-second (FEV1)	21.5	72.5	112.4	-9.8	-4.2	-10.1	-9.0	-8.6	-10.6	-7.8	-9.7	-3.8	-10.0	-7.2	-9.3	-7.3
Peak expiratory flow (PEF)	20.0	46.4	70.6	-7.8	-3.6	-8.1	-7.1	-7.0	-8.4	-6.7	-7.7	-2.9	-8.0	-5.2	-7.7	-5.6
Trunk predicted mass	17.4	99.2	166.4	-12.3	-3.9	-12.8	-10.2	-9.3	-12.9	-8.7	-12.5	-2.6	-12.6	-6.3	-10.5	-7.5
Trunk fat-free mass	17.0	97.5	163.8	-12.2	-3.7	-12.7	-10.1	-9.2	-12.8	-8.5	-12.5	-2.4	-12.6	-6.2	-10.4	-7.3
Hand grip strength (right)	16.8	45.7	72.8	-8.2	-2.8	-8.4	-6.9	-6.7	-8.5	-6.2	-8.2	-1.9	-8.3	-4.7	-7.5	-5.1
Arm fat-free mass (right)	16.2	83.2	139.2	-11.3	-3.6	-11.8	-9.2	-8.7	-11.7	-8.0	-11.5	-2.1	-11.6	-5.4	-9.4	-7.1
Arm predicted mass (right)	15.8	81.0	136.9	-11.3	-3.5	-11.7	-9.2	-8.5	-11.6	-7.7	-11.3	-2.0	-11.5	-5.4	-9.2	-6.9
Arm predicted mass (left)	15.1	76.6	127.7	-11.0	-3.3	-11.3	-8.8	-8.2	-11.3	-7.5	-11.1	-2.2	-11.2	-5.2	-9.3	-6.5
Arm fat-free mass (left)	15.0	75.9	127.7	-11.0	-3.1	-11.3	-8.8	-8.1	-11.3	-7.4	-11.1	-2.0	-11.2	-5.1	-9.2	-6.4
Hand grip strength (left)	14.9	39.2	63.7	-7.5	-2.8	-7.8	-6.4	-6.1	-8.0	-5.7	-7.7	-2.0	-7.7	-4.3	-7.1	-4.2
Whole body fat-free mass	14.4	82.0	141.6	-11.4	-3.1	-11.8	-9.1	-8.3	-11.9	-7.6	-11.6	-1.8	-11.7	-5.3	-9.4	-6.7
Whole body water mass	14.0	80.1	136.9	-11.3	-3.0	-11.7	-9.0	-8.2	-11.7	-7.5	-11.4	-1.8	-11.6	-5.2	-9.3	-6.6
Basal metabolic rate	14.0	77.7	132.2	-11.2	-3.1	-11.5	-8.8	-8.1	-11.5	-7.4	-11.3	-1.8	-11.4	-5.0	-9.2	-6.5
Weight	12.1	59.5	100.0	-9.8	-3.0	-10.0	-7.6	-7.1	-9.9	-6.5	-10.0	-1.5	-10.0	-4.2	-8.1	-6.0
Leg predicted mass (left)	10.2	54.3	96.9	-9.6	-2.0	-9.8	-7.3	-6.4	-9.8	-5.9	-9.6	-0.8	-9.7	-3.7	-7.6	-5.3
Leg fat-free mass (left)	10.1	53.4	95.4	-9.5	-2.0	-9.8	-7.2	-6.3	-9.8	-5.9	-9.6	-0.8	-9.7	-3.7	-7.5	-5.2
Trunk fat mass	9.5	41.0	69.4	-8.2	-2.7	-8.3	-6.3	-6.0	-8.0	-5.6	-8.3	-1.0	-8.3	-3.4	-6.5	-5.2
Hip circumference	9.0	38.6	64.0	-7.7	-2.7	-8.0	-6.1	-5.7	-7.9	-5.3	-8.0	-1.6	-8.0	-3.3	-6.6	-5.0
Leg predicted mass (right)	9.0	48.2	87.6	-9.1	-1.7	-9.3	-6.8	-5.9	-9.4	-5.4	-9.2	-0.6	-9.2	-3.4	-7.2	-4.9
Leg fat-free mass (right)	8.9	47.6	86.5	-9.0	-1.7	-9.3	-6.7	-5.9	-9.3	-5.4	-9.1	-0.7	-9.2	-3.3	-7.2	-4.9
Blood Red Count	7.8	75.3	98.0	9.6	6.2	9.9	9.4	9.9	9.3	9.6	9.4	4.1	9.8	7.0	8.1	8.5
Impedance of leg (right)	7.3	35.5	52.2	-5.6	-5.4	-5.7	-6.5	-7.2	-5.6	-7.2	-5.7	-4.0	-5.7	-6.5	-5.8	-5.8
Pulse wave peak to peak time	7.0	8.2	11.6	-3.1	-1.7	-3.2	-3.0	-3.2	-3.3	-2.7	-3.2	-1.5	-3.2	-2.3	-3.4	-2.7
Waist circumference	6.7	24.6	45.0	-6.4	-1.8	-6.7	-4.7	-4.3	-6.5	-4.0	-6.7	-0.4	-6.6	-2.1	-5.0	-3.6
Whole body fat mass	6.5	27.2	47.5	-6.8	-2.0	-6.9	-5.1	-4.8	-6.6	-4.4	-6.9	-0.6	-6.8	-2.5	-5.2	-4.2
Risk taking	6.3	9.2	14.0	-3.7	-1.9	-3.7	-3.3	-3.1	-3.7	-2.6	-3.4	-1.7	-3.6	-2.6	-3.2	-2.1
Impedance of leg (left)	6.2	30.2	45.7	-5.1	-5.2	-5.2	-6.0	-6.8	-5.0	-6.7	-5.1	-3.7	-5.1	-6.1	-5.3	-5.5
Supplements: Glucosamine	5.1	6.6	11.0	-2.8	-1.8	-3.2	-2.7	-2.6	-3.3	-2.5	-2.8	-0.9	-3.1	-2.0	-2.6	-2.1
Migraine (self-reported)	5.1	6.3	9.8	2.4	2.1	2.1	2.6	2.8	2.3	2.3	2.2	2.3	2.1	3.1	2.9	2.9
Impedance of whole body	4.9	24.8	36.2	-4.7	-4.6	-4.7	-5.5	-5.9	-4.6	-6.0	-4.8	-3.0	-4.7	-5.6	-4.8	-5.1
Worry (Nagel 2018)	4.8	10.2	16.8	2.5	3.7	2.7	3.4	3.7	2.7	3.6	2.7	2.9	2.6	3.2	4.1	3.4
Waist Hip Ratio (WHR)	4.7	21.0	35.0	-5.6	-2.3	-5.8	-4.9	-4.2	-5.9	-4.2	-5.7	-1.2	-5.8	-3.4	-4.0	-3.6
Trunk fat percentage	4.7	18.9	32.4	-5.5	-2.1	-5.6	-4.2	-4.1	-5.2	-3.9	-5.7	-0.6	-5.6	-2.2	-4.3	-3.8
Ever highly irritable/argumentative for 2 days	4.6	5.6	9.7	1.7	3.1	2.0	2.5	2.7	2.2	2.7	2.2	2.1	2.0	2.6	2.8	1.6
Suffer from ‘nerves’	4.6	7.2	10.1	2.6	2.0	3.0	2.8	3.2	3.0	2.6	2.9	1.1	3.0	1.9	3.1	2.8
Neuroticism (Nagel 2018)	4.2	9.9	20.9	2.1	3.2	2.5	3.2	3.5	2.7	3.6	2.9	2.8	2.4	3.3	4.6	3.3
Impedance of arm (left)	4.1	18.9	25.5	-4.1	-4.1	-4.1	-4.8	-4.8	-4.1	-5.0	-4.3	-2.6	-4.1	-5.0	-4.3	-4.6
Age started oral contraceptive pill	4.0	5.0	8.9	-2.6	-1.0	-2.8	-2.4	-1.9	-2.8	-2.0	-3.0	-0.6	-2.8	-1.5	-2.5	-1.2
Neuroticism (2016)	3.9	5.6	11.2	1.3	3.3	1.3	2.2	2.6	1.4	2.7	1.7	3.3	1.3	2.8	2.6	2.7
Qualifications: NVQ or HND or HNC or equivalent	3.9	4.7	7.6	2.1	1.9	2.2	2.2	2.5	2.2	2.0	2.0	2.8	2.1	2.0	2.4	1.6
Alcohol drinker status: Previous	3.8	4.3	6.9	1.3	2.6	1.5	2.0	2.2	1.9	2.5	1.8	1.8	1.4	2.6	2.5	2.2
