Best TWAS P=3.56e-16 · Best GWAS P=8.93e-13 conditioned to 0.49
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AGT | 0.67 | 0.50 | enet | 12 | 0.40 | 3.4e-11 | 5.9 | -5.8 | 5.2e-09 | -0.37 | 0.81 | 0.19 | FALSE |
| 2 | GTEx | Brain Cerebellum | AGT | 0.60 | 0.40 | lasso | 6 | 0.36 | 1.4e-11 | 6.2 | 6.8 | 7.2e-12 | 0.36 | 0.74 | 0.26 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AGT | 0.07 | 0.02 | enet | 12 | 0.04 | 1.8e-05 | 7.1 | 8.2 | 3.6e-16 | 0.83 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AGT | 0.11 | 0.05 | blup | 125 | 0.04 | 1.4e-03 | 5.8 | 5.8 | 7.2e-09 | 0.44 | 0.10 | 0.23 | FALSE |