Best TWAS P=5.12e-10 · Best GWAS P=3.95e-10 conditioned to 0.0285
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | INTS8 | 0.27 | 0.26 | lasso | 3 | 0.24 | 1.9e-08 | 5.8 | 5.7 | 9.3e-09 | 0.54 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Heart Left Ventricle | NDUFAF6 | 0.10 | 0.05 | lasso | 11 | 0.07 | 1.6e-04 | 6.0 | -5.9 | 3.0e-09 | -0.79 | 0.03 | 0.96 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C8orf38 | 0.02 | 0.00 | blup | 127 | 0.01 | 4.0e-04 | 5.8 | -5.9 | 3.4e-09 | -0.71 | 0.04 | 0.79 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C8orf38 | 0.07 | 0.04 | lasso | 8 | 0.04 | 5.1e-05 | 6.0 | -6.2 | 5.1e-10 | -0.79 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | C8orf38 | 0.03 | 0.02 | blup | 127 | 0.02 | 1.6e-03 | 3.8 | -5.7 | 1.6e-08 | -0.78 | 0.03 | 0.79 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C8orf38 | 0.11 | 0.12 | lasso | 4 | 0.11 | 1.8e-11 | 5.6 | -5.6 | 2.7e-08 | -0.59 | 0.13 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TP53INP1 | 0.04 | 0.00 | blup | 56 | 0.02 | 8.5e-03 | 5.9 | 5.4 | 6.0e-08 | 0.59 | 0.01 | 0.82 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | C8orf38 | 0.12 | 0.04 | lasso | 3 | 0.08 | 8.3e-08 | 6.0 | -5.6 | 2.6e-08 | -0.76 | 0.02 | 0.98 | FALSE |