Best TWAS P=1.04e-17 · Best GWAS P=6.14e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -3.6 | -6.5 | 6.0e-11 | 0.78 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -6.9 | -7.4 | 1.9e-13 | 0.78 | 0.06 | 0.71 | FALSE |
| 3 | GTEx | Artery Tibial | NOV | 0.09 | 0.00 | enet | 33 | 0.00 | 2.7e-01 | -8.5 | -5.6 | 1.8e-08 | 0.57 | 0.02 | 0.94 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -8.2 | -6.1 | 1.1e-09 | 0.66 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -8.5 | -8.6 | 1.0e-17 | 0.99 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | -8.5 | -6.6 | 3.5e-11 | 0.73 | 0.02 | 0.96 | FALSE |
| 7 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -4.3 | -7.2 | 6.3e-13 | 0.68 | 0.14 | 0.61 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -8.3 | -8.1 | 4.0e-16 | 0.89 | 0.03 | 0.96 | FALSE |
| 9 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -8.5 | -7.1 | 9.4e-13 | 0.81 | 0.01 | 0.99 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | NOV | 0.10 | 0.02 | bslmm | 475 | 0.07 | 5.7e-09 | -8.3 | 5.2 | 1.9e-07 | -0.63 | 0.07 | 0.92 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -8.3 | -8.2 | 1.9e-16 | 0.94 | 0.02 | 0.79 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -8.3 | -7.5 | 4.5e-14 | 0.82 | 0.01 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOV | 0.06 | 0.00 | blup | 42 | 0.03 | 4.3e-04 | -8.5 | -5.2 | 2.5e-07 | 0.62 | 0.01 | 0.64 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -8.3 | -6.9 | 4.2e-12 | 0.80 | 0.02 | 0.57 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -8.5 | -7.9 | 3.4e-15 | 0.91 | 0.01 | 0.99 | FALSE |