Hair/balding pattern: Pattern 3	3.7	5.4	7.4	2.0	2.6	2.1	2.5	2.7	2.0	2.7	2.0	1.9	2.1	2.6	2.6	2.3
Sitting height	3.6	25.9	42.9	-6.4	-2.4	-6.5	-4.9	-5.2	-6.5	-4.9	-6.2	-0.6	-6.4	-2.9	-5.4	-3.5
Comparative body size at age 10	3.6	9.8	15.7	3.0	2.1	3.5	3.4	3.2	3.8	2.6	3.6	2.0	3.5	3.1	4.0	2.1
Neuroticism	3.4	8.1	14.0	2.1	3.1	2.3	2.9	3.2	2.4	3.1	2.4	3.0	2.2	2.9	3.7	3.2
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.6	8.7	2.0	2.1	2.3	2.4	2.9	2.3	2.9	2.1	1.8	2.2	2.3	2.5	2.4
Leg fat mass (right)	3.4	13.2	24.6	-4.9	-1.0	-5.0	-3.4	-3.2	-4.7	-2.9	-5.0	0.0	-4.9	-1.1	-3.6	-2.5
Leg fat mass (left)	3.4	13.2	24.7	-4.8	-1.1	-5.0	-3.4	-3.2	-4.7	-2.9	-5.0	0.0	-5.0	-1.1	-3.7	-2.6
Mineral and other dietary supplements	3.2	4.4	7.2	2.4	1.5	2.3	2.1	1.9	2.6	2.2	2.4	0.7	2.2	1.7	2.7	1.5
Guilty feelings	3.2	4.8	6.3	1.4	2.4	1.8	2.4	2.5	1.9	2.3	1.9	2.5	1.8	2.4	2.3	2.5
Ulcerative Colitis (UC)	3.0	5.6	9.4	2.6	2.0	2.6	2.4	2.8	2.7	3.1	2.5	0.8	2.6	1.9	2.2	1.7
Mouth/teeth dental problems: Bleeding gums	3.0	3.8	6.4	2.5	0.3	2.4	2.0	2.0	2.4	1.6	2.3	0.7	2.3	1.4	2.5	1.4
Mouth/teeth dental problems: Dentures	2.9	4.8	7.7	-2.0	-1.6	-2.6	-2.5	-2.2	-2.6	-2.0	-2.8	-1.4	-2.6	-1.8	-2.0	-2.0
Medication: Paracetamol	2.9	4.5	7.6	1.8	1.6	1.7	2.3	2.2	1.8	2.2	1.9	2.2	1.7	2.8	2.3	2.7
Myopia	2.9	4.3	9.7	1.4	3.1	1.7	2.1	2.3	1.4	2.9	1.7	1.9	1.7	1.9	1.3	2.5
Prostate Cancer	2.8	3.9	7.3	2.2	1.5	2.5	1.8	2.1	2.3	2.7	2.2	-0.4	2.4	0.9	1.4	1.9
Allergy or Eczema	2.7	7.2	12.6	3.5	1.7	3.2	3.0	3.1	3.1	2.7	2.8	1.1	3.2	2.7	1.3	1.9
Impedance of arm (right)	2.7	12.6	18.1	-3.5	-3.5	-3.2	-3.9	-3.9	-3.3	-4.3	-3.4	-2.0	-3.2	-4.2	-3.5	-3.5
Worrier / anxious feelings	2.7	5.0	8.3	1.6	2.7	1.8	2.3	2.6	1.8	2.7	1.9	1.5	1.7	2.4	2.9	2.7
Pulse rate	2.7	4.5	6.1	2.1	1.3	2.4	2.3	2.5	2.5	2.2	2.4	0.8	2.5	2.1	1.9	2.0
Average weekly red wine intake	2.6	3.8	6.6	1.9	1.8	1.6	2.0	2.2	1.2	2.6	1.8	2.3	1.7	1.9	1.6	2.5
Arm fat mass (left)	2.6	10.5	21.0	-4.4	-0.9	-4.4	-3.0	-2.5	-4.3	-2.2	-4.6	-0.0	-4.4	-1.0	-3.4	-2.3
Lung FVC	2.5	12.7	19.7	-3.2	-2.3	-3.6	-4.0	-3.3	-4.4	-2.0	-3.7	-3.7	-3.7	-4.4	-4.0	-3.2
Chronotype (morning person)	2.5	5.7	8.2	2.4	1.9	2.5	2.8	2.1	2.6	1.3	2.3	2.3	2.5	2.7	2.6	2.9
Average weekly champagne plus white wine intake	2.5	3.4	6.4	-1.8	-2.1	-1.8	-2.2	-1.9	-1.7	-2.5	-1.9	-1.3	-1.8	-1.9	-1.4	-1.3
Happiness	2.4	2.9	6.9	-2.5	0.3	-2.4	-1.4	-1.0	-2.6	-0.5	-2.2	0.3	-2.4	-0.6	-1.7	-1.3
Worry too long after embarrassment	2.4	4.0	6.1	1.6	1.7	2.1	2.2	2.2	2.3	1.9	1.9	1.1	2.1	1.6	2.5	2.3
Commuting to job workplace: Walk	2.4	2.5	3.8	1.8	0.5	1.8	1.9	1.6	1.8	1.0	1.8	0.9	2.0	1.7	1.5	1.6
Osteoarthritis (self-reported)	2.4	3.2	6.2	-2.3	-0.5	-2.5	-1.7	-1.4	-2.3	-1.6	-2.4	-0.0	-2.5	-0.5	-1.7	-1.2
Loud music exposure frequency	2.3	2.5	4.6	-1.2	-1.6	-1.3	-1.9	-1.4	-1.4	-1.5	-1.8	-1.0	-1.4	-2.1	-1.5	-2.1
Medication: Paracetamol	2.3	3.8	8.4	1.5	1.7	1.4	2.1	2.0	1.6	2.1	1.6	2.3	1.4	2.9	1.9	2.4
Body fat percentage	2.3	9.1	16.5	-3.9	-1.5	-3.9	-2.9	-2.8	-3.6	-2.7	-4.1	-0.2	-3.9	-1.2	-3.0	-2.6
Supplements: Fish oil (including cod liver oil)	2.3	3.0	4.5	-1.7	-1.9	-1.5	-1.7	-1.7	-1.8	-1.9	-1.8	-1.0	-1.5	-1.9	-2.1	-1.7
Neuroticism score	2.2	4.6	8.0	1.4	2.2	1.8	2.3	2.5	1.8	2.3	1.7	2.4	1.7	2.2	2.8	2.3
Illnesses of father: Heart disease	2.2	3.0	6.1	2.5	-0.5	2.4	1.6	1.4	2.4	1.2	2.4	-0.2	2.4	0.7	1.8	0.9
Number of self-reported non-cancer illnesses	2.2	3.7	7.7	1.2	2.2	1.4	2.1	2.4	1.5	2.8	1.3	2.4	1.4	2.6	1.5	1.5
Nervous feelings	2.1	3.9	5.8	1.5	2.4	1.7	2.4	2.0	1.8	1.5	1.7	2.2	1.7	2.3	2.0	2.1
Arm fat mass (right)	2.1	8.6	17.6	-4.2	-0.6	-4.1	-2.6	-2.1	-3.9	-1.9	-4.2	0.2	-4.1	-0.6	-3.0	-2.0
Smoking status: Previous	2.1	3.1	5.2	2.0	1.0	1.6	2.1	1.4	1.9	1.6	1.9	1.5	1.6	2.3	1.8	1.9
Overall health rating	2.0	4.4	9.4	1.3	2.7	1.3	2.3	2.6	1.4	3.1	1.4	2.1	1.3	3.0	1.9	1.5
Ovarian Cancer	1.9	2.5	5.0	1.2	2.2	1.1	1.6	1.9	0.9	2.1	1.1	2.2	1.0	1.7	1.4	1.4
Time employed in main current job	1.9	2.2	3.9	-1.6	-1.4	-1.5	-1.5	-1.4	-1.5	-2.0	-1.6	-0.6	-1.5	-1.3	-1.1	-1.7
Age at first live birth	1.8	3.1	5.6	-2.2	-1.2	-1.9	-1.6	-2.0	-2.0	-2.4	-1.9	-0.3	-1.8	-1.4	-1.7	-1.7
Shortness of breath walking on level ground	1.8	2.1	3.6	1.3	1.2	1.5	1.4	1.9	1.7	1.5	1.4	0.6	1.5	1.6	1.9	0.8
