Hub : Genes

ITGB5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1350	0.0390	1.1e-05	0.028	0.041	0.063	0.048	0.029	1.8e-04	9.1e-06	4.0e-08	1.6e-06	1.6e-04
2	GTEx	Artery Tibial	0.3371	0.0511	2.3e-15	0.279	NA	0.316	NA	0.325	4.7e-22	NA	2.6e-25	NA	4.4e-26
3	GTEx	Cells Transformed fibroblasts	0.1550	0.0400	2.6e-06	0.137	NA	0.094	NA	0.108	1.8e-10	NA	1.6e-07	NA	1.8e-08
4	GTEx	Esophagus Gastroesophageal Junction	0.3020	0.1020	9.0e-03	0.168	NA	0.189	NA	0.190	1.1e-06	NA	2.1e-07	NA	2.0e-07
5	GTEx	Esophagus Mucosa	0.2340	0.0480	1.4e-09	0.162	NA	0.206	NA	0.190	5.9e-11	NA	8.1e-14	NA	9.7e-13
6	GTEx	Esophagus Muscularis	0.3670	0.0750	1.5e-06	0.127	NA	0.165	NA	0.221	4.1e-08	NA	3.0e-10	NA	1.5e-13
7	GTEx	Nerve Tibial	0.0972	0.0367	2.7e-03	0.008	NA	0.030	NA	0.032	7.9e-02	NA	3.2e-03	NA	2.3e-03
8	METSIM	Adipose	0.0502	0.0181	1.9e-04	0.040	0.024	0.034	0.027	0.038	1.1e-06	1.4e-04	7.4e-06	5.4e-05	2.2e-06
9	YFS	Blood	0.0333	0.0103	3.6e-06	0.021	0.022	0.018	0.023	0.018	1.8e-07	5.7e-08	1.4e-06	4.6e-08	9.3e-07
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0304	0.0158	7.1e-04	0.024	0.035	0.022	NA	0.023	9.8e-04	8.2e-05	1.5e-03	NA	1.3e-03
11	TCGA	Brain Lower Grade Glioma	0.0460	0.0237	6.1e-03	-0.002	0.010	0.002	NA	0.001	7.8e-01	2.4e-02	1.7e-01	NA	2.7e-01
12	TCGA	Thyroid Carcinoma	0.0790	0.0360	7.5e-04	0.006	0.024	0.013	NA	0.011	7.0e-02	1.9e-03	1.9e-02	NA	2.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.5	0.7	2.1	0.4	0.9	0.7	1.2	-0.5	1.1	0.5	-1.0	1.4	0.6	0.5	-0.3
Bipolar Disorder or Schizophrenia	0.9	2.1	6.1	-0.9	1.8	-1.2	1.1	-1.4	0.9	2.4	-2.5	-1.1	-1.6	-0.4	0.7
Depressed Affect (Nagel 2018)	0.4	0.8	3.4	0.7	0.8	0.7	0.6	0.8	0.8	0.3	-0.5	-1.2	0.0	1.9	-0.9
Depression (Nagel 2018)	0.5	0.8	4.8	0.5	0.4	-0.4	0.4	0.8	0.8	-0.5	0.7	-1.1	-0.0	2.2	-1.0
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.1	1.9	-0.3	2.3	0.5	0.4	0.6	-1.2	0.8	1.5	2.1	1.4	-1.8
Neuroticism (Nagel 2018)	0.3	0.8	4.1	0.7	0.5	2.0	0.7	0.6	0.6	-0.1	-0.8	0.6	1.1	0.8	-0.8
Schizophrenia (2018)	1.6	3.2	7.0	-1.7	1.5	-2.0	0.4	-1.3	0.3	2.6	-2.4	-2.5	-2.6	-0.9	1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	0.5	0.6	-1.0	0.3	-0.2	0.2	1.1	-0.6	-1.1	-1.0	0.6	0.2
Worry (Nagel 2018)	0.0	0.1	0.5	0.1	0.1	0.3	0.0	-0.2	-0.1	0.2	-0.4	-0.0	0.1	-0.7	0.4
Alzheimer’s Disease (in mother)	1.5	1.7	3.0	1.1	-1.7	0.6	-1.4	1.0	-1.6	-1.5	1.5	1.4	1.4	-0.6	-1.3
Alzheimer’s Disease (in father)	0.9	1.0	2.0	0.1	-1.3	-1.2	-1.3	-0.1	-1.3	-0.9	1.4	-0.4	-0.6	-1.2	0.9
Alzheimer’s Disease (including proxy)	2.1	3.0	6.7	1.3	-2.6	-0.1	-2.3	1.3	-2.4	-2.2	2.6	0.9	0.9	-1.3	-0.4
Crohns Disease (2017)	0.8	1.8	3.5	1.1	-1.8	1.3	-1.2	0.8	-1.5	-1.6	1.2	0.9	1.9	-1.5	-0.6
Irritable Bowel Disease (IBD)	0.6	1.4	4.7	0.8	-1.6	1.1	-0.7	1.0	-0.8	-1.3	1.0	0.5	2.2	-1.7	0.1
Ulcerative Colitis (UC)	0.3	0.5	2.5	-0.1	-0.7	-0.1	0.2	0.5	0.3	-0.3	0.6	-0.7	1.1	-1.6	0.8
Major Depression (MDD)	0.5	0.7	1.7	0.2	-0.9	0.1	-1.0	1.3	-1.0	-1.2	1.0	0.6	0.6	-0.1	0.0
Reaction Time	0.1	0.2	0.8	-0.5	-0.2	-0.8	-0.1	-0.6	-0.1	0.4	0.0	-0.2	0.1	-0.5	-0.9
Verbal and Numeric Reasoning (VNR)	0.9	2.3	7.1	0.8	-0.3	2.7	0.4	0.8	0.4	-1.5	0.7	1.8	2.4	1.5	-2.1
Breast Cancer	0.4	0.9	7.3	2.7	0.6	0.8	0.2	-0.1	0.2	0.3	-0.8	0.8	0.2	0.7	-0.6
Ovarian Cancer	0.2	0.2	0.6	-0.6	0.4	0.5	0.6	0.1	0.5	0.4	-0.8	-0.0	0.3	-0.4	-0.4
Prostate Cancer	0.3	0.4	1.8	0.7	0.3	1.3	0.5	0.0	0.4	-0.1	-0.1	1.2	0.9	0.3	-0.2
Age at First Birth	1.4	2.0	4.6	2.1	-1.5	1.3	-1.4	2.1	-1.2	-1.7	1.3	1.3	1.4	-0.4	0.3
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	0.1	0.7	0.4	-0.7	0.2	0.5	-0.6	0.6	0.3	-0.6	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	1.1	-0.3	0.5	-0.2	0.3	-0.8	0.4	0.3	-0.7	0.2	0.3	0.2	-1.1
Coronary Artery Disease (CAD)	0.9	1.1	2.0	-1.4	-1.3	-1.2	-1.4	1.1	-1.3	-0.4	1.0	-0.3	-0.1	-1.2	0.5
Crohns Disease (2012)	1.0	1.6	3.2	-0.1	-1.5	1.4	-1.4	1.5	-1.4	-1.6	1.1	1.1	1.8	-0.2	-0.8
Mean Putamen Volume	1.1	1.3	2.7	1.2	-1.4	1.2	-1.5	1.0	-1.6	-0.7	0.6	1.1	1.1	-1.1	0.3
Fasting Glucose	0.2	0.2	0.6	-0.7	0.1	0.1	-0.1	0.3	-0.3	0.2	-0.8	0.2	0.5	0.3	-0.8
HbA1C	0.5	0.5	1.6	0.8	-0.4	0.8	0.3	1.1	0.2	-1.0	0.6	0.7	1.3	0.4	-0.5
HDL Cholesterol	1.2	2.0	4.1	-1.1	-1.7	1.2	-1.4	2.0	-1.9	-1.3	1.1	-0.1	1.3	-1.9	0.3
LDL Cholesterol	1.1	1.7	4.2	0.7	-0.9	1.9	-0.3	2.1	-0.3	-1.5	0.7	1.7	2.0	0.6	-1.2
Lupus	0.2	0.3	0.7	0.7	-0.1	-0.7	-0.6	0.0	-0.5	0.5	0.1	-0.8	-0.1	0.8	-0.5
