Best TWAS P=1.02e-11 · Best GWAS P=7.93e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRRC45 | 0.09 | 0.10 | enet | 7 | 0.10 | 1.2e-11 | -5.9 | 5.8 | 6.1e-09 | -0.74 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | LRRC45 | 0.23 | 0.06 | lasso | 3 | 0.05 | 1.0e-04 | -5.9 | 6.0 | 2.1e-09 | -0.77 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | LRRC45 | 0.18 | 0.03 | enet | 12 | 0.10 | 9.0e-06 | -5.9 | 5.4 | 7.0e-08 | -0.77 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Artery Tibial | LRRC45 | 0.09 | 0.07 | lasso | 4 | 0.04 | 2.0e-04 | -5.9 | 6.1 | 1.0e-09 | -0.84 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | LRRC45 | 0.08 | 0.08 | enet | 3 | 0.08 | 2.6e-06 | -5.9 | 6.2 | 5.7e-10 | -0.78 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | LRRC45 | 0.19 | 0.06 | enet | 9 | 0.12 | 6.7e-06 | -5.0 | 6.2 | 5.8e-10 | -0.85 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | STRA13 | 0.25 | 0.15 | enet | 4 | 0.16 | 1.2e-07 | -4.3 | 5.2 | 1.8e-07 | -0.67 | 0.25 | 0.73 | FALSE |
| 8 | GTEx | Thyroid | ASPSCR1 | 0.23 | 0.15 | enet | 19 | 0.09 | 1.2e-07 | -5.6 | 5.5 | 3.1e-08 | -0.81 | 0.03 | 0.97 | FALSE |
| 9 | YFS | Blood | ASPSCR1 | 0.11 | 0.07 | lasso | 9 | 0.06 | 7.9e-20 | -6.5 | 6.8 | 1.0e-11 | -0.98 | 0.00 | 1.00 | TRUE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LRRC45 | 0.02 | 0.03 | blup | 36 | 0.02 | 1.5e-03 | -5.9 | 6.0 | 1.9e-09 | -0.76 | 0.02 | 0.64 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PYCR1 | 0.02 | 0.01 | blup | 9 | 0.01 | 1.1e-02 | -5.1 | 5.8 | 8.9e-09 | -0.83 | 0.00 | 0.56 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STRA13 | 0.05 | 0.04 | blup | 33 | 0.05 | 5.0e-06 | -5.9 | 5.3 | 1.1e-07 | -0.71 | 0.04 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC45 | 0.05 | 0.07 | lasso | 6 | 0.06 | 9.5e-08 | -5.9 | 6.1 | 1.3e-09 | -0.77 | 0.04 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYADML2 | 0.03 | 0.03 | blup | 10 | 0.03 | 1.1e-04 | -5.5 | -5.5 | 2.8e-08 | 0.83 | 0.02 | 0.89 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOTUM | 0.06 | 0.02 | enet | 2 | 0.02 | 4.7e-03 | -4.2 | -5.3 | 1.1e-07 | 0.79 | 0.00 | 0.77 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRRC45 | 0.10 | 0.02 | blup | 35 | 0.04 | 8.0e-03 | -4.0 | 6.0 | 1.6e-09 | -0.70 | 0.01 | 0.28 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STRA13 | 0.05 | 0.03 | lasso | 3 | 0.02 | 1.8e-03 | -5.9 | 5.9 | 3.2e-09 | -0.76 | 0.03 | 0.82 | FALSE |