Hearing difficulty/problems: Yes	1.7	2.7	7.5	1.5	0.5	1.6	1.4	1.8	1.7	1.7	1.7	0.9	1.5	1.2	2.7	1.7
Serious illness, injury or assault to yourself	1.7	2.1	6.7	0.6	2.6	0.5	1.5	1.3	0.3	2.3	0.7	0.9	0.6	2.1	0.6	2.1
Hayfever, allergic rhinitis or eczema	1.7	3.7	7.7	2.8	1.2	2.4	2.1	2.2	2.4	1.9	1.9	0.4	2.4	1.8	0.5	1.0
Had other major operations	1.7	2.0	3.8	-1.8	-0.1	-1.9	-1.6	-1.0	-1.8	-0.9	-1.9	0.4	-1.9	-0.9	-1.1	-1.4
Headache pain in last month	1.7	3.0	4.6	1.6	1.8	1.6	1.8	2.1	1.5	1.9	1.6	1.1	1.5	2.0	1.8	2.0
Age at last live birth	1.7	2.5	5.2	-1.6	-1.2	-1.9	-1.4	-1.6	-2.0	-2.3	-1.8	-0.5	-1.8	-0.8	-1.1	-1.6
Wears glasses or contact lenses	1.7	2.0	2.7	1.4	1.4	1.4	1.5	1.6	1.5	1.6	1.6	1.1	1.5	1.4	1.4	0.7
Father’s age at death	1.6	2.1	3.9	-2.0	0.0	-2.0	-1.4	-1.2	-1.9	-1.1	-1.8	-0.0	-1.9	-0.6	-1.8	-1.1
Medication: Blood pressure	1.6	2.8	4.7	1.9	0.6	2.2	1.8	1.9	2.1	1.4	1.8	0.5	2.2	1.1	2.0	1.0
Illnesses of father: None of the above (group 1)	1.6	2.0	3.5	-1.8	-0.4	-1.7	-1.6	-1.3	-1.7	-1.6	-1.9	-0.2	-1.7	-1.3	-0.9	-1.1
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.8	1.1	1.8	0.8	1.5	1.4	1.0	1.4	1.0	1.2	0.9	2.2	1.6	1.2
Fractured/broken bones in last 5 years	1.6	2.1	5.0	-2.1	0.4	-2.2	-1.4	-0.5	-2.2	-0.4	-1.9	0.6	-2.1	-0.4	-1.2	-0.2
Irritable Bowel Disease (IBD)	1.5	3.5	6.6	2.2	1.6	2.0	1.8	2.1	2.1	2.6	2.1	-0.0	2.0	1.4	1.9	1.0
Medication for hormone replacement therapy	1.5	1.7	4.7	1.6	-0.1	1.6	1.0	1.1	1.7	1.1	1.7	-0.2	1.5	0.5	2.2	0.4
Allergy	1.5	3.6	7.0	-2.6	-1.6	-2.1	-2.0	-2.5	-2.0	-2.2	-1.3	-1.2	-2.0	-2.1	-0.8	-1.0
Severe depression (siblings)	1.4	1.6	3.4	-1.1	-1.2	-1.1	-1.3	-0.9	-1.3	-1.1	-1.2	-1.4	-1.2	-1.3	-1.2	-1.8
Qualifications: CSEs or equivalent	1.4	1.8	3.4	1.5	1.0	1.6	1.5	1.0	1.7	1.0	1.8	1.0	1.7	0.9	1.2	1.2
Back pain experienced in last month	1.4	2.0	3.2	-1.8	-1.1	-1.8	-1.4	-1.2	-1.5	-1.5	-1.5	-0.4	-1.8	-0.6	-1.3	-1.6
Illnesses of father: High blood pressure	1.4	1.7	4.6	0.6	1.5	0.6	1.4	1.4	0.5	1.2	0.8	1.9	0.6	2.2	1.3	1.5
Medication: Atenolol	1.3	1.7	3.2	-1.4	-0.5	-1.7	-1.1	-1.2	-1.7	-1.3	-1.8	0.6	-1.7	-0.2	-1.5	-1.1
Pulse wave Arterial Stiffness index	1.3	1.5	2.7	1.1	0.7	1.2	1.2	1.5	1.3	1.0	1.3	0.9	1.2	1.0	1.6	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.7	0.6	1.5	1.0	1.4	2.2	1.1	1.9	0.9	1.6	1.0	1.5	2.0	0.7
Birth weight of first child	1.3	2.3	5.0	-1.9	0.1	-1.6	-1.4	-1.0	-2.0	-1.3	-1.9	-0.2	-1.6	-1.5	-2.2	-1.5
Wheeze or whistling in the chest in last year	1.3	2.3	3.9	1.6	1.0	1.6	1.6	2.0	1.8	1.6	1.2	1.2	1.5	1.6	1.5	1.4
Medication: Omeprazole	1.3	1.5	4.5	-1.0	-0.5	-1.3	-1.2	-0.8	-1.5	-0.4	-1.6	-1.1	-1.3	-0.9	-2.1	-1.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.0	1.1	1.1	0.8	1.1	1.0	1.0	1.5	1.0	1.2	0.8	1.5	1.3	1.7
Asthma	1.2	2.4	4.7	1.8	1.0	1.6	1.5	2.2	1.7	1.5	1.2	1.2	1.6	1.7	1.7	1.1
Knee pain experienced in last month	1.2	1.8	3.9	-1.9	-0.2	-2.0	-1.0	-0.8	-1.8	-1.0	-1.8	1.1	-1.9	0.2	-0.3	-1.3
Ever had bowel cancer screening	1.2	1.4	2.5	-1.0	-0.8	-1.5	-1.4	-1.3	-1.5	-0.7	-1.4	-0.2	-1.6	-1.1	-1.2	-0.9
Crohns Disease (2012)	1.1	1.7	4.6	0.0	2.2	0.0	1.3	1.8	0.0	2.1	1.2	1.1	1.2	1.2	1.5	0.7
Ulcerative Colitis	1.1	1.5	4.9	0.0	0.8	0.0	1.2	1.8	0.0	2.2	1.7	-0.0	1.9	0.4	1.5	0.8
Lung cancer (father)	1.1	1.3	3.8	-0.5	-2.0	-0.7	-1.4	-1.3	-0.3	-1.3	-0.5	-1.1	-0.7	-1.7	-0.1	-1.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.2	-1.6	-0.5	-1.8	-1.4	-1.4	-1.8	-1.3	-1.5	-0.0	-1.8	-0.8	-1.6	-0.7
Osteoporosis (self-reported)	1.1	1.3	2.5	-1.5	-0.5	-1.6	-1.0	-1.3	-1.5	-0.7	-1.4	0.2	-1.6	-0.3	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	4.2	-0.9	-0.8	-1.3	-1.7	-1.5	-1.6	-0.8	-1.3	-1.4	-1.4	-2.0	-1.9	-1.9
Medication: Blood pressure	1.1	2.0	4.6	-1.6	-0.3	-1.7	-1.2	-1.0	-2.0	-0.9	-2.1	1.0	-1.8	-0.5	-2.0	-0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.6	-1.6	-0.2	-1.6	-1.1	-1.0	-1.6	-0.7	-1.4	-0.9	-1.6	-0.4	-1.3	-1.0
Supplements: Calcium	1.1	1.2	3.2	-1.1	-1.0	-1.1	-1.0	-1.1	-1.3	-1.3	-1.1	-0.1	-1.1	-0.8	-1.8	-0.7
Mean Putamen Volume	1.0	1.2	3.2	0.0	-0.7	0.0	-1.4	-1.1	0.0	-1.2	-1.3	-0.9	-1.4	-1.3	-0.6	-1.8
Ever had hysterectomy (womb removed)	1.0	1.2	4.1	0.8	1.1	0.4	0.9	0.9	0.6	1.1	0.6	2.0	0.4	1.6	0.9	1.4
Past tobacco smoking	1.0	1.8	3.6	-1.3	-0.6	-1.1	-1.5	-1.0	-1.4	-1.2	-1.5	-1.2	-1.1	-1.9	-1.6	-1.4
