[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr1:11,032,827-12,600,396

Best TWAS P=7.63e-35 · Best GWAS P=3.59e-32 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CLCN6	0.14	0.05	enet	36	0.08	1.9e-09	2.8	-5.3	1.5e-07	0.20	0.48	0.08	TRUE
2	CommonMind	Brain Pre-frontal Cortex	MTHFR	0.08	0.08	lasso	3	0.07	9.6e-09	-7.2	-7.2	7.7e-13	0.35	1.00	0.00	TRUE
3	GTEx	Artery Tibial	CLCN6	0.14	0.04	lasso	6	0.04	5.0e-04	-9.5	-8.8	8.8e-19	0.66	0.11	0.88	FALSE
4	GTEx	Brain Cerebellum	MTHFR	0.25	0.09	lasso	4	0.03	3.5e-02	-7.2	-7.5	8.0e-14	0.34	0.15	0.10	FALSE
5	GTEx	Breast Mammary Tissue (Male)	FBXO6	0.39	0.01	lasso	6	0.07	1.1e-02	3.3	5.2	2.0e-07	-0.42	0.04	0.41	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	MTHFR	0.33	0.12	lasso	6	0.09	7.9e-04	-9.0	-9.0	2.1e-19	0.80	0.34	0.27	FALSE
7	GTEx	Cells Transformed fibroblasts	CLCN6	0.08	0.02	enet	17	0.05	1.6e-04	-11.8	-9.6	7.5e-22	0.75	0.01	0.99	FALSE
8	GTEx	Cells Transformed fibroblasts	MTHFR	0.13	0.03	enet	30	0.05	6.8e-05	-8.8	-10.4	3.7e-25	0.57	0.05	0.92	TRUE
9	GTEx	Skin Not Sun Exposed Suprapubic	CLCN6	0.12	0.03	lasso	3	0.04	3.3e-03	-4.2	-8.4	2.8e-17	0.83	0.02	0.92	FALSE
10	GTEx	Skin Sun Exposed Lower leg	CLCN6	0.08	0.00	lasso	3	0.01	7.9e-02	-7.8	-9.3	1.6e-20	0.67	0.03	0.73	FALSE
11	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	-9.0	-10.2	2.9e-24	0.86	0.04	0.69	TRUE
12	GTEx	Whole Blood	CLCN6	0.10	0.02	lasso	3	0.04	2.1e-04	-9.5	-6.3	3.6e-10	0.47	0.36	0.06	FALSE
13	METSIM	Adipose	CLCN6	0.09	0.04	blup	480	0.06	1.6e-09	-7.8	-8.7	4.2e-18	0.65	0.06	0.94	FALSE
14	NTR	Blood	CLCN6	0.01	0.01	lasso	2	0.01	3.0e-04	-9.5	-7.9	2.5e-15	0.78	0.38	0.53	FALSE
15	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	-7.2	-10.5	9.2e-26	0.66	1.00	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	CLCN6	0.06	0.00	bslmm	467	0.02	9.9e-04	-1.1	-5.3	1.4e-07	0.41	0.16	0.09	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	C1orf167	0.07	0.01	blup	475	0.03	1.4e-04	-8.0	-7.0	3.7e-12	0.43	0.36	0.05	TRUE
18	YFS	Blood	MTHFR	0.50	0.49	enet	40	0.62	5.5e-264	-7.2	-9.2	3.0e-20	0.52	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCN6	0.06	0.06	blup	104	0.06	5.0e-12	-10.3	-12.3	7.6e-35	0.75	0.22	0.78	TRUE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCN6	0.14	0.05	blup	104	0.09	1.2e-05	-11.4	-7.8	7.1e-15	0.81	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFR	0.07	0.01	blup	92	0.04	2.9e-03	-1.3	-9.0	2.4e-19	0.76	0.04	0.46	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLCN6	0.04	0.06	lasso	2	0.05	1.1e-06	-10.3	-11.3	1.8e-29	0.69	0.10	0.89	TRUE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AGTRAP	0.04	0.02	blup	69	0.02	8.0e-04	-7.2	-5.5	3.4e-08	0.32	0.02	0.29	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLCN6	0.05	0.05	lasso	6	0.05	9.2e-07	-7.8	-10.2	2.7e-24	0.51	0.47	0.50	TRUE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLCN6	0.07	0.00	blup	104	0.03	7.9e-03	1.1	-8.2	1.6e-16	0.60	0.06	0.28	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	CLCN6	0.06	0.04	blup	104	0.04	5.2e-06	-11.8	-12.2	1.8e-34	0.91	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	MTHFR	0.05	0.02	blup	92	0.02	2.5e-03	-7.2	-7.3	3.4e-13	0.44	0.16	0.06	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCN6	0.10	0.07	blup	104	0.07	3.9e-08	-6.1	-10.1	3.8e-24	0.59	0.20	0.79	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLCN6	0.07	0.04	blup	104	0.05	2.4e-04	-11.4	-11.3	8.3e-30	0.94	0.01	0.98	TRUE
30	The Cancer Genome Atlas	Thyroid Carcinoma	CLCN6	0.08	0.02	blup	104	0.05	2.5e-05	-8.0	-8.5	2.7e-17	0.64	0.15	0.84	TRUE