Neuroticism (2016)	0.3	0.5	1.0	0.4	-0.7	0.6	-0.7	1.0	-0.6	-1.0	1.0	-0.5	0.7	0.5	0.2
Primary Biliary Cirrhosis	1.1	1.6	2.7	-1.6	1.5	-1.4	1.3	-1.0	1.4	1.2	-1.2	-1.0	-1.2	1.3	-1.0
Rheumatoid Arthritis	0.5	0.6	1.8	-0.1	0.9	-0.5	0.3	-0.3	0.4	1.4	-0.9	-1.3	-1.0	0.7	0.5
Schizophrenia (2014)	1.8	4.1	10.8	-1.0	2.3	-2.2	1.3	-1.8	1.2	3.3	-3.1	-1.7	-2.8	-0.1	0.6
Triglycerides	0.1	0.1	0.2	-0.3	0.1	0.1	0.3	-0.2	0.5	-0.5	0.4	0.5	0.0	0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	-0.4	-0.9	-0.2	-0.9	-0.2	-1.0	-0.5	0.5	0.2	0.3	-1.2	1.3
Ulcerative Colitis	0.9	1.3	3.3	0.8	-1.3	0.9	-0.7	1.3	-0.6	-0.9	0.7	0.9	1.8	-1.6	1.1
Blood Eosinophil Count	0.2	1.8	4.4	-2.1	-1.4	-0.2	-1.8	1.6	-2.0	-0.6	0.5	0.9	0.2	-1.9	0.1
Blood Platelet Count	0.2	2.2	6.2	-1.7	-0.5	0.4	-0.7	0.9	-0.2	-2.5	2.5	2.1	-0.5	2.0	0.2
Blood Red Count	0.2	2.2	8.5	1.3	1.2	1.5	1.3	-0.8	1.4	0.2	-0.9	1.7	0.8	2.9	-1.8
Blood White Count	0.3	2.3	5.4	-2.3	0.0	-2.0	-0.7	-0.7	-0.8	1.1	-0.3	-2.3	-2.2	-2.1	0.9
Heel T-Score	1.6	12.7	31.1	3.5	-1.5	5.6	1.1	3.5	1.2	-4.8	2.7	5.1	5.2	1.8	-2.7
BMI	0.2	1.0	4.5	-1.3	0.0	-0.9	-0.7	-0.3	-0.5	1.1	-0.2	-2.1	-1.1	-1.0	1.0
Height	0.4	7.8	28.3	-0.1	-3.9	0.9	-3.0	3.0	-2.5	-4.0	5.3	0.2	2.5	0.4	-1.7
Waist Hip Ratio (WHR)	0.3	1.2	4.5	-2.1	-0.4	0.2	-1.4	-0.3	-1.6	0.5	-0.6	-1.1	-0.6	-1.5	0.8
Systolic Blood Pressure	8.9	44.8	92.2	1.6	-9.6	2.0	-9.0	6.8	-8.9	-8.8	9.0	3.5	4.4	-5.9	2.3
Smoking Status	0.8	1.8	4.6	-0.7	-1.7	0.4	-2.1	1.5	-2.1	-1.1	1.6	-0.9	-0.1	-1.0	1.4
Allergy or Eczema	0.4	0.9	4.0	-0.3	0.1	0.7	0.3	0.8	0.4	-0.8	0.1	1.6	0.8	1.4	-2.0
Cardiovascular Disease	3.6	12.1	25.4	-1.1	-5.0	-0.1	-4.7	3.9	-4.8	-3.9	4.6	0.9	1.7	-4.0	1.5
Hypothyroidism (self reported)	0.2	0.5	2.4	-0.4	-0.4	-0.7	-0.7	0.1	-0.7	-0.3	0.6	-0.1	-0.9	-1.0	1.5
Respiratory disease	0.4	0.8	2.6	-1.6	0.7	-0.6	0.7	-0.7	0.7	1.3	-1.2	0.1	-0.9	-0.8	0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	-0.7	-0.8	0.8	-1.4	0.0	-1.6	-0.4	0.0	0.4	0.8	-0.4	-0.9
Lung FEV1/FVC ratio	1.0	4.9	11.4	-0.7	-1.0	3.0	-0.1	2.4	-0.3	-2.4	1.4	2.9	3.4	2.2	-3.2
Lung FVC	0.6	2.9	12.5	0.3	2.3	0.2	1.0	-2.5	0.7	2.4	-3.5	0.4	-1.0	1.2	0.3
Neuroticism	0.2	0.4	1.4	1.2	-0.0	1.0	0.2	0.9	0.3	-0.5	0.4	-0.9	0.6	0.7	-0.3
Chronotype (morning person)	0.4	1.0	2.9	1.0	0.7	-1.7	0.6	-1.3	0.8	0.8	-0.2	-0.3	-1.7	-0.5	1.0
Hair Pigment	0.1	1.7	5.3	-1.5	0.6	2.3	0.8	0.1	0.8	-0.1	-1.4	1.7	1.7	1.6	-1.0
Tanning	0.2	2.3	6.5	1.6	-1.4	-0.8	-2.0	0.6	-1.9	-0.4	1.2	-0.1	-0.9	-2.4	2.6
Hand grip strength (left)	0.4	1.1	3.5	-0.4	-0.6	-1.5	-0.2	0.8	-0.1	-0.5	1.4	-1.9	-1.4	-1.3	0.6
Number of treatments/medications taken	0.5	1.0	3.0	-1.6	-0.8	-0.9	-0.9	0.6	-0.8	-0.4	0.6	-1.0	-0.5	-1.7	0.8
Average weekly spirits intake	4.2	5.2	15.4	0.0	-2.1	3.3	-0.6	2.9	-0.7	-2.8	2.0	2.4	3.9	0.1	-2.2
Sensitivity / hurt feelings	0.6	1.0	2.6	0.3	-0.9	1.6	-0.4	1.6	-0.7	-0.6	0.1	1.3	1.6	-0.7	-0.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.4	0.4	-0.9	0.4	-1.0	1.8	-0.7	-1.5	1.4	0.1	0.5	0.5	0.3
Hearing difficulty/problems: Yes	1.0	1.5	4.0	-0.6	-1.5	0.6	-1.8	1.8	-2.0	-0.6	0.5	-0.1	0.3	-1.8	1.0
Relative age of first facial hair	2.2	4.5	11.0	1.9	-2.0	2.7	-1.0	3.3	-1.2	-2.5	1.7	2.3	3.1	-0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	6.0	1.0	-2.0	0.9	-1.5	2.0	-1.6	-1.7	1.5	0.9	1.3	-2.4	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.2	-0.6	0.1	-0.0	0.3	-1.1	0.2	0.8	-0.5	-0.1	0.5	-0.5	-0.6
Ever had hysterectomy (womb removed)	0.9	1.1	2.8	-1.4	-1.2	-0.2	-1.4	0.7	-1.4	0.2	0.8	-0.5	-0.1	-1.1	1.7
Systolic blood pressure, automated reading	7.9	23.0	50.0	0.3	-7.1	0.6	-6.5	4.7	-6.5	-5.9	6.5	1.5	2.8	-5.3	1.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.8	-0.5	0.9	0.7	0.9	-0.5	0.7	0.4	-1.3	1.2	0.5	0.4	-0.6
Angina	0.8	1.1	3.3	-1.8	1.2	-0.6	1.2	-0.1	1.2	1.1	-0.9	-1.4	-0.5	0.7	-0.9
Medication for hormone replacement therapy	0.4	0.4	1.3	0.2	-0.3	0.9	-0.2	0.7	-0.4	-0.1	-0.3	0.9	1.1	0.1	-1.2
Vitamin and mineral supplements	0.5	0.7	2.0	0.7	1.0	-0.6	0.5	-1.4	0.7	1.1	-0.8	-0.5	-1.1	0.7	0.3
Supplements: Zinc	1.0	1.1	2.2	-0.8	-1.4	0.7	-1.1	1.5	-1.4	-1.1	1.5	-0.1	0.9	-0.2	-0.9
Medication: Co-codamol	2.1	2.4	4.3	-0.1	1.8	-1.3	1.6	-1.7	1.8	1.7	-1.4	-1.9	-2.1	-0.1	1.6
Medication: Metformin	1.3	1.8	5.8	-1.3	-1.6	-0.1	-2.4	1.4	-2.4	-0.5	0.7	-0.5	0.0	-1.4	0.7
