TWAS
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Usage
Models
Genes
Traits
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Traits
:
Diastolic blood pressure, automated reading
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chr4:80,488,345-82,578,407
Best TWAS P=2.5e-10 · Best GWAS P=2.34e-34 conditioned to 7.48e-26
80.5M
81M
81.5M
82M
82.5M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
C4orf22
0.09
0.08
lasso
5
0.07
4.5e-09
5.8
6.3
2.5e-10
0.59
1.00
0.00
TRUE
2
CommonMind
Brain Pre-frontal Cortex
FGF5
0.07
0.06
lasso
2
0.05
5.4e-07
5.8
5.2
2.1e-07
0.53
0.76
0.14
FALSE