Best TWAS P=5.98e-11 · Best GWAS P=3.2e-17 conditioned to 2.36e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | NSUN6 | 0.18 | 0.11 | lasso | 8 | 0.10 | 4.9e-08 | -4.4 | 6.5 | 6.0e-11 | -0.14 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CACNB2 | 0.05 | 0.05 | enet | 4 | 0.04 | 8.8e-06 | 5.9 | 6.5 | 6.9e-11 | -0.03 | 0.99 | 0.00 | TRUE |
| 4 | YFS | Blood | NSUN6 | 0.07 | 0.07 | enet | 21 | 0.08 | 2.8e-25 | -4.5 | 5.6 | 2.1e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | NSUN6 | 0.08 | 0.01 | blup | 119 | 0.05 | 5.6e-04 | -4.5 | 5.6 | 2.2e-08 | -0.23 | 0.06 | 0.50 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | NSUN6 | 0.25 | 0.14 | lasso | 6 | 0.16 | 4.0e-05 | -4.5 | 5.3 | 1.5e-07 | -0.19 | 0.25 | 0.20 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | NSUN6 | 0.14 | 0.10 | enet | 32 | 0.09 | 1.0e-05 | -4.2 | 5.1 | 3.1e-07 | -0.18 | 0.83 | 0.02 | FALSE |