Diabetes (father)	2.1	2.6	10.0	1.0	-1.3	2.2	-0.1	0.9	-0.4	-2.1	0.8	2.6	3.2	-0.4	-0.6
Diabetes (mother)	1.0	1.3	2.6	-0.6	-1.4	-1.5	-1.6	-0.4	-1.6	-0.4	1.0	-0.9	-0.5	-1.5	0.9
Severe depression (siblings)	1.8	2.0	6.6	-1.5	-2.0	0.4	-1.5	1.1	-1.6	-1.5	1.5	-0.5	0.8	-2.6	0.1
Pack years adult smoking proportion	1.3	1.9	6.1	-0.9	-1.5	-1.1	-2.5	0.9	-2.4	-0.2	1.2	-1.6	-0.7	-0.5	1.4
Impedance of leg (right)	0.2	0.9	3.2	-0.8	0.1	-0.8	0.8	0.3	1.1	-0.7	1.8	-0.3	-0.3	1.7	-0.6
Leg fat-free mass (left)	0.5	2.6	6.0	-0.8	-2.3	-0.0	-2.4	2.0	-2.3	-1.2	1.7	-1.3	0.8	-1.8	0.3
Trunk fat percentage	0.5	2.0	10.7	-1.7	-0.7	-1.7	-1.2	0.8	-0.6	-0.1	1.7	-3.3	-1.1	-0.3	0.6
Hand grip strength (right)	0.4	1.2	2.5	-0.5	-1.1	-1.5	-0.7	1.3	-0.7	-0.8	1.6	-1.4	-1.0	-1.3	0.7
Townsend deprivation index at recruitment	0.7	1.0	3.1	-1.0	-0.7	-0.5	-1.8	1.4	-1.6	-0.3	0.5	-0.5	-0.3	0.1	1.2
Current tobacco smoking	0.4	0.7	2.5	-0.1	-0.9	0.9	-1.5	0.8	-1.6	-0.9	0.5	0.4	0.3	0.0	0.4
Average weekly fortified wine intake	1.0	1.2	4.7	1.5	0.5	1.2	1.2	-0.9	1.3	-0.6	-0.0	2.2	0.9	0.3	-0.1
Maternal smoking around birth	3.0	4.3	11.8	-1.5	3.0	-0.1	2.1	-2.6	1.8	3.1	-3.4	-0.1	-1.7	0.9	1.2
Fed-up feelings	0.6	1.0	2.5	-0.2	1.2	-0.3	0.7	-0.2	0.9	1.3	-1.5	-1.3	-0.4	1.6	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	1.2	-0.1	-0.6	-0.7	0.7	-0.2	-0.7	0.8	-0.7	-0.5	1.4	0.1
Relative age voice broke	2.6	3.9	9.7	1.7	-2.3	1.8	-1.5	2.6	-1.5	-3.1	2.6	1.6	2.1	-0.5	0.3
Taking other prescription medications	0.4	0.7	3.6	-0.6	-0.9	0.6	-0.6	0.4	-0.7	-0.6	0.3	0.7	0.8	-1.9	0.7
Age when periods started (menarche)	0.9	2.3	6.2	0.9	1.1	2.5	1.7	-1.0	1.4	0.9	-1.7	1.7	1.9	0.6	-1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.8	-1.6	0.9	-0.9	0.4	-1.2	0.4	1.7	-1.0	-1.5	-1.6	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	10.6	2.2	-1.9	2.9	-0.8	2.3	-0.7	-3.3	2.6	2.3	2.8	0.5	-1.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.2	0.1	-0.8	-0.1	-0.6	0.1	-0.7	-0.2	0.4	0.0	0.1	-1.5	-0.1
Qualifications: CSEs or equivalent	0.8	1.1	4.0	2.0	1.3	-0.0	1.2	0.0	1.5	1.0	-1.2	-0.1	-0.5	1.2	0.1
Serious illness, injury or assault to yourself	2.6	3.1	5.3	1.3	-2.3	1.7	-1.8	2.2	-1.9	-2.2	2.0	1.0	1.8	-1.5	-0.3
High blood pressure	4.2	11.8	24.4	-1.5	-4.8	-0.1	-4.9	3.9	-4.9	-3.2	3.9	-0.2	1.2	-4.6	2.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	4.9	0.3	0.3	0.6	0.9	0.4	0.9	-0.6	-0.1	1.6	0.9	1.1	-2.2
Multivitamins +/- minerals	1.5	2.0	4.3	-0.6	-1.7	1.1	-0.7	2.1	-0.8	-2.0	1.7	0.8	1.9	-1.3	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.0	0.5	-0.6	0.4	-0.5	0.5	0.1	0.0	0.6	-0.4	0.8	0.2
Supplements: Glucosamine	1.8	2.4	6.7	0.7	-1.9	1.1	-1.5	1.8	-1.7	-1.6	1.2	1.3	1.3	-2.6	0.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.2	0.2	1.0	-1.0	0.2	-1.7	0.1	1.8	-1.6	-0.5	-2.0	-1.2	0.7
Medication: Atenolol	2.1	2.7	6.0	-2.2	-1.9	-1.0	-2.1	1.7	-1.9	-0.9	1.6	-1.1	-0.3	-2.5	0.9
Medication: Levothyroxine sodium	0.5	0.8	2.7	-0.8	-0.7	-0.8	-0.8	0.4	-0.8	-0.8	1.1	0.1	-0.8	-1.0	1.6
Sitting height	0.7	5.1	15.5	-1.4	-3.3	-0.4	-2.9	2.7	-2.6	-2.7	3.9	-1.2	1.0	-0.7	-0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-0.6	0.8	-1.0	0.8	-0.2	0.6	1.1	-0.6	-1.4	-1.0	-0.0	0.5
High blood pressure (mother)	6.4	9.0	19.1	-0.7	-4.4	1.2	-3.8	3.4	-4.0	-3.6	4.1	1.5	1.9	-2.9	1.2
Body mass index (BMI)	0.8	3.3	12.6	-1.8	-0.1	-2.5	-1.4	-0.2	-1.2	1.5	-0.4	-3.5	-2.4	-1.7	2.0
Impedance of leg (left)	0.2	0.8	2.9	-0.5	0.2	-0.5	1.0	0.3	1.3	-0.8	1.7	-0.0	-0.1	1.6	-0.8
Leg predicted mass (left)	0.5	2.7	6.3	-0.7	-2.4	-0.1	-2.5	2.0	-2.4	-1.2	1.8	-1.3	0.8	-1.8	0.3
Trunk fat mass	0.6	2.7	12.3	-1.8	-1.3	-1.6	-1.8	1.3	-1.3	-0.3	2.0	-3.5	-0.9	-0.7	0.6
Waist circumference	0.9	3.2	10.0	-1.9	-1.2	-1.2	-2.6	0.7	-2.3	0.5	0.6	-3.2	-1.5	-1.8	1.8
Number of incorrect matches in round	1.0	1.6	3.8	-1.2	1.0	-1.8	0.4	-0.8	0.5	1.2	-1.0	-1.9	-2.0	-0.4	1.5
Past tobacco smoking	0.5	0.9	2.2	0.9	1.3	-0.2	1.4	-1.2	1.5	0.9	-1.1	0.5	-0.3	1.0	-0.4
Alcohol usually taken with meals	0.3	0.4	1.6	-0.5	-0.0	-1.3	-0.2	-1.0	-0.1	-0.1	0.5	-0.9	-0.8	0.2	-0.6
Nervous feelings	0.2	0.3	1.1	0.3	-0.5	-0.3	-0.6	0.0	-0.5	0.1	0.3	-0.7	-0.2	-0.9	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.0	0.3	1.7	0.3	1.2	-1.4	1.3	0.9	-1.2	0.0	-0.5	2.0	-0.2
Hearing difficulty/problems with background noise	0.7	1.2	3.9	-0.1	0.5	-1.2	-0.6	-0.5	-0.7	1.1	-0.7	-2.0	-1.8	0.0	1.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	0.9	-0.7	0.6	-0.5	0.5	-0.6	-0.7	0.3	1.1	0.4	-1.2	0.2