Had menopause	1.0	1.2	2.5	-1.1	-1.2	-1.2	-1.1	-1.4	-1.1	-1.6	-1.0	-0.3	-1.2	-0.8	-1.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.3	1.2	0.6	1.4	1.0	1.2	1.4	1.0	1.4	0.4	1.5	0.2	1.1	1.1
Pulse rate, automated reading	1.0	3.2	5.2	1.8	1.8	1.9	1.9	2.3	1.7	2.0	1.6	0.9	1.9	1.9	1.4	1.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.3	-0.2	-1.8	-0.5	-1.2	-1.0	-0.4	-1.5	-0.6	-1.6	-0.5	-1.4	-0.5	-1.6
Asthma (self-reported)	1.0	2.1	4.1	1.8	0.9	1.6	1.4	2.0	1.7	1.4	1.1	1.0	1.5	1.4	1.5	0.9
Reaction Time	0.9	1.8	3.3	1.6	1.2	1.0	1.4	1.2	1.0	1.0	1.0	1.6	0.9	1.7	1.5	1.8
Stomach or abdominal pain in last month	0.9	1.2	2.6	1.1	-0.6	1.5	0.7	0.9	1.6	0.7	1.4	-0.8	1.5	0.0	1.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.9	0.6	1.1	0.9	1.2	1.4	1.0	1.6	1.0	0.8	1.0	1.2	1.7	1.2
Medication: Ramipril	0.9	1.2	2.0	1.4	0.7	1.2	1.2	1.3	1.1	1.4	1.1	0.5	1.2	0.9	0.8	0.8
Pulse wave reflection index	0.9	1.1	2.0	1.0	1.1	0.8	0.9	1.2	0.9	1.1	0.6	1.4	0.8	0.8	1.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.4	0.5	1.4	0.6	0.9	1.4	0.4	1.5	0.6	0.2	0.5	1.0	1.1	1.6
Supplements: Vitamin C	0.9	1.0	2.4	-1.3	0.5	-1.4	-0.6	-0.7	-1.5	-0.5	-1.3	0.5	-1.3	0.4	-1.6	-0.2
Qualifications: nursing, teaching	0.9	1.3	3.6	-0.7	-1.3	-0.6	-1.2	-1.0	-1.0	-1.2	-1.0	-1.4	-0.6	-1.9	-1.4	-0.9
Eye problems/disorders: Cataract	0.9	1.0	1.6	-0.8	-0.1	-1.2	-1.2	-0.8	-1.2	-0.1	-1.3	-1.2	-1.2	-0.7	-1.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.1	1.2	-1.1	1.4	0.8	0.6	1.4	0.7	1.5	-0.6	1.4	-0.0	1.2	0.6
Hearing aid user	0.9	1.1	1.7	1.2	0.7	1.1	1.0	0.9	1.2	1.1	1.3	0.5	1.1	0.7	1.1	1.2
Financial situation satisfaction	0.9	1.2	2.0	-1.3	-0.5	-1.1	-1.3	-0.9	-1.1	-0.7	-1.1	-0.6	-1.1	-1.4	-1.2	-1.3
Unable to work because of sickness or disability	0.9	1.2	2.6	-1.1	-0.4	-1.1	-1.2	-0.9	-1.1	-0.5	-1.2	-0.7	-1.1	-1.2	-1.1	-1.6
Pain experienced in last month	0.9	1.5	2.6	1.5	0.7	1.6	1.4	0.9	1.4	0.9	1.4	0.5	1.6	0.8	0.9	1.5
Cardiovascular Disease	0.8	2.6	4.2	1.3	1.2	1.4	1.7	2.0	1.5	1.8	1.4	2.0	1.4	1.9	1.5	1.4
High blood pressure (mother)	0.8	1.1	2.5	-0.8	-1.4	-0.8	-1.0	-1.2	-1.0	-1.6	-0.9	-0.2	-0.8	-1.1	-1.0	-1.4
Falls in the last year	0.8	1.1	2.8	-1.7	0.7	-1.5	-0.5	-0.1	-1.4	0.0	-1.5	0.9	-1.6	0.6	-0.5	-0.6
Depression (self-reported)	0.8	0.9	1.9	0.9	-0.2	1.3	1.0	1.1	1.4	0.7	1.1	0.6	1.2	0.9	1.1	0.0
Heart disease (mother)	0.8	1.0	3.9	-0.2	1.7	-0.2	0.8	0.9	-0.4	0.9	-0.1	2.0	-0.1	1.4	0.2	1.3
Family relationship satisfaction	0.8	0.9	2.4	-0.5	-0.8	-0.9	-1.0	-0.4	-0.8	-1.1	-1.2	-1.1	-0.9	-0.8	-1.0	-1.5
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	-0.8	-0.8	-0.6	-1.0	-1.0	-0.5	-1.3	-0.9	-1.3	-0.7	-1.1	-1.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	1.3	-0.2	1.6	0.9	1.1	1.7	0.0	1.4	0.2	1.6	0.5	1.5	0.8
Bipolar Disorder (2018)	0.7	1.2	2.6	0.0	0.6	0.0	1.3	1.6	0.0	1.4	1.0	1.4	1.0	1.3	1.2	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.7	-1.0	-1.1	-1.4	-1.6	-1.5	-1.3	-1.4	-1.2	0.1	-1.4	-1.4	-1.3	-1.5
Respiratory disease	0.7	1.6	2.8	1.4	0.9	1.2	1.4	1.7	1.3	1.0	0.7	1.5	1.1	1.7	1.4	0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.2	-1.4	-0.3	-1.2	-1.1	-0.6	-1.3	-0.7	-1.5	-0.8	-1.2	-0.8	-1.8	-1.4
Sensitivity / hurt feelings	0.7	1.2	3.1	0.0	1.3	0.5	1.1	1.5	0.6	1.0	0.6	1.1	0.5	1.4	1.8	1.2
Townsend deprivation index at recruitment	0.7	1.0	1.7	-0.7	-1.1	-1.0	-1.2	-1.0	-0.9	-0.4	-1.1	-1.3	-1.0	-1.0	-0.5	-1.1
Body mass index (BMI)	0.7	3.0	7.8	0.9	1.8	1.1	2.0	2.3	1.3	2.4	1.0	1.6	1.1	2.8	1.5	1.6
Financial difficulties in last 2 years	0.7	0.9	1.5	0.5	1.2	0.8	0.9	1.2	0.8	1.2	0.8	1.1	0.7	1.0	1.2	0.6
Mouth/teeth dental problems	0.7	1.1	2.4	-1.4	-0.2	-1.1	-0.9	-1.1	-1.1	-0.9	-1.1	-0.8	-1.1	-0.8	-1.5	-0.8
Heart attack	0.7	0.9	1.4	1.0	0.6	1.2	1.1	1.0	1.0	1.1	1.2	0.4	1.2	0.6	1.0	0.4
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.1	1.2	0.7	1.4	0.8	1.5	1.2	1.3	1.0	-0.5	1.3	0.2	0.2	-0.1
Prospective memory result	0.7	0.9	2.0	-1.3	0.1	-1.3	-0.8	-0.9	-1.4	-0.3	-1.4	-0.5	-1.4	-0.3	-0.8	-0.3
Breastfed as a baby	0.7	0.8	1.9	-0.8	0.2	-1.2	-0.7	-0.7	-1.4	-1.0	-1.3	0.6	-1.2	0.1	-1.2	-0.0
Tense / ‘highly strung’	0.7	1.1	2.9	0.7	1.1	0.8	1.0	1.4	0.9	1.4	0.9	0.8	0.8	0.8	1.7	0.6
Hair/balding pattern: Pattern 4	0.7	1.6	2.4	1.6	0.9	1.5	1.5	1.1	1.4	1.0	1.1	1.0	1.5	1.2	0.9	1.6
