[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr1:242,590,540-244,359,621

Best TWAS P=3.8e-22 · Best GWAS P=3.78e-22 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Cells Transformed fibroblasts	RP11-261C10.5	0.15	0.13	lasso	2	0.14	2.2e-10	9.7	9.7	3.8e-22	1.00	0.00	1.00	TRUE
27	GTEx	Whole Blood	SDCCAG8	0.18	0.15	lasso	7	0.14	6.2e-13	9.4	9.6	7.1e-22	0.97	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	SDCCAG8	0.18	0.10	enet	25	0.11	1.4e-09	9.6	9.5	1.4e-21	0.91	0.01	0.99	FALSE
13	GTEx	Cells Transformed fibroblasts	SDCCAG8	0.23	0.25	enet	13	0.28	3.5e-21	9.6	9.5	2.8e-21	0.96	0.01	0.99	FALSE
28	METSIM	Adipose	SDCCAG8	0.12	0.13	enet	17	0.14	5.6e-21	9.2	9.4	4.4e-21	0.95	0.01	0.99	FALSE
16	GTEx	Colon Transverse	SDCCAG8	0.17	0.02	lasso	3	0.02	2.8e-02	9.6	9.4	7.7e-21	0.97	0.01	0.97	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEP170	0.03	0.03	enet	4	0.02	7.9e-04	9.6	9.4	7.7e-21	0.98	0.00	0.98	FALSE
14	GTEx	Cells Transformed fibroblasts	CEP170	0.21	0.17	enet	15	0.19	5.3e-14	9.7	9.2	2.2e-20	0.95	0.00	1.00	FALSE
23	GTEx	Nerve Tibial	CEP170	0.09	0.08	lasso	1	0.05	1.1e-04	9.2	9.2	2.8e-20	0.92	0.08	0.91	FALSE
17	GTEx	Esophagus Mucosa	SDCCAG8	0.17	0.15	lasso	4	0.15	3.3e-10	9.2	9.2	3.6e-20	0.92	0.09	0.91	FALSE
20	GTEx	Esophagus Muscularis	CEP170	0.09	0.11	lasso	4	0.10	1.2e-06	9.2	9.2	5.8e-20	0.92	0.10	0.90	FALSE
7	GTEx	Artery Tibial	SDCCAG8	0.14	0.02	lasso	3	0.03	1.9e-03	8.6	9.0	2.3e-19	0.94	0.02	0.98	FALSE
8	GTEx	Breast Mammary Tissue	SDCCAG8	0.15	0.04	enet	13	0.09	2.8e-05	8.0	9.0	2.4e-19	0.89	0.01	0.98	FALSE
21	GTEx	Heart Atrial Appendage	SDCCAG8	0.14	0.06	lasso	7	0.06	1.6e-03	9.3	9.0	2.7e-19	0.90	0.02	0.95	FALSE
22	GTEx	Nerve Tibial	SDCCAG8	0.25	0.27	enet	14	0.27	2.3e-19	7.3	8.9	5.3e-19	0.87	0.69	0.31	FALSE
5	GTEx	Artery Aorta	SDCCAG8	0.21	0.06	enet	21	0.09	8.9e-06	8.9	8.9	7.8e-19	0.87	0.12	0.88	FALSE
35	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SDCCAG8	0.19	0.18	lasso	5	0.16	1.9e-07	9.4	8.7	2.7e-18	0.91	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CEP170	0.08	0.06	enet	7	0.06	2.0e-03	9.6	8.7	4.6e-18	0.94	0.01	0.83	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	SDCCAG8	0.30	0.06	blup	113	0.12	8.0e-04	8.9	8.4	4.0e-17	0.83	0.02	0.81	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	SDCCAG8	0.36	0.24	lasso	8	0.34	5.7e-12	5.1	8.4	4.9e-17	0.90	0.01	0.99	FALSE
29	NTR	Blood	SDCCAG8	0.03	0.01	blup	356	0.01	1.4e-04	8.0	8.3	1.3e-16	0.69	0.20	0.79	FALSE
11	GTEx	Breast Mammary Tissue (Female)	CEP170	0.26	0.04	lasso	4	0.09	1.5e-03	9.2	8.1	5.1e-16	0.86	0.03	0.74	FALSE
26	GTEx	Prostate	CEP170	0.28	0.05	lasso	4	0.12	6.9e-04	9.5	8.0	1.4e-15	0.82	0.02	0.82	FALSE
19	GTEx	Esophagus Muscularis	SDCCAG8	0.10	0.06	enet	6	0.05	3.5e-04	-6.4	8.0	1.6e-15	0.83	0.15	0.82	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEP170	0.03	0.01	lasso	4	0.02	4.4e-03	-2.8	7.5	8.4e-14	0.70	0.02	0.44	FALSE
9	GTEx	Breast Mammary Tissue	CEP170	0.16	0.09	enet	19	0.08	1.0e-04	9.2	7.4	1.3e-13	0.81	0.03	0.96	FALSE
10	GTEx	Breast Mammary Tissue (Female)	SDCCAG8	0.17	0.07	enet	15	0.06	5.5e-03	9.2	7.3	2.2e-13	0.80	0.02	0.87	FALSE
25	GTEx	Pancreas	SDCCAG8	0.16	0.08	enet	20	0.07	9.3e-04	-6.5	7.0	2.0e-12	0.79	0.03	0.96	FALSE
18	GTEx	Esophagus Mucosa	CEP170	0.07	0.01	enet	25	0.00	2.5e-01	8.6	6.8	8.7e-12	0.72	0.08	0.35	FALSE
24	GTEx	Ovary	SDCCAG8	0.25	0.21	enet	6	0.20	1.3e-05	-6.4	6.8	1.4e-11	0.76	0.22	0.53	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SDCCAG8	0.09	0.04	blup	114	0.08	4.6e-07	9.6	6.7	2.0e-11	0.73	0.01	0.99	FALSE
6	GTEx	Artery Coronary	SDCCAG8	0.18	0.00	enet	22	0.09	4.3e-04	7.5	6.7	2.6e-11	0.51	0.06	0.46	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG8	0.10	0.05	lasso	4	0.06	5.8e-07	-3.8	6.4	2.0e-10	0.64	0.79	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SDCCAG8	0.13	0.10	enet	32	0.11	5.6e-13	7.2	-6.0	1.7e-09	-0.60	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SDCCAG8	0.11	0.04	blup	114	0.06	1.1e-07	-1.3	5.8	6.8e-09	0.71	0.12	0.87	FALSE
4	GTEx	Adipose Visceral Omentum	SDCCAG8	0.15	0.00	enet	24	0.00	1.8e-01	8.9	5.7	1.5e-08	0.57	0.02	0.80	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG8	0.06	0.02	blup	114	0.04	1.9e-05	-2.1	5.5	3.1e-08	0.70	0.06	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CEP170	0.05	0.02	bslmm	378	0.03	1.9e-04	5.6	-5.2	1.5e-07	-0.55	0.34	0.10	FALSE