Had menopause	0.1	0.2	0.7	-0.4	-0.3	-0.1	-0.9	-0.2	-0.8	0.3	-0.1	-0.2	-0.1	-0.5	0.3
Had other major operations	2.0	2.5	6.0	0.4	-2.1	0.6	-1.9	2.2	-2.0	-1.6	1.3	0.6	0.9	-2.5	1.0
Forced vital capacity (FVC)	0.1	0.4	2.4	-0.1	0.6	0.1	0.7	-0.1	0.9	-0.2	-0.0	0.1	0.2	1.5	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	6.4	1.6	-1.3	2.1	-0.4	1.5	-0.3	-2.5	1.9	1.9	1.9	0.5	-0.7
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.2	0.9	-2.2	1.4	-1.9	2.3	-2.0	-1.9	1.5	1.0	1.8	-1.3	-0.1
Qualifications: None of the above	0.8	1.6	5.2	-1.5	0.3	-2.3	-0.5	-0.7	-0.3	0.6	0.1	-1.3	-2.3	-0.2	2.0
Financial difficulties in last 2 years	1.0	1.4	5.8	-1.1	-1.2	0.2	-0.8	1.7	-1.1	-0.8	0.7	0.7	0.6	-2.4	1.0
Mouth/teeth dental problems	1.5	2.3	4.8	-1.2	2.0	0.0	2.0	-2.2	1.8	1.7	-2.2	0.2	-0.9	1.0	-0.6
Heart attack	1.4	1.8	4.2	0.8	-1.0	1.2	-0.4	1.5	-0.3	-1.7	1.4	1.9	1.9	-0.1	-2.1
Allergy	0.4	0.9	2.4	0.6	-1.0	0.6	-1.1	0.7	-1.0	-1.0	1.1	-0.8	0.4	-0.9	1.5
Pain all over the body in last month	0.4	0.4	3.0	-1.0	-0.3	0.5	-0.1	1.7	0.1	-0.3	0.0	-0.3	0.2	-0.9	0.1
Diabetes (self-reported)	0.3	0.4	1.5	-1.1	-0.2	0.1	-1.2	0.1	-1.2	0.3	-0.5	0.1	-0.2	0.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	7.4	2.7	-0.3	0.9	0.7	1.0	0.6	-0.9	0.5	1.1	1.2	-0.3	-0.7
Medication: Ramipril	0.5	0.7	4.1	-2.0	-0.6	-0.7	-0.5	0.1	-0.5	-0.3	0.6	-1.0	-0.3	-0.9	-0.6
Medication: Simvastatin	0.8	1.1	2.7	-0.9	-0.8	-1.6	-1.5	0.0	-1.6	-0.1	0.7	-0.8	-1.2	-1.1	0.7
Fluid intelligence score	1.7	3.6	9.1	0.8	-0.1	3.0	0.9	1.6	0.7	-1.5	0.5	2.3	2.9	2.4	-2.7
Illnesses of siblings	2.7	3.8	7.6	0.7	1.8	1.5	2.7	-0.9	2.6	0.0	-1.4	2.3	1.4	2.8	-2.8
Neuroticism score	0.2	0.3	1.4	0.7	0.5	-0.1	0.1	-0.1	0.0	0.7	-0.7	-1.2	-0.5	-0.0	0.5
Weight	0.6	2.8	11.9	-1.9	-1.5	-1.6	-2.1	1.4	-1.7	-0.2	1.6	-3.5	-0.9	-1.1	0.6
Impedance of arm (right)	0.6	2.6	6.0	0.8	0.5	1.5	1.7	0.1	2.0	-1.5	1.5	1.3	1.8	2.4	-2.4
Arm fat percentage (right)	0.4	1.6	8.7	-1.8	0.1	-1.5	-0.6	0.1	-0.1	0.9	0.3	-3.0	-1.4	-0.6	1.1
Trunk fat-free mass	0.3	1.7	3.8	-1.3	-1.7	-0.5	-1.9	1.4	-1.8	-0.5	1.1	-1.8	0.0	-1.2	0.2
Hip circumference	0.8	3.4	12.2	-1.5	-1.6	-2.0	-2.2	1.2	-1.7	-0.2	1.9	-3.5	-1.4	-1.6	1.6
Time employed in main current job	0.6	0.7	1.9	1.0	0.4	1.2	0.1	-0.1	-0.2	1.0	-1.4	1.2	0.7	0.0	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-0.9	0.2	-0.8	0.1	-0.2	0.1	0.6	0.0	-1.0	-1.0	-0.6	0.4
Father’s age at death	0.2	0.3	1.0	0.7	-0.5	0.4	-0.2	0.8	-0.0	-0.6	0.6	-0.4	0.6	0.1	-1.0
Worrier / anxious feelings	0.2	0.3	0.7	0.7	-0.6	0.4	-0.1	0.7	-0.2	-0.8	0.6	0.4	0.7	-0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	2.0	-0.7	0.0	-0.1	-0.3	0.5	-0.1	-0.4	0.4	-0.7	-0.2	1.4	-0.6
Falls in the last year	0.8	1.1	2.7	0.7	-1.1	1.3	-0.9	1.6	-0.8	-1.1	0.8	0.6	1.5	-0.5	1.0
Hair/balding pattern: Pattern 3	1.0	1.5	10.0	1.1	0.5	-1.1	-0.6	-1.0	-0.5	0.7	-0.5	-0.9	-1.4	0.2	3.2
Number of live births	0.3	0.4	1.1	0.5	-0.0	-0.9	-0.7	-0.8	-0.7	0.7	-0.5	0.0	-0.7	-0.5	1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.4	-0.2	0.5	0.8	0.9	0.6	1.1	-0.8	0.4	1.0	1.1	2.3	-1.6
Pulse rate	0.7	1.2	3.4	-1.5	1.5	0.1	1.2	-0.9	1.1	1.4	-1.9	0.3	-0.7	0.7	0.1
Happiness	1.4	1.6	4.2	0.8	-1.0	1.6	-0.5	2.1	-0.5	-1.7	1.2	0.6	1.8	1.2	-1.2
Noisy workplace	1.4	1.7	6.4	-2.5	0.3	-1.4	0.0	-0.6	-0.1	0.7	-0.1	-1.9	-1.6	-1.6	1.7
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.7	0.6	-1.3	0.5	-0.7	1.0	-0.5	-1.9	1.9	0.7	1.4	0.3	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	1.2	-0.8	0.7	-0.6	0.8	-0.6	-1.1	0.9	1.2	1.2	0.0	0.6
Mouth/teeth dental problems: Dentures	1.3	2.2	4.7	-0.5	-1.6	-1.4	-2.0	1.0	-1.8	-1.3	2.2	-1.8	-1.0	-1.5	0.9
Asthma	0.4	0.9	2.1	-0.9	1.0	-0.1	1.2	-1.1	1.0	1.4	-1.4	0.7	-0.4	-0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	5.8	-1.2	1.7	0.0	1.2	-1.4	1.2	2.0	-2.4	0.1	-0.7	0.6	-0.2
Medication: Cholesterol lowering	1.3	2.0	5.9	-2.4	0.5	-2.4	-0.9	-0.4	-0.9	1.5	-0.9	-1.9	-2.0	0.5	-0.1
Depression (self-reported)	1.7	2.0	5.1	0.5	-1.4	1.3	-0.9	2.3	-0.6	-2.1	1.8	0.3	2.1	0.6	-1.2
Medication: Lansoprazole	0.9	1.0	2.9	-0.2	-1.1	-0.4	-1.4	1.2	-1.2	-1.2	1.7	-0.6	-0.3	-0.3	1.0
Prospective memory result	4.2	5.1	10.7	-2.3	2.0	-2.8	0.8	-3.0	1.0	2.8	-2.1	-2.6	-3.3	-0.3	1.9