Qualifications: College or University degree	0.7	2.1	3.1	-1.7	-1.2	-1.6	-1.6	-1.2	-1.8	-1.1	-1.5	-1.1	-1.5	-1.4	-1.4	-1.4
Medication: Allopurinol	0.7	1.0	3.3	-1.2	-0.2	-0.9	-0.6	-1.0	-1.1	-1.2	-1.1	-0.4	-0.9	-0.2	-1.8	-0.9
Mean time to correctly identify matches	0.7	1.4	3.0	1.5	1.2	0.7	1.3	0.8	0.8	0.8	0.6	1.5	0.7	1.7	1.0	1.7
Mood swings	0.7	1.3	4.1	1.1	0.2	1.3	1.0	1.2	1.5	1.4	1.4	0.3	1.3	0.5	2.0	0.5
Smoking status: Current	0.7	1.1	3.1	-1.0	-1.8	-0.9	-1.2	-0.9	-0.6	-1.2	-0.8	-1.1	-0.9	-0.8	-0.0	-1.6
Mother’s age at death	0.7	0.9	3.4	-0.5	-0.2	-0.9	-1.0	-0.7	-1.1	-0.6	-1.1	-0.4	-0.9	-0.8	-1.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.9	-0.8	0.2	-1.1	-0.7	-0.2	-1.3	0.1	-1.4	-0.2	-1.1	-0.3	-2.0	-0.6
Depressed Affect (Nagel 2018)	0.6	1.3	5.5	0.4	0.8	0.7	1.0	1.1	0.9	1.6	1.1	1.0	0.7	1.1	2.3	1.1
Medication: Metformin	0.6	0.9	2.0	-1.2	-0.4	-1.0	-0.8	-0.7	-1.1	-0.9	-1.3	-0.3	-1.0	-0.7	-1.4	-0.9
Current tobacco smoking	0.6	1.0	2.6	-1.0	-1.6	-0.9	-1.1	-0.9	-0.6	-1.1	-0.8	-1.1	-0.9	-0.8	-0.1	-1.6
Taking other prescription medications	0.6	0.9	2.2	-0.9	-0.5	-1.2	-1.0	-0.5	-1.0	-0.1	-1.4	0.2	-1.2	-0.3	-1.0	-1.5
Age when periods started (menarche)	0.6	1.4	2.8	-1.7	-1.0	-1.4	-1.3	-1.2	-1.1	-1.2	-1.2	-0.8	-1.3	-0.9	-0.9	-1.4
Medication: Lansoprazole	0.6	0.7	2.7	0.7	1.6	0.1	0.7	0.6	-0.0	1.4	0.1	0.6	0.0	1.2	-0.3	0.6
Leg fat percentage (right)	0.6	2.1	4.5	-1.9	-0.8	-1.9	-1.3	-1.4	-1.6	-1.2	-2.1	-0.1	-2.0	-0.2	-1.5	-1.1
Medication for pain relief, constipation, heartburn	0.6	1.0	3.4	-0.6	-0.8	-0.3	-0.9	-1.1	-0.4	-1.2	-0.2	-1.7	-0.2	-1.9	-0.6	-1.2
Number of full sisters	0.6	0.7	2.3	-0.7	1.5	-0.8	0.1	0.6	-0.8	1.1	-0.6	0.1	-0.8	1.2	0.1	1.2
Alcohol drinker status: Never	0.6	0.7	2.5	-0.3	-0.3	-0.7	-0.9	-0.6	-0.6	-0.6	-1.0	-1.6	-0.6	-0.9	-1.1	-0.7
Commuting to job workplace: Cycle	0.6	0.7	1.9	-1.1	-0.3	-0.9	-0.8	-0.8	-1.1	0.1	-0.6	-1.4	-0.9	-0.8	-0.5	-0.6
Pack years of smoking	0.6	0.9	2.3	-1.3	0.7	-1.2	-0.6	-0.2	-1.4	-0.1	-1.5	0.2	-1.1	-0.0	-1.3	-0.2
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.0	-0.8	-1.2	-1.0	-1.4	-1.5	-1.1	-1.7	-1.1	-0.3	-1.1	-1.5	-1.4	-1.5
Lupus	0.5	0.8	2.4	-0.7	-1.5	-0.7	-0.7	-0.8	-0.8	-0.8	-0.9	-1.2	-0.7	-0.9	-1.0	-0.6
Schizophrenia (2014)	0.5	1.0	4.3	0.0	0.4	0.0	-1.0	-0.5	0.0	0.4	-2.1	-1.0	-1.8	0.0	-1.8	-0.4
Vitamin and mineral supplements	0.5	0.6	3.1	0.2	-1.3	-0.1	-0.7	-0.8	0.1	-0.8	-0.1	-1.8	-0.1	-1.1	0.3	-0.5
Medication: Co-codamol	0.5	0.6	1.0	-0.9	-0.2	-0.9	-0.9	-0.8	-0.9	-0.4	-0.8	-0.1	-1.0	-0.7	-0.9	-0.7
Diabetes (mother)	0.5	0.6	2.0	-1.1	0.3	-1.0	-0.4	-0.4	-1.4	-0.4	-1.1	0.6	-1.0	0.1	-1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	-1.0	-0.4	-0.8	-0.6	-0.4	-1.0	-0.5	-0.8	-0.5	-0.9	-0.4	-0.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	0.0	-1.6	-0.3	-1.0	-1.3	-0.3	-1.6	-0.6	-1.1	-0.3	-1.4	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.8	0.4	1.7	0.3	0.6	0.8	0.4	0.7	0.5	1.3	0.3	1.1	0.4	0.2
Qualifications: None of the above	0.5	1.1	2.1	1.0	0.5	1.3	1.0	0.7	1.4	1.1	1.4	-0.1	1.2	0.8	1.2	1.1
Illnesses of siblings	0.5	0.7	1.4	-0.8	0.0	-1.0	-0.8	-1.2	-0.9	-0.7	-1.0	-0.7	-0.9	-0.4	-1.1	-0.5
Illnesses of mother	0.5	0.6	4.5	0.0	-1.0	0.1	-0.6	-0.6	0.5	-0.1	0.1	-2.1	0.0	-1.0	0.1	-0.4
Chest pain or discomfort	0.5	0.8	1.3	1.0	0.8	1.1	0.9	1.0	1.1	1.1	1.0	0.2	1.1	0.3	0.7	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.6	-0.7	-1.1	-0.2	-0.7	-0.5	-0.2	-1.0	-0.2	-1.3	-0.3	-1.2	0.4	-0.6
Breast cancer (self-reported)	0.5	0.6	2.2	-0.5	1.5	-0.6	0.2	0.3	-0.7	0.9	-0.7	1.3	-0.6	0.7	-0.2	0.8
Average weekly beer plus cider intake	0.5	0.7	1.3	1.0	0.3	0.9	0.8	0.7	1.0	0.6	1.0	0.5	0.8	0.9	1.2	0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	0.0	-0.0	0.0	-0.9	-0.8	0.0	-0.3	-1.2	-0.6	-1.0	0.0	-1.4	-0.5
Alzheimer’s Disease (in father)	0.4	0.5	0.9	-0.6	-0.7	-0.6	-0.7	-0.9	-0.6	-0.8	-0.6	-0.2	-0.5	-0.9	-0.8	-0.6
Crohns Disease (2017)	0.4	0.9	2.3	1.2	1.3	0.9	0.8	0.9	1.0	1.5	1.1	-0.7	0.9	0.7	0.7	0.3
Fasting Glucose	0.4	0.5	1.7	0.6	0.0	0.9	0.3	0.1	1.1	0.0	0.9	-0.1	0.9	-0.5	1.3	-0.1
Number of treatments/medications taken	0.4	0.8	2.3	0.5	0.9	0.2	0.7	1.2	0.4	1.4	-0.1	1.3	0.2	1.5	0.5	0.6
Average weekly fortified wine intake	0.4	0.5	2.6	0.5	0.4	0.6	0.5	0.8	0.7	0.6	0.6	0.1	0.6	0.4	1.6	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.7	-0.3	-0.7	-0.1	-0.7	-0.3	-0.4	-0.6	-0.3	-0.9	-0.1	-1.6	-0.1	-1.6
