Hub : Genes

CACNB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1377	0.0444	1.2e-03	0.066	NA	0.060	NA	0.066	4.7e-07	NA	1.4e-06	NA	5.0e-07
2	GTEx	Thyroid	0.2010	0.0610	1.1e-04	0.125	NA	0.109	NA	0.103	8.2e-10	NA	1.1e-08	NA	2.9e-08
3	NTR	Blood	0.0327	0.0094	2.1e-06	0.038	0.019	0.037	0.030	0.036	3.0e-12	6.3e-07	5.9e-12	4.8e-10	6.8e-12
4	ROSMAP	Brain Pre-frontal Cortex	0.0681	0.0256	8.2e-04	0.067	0.024	0.057	0.047	0.065	5.3e-09	4.1e-04	7.1e-08	9.8e-07	9.8e-09
5	TCGA	Brain Lower Grade Glioma	0.0545	0.0213	1.2e-03	0.047	0.019	0.044	NA	0.043	4.4e-06	2.6e-03	8.8e-06	NA	1.1e-05
6	TCGA	Lung Squamous Cell Carcinoma	0.0477	0.0205	6.0e-03	-0.002	0.013	0.000	NA	0.012	6.8e-01	1.2e-02	3.0e-01	NA	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.4	4.1	0.3	-0.6	-1.7	-0.1	-1.0	-2.0
Bipolar Disorder or Schizophrenia	2.6	6.4	22.2	0.4	-1.9	-2.9	1.3	-1.5	-4.7
Depressed Affect (Nagel 2018)	0.8	1.7	5.9	-2.4	-0.6	-0.0	-0.2	-2.0	0.2
Depression (Nagel 2018)	1.2	1.8	2.3	-1.5	-1.4	-1.1	1.0	-1.5	-1.5
Intelligence (Savage-Jansen 2018)	1.5	4.7	11.6	3.4	3.4	1.4	-1.5	-0.0	-0.7
Neuroticism (Nagel 2018)	0.6	1.3	3.9	-1.7	0.2	0.5	0.1	-2.0	0.9
Schizophrenia (2018)	2.7	5.7	19.5	0.3	-2.0	-2.4	1.8	-1.1	-4.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	-0.7	0.2	1.2	0.2	1.4	-0.2
Worry (Nagel 2018)	0.5	1.1	2.9	-1.0	0.3	0.7	-0.1	-1.7	1.4
Alzheimer’s Disease (in mother)	0.9	1.1	4.6	0.8	0.5	-2.1	1.0	0.4	-0.1
Alzheimer’s Disease (in father)	1.4	1.5	8.7	0.0	0.3	0.4	-0.2	0.2	2.9
Alzheimer’s Disease (including proxy)	1.1	1.6	5.6	0.3	-0.3	-2.4	1.3	-0.1	1.4
Crohns Disease (2017)	0.2	0.4	1.2	0.5	1.1	-0.4	-0.5	0.6	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	0.4	0.8	-0.2	0.2	1.1	0.2
Ulcerative Colitis (UC)	0.3	0.5	2.1	0.4	-0.2	-0.3	0.9	1.4	0.0
Major Depression (MDD)	1.1	1.3	6.6	-0.3	-0.9	-0.6	0.4	0.1	-2.6
Reaction Time	0.1	0.2	0.6	-0.8	-0.4	-0.4	0.2	0.1	0.4
Verbal and Numeric Reasoning (VNR)	1.2	2.9	7.0	1.7	2.6	1.6	-2.2	0.1	-0.0
Breast Cancer	0.3	0.7	1.4	-0.2	-0.0	-0.9	1.2	1.2	-0.7
Ovarian Cancer	0.2	0.2	0.5	-0.0	0.5	0.5	0.2	0.6	-0.7
Prostate Cancer	1.0	1.4	6.0	-0.0	0.3	1.5	-2.4	-0.1	-0.1
Age at First Birth	1.4	2.1	8.5	1.8	2.9	0.6	0.0	0.0	-0.6
Bipolar Disorder (2011)	1.5	1.5	5.3	0.0	-1.4	-2.3	0.6	-0.4	-1.1
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	-1.6	-1.9	-0.4	0.3	-0.3	0.2
Coronary Artery Disease (CAD)	1.7	2.0	6.2	0.6	1.1	1.1	-1.2	1.2	2.5
Crohns Disease (2012)	0.4	0.7	2.3	0.8	1.5	0.2	-0.7	0.9	0.1