Lung cancer (father)	1.9	2.2	6.6	-0.7	1.9	-0.3	1.5	-2.1	1.3	2.2	-2.6	-0.7	-1.5	-0.5	0.1
Illnesses of mother	5.0	6.1	15.0	1.4	3.6	-0.2	3.6	-2.7	3.9	2.2	-2.5	-0.8	-1.3	3.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.7	-0.4	0.0	0.2	0.2	0.7	0.4	-0.8	0.7	0.1	0.6	1.6	-1.4
Pulse wave Arterial Stiffness index	1.2	1.4	3.2	1.4	-1.6	0.5	-1.8	1.2	-1.7	-1.2	1.2	0.1	1.0	-0.9	0.2
Impedance of arm (left)	0.4	1.9	3.8	0.9	-0.1	1.2	0.9	0.5	1.2	-1.7	1.9	1.1	1.6	1.9	-1.9
Arm fat mass (right)	0.5	2.1	10.8	-2.0	-0.6	-1.6	-1.4	0.7	-0.9	0.6	0.7	-3.3	-1.3	-0.9	1.1
Trunk predicted mass	0.3	1.7	3.9	-1.2	-1.8	-0.5	-2.0	1.5	-1.9	-0.5	1.1	-1.7	0.1	-1.3	0.2
Standing height	0.6	5.6	17.1	-0.5	-2.9	1.4	-1.4	3.1	-1.2	-3.2	4.1	-0.4	2.7	0.8	-2.8
Length of working week for main job	0.6	0.7	1.6	1.2	0.1	1.0	0.4	-0.0	0.3	-0.1	-0.0	1.1	1.1	1.2	-1.1
Exposure to tobacco smoke at home	3.7	4.2	10.4	-2.9	2.1	-1.8	1.2	-2.1	1.0	3.2	-2.9	-1.4	-2.4	0.6	0.5
Breastfed as a baby	1.8	2.2	5.1	0.5	-2.3	0.2	-2.1	1.7	-2.2	-1.7	1.7	-0.2	1.1	-1.2	-0.4
Tense / ‘highly strung’	0.2	0.3	0.6	0.7	-0.8	-0.3	-0.7	-0.0	-0.7	-0.2	0.7	-0.3	0.2	-0.7	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	-0.9	-0.2	-0.4	-0.5	-0.4	-0.6	0.3	-0.1	-1.2	-0.5	-0.8	-0.1
Hair/balding pattern: Pattern 4	0.6	1.5	5.2	0.0	-0.0	2.3	0.8	1.1	0.7	-1.1	0.4	1.1	1.9	0.8	-2.0
Birth weight of first child	1.6	2.8	6.5	1.4	-0.9	2.4	-0.2	2.3	-0.1	-1.9	1.4	1.3	2.2	1.1	-2.5
Peak expiratory flow (PEF)	0.7	1.6	6.7	0.1	0.4	0.8	1.3	1.0	1.4	-1.2	0.6	0.4	1.4	1.7	-2.6
Pulse wave reflection index	3.2	3.9	8.8	0.7	-2.7	-0.3	-3.0	2.0	-2.9	-1.5	2.2	-0.4	0.7	-2.8	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.6	4.0	0.7	-1.7	0.4	-1.5	1.7	-1.4	-1.7	2.0	0.1	1.3	-0.4	-0.7
Loud music exposure frequency	0.7	0.8	5.0	-0.4	-0.4	0.7	0.5	1.1	0.3	-0.6	0.4	0.1	1.4	0.1	-2.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	0.3	0.8	-0.3	0.8	-1.0	0.6	0.7	-1.2	0.0	-0.1	0.3	-1.0
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	7.5	2.2	-1.6	2.1	-0.6	2.4	-0.6	-1.9	1.7	2.3	2.7	-0.4	-1.0
Blood clot in the leg (DVT)	0.9	1.2	3.8	0.5	-1.5	-0.4	-1.8	0.7	-2.0	-0.8	0.6	0.5	0.4	-1.4	-0.4
Medication: Paracetamol	1.0	1.6	4.6	-1.2	1.9	-0.3	0.6	-1.1	0.9	1.5	-1.8	-0.2	-1.4	2.1	0.4
Headache pain in last month	1.0	1.8	5.4	-0.9	1.9	-0.3	0.9	-1.6	0.7	2.0	-2.3	0.5	-1.0	1.5	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	3.0	1.7	0.4	0.6	1.0	-0.3	1.0	-0.1	0.3	0.2	-0.2	0.1	1.2
Glaucoma (self-reported)	2.2	2.6	7.6	0.1	1.4	2.1	2.8	-0.5	2.5	-0.1	-1.3	1.0	1.7	0.3	-2.3
Gout (self-reported)	1.3	1.7	4.0	-0.8	-1.3	-1.6	-2.0	0.7	-1.9	-0.1	1.3	-1.4	-0.9	-1.0	1.4
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.5	-0.2	-1.9	-0.3	-2.1	1.3	-2.0	-1.4	2.0	-0.1	-0.4	-2.1	2.1
Medication: Amlodipine	0.8	1.2	4.5	-2.1	-0.8	-1.2	-1.2	1.0	-1.2	-0.4	0.5	-1.0	-0.7	-1.1	0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.2	-1.5	-0.9	0.1	-1.4	0.8	-1.3	-0.6	0.4	0.1	0.0	-0.9	0.2
Birth weight	1.7	3.7	6.8	2.0	-2.2	1.9	-1.5	2.4	-1.4	-2.6	2.5	1.6	2.2	0.1	-1.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	4.3	-1.4	-1.1	0.4	-0.9	0.7	-1.0	-0.6	0.4	0.1	0.7	-2.1	0.9
High blood pressure (siblings)	0.6	0.8	1.5	-1.1	-0.6	-0.8	-1.1	1.1	-1.2	0.1	0.5	-0.8	-0.8	-1.0	1.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	-0.6	-0.3	-0.1	-0.4	0.4	-0.3	-0.6	0.7	-0.3	0.0	0.7	-0.5
Body fat percentage	0.6	2.3	11.7	-1.7	-0.7	-1.9	-1.3	0.8	-0.8	0.3	1.4	-3.4	-1.4	-0.6	1.2
Leg fat percentage (right)	0.9	3.4	13.5	-1.9	-0.9	-2.3	-1.8	0.9	-1.3	0.5	1.4	-3.7	-1.9	-1.2	2.0
Arm fat-free mass (right)	0.4	2.1	5.2	-1.2	-2.0	-0.7	-2.3	1.8	-2.2	-0.6	1.4	-1.6	0.1	-1.4	0.3
Exposure to tobacco smoke outside home	1.7	2.3	4.8	-2.1	1.7	-0.4	2.0	-0.8	1.8	2.2	-2.1	-1.0	-0.0	0.6	-1.1
Comparative body size at age 10	0.4	1.2	3.4	1.5	1.1	0.4	1.2	-1.4	1.0	1.2	-1.9	1.0	0.3	-0.1	0.9
Number of full brothers	1.8	2.3	5.5	1.5	-2.0	0.0	-1.6	1.5	-1.4	-1.7	2.3	0.1	0.7	-2.1	1.0
Worry too long after embarrassment	0.5	0.8	4.7	0.4	0.1	2.2	0.1	0.1	0.0	-0.4	-0.6	1.6	1.2	-0.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.5	-0.3	-1.5	0.1	-1.0	0.9	-0.9	-1.5	1.6	-0.6	1.3	-1.0	-0.6
Wheeze or whistling in the chest in last year	0.5	0.9	3.7	-1.2	-0.9	-0.1	-1.0	1.2	-1.1	-0.1	0.2	-1.0	0.0	-1.9	0.6
Number of children fathered	0.4	0.5	1.5	0.2	0.4	0.4	1.0	0.5	1.2	-0.2	0.2	-0.3	0.6	1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	-1.3	-0.7	0.3	-0.3	0.5	-0.3	-1.2	1.2	1.0	0.6	-0.3	-0.1