Medication: Amlodipine	0.4	0.5	2.2	0.4	1.5	0.2	0.8	0.8	0.0	1.4	-0.1	0.4	0.2	0.9	-0.2	0.6
Health satisfaction	0.4	0.5	2.7	-0.1	1.0	0.3	0.5	1.0	0.5	1.7	0.4	-0.2	0.3	0.8	0.5	-0.3
Leg pain on walking	0.4	0.5	1.3	-1.1	0.7	-0.9	-0.4	0.1	-0.9	0.2	-0.9	-0.4	-1.0	0.3	-0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.1	0.1	-0.4	-0.3	-0.7	-0.7	-0.5	-0.2	-0.6	-0.5	-0.4	-0.9	-1.4	-1.0
Loneliness, isolation	0.4	0.6	2.4	-1.5	0.2	-0.9	-0.1	0.2	-0.9	0.1	-0.8	0.9	-0.9	0.4	0.3	0.8
Long-standing illness, disability or infirmity	0.4	0.5	1.2	-0.9	0.7	-1.0	-0.5	0.1	-0.9	0.9	-1.1	0.1	-1.1	0.4	-0.1	-0.5
Diabetes diagnosed by doctor	0.4	0.6	1.7	-1.1	-0.1	-0.8	-0.7	-0.2	-0.8	-0.4	-1.0	-0.4	-0.8	-0.4	-1.3	-0.8
Medication: Gliclazide	0.4	0.4	1.2	-0.8	-0.3	-0.7	-0.5	-0.6	-0.9	-0.3	-0.8	0.1	-0.7	-0.4	-1.1	-0.5
Leg fat percentage (left)	0.4	1.4	3.2	-1.6	-0.7	-1.6	-0.9	-1.1	-1.3	-0.9	-1.8	0.0	-1.6	0.2	-1.2	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.0	0.9	0.7	0.9	0.9	0.8	0.7	1.0	0.9	0.4	0.9	0.5	0.8	0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	3.5	0.0	1.4	0.0	0.6	1.2	0.0	1.9	-0.1	0.5	-0.1	0.0	0.2	1.1
Schizophrenia (2018)	0.3	0.6	1.6	0.0	1.2	0.0	-0.5	0.1	0.0	1.1	-1.3	-0.8	-1.2	0.0	-0.8	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	0.5	0.8	0.3	0.6	0.6	0.3	0.5	0.4	1.1	0.4	0.8	0.6	0.7
Coronary Artery Disease (CAD)	0.3	0.4	1.8	0.0	0.0	0.0	-1.0	-1.3	0.0	0.0	0.0	-0.8	-0.7	0.0	-0.2	-1.0
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.5	-1.1	-0.4	-0.6	-0.5	-0.2	-0.6	-0.3	-0.6	-0.4	-0.5	-0.9	-0.7
Blood Platelet Count	0.3	3.7	7.8	1.5	2.8	1.4	2.0	2.3	1.3	2.5	1.2	2.1	1.3	2.6	0.4	2.4
Systolic Blood Pressure	0.3	1.6	2.9	1.7	0.4	1.7	1.5	1.4	1.3	0.7	1.5	0.5	1.7	1.0	0.8	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	-0.2	0.7	0.2	0.5	0.8	0.3	0.7	0.2	1.2	0.2	0.6	0.7	0.5
Diabetes (father)	0.3	0.4	1.7	-0.8	-0.1	-0.6	-0.5	-0.4	-0.7	-0.4	-0.6	0.5	-0.6	-0.5	-1.3	-0.5
Pack years adult smoking proportion	0.3	0.5	1.2	-1.0	1.0	-0.8	-0.2	0.4	-1.0	0.3	-1.1	0.6	-0.8	0.3	-0.7	0.2
Fed-up feelings	0.3	0.6	2.3	0.1	0.2	0.4	0.6	0.8	0.7	0.7	0.6	1.2	0.4	0.7	1.5	0.3
Relative age voice broke	0.3	0.4	1.2	0.9	1.1	0.5	0.3	0.6	0.7	0.8	0.5	0.7	0.5	0.5	0.6	-0.1
Multivitamins +/- minerals	0.3	0.4	2.4	-0.6	0.5	-0.3	0.3	0.4	-0.5	0.2	-0.2	1.5	-0.2	0.6	-0.6	0.6
Alcohol usually taken with meals	0.3	0.5	1.4	-0.4	-1.1	-0.5	-0.5	-0.3	-0.8	-1.2	-0.8	0.4	-0.4	-0.8	-0.8	-0.0
Diabetes (self-reported)	0.3	0.5	1.8	-0.9	-0.1	-0.7	-0.6	-0.3	-0.7	-0.6	-0.9	-0.1	-0.7	-0.2	-1.4	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	0.8	-0.3	1.0	0.5	0.7	0.7	0.3	1.0	-1.4	1.1	-0.4	0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.0	0.2	0.6	0.1	0.4	0.3	0.2	0.5	0.3	1.0	0.1	0.8	0.8	0.7
Medication: Cholesterol lowering	0.3	0.4	0.9	0.8	-0.3	1.0	0.4	0.4	1.0	0.4	0.8	-0.8	0.9	-0.2	0.4	-0.6
Number of full brothers	0.3	0.4	1.2	-0.2	-0.3	-0.6	-0.2	-0.7	-0.9	-0.4	-0.5	-1.1	-0.6	0.1	-1.1	0.2
Number of children fathered	0.3	0.3	1.2	0.5	-0.7	0.3	-0.3	-0.5	0.5	-0.4	0.5	-1.1	0.3	-0.7	0.3	-0.9
Friendships satisfaction	0.3	0.3	1.2	-0.2	1.1	-0.0	0.6	0.8	-0.1	0.7	0.0	0.9	0.0	0.9	0.2	0.2
Medication for cholesterol	0.3	0.5	1.0	0.5	0.9	0.7	0.7	0.6	0.9	0.7	1.0	-0.2	0.8	0.4	1.0	0.5
Number of operations (self-reported)	0.3	0.5	1.4	0.3	0.8	0.1	0.6	0.7	0.3	0.7	0.3	1.1	0.1	1.2	1.0	0.7
Alzheimer’s Disease (including proxy)	0.2	0.2	1.3	0.3	0.5	0.3	0.4	0.4	0.3	0.3	0.4	1.1	0.4	0.4	0.6	0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	0.0	0.0	0.0	0.4	0.4	0.0	0.0	0.1	1.0	-0.2	0.9	0.7	-0.1
HDL Cholesterol	0.2	0.3	1.2	0.0	0.0	0.0	0.7	0.8	0.0	0.0	1.1	0.0	1.0	0.2	0.7	0.6
Triglycerides	0.2	0.3	0.8	0.0	0.0	0.0	-0.7	-0.6	0.0	0.0	-0.7	0.6	-0.9	-0.3	-0.6	-0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.1	0.0	0.0	0.0	0.6	0.4	0.0	0.0	0.4	0.4	0.4	0.7	1.1	0.3
Blood White Count	0.2	1.2	4.5	-0.8	1.8	-0.5	0.9	1.0	-0.8	0.6	-0.3	2.1	-0.5	1.4	0.7	0.9
BMI	0.2	1.3	4.5	0.3	1.0	0.5	1.3	1.5	0.8	1.7	0.5	0.9	0.4	2.1	1.3	0.9
Smoking Status	0.2	0.4	3.0	-0.0	-1.7	-0.2	-0.4	-0.7	0.3	-0.5	0.2	-0.5	-0.1	-0.2	0.4	-0.9
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.9	-0.8	-0.7	-0.6	-0.5	-0.6	-0.7	-0.5	0.2	-0.7	-0.3	-0.2	-0.7