Mean Putamen Volume	0.2	0.2	0.4	-0.2	-0.6	0.5	-0.4	0.4	-0.4
Fasting Glucose	0.3	0.3	1.1	0.3	0.1	0.7	-1.1	-0.5	0.4
HbA1C	1.1	1.2	2.7	-1.4	-1.6	0.6	-0.5	-1.3	-0.2
HDL Cholesterol	0.7	1.2	3.0	1.1	0.9	-0.5	1.4	1.7	-0.0
LDL Cholesterol	1.8	2.9	9.5	-0.3	-0.4	1.0	-1.3	-2.2	3.1
Lupus	1.3	2.0	2.9	-1.5	-1.6	1.7	-1.7	-1.2	0.4
Neuroticism (2016)	0.5	0.7	2.9	-0.5	-0.6	0.2	-0.3	-1.7	0.8
Primary Biliary Cirrhosis	0.8	1.1	2.0	1.1	-0.2	-1.4	1.4	0.4	-1.2
Rheumatoid Arthritis	0.4	0.5	1.8	-0.3	-0.5	-1.3	0.7	0.6	-0.5
Schizophrenia (2014)	3.0	6.6	21.4	0.7	-1.8	-2.9	2.2	-1.3	-4.6
Triglycerides	0.2	0.3	1.5	0.4	-0.5	0.1	-1.2	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.2	0.8	0.3	-1.0	0.5	-1.8	0.4
Ulcerative Colitis	0.6	0.9	1.6	0.3	-0.7	-1.0	1.0	1.3	-1.1
Blood Eosinophil Count	0.1	0.5	1.1	0.7	0.2	1.0	-0.8	-0.6	0.6
Blood Platelet Count	0.1	1.6	3.9	1.5	0.2	1.4	0.6	-1.2	2.0
Blood Red Count	0.1	0.9	4.4	0.7	0.3	0.2	-0.3	0.1	-2.1
Blood White Count	0.2	1.6	3.7	-0.3	0.7	1.9	-1.3	-0.2	1.9
Heel T-Score	0.1	0.8	1.7	-1.3	-0.3	-0.6	-0.3	-1.0	-1.2
BMI	1.1	6.2	15.6	-3.4	-4.0	-1.6	2.1	-1.7	-0.3
Height	0.3	5.7	15.8	-2.1	-2.1	-1.4	2.7	4.0	-0.6
Waist Hip Ratio (WHR)	0.1	0.6	1.4	0.2	-0.5	-0.5	0.9	-1.2	-0.9
Systolic Blood Pressure	8.7	43.5	153.8	1.0	6.0	6.5	-4.9	12.4	2.0
Smoking Status	1.6	3.9	6.4	-1.1	-2.3	-2.5	2.4	1.3	-1.7
Allergy or Eczema	0.2	0.6	1.8	0.6	-0.8	0.7	-0.2	-1.3	0.2
Cardiovascular Disease	4.5	14.8	59.6	0.3	2.8	3.5	-1.8	7.7	2.4
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.7	-0.5	0.6	-0.7	0.8	0.2
Respiratory disease	1.8	4.1	7.3	-1.4	-2.7	-1.9	1.6	-1.7	-2.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.4	-1.4	-0.8	1.4	-1.5	-0.5	2.3
Lung FEV1/FVC ratio	1.3	6.4	24.3	-1.4	-3.2	-0.7	1.0	-4.9	-0.8
Lung FVC	0.2	1.2	2.0	-1.1	0.8	1.2	-1.2	0.6	1.4
Neuroticism	0.9	2.1	6.6	-2.6	-1.4	0.8	0.1	-1.4	1.1
Chronotype (morning person)	0.3	0.7	1.6	1.0	0.7	-0.2	1.3	0.8	-0.6
Hair Pigment	0.0	1.1	4.0	0.1	0.2	1.6	-2.0	0.4	-0.2
Tanning	0.0	0.6	1.7	0.3	0.3	0.7	1.3	0.9	-0.6
Hand grip strength (left)	1.0	2.6	7.3	-2.7	-1.0	0.6	-1.1	1.1	2.1
Number of treatments/medications taken	1.2	2.2	5.8	0.7	1.2	1.2	-2.4	1.9	0.7
Average weekly spirits intake	1.2	1.4	3.9	-1.1	-1.1	0.9	-0.9	0.8	2.0
Sensitivity / hurt feelings	0.6	1.1	2.1	-0.9	-0.6	-1.3	1.4	-1.3	-0.3
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.7	-0.7	-0.3	-0.5	1.4	-1.6	-0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.6	-0.7	0.5	0.1	-0.3	0.8