Age at first live birth	0.4	0.8	3.8	0.2	0.9	0.7	1.2	-0.5	1.1	0.3	-0.5	0.8	0.1	1.9	-0.6
Pulse wave peak to peak time	0.9	1.0	2.9	-1.2	1.3	-0.2	1.7	-0.8	1.6	0.8	-0.8	-0.0	-0.6	0.9	-0.3
Health satisfaction	0.4	0.5	2.2	-1.5	-0.7	0.1	-0.4	1.2	-0.4	-0.3	0.4	-0.8	0.5	-0.3	-0.2
Shortness of breath walking on level ground	0.5	0.5	1.7	-1.3	0.4	-0.1	0.3	-0.8	0.1	0.9	-1.1	-0.7	-0.4	-0.8	-0.7
Qualifications: College or University degree	1.9	6.1	13.7	0.9	-2.3	3.1	-0.7	2.8	-0.8	-3.3	2.9	1.7	3.7	0.8	-3.4
Eye problems/disorders: None of the above	2.4	2.8	7.2	-1.6	1.1	-2.6	-0.1	-2.2	0.0	1.9	-1.0	-2.0	-2.7	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.9	0.4	-1.0	0.7	-1.0	0.9	-1.1	-1.0	0.7	1.4	1.1	-0.6	0.6
Emphysema/chronic bronchitis	0.9	1.0	3.9	-2.0	0.1	-1.5	-0.4	0.0	-0.3	0.3	0.1	-1.6	-1.5	-0.0	0.8
Medication for pain relief, constipation, heartburn	0.7	1.1	3.2	0.8	-1.5	0.6	-0.5	0.9	-0.8	-1.3	1.5	0.2	0.9	-1.8	0.6
Neck or shoulder pain in last month	0.5	0.7	2.5	-1.2	-0.2	-1.3	-0.4	-0.5	-0.3	0.3	0.0	-0.5	-0.8	-1.6	1.4
Medication: Blood pressure	0.7	1.2	2.5	-1.3	-1.2	0.5	-1.3	1.5	-1.3	-1.1	0.6	0.4	1.0	-0.5	-1.6
Angina (self-reported)	1.0	1.4	4.0	-2.0	1.3	-0.6	1.3	-0.2	1.3	1.2	-1.1	-1.4	-0.6	0.8	-1.0
Migraine (self-reported)	1.3	1.6	3.5	1.5	1.4	0.5	1.9	-0.5	1.8	1.3	-1.6	1.1	0.3	0.9	-1.3
Medication: Ibuprofen	0.8	1.0	3.5	-1.0	1.3	0.2	1.1	-0.8	1.1	1.4	-1.9	0.2	-0.5	0.5	-0.5
Medication: Allopurinol	0.6	0.8	1.7	-0.8	-0.6	-1.2	-1.3	-0.0	-1.2	0.2	0.8	-0.9	-1.0	-0.5	1.0
Medication: Omeprazole	1.1	1.3	2.5	0.4	-1.3	0.6	-1.6	1.3	-1.4	-1.4	1.5	0.7	1.0	0.9	-0.6
Medication: Seretide 50 evohaler	1.1	1.3	3.6	-0.2	1.0	-1.5	0.1	-1.4	0.1	1.3	-1.3	-0.9	-1.9	-0.4	1.4
Mean time to correctly identify matches	0.2	0.4	3.1	0.6	-0.3	0.0	-0.3	-0.4	-0.2	0.1	0.0	0.1	0.7	-0.1	-1.8
Heart disease (mother)	0.2	0.2	1.0	-0.9	0.1	-1.0	-0.0	-0.2	-0.0	0.2	-0.2	0.1	-0.4	-0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.5	1.1	-0.9	0.7	-0.4	0.8	0.6	-0.8	-0.7	-1.4	1.3	-0.5
Whole body fat mass	0.6	2.7	12.5	-1.6	-1.1	-1.8	-1.9	1.1	-1.4	0.1	1.5	-3.5	-1.2	-0.9	1.2
Leg fat mass (right)	0.7	2.9	12.2	-1.7	-1.1	-1.9	-1.9	1.1	-1.5	0.4	1.2	-3.5	-1.5	-1.3	1.6
Arm predicted mass (right)	0.5	2.7	6.3	-1.2	-2.2	-0.6	-2.5	2.0	-2.4	-0.8	1.7	-1.7	0.1	-1.5	0.3
Pulse rate, automated reading	0.5	1.7	6.9	-2.1	1.4	0.5	0.6	-1.4	0.4	1.9	-2.6	0.7	-0.8	-0.3	0.5
Alcohol intake frequency.	0.6	1.4	3.8	-1.5	0.4	-1.7	-0.7	-1.0	-0.7	1.3	-0.7	-1.6	-1.9	-0.5	0.6
Comparative height size at age 10	0.3	1.6	7.4	-0.7	-1.5	-0.1	-1.2	1.1	-1.0	-1.6	2.7	-1.4	0.1	0.4	-0.2
Number of full sisters	0.7	0.8	3.8	-0.4	-0.3	-1.0	-0.5	-0.7	-0.6	0.3	0.1	-0.4	-0.8	-1.8	1.9
Suffer from ‘nerves’	0.3	0.5	2.1	-1.2	0.3	-0.7	0.1	0.2	0.0	0.7	-0.3	-1.5	-0.7	-0.3	0.1
Overall health rating	1.1	2.4	6.8	-0.8	-2.0	0.8	-1.8	2.6	-1.8	-1.2	1.2	0.1	1.0	-2.4	0.8
Chest pain or discomfort	0.6	0.9	2.2	-1.5	0.1	-1.4	-0.2	-0.4	-0.4	1.0	-0.2	-1.0	-1.0	-0.8	1.5
Had major operations	1.1	1.3	6.7	-1.6	-0.6	-0.6	-0.9	0.1	-1.2	0.6	-0.4	-0.7	-0.9	-2.6	1.0
Age at last live birth	0.1	0.1	0.3	-0.3	-0.2	0.3	0.2	-0.2	0.0	0.1	-0.1	0.3	0.2	-0.5	0.5
Family relationship satisfaction	1.9	2.4	5.4	1.9	-1.3	2.2	-1.0	2.1	-1.1	-1.6	0.8	1.5	2.3	-0.2	-0.8
Leg pain on walking	1.4	1.8	4.7	-0.2	-1.6	1.2	-0.8	1.4	-0.7	-2.2	1.9	1.4	1.6	-0.9	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.9	-0.7	-1.1	0.8	-1.1	1.1	-1.4	-0.5	0.3	0.9	0.9	-1.2	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	-0.4	1.1	-0.4	0.7	-1.3	0.8	1.0	-0.9	0.3	-1.0	1.2	0.9
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	5.8	-0.8	2.0	-0.8	1.5	-2.4	1.5	2.2	-1.9	-1.8	-1.5	1.2	-1.0
Medication: Aspirin	0.4	0.5	1.3	-1.1	-0.6	-0.4	-0.8	0.8	-0.9	0.2	0.0	-0.6	0.3	-0.9	-0.7
Supplements: Vitamin C	1.7	2.0	4.7	-2.2	1.7	-1.3	1.3	-1.0	1.3	1.6	-1.4	-1.5	-1.4	1.1	0.1
Knee pain experienced in last month	2.8	4.3	10.9	1.8	-2.7	1.3	-2.1	3.3	-1.9	-2.6	2.8	0.9	1.7	-1.5	0.6
Hypertension (Self-reported)	3.9	10.9	22.0	-1.6	-4.7	0.2	-4.7	4.1	-4.6	-3.3	3.9	-0.1	1.6	-4.0	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	1.0	-0.4	0.7	-0.7	0.7	-0.4	-1.0	0.8	-0.0	0.1	0.4	-0.4
Illnesses of father: Heart disease	0.8	1.0	3.2	0.1	0.3	-1.8	-0.5	-1.3	-0.4	1.1	-0.4	-0.2	-1.6	-0.6	1.7