Hair Pigment	0.2	6.0	22.5	-2.3	0.7	-2.9	-2.0	-1.4	-3.7	-0.8	-3.3	0.2	-3.0	-1.1	-4.7	-0.5
Relative age of first facial hair	0.2	0.5	2.0	0.3	1.4	-0.5	0.1	0.4	-0.2	0.8	-0.3	1.1	-0.5	1.2	0.6	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.3	0.1	-0.6	-0.2	-0.3	-0.6	-0.1	-0.6	0.8	-0.7	0.7	-0.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.5	-0.5	0.6	0.1	0.3	0.5	0.0	0.3	-0.7	0.5	-0.4	-0.2	-0.2
Supplements: Zinc	0.2	0.2	0.8	-0.4	-0.7	0.0	0.4	0.3	-0.1	-0.5	0.1	0.8	-0.0	0.5	0.9	0.5
Number of incorrect matches in round	0.2	0.3	1.7	0.4	-0.4	0.5	-0.0	0.1	0.5	0.3	0.8	-1.3	0.6	-0.6	0.4	-0.4
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.7	-0.3	0.6	0.4	0.6	0.6	0.6	0.6	-0.5	0.5	0.4	1.1	0.7
Pain all over the body in last month	0.2	0.2	0.5	-0.6	0.7	-0.5	-0.3	0.1	-0.5	0.5	-0.4	0.3	-0.5	0.0	-0.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	-0.6	-0.6	-0.7	-0.4	-0.3	-0.4	-0.6	-0.6	0.0	-0.7	0.1	-0.2	-0.2
Length of working week for main job	0.2	0.2	0.9	0.2	0.4	0.1	0.1	0.7	0.3	0.5	0.2	0.5	0.1	0.4	1.0	0.2
Exposure to tobacco smoke at home	0.2	0.2	1.0	0.1	-1.0	0.1	-0.5	-0.5	0.2	-0.6	0.1	-0.5	0.1	-0.7	0.1	-0.6
Gout (self-reported)	0.2	0.2	0.5	-0.7	-0.1	-0.5	-0.1	-0.5	-0.5	-0.5	-0.6	0.2	-0.5	0.4	-0.7	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.3	0.7	-0.8	-0.1	-0.4	-0.6	0.1	-0.6	-0.1	-0.6	-0.1	0.1	-0.3	-1.2
Birth weight	0.2	0.4	0.8	-0.6	0.4	-0.9	-0.5	-0.3	-0.9	0.0	-0.9	0.5	-0.8	-0.0	0.1	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	-0.3	-0.8	-0.1	-0.4	-0.3	-0.3	-0.9	-0.2	0.2	-0.1	-0.8	-0.3	-0.6
High blood pressure (siblings)	0.2	0.2	1.1	-0.4	-0.2	0.1	0.1	0.7	-0.0	0.3	0.1	1.1	-0.0	-0.0	1.0	0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.5	0.1	1.2	0.1	0.6	0.6	0.1	0.4	-0.0	0.9	0.1	0.8	0.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.2	-0.7	0.5	0.2	0.7	0.3	0.6	0.3	-1.0	0.4	-0.3	0.7	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.5	-0.4	0.6	0.0	-0.1	0.4	0.2	0.5	0.1	0.5	-0.9	-0.4	0.2
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.8	-0.4	-0.5	-0.7	-0.6	-0.4	-0.3	-0.5	0.1	-0.6	-0.6	-0.4	-0.7
Medication: Ibuprofen	0.2	0.3	0.7	-0.5	-0.8	-0.7	-0.6	-0.4	-0.3	-0.8	-0.6	-0.1	-0.7	-0.1	0.1	-0.1
Alcohol intake frequency.	0.2	0.4	0.9	-0.8	0.8	-0.9	-0.2	-0.2	-0.7	0.1	-0.7	0.4	-1.0	0.8	-0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.8	-0.7	-0.8	-0.5	-0.6	-0.1	-0.4	-0.3	-0.3	-0.9	-0.5	-0.3	0.1	-0.4
Miserableness	0.2	0.3	0.9	-0.3	0.8	0.0	0.3	0.7	-0.1	0.9	0.1	0.1	-0.0	0.6	0.9	0.7
Ever taken oral contraceptive pill	0.2	0.2	1.9	0.1	0.2	0.2	0.3	0.3	0.2	0.5	0.3	-1.4	0.3	0.3	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.2	0.0	0.8	0.1	0.5	0.6	-0.2	0.7	0.1	1.1	0.1	0.4	-0.2	0.1
Commuting to job workplace: Public transport	0.2	0.2	1.0	-0.2	0.4	0.1	0.2	0.7	0.1	0.9	0.3	0.6	0.2	0.1	1.0	0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.5	-0.6	-0.2	-0.5	-0.5	-0.0	-0.4	-0.1	0.6	-0.2	-0.6	0.1	-0.8
High cholesterol (Self-reported)	0.2	0.3	1.1	0.2	-1.0	0.3	-0.3	-0.2	0.3	-0.2	0.2	-0.5	0.3	-0.9	-0.2	-1.0
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.8	0.1	0.6	0.5	0.6	0.7	0.7	0.4	0.3	0.6	0.5	0.3	-0.1
Medication: Lisinopril	0.2	0.3	1.4	0.1	1.2	0.1	0.6	0.4	-0.1	0.2	-0.2	0.4	0.1	1.0	0.0	0.7
Medication: Atorvastatin	0.2	0.2	1.3	0.3	-0.9	0.3	0.0	-0.2	0.2	-0.3	0.1	-1.1	0.3	-0.1	-0.1	-0.1
Ever depressed for a whole week	0.2	0.2	1.5	0.1	0.9	-0.0	0.2	0.4	0.0	0.5	0.2	1.2	-0.0	0.4	0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-0.7	-0.6	-0.7	-0.9	-1.0	-0.5	-0.6	-0.3	-0.9	-0.7	-0.9	-0.3	-0.3
Cholesterol lowering medication	0.2	0.2	0.9	-0.2	0.0	-0.5	-0.3	-0.1	-0.6	0.2	-0.5	0.9	-0.5	-0.1	-0.8	-0.2
Depression (Nagel 2018)	0.1	0.1	0.7	-0.9	-0.0	-0.3	-0.2	0.0	-0.1	0.5	-0.0	0.3	-0.3	-0.2	0.6	-0.2
Major Depression (MDD)	0.1	0.2	1.6	0.0	0.0	0.0	0.1	0.3	0.0	0.5	0.0	1.3	-0.3	0.0	-0.1	-0.1
Breast Cancer	0.1	0.3	0.7	0.6	-0.5	0.8	0.5	0.6	0.6	-0.2	0.7	0.1	0.9	-0.4	0.8	0.4
Age at First Birth	0.1	0.2	0.8	-0.6	0.0	0.0	-0.3	-0.1	-0.6	0.0	-0.7	0.9	-0.4	-0.2	-0.2	-0.1
HbA1C	0.1	0.1	0.7	0.0	0.0	0.0	-0.2	-0.4	0.0	0.0	0.4	-0.3	0.1	-0.4	0.8	-0.1
LDL Cholesterol	0.1	0.2	0.8	0.0	0.0	0.0	0.4	0.8	0.0	0.0	0.8	0.4	0.7	0.2	0.9	-0.0
