[Hub]/) : Traits : Diastolic blood pressure, automated reading :

chr1:11,032,827-12,600,396

Best TWAS P=7.63e-35 · Best GWAS P=3.59e-32 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CLCN6 0.14 0.05 enet 36 0.08 1.9e-09 2.8 -5.3 1.5e-07 0.20 0.48 0.08 TRUE
2 CommonMind Brain Pre-frontal Cortex MTHFR 0.08 0.08 lasso 3 0.07 9.6e-09 -7.2 -7.2 7.7e-13 0.35 1.00 0.00 TRUE
3 GTEx Artery Tibial CLCN6 0.14 0.04 lasso 6 0.04 5.0e-04 -9.5 -8.8 8.8e-19 0.66 0.11 0.88 FALSE
4 GTEx Brain Cerebellum MTHFR 0.25 0.09 lasso 4 0.03 3.5e-02 -7.2 -7.5 8.0e-14 0.34 0.15 0.10 FALSE
5 GTEx Breast Mammary Tissue (Male) FBXO6 0.39 0.01 lasso 6 0.07 1.1e-02 3.3 5.2 2.0e-07 -0.42 0.04 0.41 FALSE
6 GTEx Cells EBV-transformed lymphocytes MTHFR 0.33 0.12 lasso 6 0.09 7.9e-04 -9.0 -9.0 2.1e-19 0.80 0.34 0.27 FALSE
7 GTEx Cells Transformed fibroblasts CLCN6 0.08 0.02 enet 17 0.05 1.6e-04 -11.8 -9.6 7.5e-22 0.75 0.01 0.99 FALSE
8 GTEx Cells Transformed fibroblasts MTHFR 0.13 0.03 enet 30 0.05 6.8e-05 -8.8 -10.4 3.7e-25 0.57 0.05 0.92 TRUE
9 GTEx Skin Not Sun Exposed Suprapubic CLCN6 0.12 0.03 lasso 3 0.04 3.3e-03 -4.2 -8.4 2.8e-17 0.83 0.02 0.92 FALSE
10 GTEx Skin Sun Exposed Lower leg CLCN6 0.08 0.00 lasso 3 0.01 7.9e-02 -7.8 -9.3 1.6e-20 0.67 0.03 0.73 FALSE
11 GTEx Spleen CLCN6 0.21 0.10 lasso 3 0.06 1.3e-02 -9.0 -10.2 2.9e-24 0.86 0.04 0.69 TRUE
12 GTEx Whole Blood CLCN6 0.10 0.02 lasso 3 0.04 2.1e-04 -9.5 -6.3 3.6e-10 0.47 0.36 0.06 FALSE
13 METSIM Adipose CLCN6 0.09 0.04 blup 480 0.06 1.6e-09 -7.8 -8.7 4.2e-18 0.65 0.06 0.94 FALSE
14 NTR Blood CLCN6 0.01 0.01 lasso 2 0.01 3.0e-04 -9.5 -7.9 2.5e-15 0.78 0.38 0.53 FALSE
15 NTR Blood MTHFR 0.09 0.07 enet 17 0.10 4.4e-31 -7.2 -10.5 9.2e-26 0.66 1.00 0.00 FALSE
16 ROSMAP Brain Pre-frontal Cortex CLCN6 0.06 0.00 bslmm 467 0.02 9.9e-04 -1.1 -5.3 1.4e-07 0.41 0.16 0.09 FALSE
17 ROSMAP Brain Pre-frontal Cortex C1orf167 0.07 0.01 blup 475 0.03 1.4e-04 -8.0 -7.0 3.7e-12 0.43 0.36 0.05 TRUE
18 YFS Blood MTHFR 0.50 0.49 enet 40 0.62 5.5e-264 -7.2 -9.2 3.0e-20 0.52 1.00 0.00 FALSE
19 The Cancer Genome Atlas Breast Invasive Carcinoma CLCN6 0.06 0.06 blup 104 0.06 5.0e-12 -10.3 -12.3 7.6e-35 0.75 0.22 0.78 TRUE
20 The Cancer Genome Atlas Colon Adenocarcinoma CLCN6 0.14 0.05 blup 104 0.09 1.2e-05 -11.4 -7.8 7.1e-15 0.81 0.01 0.98 FALSE
21 The Cancer Genome Atlas Colon Adenocarcinoma MTHFR 0.07 0.01 blup 92 0.04 2.9e-03 -1.3 -9.0 2.4e-19 0.76 0.04 0.46 FALSE
22 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CLCN6 0.04 0.06 lasso 2 0.05 1.1e-06 -10.3 -11.3 1.8e-29 0.69 0.10 0.89 TRUE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AGTRAP 0.04 0.02 blup 69 0.02 8.0e-04 -7.2 -5.5 3.4e-08 0.32 0.02 0.29 FALSE
24 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CLCN6 0.05 0.05 lasso 6 0.05 9.2e-07 -7.8 -10.2 2.7e-24 0.51 0.47 0.50 TRUE
25 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CLCN6 0.07 0.00 blup 104 0.03 7.9e-03 1.1 -8.2 1.6e-16 0.60 0.06 0.28 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma CLCN6 0.06 0.04 blup 104 0.04 5.2e-06 -11.8 -12.2 1.8e-34 0.91 0.01 0.99 FALSE
27 The Cancer Genome Atlas Lung Adenocarcinoma MTHFR 0.05 0.02 blup 92 0.02 2.5e-03 -7.2 -7.3 3.4e-13 0.44 0.16 0.06 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma CLCN6 0.10 0.07 blup 104 0.07 3.9e-08 -6.1 -10.1 3.8e-24 0.59 0.20 0.79 FALSE
29 The Cancer Genome Atlas Stomach Adenocarcinoma CLCN6 0.07 0.04 blup 104 0.05 2.4e-04 -11.4 -11.3 8.3e-30 0.94 0.01 0.98 TRUE
30 The Cancer Genome Atlas Thyroid Carcinoma CLCN6 0.08 0.02 blup 104 0.05 2.5e-05 -8.0 -8.5 2.7e-17 0.64 0.15 0.84 TRUE