Relative age of first facial hair	0.3	0.5	1.1	0.5	1.1	1.0	-0.9	0.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.0	-0.3	-1.4	-0.1	-0.8	-0.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.1	-1.0	-0.6	-0.7	-0.7	-0.4
Ever had hysterectomy (womb removed)	0.9	1.0	4.4	0.0	-0.4	0.7	-2.1	0.7	0.5
Systolic blood pressure, automated reading	5.9	17.1	45.6	1.2	4.0	4.8	-3.9	6.8	1.1
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	11.1	0.6	0.6	3.3	-1.7	-0.5	2.1
Angina	0.5	0.6	2.6	-0.5	0.4	0.8	-1.6	-0.2	0.3
Medication for hormone replacement therapy	1.1	1.2	2.9	-1.5	-1.7	-0.5	-1.0	-0.7	-0.7
Vitamin and mineral supplements	2.2	3.0	7.0	-2.6	-1.7	1.1	-0.9	-1.9	-1.6
Supplements: Zinc	1.0	1.1	2.4	-1.5	-0.7	0.6	-1.5	0.3	1.1
Medication: Co-codamol	1.2	1.4	3.6	-0.7	-1.9	-1.7	1.0	0.8	-0.2
Medication: Metformin	0.8	1.2	6.4	-0.5	-0.6	-0.1	0.2	-2.5	0.0
Diabetes (father)	2.5	3.1	6.9	-2.0	-2.6	-1.1	1.1	-1.4	-1.7
Diabetes (mother)	1.2	1.5	3.6	-1.4	-1.9	1.1	-1.2	-0.6	0.5
Severe depression (siblings)	1.9	2.2	4.2	1.5	1.8	1.8	-0.2	-2.1	0.2
Pack years adult smoking proportion	0.5	0.7	1.4	-1.1	-0.7	-1.2	-0.3	-0.6	-0.8
Impedance of leg (right)	0.5	2.4	8.0	2.8	2.0	-1.3	0.2	-0.5	-0.2
Leg fat-free mass (left)	0.7	3.5	7.4	-2.4	-2.7	-0.8	2.2	1.1	-0.8
Trunk fat percentage	0.4	1.6	5.6	0.2	-1.1	-0.5	1.3	-2.4	-0.9
Hand grip strength (right)	1.5	4.1	11.6	-3.4	-1.6	0.9	-0.4	1.7	2.6
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.4	-0.6	1.0	0.1	-0.8	-0.2
Current tobacco smoking	0.5	0.8	1.6	-1.3	-1.3	-0.6	0.6	0.4	-0.8
Average weekly fortified wine intake	0.9	1.1	2.5	-1.1	-0.3	0.3	-1.4	-0.9	1.6
Maternal smoking around birth	1.1	1.5	4.7	-1.1	-2.2	1.3	-0.6	-1.0	0.7
Fed-up feelings	0.2	0.4	1.0	-1.0	0.4	-0.2	0.2	-0.5	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.7	-1.4	-1.2	-0.3	0.9	-2.2	-0.9
Relative age voice broke	0.2	0.3	1.2	-0.1	-0.2	0.2	-1.1	-0.2	0.6
Taking other prescription medications	0.3	0.5	1.0	0.5	-0.9	-1.0	0.7	-0.4	-0.6
Age when periods started (menarche)	0.1	0.2	0.5	0.7	0.7	0.6	-0.2	-0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.4	-0.8	-0.8	-0.0	-1.6	0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.5	-0.2	0.3	0.2	-1.2	0.3	-1.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.2	-1.1	-1.0	0.1	0.1	1.5	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.8	-0.3	-0.3	0.6	0.6	0.3