Rheumatoid Arthritis	0.1	0.2	0.9	0.0	-0.7	0.0	0.3	-0.0	0.0	0.1	0.9	-0.3	0.9	-0.3	0.0	-0.2
Heel T-Score	0.1	0.6	1.8	1.1	-0.6	0.8	0.3	-0.3	0.9	-0.7	0.9	0.4	0.9	-0.1	1.3	0.8
Lung FEV1/FVC ratio	0.1	0.6	2.1	-0.8	0.2	-0.7	-0.3	-0.9	-0.6	-1.4	-0.4	0.6	-0.6	0.3	-1.3	-1.1
Tanning	0.1	0.6	1.6	0.8	0.3	0.9	0.7	0.4	1.1	0.9	1.2	0.2	0.9	0.4	1.3	0.2
Average weekly spirits intake	0.1	0.2	0.4	-0.4	0.2	-0.6	-0.3	-0.4	-0.4	-0.2	-0.5	-0.3	-0.6	0.2	0.2	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.4	-0.6	-0.3	-0.3	-0.6	0.4	-0.5	-0.2	-0.7	-0.1	-0.3	-0.3
Angina	0.1	0.1	0.4	0.1	-0.6	0.3	-0.0	0.2	0.4	-0.1	0.3	-0.4	0.3	-0.5	0.3	-0.1
Maternal smoking around birth	0.1	0.2	0.7	0.2	-0.1	0.6	0.2	0.4	0.6	0.8	0.6	-0.2	0.5	-0.1	0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.6	0.3	-0.3	0.0	0.3	-0.2	0.7	-0.2	0.3	-0.3	-0.0	0.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.5	-0.8	0.2	-0.2	-0.5	0.3	-0.7	-0.0	-0.5	0.3	-0.6	-0.4	-0.4
High blood pressure	0.1	0.2	0.6	0.5	-0.0	0.5	0.5	0.5	0.3	0.1	0.0	0.8	0.5	0.5	0.1	0.1
Medication: Levothyroxine sodium	0.1	0.1	0.8	-0.3	0.2	-0.2	0.1	0.2	-0.0	0.3	0.1	0.9	-0.2	0.5	0.6	0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	0.0	0.4	-0.1	0.3	-0.1	-0.1	0.3	-0.0	0.2	-0.2	0.8	0.0	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.6	0.1	-0.5	0.0	0.1	-0.2	0.1	-0.5	0.1	-0.8	0.1	0.2	-0.4	-0.5
Medication: Simvastatin	0.1	0.1	0.7	-0.0	-0.1	-0.1	-0.3	-0.0	-0.1	-0.0	-0.2	0.4	-0.2	-0.3	-0.4	-0.8
Arm fat percentage (right)	0.1	0.5	2.0	-0.5	0.6	-0.3	0.5	0.9	-0.1	0.8	-0.5	1.1	-0.4	1.4	0.2	0.3
Alcohol intake versus 10 years previously	0.1	0.1	1.0	-1.0	0.1	-0.4	-0.4	-0.4	-0.2	-0.1	-0.2	-0.0	-0.5	-0.3	0.3	-0.1
Number of live births	0.1	0.2	0.5	-0.4	0.7	-0.5	0.0	0.3	-0.5	0.4	-0.3	0.1	-0.5	0.7	-0.5	-0.3
Noisy workplace	0.1	0.1	0.4	0.1	0.5	0.2	0.1	0.2	0.2	0.4	0.1	0.2	0.1	-0.0	0.6	-0.0
Glaucoma (self-reported)	0.1	0.2	0.6	-0.6	-0.0	-0.3	-0.4	-0.3	-0.2	-0.1	-0.4	0.7	-0.3	-0.5	-0.3	-0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	-0.6	-0.2	-0.5	-0.2	-0.2	-0.3	-0.1	-0.2	0.4	-0.5	0.2	0.4	0.0
Eye problems/disorders: None of the above	0.1	0.1	0.8	0.3	0.0	0.2	0.5	0.1	0.1	-0.4	0.4	0.9	0.2	0.5	0.1	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.0	-0.2	-0.1	-0.3	-0.4	-0.2	-0.3	-0.1	-0.5	-0.2	-0.4	0.1	-0.6
Angina (self-reported)	0.1	0.1	0.5	0.1	-0.6	0.3	-0.1	0.0	0.3	-0.1	0.2	-0.5	0.3	-0.7	0.2	-0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.5	0.5	-0.7	0.2	-0.3	-0.1	0.5	-0.3	-0.2	-0.3	0.2	-0.2	-0.1	-0.6
Had major operations	0.1	0.1	0.6	0.1	0.3	-0.3	0.3	-0.2	-0.2	-0.0	-0.1	-0.5	-0.3	0.8	0.0	0.2
Hypertension (Self-reported)	0.1	0.2	0.9	0.4	0.2	0.5	0.5	0.7	0.3	0.1	-0.0	1.0	0.5	0.5	0.0	0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.3	0.6	0.3	0.4	0.5	0.1	0.6	0.2	-0.0	0.3	0.4	-0.2	0.1
Arm fat percentage (left)	0.1	0.4	1.1	-0.9	0.2	-0.7	0.1	0.4	-0.5	0.4	-1.0	0.8	-0.8	1.0	-0.2	-0.3
Ever smoked	0.1	0.2	1.1	0.0	0.4	-0.1	0.4	0.2	0.2	0.4	0.3	0.5	-0.1	1.0	0.7	0.5
Irritability	0.1	0.1	1.1	-0.1	-0.0	0.1	0.1	0.2	0.3	0.3	0.4	0.5	0.1	0.3	1.0	0.0
Diastolic blood pressure, automated reading	0.1	0.2	1.0	0.9	-0.2	0.6	0.3	0.4	0.5	0.3	0.3	-1.0	0.5	0.3	-0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	-0.3	-0.3	-0.4	-0.2	-0.2	-0.5	-0.0	-0.8	-0.1	-0.4	-0.0	-0.5	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.3	1.0	-0.4	-0.7	-0.4	-0.4	-0.5	-0.2	-1.0	-0.0	1.0	-0.4	-0.1	0.2	-0.2
Systolic blood pressure, automated reading	0.0	0.1	0.7	0.1	-0.2	0.1	0.1	0.2	-0.2	-0.1	-0.0	-0.8	0.1	-0.0	-0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.2	0.1	0.0	0.1	-0.0	-0.1	-0.1	-0.2	0.1	0.1	-0.2	0.3
Fluid intelligence score	0.0	0.1	0.4	0.2	-0.3	-0.0	-0.3	-0.3	0.1	-0.4	0.4	0.4	-0.1	-0.1	-0.1	-0.6
Blood clot in the leg (DVT)	0.0	0.0	0.2	0.1	-0.1	-0.0	0.1	0.2	-0.1	0.3	-0.4	0.1	-0.1	0.2	-0.0	0.4
Medication: Aspirin	0.0	0.0	0.1	0.3	-0.3	0.1	-0.1	-0.2	0.1	0.1	-0.1	0.0	0.1	-0.1	-0.2	-0.3
Medication: Aspirin	0.0	0.0	0.1	0.4	-0.2	0.3	0.1	-0.1	0.3	0.2	0.1	0.3	0.3	-0.1	-0.1	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.3	0.2	-0.0	-0.1	0.1	-0.3	-0.1	-0.2	-0.1	0.2	-0.1	0.2	-0.5	0.2
Heart disease (siblings)	0.0	0.0	0.3	-0.1	-0.1	0.2	0.1	0.1	0.2	0.2	-0.0	0.0	0.1	-0.1	-0.6	-0.3

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