Illnesses of siblings: Diabetes	0.5	0.6	1.8	0.4	-0.5	-0.7	-1.0	-0.8	-1.1	0.3	0.1	-0.9	-0.5	-1.3	0.8
Smoking status: Previous	1.0	1.5	2.8	-0.8	-1.7	-0.2	-1.5	1.5	-1.5	-1.2	1.7	-0.9	0.2	-1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	5.7	-0.6	-2.0	0.2	-2.4	1.1	-2.1	-1.5	2.0	0.3	0.4	-0.5	0.9
Whole body fat-free mass	0.4	2.2	5.2	-1.1	-2.1	-0.3	-2.3	1.8	-2.2	-0.9	1.4	-1.5	0.4	-1.6	0.2
Leg fat-free mass (right)	0.4	2.1	4.7	-0.4	-2.1	0.2	-2.2	1.8	-2.1	-1.1	1.4	-1.0	0.9	-1.8	0.1
Arm fat percentage (left)	0.5	1.9	9.8	-1.8	-0.2	-1.7	-1.0	0.4	-0.6	0.7	0.5	-3.1	-1.5	-0.7	1.2
Average weekly red wine intake	1.0	1.4	3.1	1.0	-1.4	1.1	-1.5	0.6	-1.8	-1.3	1.0	1.0	1.4	-0.7	-1.1
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.6	0.9	-1.2	-0.9	-1.6	-0.2	-1.6	0.4	0.6	-1.3	-0.5	-1.1	0.6
Mood swings	0.3	0.5	2.6	0.4	0.5	0.2	0.5	0.7	0.7	0.1	0.1	-1.3	-0.2	1.6	-0.6
Loneliness, isolation	1.1	1.5	4.6	0.7	-1.5	0.9	-1.6	2.1	-1.4	-1.2	1.6	-0.1	0.7	-0.6	0.6
Long-standing illness, disability or infirmity	3.0	4.6	14.8	-1.6	-2.8	0.0	-2.6	2.4	-2.6	-2.0	2.1	0.2	1.0	-3.8	1.3
Ever had bowel cancer screening	0.8	0.9	4.1	0.5	1.2	-0.8	0.5	-0.8	0.3	1.7	-2.0	0.1	-1.0	0.4	-0.4
Diabetes diagnosed by doctor	0.3	0.6	2.2	-0.8	-0.5	0.7	-1.4	0.3	-1.5	0.1	-0.7	0.1	0.2	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.6	-0.3	-0.0	-0.0	-0.5	-0.1	-0.5	0.4	0.3	0.4	0.3	-0.0
Friendships satisfaction	1.2	1.5	4.2	2.1	-1.0	1.5	-1.0	1.2	-0.9	-1.2	1.1	0.7	1.6	0.7	-1.1
Qualifications: nursing, teaching	0.5	0.7	1.5	-1.0	0.6	-0.6	1.1	-0.6	0.9	1.2	-1.1	-0.0	-0.1	-0.7	-1.2
Commuting to job workplace: Walk	0.8	0.9	3.4	1.2	0.1	0.6	0.3	0.4	0.1	-0.1	-0.6	1.8	1.3	0.8	-1.7
Eye problems/disorders: Cataract	1.0	1.2	2.7	1.1	-1.4	0.9	-0.7	1.2	-0.7	-1.6	1.6	0.6	1.3	-0.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.3	0.5	-0.6	0.6	-0.4	0.6	-0.4	-0.7	0.4	0.8	1.1	0.3	0.1
Medication for cholesterol	2.2	3.3	9.0	1.5	2.4	1.1	2.4	-1.3	2.3	1.2	-2.0	0.8	-0.0	3.0	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	7.2	0.3	0.1	2.2	1.0	1.0	0.8	-1.1	-0.1	1.5	1.9	1.1	-2.7
Back pain experienced in last month	1.7	2.5	6.3	-0.9	-2.3	-0.2	-1.9	2.2	-1.8	-1.9	2.5	-0.5	0.8	-0.9	0.6
Mineral and other dietary supplements	2.9	3.9	7.1	-1.0	2.5	-1.5	1.6	-2.4	1.8	2.7	-2.3	-2.0	-2.3	1.9	0.6
Breast cancer (self-reported)	0.2	0.2	0.7	0.3	-0.4	-0.1	-0.2	0.7	-0.3	-0.4	0.6	0.5	0.2	-0.9	0.0
Asthma (self-reported)	0.5	1.1	2.3	-0.8	1.2	-0.0	1.4	-1.3	1.3	1.5	-1.5	0.6	-0.4	-0.4	0.2
Osteoporosis (self-reported)	0.8	1.0	2.1	0.1	-1.4	0.7	-1.0	0.8	-1.1	-1.2	1.3	0.2	1.5	-0.5	-1.0
Osteoarthritis (self-reported)	0.8	1.0	3.2	-0.1	-1.1	-0.4	-0.7	1.8	-0.6	-1.3	1.7	-0.1	-0.0	-1.5	0.3
Medication: Aspirin	0.9	1.2	2.5	-1.1	-1.3	-0.3	-1.5	1.5	-1.6	-0.5	0.8	-0.8	0.5	-1.5	-0.5
Medication: Gliclazide	0.5	0.5	1.5	-0.9	-0.7	0.5	-1.2	0.7	-1.0	-0.4	0.6	0.5	0.6	0.7	0.1
Illnesses of father: None of the above (group 1)	1.5	1.9	5.0	1.6	1.2	1.3	1.5	-0.5	1.4	0.4	-1.2	1.3	0.5	2.1	-2.2
Smoking status: Current	0.4	0.7	2.2	0.3	-0.8	0.9	-1.4	0.7	-1.5	-0.9	0.6	0.5	0.3	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.3	0.3	-0.6	-0.3	-0.8	-0.2	-0.1	0.1	0.4	-0.7	0.8	0.4
Whole body water mass	0.4	2.3	5.6	-1.0	-2.2	-0.2	-2.4	1.8	-2.3	-1.0	1.5	-1.4	0.4	-1.6	0.3
Leg predicted mass (right)	0.4	2.1	4.7	-0.5	-2.1	0.1	-2.2	1.8	-2.1	-1.1	1.5	-1.0	0.9	-1.7	0.1
Arm fat mass (left)	0.6	2.4	11.1	-2.0	-0.8	-1.7	-1.6	0.8	-1.2	0.5	0.9	-3.3	-1.3	-1.0	1.2
Number of self-reported non-cancer illnesses	2.2	3.8	9.1	-0.9	-2.7	0.9	-2.6	2.2	-2.6	-1.7	2.0	0.3	1.2	-3.0	1.0
Average weekly champagne plus white wine intake	1.0	1.4	4.3	-0.7	-1.3	0.6	-0.3	2.1	-0.3	-1.7	1.8	-0.2	1.4	-0.7	-1.3
Miserableness	1.0	1.7	3.5	0.0	1.6	-1.3	0.9	-1.2	0.9	1.7	-1.4	-1.9	-1.6	1.5	0.1
Guilty feelings	1.0	1.5	5.1	0.7	1.6	1.0	1.4	-1.3	1.0	1.3	-2.2	0.8	0.5	1.0	-0.9
Wears glasses or contact lenses	0.1	0.2	0.5	0.1	-0.4	0.2	-0.4	-0.3	-0.4	-0.6	0.3	0.3	0.4	-0.7	-0.3
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.3	0.5	-0.2	0.8	-0.7	0.9	0.5	-0.2	-0.2	-0.2	0.4	0.2
Hearing aid user	0.7	0.8	1.8	-0.5	1.3	0.0	1.2	-0.6	1.2	0.9	-1.2	-0.1	-0.3	1.3	-0.6
Mother’s age at death	1.2	1.5	4.6	0.5	0.1	2.1	0.5	0.8	0.4	-0.6	-0.4	1.8	1.8	1.1	-2.2