Serious illness, injury or assault to yourself	2.2	2.7	5.5	1.2	2.2	1.9	-2.3	0.7	0.2
High blood pressure	4.7	13.1	51.1	-0.2	2.8	3.6	-1.5	7.2	2.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.4	0.1	-1.5	-0.5	1.5	-0.9	-0.7
Multivitamins +/- minerals	1.4	1.7	3.3	1.8	1.4	-1.1	0.8	1.5	1.1
Stomach or abdominal pain in last month	0.5	0.6	1.9	-0.4	-0.8	-0.7	1.4	-0.0	-0.4
Supplements: Glucosamine	1.0	1.3	4.3	-0.9	-1.3	-0.1	0.6	-0.8	2.1
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	7.7	0.9	0.7	-1.3	0.1	-2.8	0.7
Medication: Atenolol	5.7	7.1	13.0	2.2	2.8	2.3	-2.1	2.6	3.6
Medication: Levothyroxine sodium	0.4	0.7	1.7	-1.1	-0.1	0.9	-1.3	-0.2	0.7
Sitting height	0.6	4.1	8.2	-1.0	-1.5	-2.0	2.7	1.3	-2.9
Chronic bronchitis/emphysema (father)	0.6	0.7	2.9	-0.3	-0.6	-0.3	0.3	1.7	0.7
High blood pressure (mother)	2.3	3.2	9.7	-2.2	-2.0	-0.5	0.4	3.1	0.1
Body mass index (BMI)	0.5	2.1	5.2	-1.6	-2.3	-0.5	1.5	-1.4	-0.2
Impedance of leg (left)	0.3	1.4	4.8	2.2	1.7	-0.7	-0.1	-0.4	-0.2
Leg predicted mass (left)	0.7	3.4	7.2	-2.4	-2.7	-0.8	2.3	1.1	-0.8
Trunk fat mass	0.5	2.0	4.1	-0.8	-2.0	-0.8	1.8	-1.6	-1.0
Waist circumference	0.6	2.3	6.1	-0.8	-1.8	-1.3	2.5	-1.1	-0.9
Number of incorrect matches in round	0.9	1.5	3.2	1.3	1.8	-1.7	1.2	0.0	0.2
Past tobacco smoking	0.4	0.8	2.0	-0.3	0.6	1.0	-1.4	-0.6	0.9
Alcohol usually taken with meals	0.8	1.3	4.8	-0.3	0.3	1.4	-2.2	-0.0	0.8
Nervous feelings	0.6	1.1	3.1	0.2	-0.1	0.9	0.5	-1.5	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.9	-0.9	-1.7	-1.1	1.1	-1.3	-1.4
Hearing difficulty/problems with background noise	0.1	0.2	0.8	0.2	0.1	0.1	0.2	0.9	0.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.9	0.5	1.7	1.1	-1.0	-0.9	0.0
Had menopause	0.3	0.4	0.9	-0.0	-0.8	-0.9	-0.3	-0.9	0.5
Had other major operations	0.2	0.3	1.0	-0.3	0.2	0.5	-0.1	0.7	-1.0
Forced vital capacity (FVC)	0.3	1.1	3.2	-1.8	-0.4	0.6	-0.1	1.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	4.0	-0.3	0.6	0.3	-0.9	-0.4	-2.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.6	1.4	1.6	-0.1	-0.5	1.3	-1.6
Qualifications: None of the above	0.5	1.0	3.0	-0.8	-0.3	0.3	-1.5	1.7	0.2
Financial difficulties in last 2 years	0.3	0.4	1.9	0.0	0.2	0.6	0.2	-1.4	-0.3
Mouth/teeth dental problems	0.7	1.1	1.8	1.4	0.8	-1.4	1.1	1.0	-0.2
Heart attack	1.7	2.2	4.6	0.3	1.9	2.2	-1.3	1.4	0.8
Allergy	0.7	1.6	4.0	0.1	2.0	1.2	-1.4	0.2	1.4
Pain all over the body in last month	0.8	0.8	3.0	-0.5	-0.4	1.7	-0.7	-0.8	-0.8
