Best TWAS P=4.91e-12 · Best GWAS P=2.26e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | KIF2A | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.1e-03 | 4.8 | -5.8 | 6.8e-09 | -0.63 | 0.10 | 0.49 | FALSE |
2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IPO11 | 0.08 | 0.02 | lasso | 4 | 0.01 | 9.3e-02 | 6.5 | 6.5 | 7.0e-11 | 0.99 | 0.02 | 0.93 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DIMT1L | 0.09 | 0.04 | lasso | 3 | 0.04 | 3.0e-08 | 6.2 | 5.6 | 2.3e-08 | 0.87 | 0.06 | 0.94 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IPO11 | 0.09 | 0.06 | blup | 127 | 0.07 | 1.7e-13 | 6.5 | 6.2 | 4.6e-10 | 0.92 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIF2A | 0.05 | 0.02 | blup | 71 | 0.02 | 5.4e-06 | 6.5 | 6.6 | 4.8e-11 | 0.85 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Esophageal Carcinoma | IPO11 | 0.14 | 0.01 | lasso | 12 | 0.01 | 1.1e-01 | 6.5 | 6.5 | 9.4e-11 | 0.98 | 0.02 | 0.87 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DIMT1L | 0.26 | 0.13 | lasso | 1 | 0.10 | 2.3e-06 | 6.2 | 6.2 | 6.0e-10 | 0.92 | 0.02 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | IPO11 | 0.06 | 0.03 | lasso | 3 | 0.03 | 4.2e-04 | 6.5 | 6.9 | 4.9e-12 | 0.96 | 0.02 | 0.94 | TRUE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | KIF2A | 0.06 | 0.02 | lasso | 1 | 0.01 | 3.9e-02 | 6.5 | 6.5 | 5.8e-11 | 0.92 | 0.01 | 0.89 | FALSE |
10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DIMT1L | 0.06 | 0.01 | blup | 53 | 0.03 | 7.2e-05 | 6.2 | 5.3 | 1.1e-07 | 0.80 | 0.01 | 0.90 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IPO11 | 0.08 | 0.04 | blup | 127 | 0.05 | 4.2e-06 | 6.5 | 6.1 | 8.8e-10 | 0.98 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KIF2A | 0.05 | 0.03 | lasso | 2 | 0.02 | 1.7e-03 | 6.5 | 6.5 | 8.7e-11 | 0.92 | 0.01 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IPO11 | 0.03 | 0.00 | blup | 127 | 0.01 | 3.0e-02 | 6.6 | 6.2 | 4.6e-10 | 0.83 | 0.02 | 0.57 | FALSE |
14 | The Cancer Genome Atlas | Rectum Adenocarcinoma | DIMT1L | 0.33 | 0.15 | lasso | 6 | 0.13 | 6.0e-04 | 6.4 | 6.0 | 2.1e-09 | 0.96 | 0.01 | 0.83 | FALSE |
15 | The Cancer Genome Atlas | Soft Tissue Sarcoma | IPO11 | 0.08 | 0.01 | lasso | 5 | 0.04 | 1.3e-03 | 4.8 | 6.2 | 5.4e-10 | 0.85 | 0.02 | 0.73 | FALSE |
16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IPO11 | 0.14 | 0.05 | lasso | 3 | 0.03 | 1.6e-03 | 6.7 | 6.7 | 2.6e-11 | 0.91 | 0.02 | 0.95 | FALSE |