Financial situation satisfaction	1.0	1.2	3.1	0.8	-0.5	1.6	-0.2	1.8	-0.2	-1.2	0.7	1.6	1.5	1.1	-0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	-0.8	-0.6	-1.3	-1.1	-0.0	-1.1	-0.1	0.7	-0.6	-1.1	-1.3	1.1
Commuting to job workplace: Public transport	0.4	0.5	2.3	-0.4	-0.8	0.4	-0.5	0.5	-0.6	-0.5	0.2	0.6	0.9	-1.5	-0.5
Eye problems/disorders: Glaucoma	2.0	2.4	5.8	0.8	0.6	2.4	2.1	0.5	2.0	-0.9	-0.3	1.4	2.2	0.7	-2.2
Medication: Blood pressure	4.0	7.7	14.0	-1.1	-3.7	-1.0	-3.7	2.9	-3.4	-2.3	3.7	-1.6	0.3	-3.7	2.6
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.7	-0.9	0.1	-1.9	-0.6	-0.7	-0.6	0.8	-0.1	-1.3	-1.7	-0.9	1.0
Supplements: Fish oil (including cod liver oil)	4.3	5.6	11.4	1.4	-3.2	0.8	-2.7	3.0	-2.6	-3.1	3.4	1.2	1.8	-2.2	0.1
High cholesterol (Self-reported)	1.4	2.6	6.0	-0.7	-2.1	-0.9	-2.4	1.3	-2.4	-1.4	1.7	-0.4	0.2	-2.4	0.9
Medication: Bendroflumethiazide	2.2	3.4	7.3	-0.9	-2.2	-1.2	-2.7	1.9	-2.4	-1.6	2.4	-1.5	-0.4	-1.9	1.4
Medication: Paracetamol	0.4	0.6	2.8	-0.9	1.0	-0.2	0.0	-0.5	0.2	0.6	-0.8	-0.4	-1.2	1.7	0.4
Medication: Lisinopril	0.3	0.4	1.2	0.4	-0.7	0.5	-0.5	1.1	-0.5	-0.7	0.6	0.3	0.8	-0.1	-0.7
Medication: Atorvastatin	0.9	1.1	2.3	-1.3	-1.4	0.0	-1.3	1.5	-1.1	-1.2	1.2	-0.3	0.8	-1.2	-0.1
Illnesses of father: High blood pressure	5.7	7.1	13.6	-0.5	-3.6	0.5	-3.4	2.9	-3.5	-3.1	3.2	0.9	1.3	-3.7	1.9
Alcohol drinker status: Never	0.5	0.7	1.3	-1.1	1.0	-0.3	0.8	0.3	1.0	0.9	-1.0	-0.3	-0.7	0.8	0.8
Ever smoked	0.3	0.6	1.9	-1.4	-0.8	0.7	-0.9	0.9	-1.1	-0.6	0.5	-0.0	0.6	-0.5	-0.3
Basal metabolic rate	0.4	2.4	5.2	-1.4	-2.0	-0.7	-2.3	1.7	-2.1	-0.7	1.6	-2.0	0.1	-1.5	0.4
Leg fat percentage (left)	0.8	3.0	11.8	-1.6	-0.9	-2.1	-1.8	1.0	-1.3	0.4	1.3	-3.4	-1.8	-1.4	1.9
Arm fat-free mass (left)	0.3	1.6	3.6	-1.3	-1.7	-0.6	-1.9	1.6	-1.7	-0.6	1.3	-1.6	0.1	-1.0	0.3
Number of operations (self-reported)	0.6	0.8	3.0	-0.8	-0.9	1.0	-0.4	1.7	-0.5	-0.6	0.3	0.4	0.9	-1.6	-0.3
Average weekly beer plus cider intake	0.7	1.0	3.0	0.8	0.9	-1.7	0.3	-0.6	0.4	1.2	-1.0	-0.1	-1.6	0.4	1.4
Irritability	0.6	1.1	3.9	0.4	-1.0	-0.6	-0.7	0.6	-0.7	-0.2	0.9	-1.8	-0.1	-2.0	1.4
Risk taking	1.7	2.4	7.4	-0.6	-2.0	0.5	-1.8	2.1	-2.0	-1.0	1.5	-0.5	0.7	-2.7	1.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.6	-0.8	1.1	0.9	1.4	-0.1	1.2	1.1	-1.6	-0.0	0.8	0.5	-1.3
Fractured/broken bones in last 5 years	0.3	0.3	1.3	-1.1	-0.7	0.4	-0.5	0.7	-0.6	-0.4	0.5	0.2	0.5	0.0	-0.4
Age started oral contraceptive pill	0.2	0.2	0.8	0.4	0.2	-0.8	-0.3	-0.4	-0.2	0.7	-0.2	-0.9	-0.3	0.4	-0.2
Diastolic blood pressure, automated reading	6.5	20.3	40.1	0.2	-6.3	1.3	-6.2	5.2	-6.1	-5.9	5.9	1.8	2.6	-4.0	2.1
Ever depressed for a whole week	1.5	1.8	5.0	-1.4	-1.8	-0.1	-1.9	1.1	-2.1	-1.0	0.9	-0.1	0.2	-2.2	0.7
Unable to work because of sickness or disability	2.5	3.2	12.6	-0.2	-1.9	-1.1	-2.7	0.8	-2.9	-0.3	0.6	-0.6	-0.8	-3.6	1.9
Commuting to job workplace: Cycle	0.5	0.6	1.7	-0.6	-1.1	0.8	-1.1	0.2	-1.3	-0.4	0.5	0.3	0.7	-1.0	-0.5
Myopia	0.9	1.3	5.1	1.3	-0.5	1.2	0.1	-0.0	-0.1	-0.8	0.2	1.4	2.0	0.2	-2.3
Vascular/heart problems diagnosed by doctor	4.0	10.9	21.8	2.1	4.7	-0.0	4.5	-3.8	4.5	3.2	-3.9	0.4	-1.4	4.5	-1.3
Cholesterol lowering medication	1.3	1.8	7.5	-0.2	-1.7	-0.1	-1.6	0.7	-1.6	-1.4	1.6	-0.1	0.3	-2.7	1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.7	0.0	-0.5	0.6	-0.7	0.4	-0.6	-0.6	0.8	0.5	0.8	1.6	-1.2
Pain experienced in last month	0.2	0.3	0.8	-0.8	0.3	-0.3	0.6	-0.9	0.6	0.2	-0.5	-0.3	0.1	0.1	-0.9
Supplements: Calcium	0.3	0.4	2.4	-0.1	-0.3	0.6	0.4	0.5	0.3	-0.1	-0.1	0.5	1.6	-0.7	-0.6
Basal cell carcinoma (self-reported)	2.2	2.7	5.9	2.0	0.0	2.4	0.9	0.5	0.8	-1.1	0.2	2.4	2.3	1.7	-2.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.2	0.7	-0.7	1.1	-0.1	1.2	-0.0	-1.6	1.2	1.6	1.7	0.1	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	4.1	0.3	-1.5	-0.5	-1.8	0.7	-2.0	-0.6	0.5	0.2	0.3	-1.7	-0.3
Heart disease (siblings)	1.6	2.0	6.5	-0.4	-0.8	-2.0	-1.5	0.5	-1.1	-0.1	1.4	-2.5	-1.6	-0.8	2.0
Alcohol drinker status: Previous	0.3	0.4	2.2	0.7	-0.6	0.4	-0.4	-0.2	-0.6	-0.4	0.0	0.1	0.6	-1.5	-0.1
Pack years of smoking	1.8	2.6	7.9	-1.2	-1.7	-1.2	-2.8	1.1	-2.7	-0.2	1.3	-1.9	-0.8	-0.8	1.8
Impedance of whole body	0.3	1.6	5.4	0.5	0.3	0.5	1.3	0.3	1.6	-1.1	1.6	0.9	0.9	2.3	-1.8
Leg fat mass (left)	0.8	2.9	11.4	-1.7	-1.2	-1.7	-2.0	1.2	-1.6	0.2	1.3	-3.4	-1.4	-1.5	1.6
Arm predicted mass (left)	0.3	1.6	3.2	-1.3	-1.6	-0.6	-1.8	1.6	-1.6	-0.5	1.2	-1.7	-0.0	-1.1	0.3