Diabetes (self-reported)	1.3	2.0	4.4	-0.1	0.4	2.1	-1.7	-1.5	1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.7	0.4	-0.5	0.9	-0.7	-0.1	1.3
Medication: Ramipril	2.4	3.1	6.0	1.0	2.4	2.5	-1.5	1.5	1.2
Medication: Simvastatin	0.7	1.1	2.9	-0.2	0.5	1.5	-1.7	0.0	1.0
Fluid intelligence score	1.7	3.5	8.4	2.2	2.9	1.7	-2.1	0.5	0.2
Illnesses of siblings	0.7	1.0	4.4	0.7	0.7	0.8	-0.3	-2.1	0.4
Neuroticism score	0.3	0.5	1.7	-1.3	-0.5	0.4	0.3	-0.9	0.5
Weight	0.6	2.8	6.8	-1.6	-2.4	-1.1	2.6	-0.0	-0.7
Impedance of arm (right)	1.1	5.2	11.2	3.3	2.3	-2.3	1.1	-1.7	-2.3
Arm fat percentage (right)	0.7	2.8	6.7	-0.3	-1.7	-1.3	1.8	-2.6	-1.4
Trunk fat-free mass	1.0	5.7	8.8	-2.8	-2.9	-1.2	3.0	2.7	-0.2
Hip circumference	0.3	1.3	5.2	-0.4	-1.2	-0.9	2.3	0.0	-0.5
Time employed in main current job	0.9	1.1	3.0	1.1	0.5	-1.7	-0.2	-0.1	-1.3
Alcohol intake versus 10 years previously	0.9	1.4	6.9	-0.9	-0.2	0.6	0.4	0.3	-2.6
Father’s age at death	1.7	2.2	5.7	2.4	0.2	-1.0	1.2	-2.0	-1.1
Worrier / anxious feelings	0.2	0.4	1.4	0.4	1.2	-0.4	0.3	-0.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.3	-1.5	-0.6	1.5	-0.3	-1.5	0.2
Falls in the last year	0.7	1.0	2.9	0.8	0.7	1.7	-0.6	0.6	1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	-0.1	-0.1	-0.3	0.6	-0.3
Number of live births	1.1	1.6	4.7	-1.4	-2.2	0.1	-0.5	-1.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.5	-1.9	-1.3	0.6	-0.1	0.2	0.5
Pulse rate	0.7	1.3	2.6	1.0	0.7	1.0	-1.6	-0.3	1.6
Happiness	0.8	1.0	2.2	1.2	1.2	-0.3	1.5	0.9	-0.0
Noisy workplace	0.7	0.9	2.4	0.3	1.1	1.2	-0.3	0.4	-1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.9	-0.4	0.4	0.9	0.1	0.1	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.7	-0.1	-1.9	-0.2	1.6	-0.8	0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-0.2	0.7	1.3	-0.8	1.0	0.3
Asthma	1.6	3.2	5.7	-0.1	-1.8	-2.4	2.3	-1.0	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	6.4	-2.5	-1.2	0.9	-1.1	-0.6	-0.1
Medication: Cholesterol lowering	0.2	0.3	1.3	1.2	0.3	-0.0	0.4	0.1	-0.1
Depression (self-reported)	2.0	2.3	10.5	-0.6	-1.3	0.1	0.3	-3.2	1.2
Medication: Lansoprazole	2.2	2.5	3.9	1.7	2.0	1.8	-1.5	-1.3	1.0
Prospective memory result	1.1	1.4	3.4	-0.2	-0.0	-1.6	1.8	1.0	-1.1
Lung cancer (father)	1.6	1.9	6.4	2.5	1.9	0.5	0.1	0.8	0.7
Illnesses of mother	0.5	0.6	2.3	0.3	0.4	0.1	0.7	-1.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.6	-1.3	-1.3	-0.0	0.2	-0.2	-0.2
Pulse wave Arterial Stiffness index	0.2	0.3	1.1	-0.1	-0.1	-0.0	-0.7	1.0	0.2
