TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Diastolic blood pressure, automated reading
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chr1:230,142,626-231,548,480
Best TWAS P=3.56e-16 · Best GWAS P=8.93e-13 conditioned to 0.49
230.2M
230.4M
230.6M
230.8M
231M
231.2M
231.4M
231.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
AGT
0.07
0.02
enet
12
0.04
1.8e-05
7.1
8.2
3.6e-16
0.83
0.01
0.99
TRUE
2
GTEx
Brain Cerebellum
AGT
0.60
0.40
lasso
6
0.36
1.4e-11
6.2
6.8
7.2e-12
0.36
0.74
0.26
FALSE
1
GTEx
Brain Cerebellar Hemisphere
AGT
0.67
0.50
enet
12
0.40
3.4e-11
5.9
-5.8
5.2e-09
-0.37
0.81
0.19
FALSE
4
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
AGT
0.11
0.05
blup
125
0.04
1.4e-03
5.8
5.8
7.2e-09
0.44
0.10
0.23
FALSE