Best TWAS P=2.38e-10 · Best GWAS P=2.36e-09 conditioned to 0.487
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ITGB5 | 0.34 | 0.28 | lasso | 4 | 0.32 | 4.4e-26 | -5.9 | -6.3 | 2.4e-10 | 0.89 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ITGB5 | 0.30 | 0.17 | lasso | 4 | 0.19 | 2.0e-07 | 4.7 | -6.2 | 7.3e-10 | 0.77 | 0.04 | 0.94 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ITGB5 | 0.23 | 0.16 | enet | 29 | 0.21 | 8.1e-14 | -5.9 | 5.2 | 1.9e-07 | -0.83 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ITGB5 | 0.37 | 0.13 | lasso | 4 | 0.22 | 1.5e-13 | 5.6 | -6.1 | 1.4e-09 | 0.72 | 0.07 | 0.93 | FALSE |
| 5 | GTEx | Nerve Tibial | ITGB5 | 0.10 | 0.01 | lasso | 4 | 0.03 | 2.3e-03 | -5.9 | -5.9 | 4.3e-09 | 0.86 | 0.01 | 0.99 | FALSE |
| 6 | METSIM | Adipose | ITGB5 | 0.05 | 0.04 | lasso | 3 | 0.04 | 2.2e-06 | -5.9 | 5.9 | 4.8e-09 | -0.95 | 0.01 | 0.99 | FALSE |