Impedance of arm (left)	0.9	4.3	11.6	3.4	2.7	-1.0	-0.2	-1.6	-1.7
Arm fat mass (right)	0.7	3.0	5.8	-1.1	-2.3	-1.2	2.4	-1.6	-1.1
Trunk predicted mass	1.0	5.7	8.8	-2.8	-2.8	-1.2	3.0	2.8	-0.2
Standing height	0.3	3.0	8.1	-0.5	-0.8	-1.3	2.4	2.8	-1.2
Length of working week for main job	1.7	1.9	4.3	-2.1	-1.9	-0.1	1.4	-0.8	-0.9
Exposure to tobacco smoke at home	1.2	1.4	3.7	-1.1	-1.3	-0.4	0.6	1.9	-1.2
Breastfed as a baby	0.5	0.6	1.9	0.8	0.5	-0.2	-0.3	1.4	0.8
Tense / ‘highly strung’	0.6	1.0	2.3	-0.3	0.2	-1.1	1.5	-0.6	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.5	-0.6	-1.9	0.4	-0.0	-1.6	-1.3
Hair/balding pattern: Pattern 4	0.6	1.6	6.0	-0.1	0.2	-1.8	2.4	0.1	-0.5
Birth weight of first child	1.0	1.8	5.8	0.8	0.4	-2.0	2.4	0.0	0.6
Peak expiratory flow (PEF)	0.4	0.8	1.5	-1.2	-1.0	1.2	-0.5	-0.7	0.6
Pulse wave reflection index	0.5	0.6	2.0	-0.5	0.4	0.4	-1.4	0.9	-0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.2	0.0	0.6	1.5	-1.8	-1.2	-0.6
Loud music exposure frequency	1.0	1.0	4.2	-0.2	0.2	-0.8	1.0	2.0	-0.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.4	-1.6	-1.4	0.3	0.6	1.8	0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	-0.5	-1.8	-0.6	0.4	-1.0	-0.2
Blood clot in the leg (DVT)	1.3	1.6	4.1	0.5	0.3	1.8	-2.0	0.6	-1.3
Medication: Paracetamol	2.6	4.3	15.8	-4.0	-2.4	-0.2	-2.0	-0.7	-0.1
Headache pain in last month	2.8	4.8	18.2	-4.3	-2.8	1.0	-0.8	-0.7	0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.1	-0.2	-0.4	-1.2	0.2	-1.5	-0.7
Glaucoma (self-reported)	0.8	1.0	3.9	0.0	-0.6	1.0	-2.0	0.8	0.2
Gout (self-reported)	0.7	0.9	2.1	0.4	-1.2	-0.8	1.4	-0.8	0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	-0.3	0.1	0.1	-0.3	-0.5	0.0
Medication: Amlodipine	3.8	5.4	14.7	-2.3	-2.0	1.7	-2.2	3.8	0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	-0.5	-0.8	-0.9	1.4	-0.8	-0.9
Birth weight	0.8	1.6	4.3	0.4	-0.3	-1.2	2.1	-0.6	-1.8
Chronic bronchitis/emphysema (mother)	1.8	2.1	6.7	-1.2	-2.6	-0.1	-0.0	-1.8	-1.2
High blood pressure (siblings)	0.6	0.8	4.3	-0.1	-0.0	-0.5	0.6	2.1	0.2
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	-1.1	-0.6	-0.2	0.7	1.3	0.1
Body fat percentage	0.5	2.0	6.2	-0.1	-1.6	-0.8	1.4	-2.5	-0.9
Leg fat percentage (right)	0.4	1.6	5.0	-0.2	-1.6	-1.0	1.1	-2.2	-0.2
Arm fat-free mass (right)	0.9	4.4	9.8	-3.0	-3.1	0.1	1.7	2.2	0.2
Exposure to tobacco smoke outside home	0.5	0.7	1.8	0.0	-0.1	0.8	1.0	-1.3	-0.9
Comparative body size at age 10	0.2	0.5	1.3	-1.1	-1.0	0.4	0.3	-0.6	0.3
Number of full brothers	1.8	2.3	5.9	-2.4	-1.9	-0.8	0.5	0.3	-1.8
Worry too long after embarrassment	1.4	2.3	5.2	1.0	1.6	2.3	-1.4	1.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	8.9	0.4	-0.6	0.3	-0.1	-3.0	-0.1
Wheeze or whistling in the chest in last year	1.1	1.9	5.5	-1.4	-2.3	-1.3	1.6	-0.0	-0.1
Number of children fathered	1.1	1.2	3.4	-1.8	-0.7	-0.4	-1.4	-0.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.6	1.6	0.7	1.0	-0.7	0.6	-1.0
Age at first live birth	0.5	0.9	2.9	0.3	0.5	-1.0	1.0	0.1	-1.7
Pulse wave peak to peak time	0.3	0.3	1.1	0.0	-0.0	0.2	0.8	-1.0	-0.2
Health satisfaction	0.7	1.0	2.9	-0.4	0.0	1.7	-1.1	1.2	0.2
Shortness of breath walking on level ground	1.0	1.2	2.6	1.1	1.6	-0.9	0.3	1.1	1.0
Qualifications: College or University degree	0.4	1.3	4.4	1.0	0.1	1.0	0.2	-2.1	-1.2
Eye problems/disorders: None of the above	0.6	0.7	2.3	-1.5	-0.1	0.0	0.7	1.2	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.2	0.4	0.3	0.2	-0.2	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.4	-0.9	-0.3	1.2	-0.5	0.2	-1.1
Medication for pain relief, constipation, heartburn	1.5	2.6	10.0	3.2	0.9	-0.5	1.9	-0.4	-0.9
Neck or shoulder pain in last month	0.9	1.2	2.7	-1.5	-1.7	1.1	-0.1	-0.2	1.0
Medication: Blood pressure	1.4	2.4	8.2	-1.1	0.2	2.0	-0.7	2.9	0.8
Angina (self-reported)	0.3	0.3	1.4	-0.3	0.5	0.5	-1.2	-0.2	0.1
Migraine (self-reported)	1.4	1.7	5.1	-1.1	-0.8	1.1	-2.3	0.3	1.3
Medication: Ibuprofen	0.8	1.0	2.6	-1.6	-0.9	0.8	-1.0	-0.8	-0.5
Medication: Allopurinol	0.5	0.7	2.4	0.7	-0.6	-0.7	1.5	-0.4	0.2
Medication: Omeprazole	0.3	0.4	0.7	0.6	0.5	0.7	-0.8	0.2	0.5
Medication: Seretide 50 evohaler	1.8	2.0	4.9	-2.1	-2.2	-0.5	0.3	1.6	-0.3
Mean time to correctly identify matches	0.3	0.6	2.2	-1.5	-0.8	0.2	-0.4	-0.1	0.8
Heart disease (mother)	0.7	0.8	2.8	0.6	0.8	1.0	-1.7	0.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.8	1.7	1.2	1.0	-1.1	-0.4	0.4
Whole body fat mass	0.7	2.8	6.1	-1.3	-2.5	-1.0	1.9	-1.8	-1.1
Leg fat mass (right)	0.7	2.8	6.7	-1.2	-2.6	-1.3	2.0	-1.5	-0.7
Arm predicted mass (right)	0.8	4.2	9.0	-2.8	-3.0	-0.1	1.9	2.2	0.3
Pulse rate, automated reading	1.6	5.1	11.9	3.5	2.3	2.2	-1.7	-0.4	2.3
Alcohol intake frequency.	0.6	1.4	2.7	-0.8	-1.5	0.1	-0.4	-1.7	-1.6
Comparative height size at age 10	0.6	3.4	16.6	-0.2	-0.8	-1.0	1.3	4.1	-0.8
Number of full sisters	0.5	0.6	2.3	-0.9	-1.5	0.4	0.1	0.1	-0.3
Suffer from ‘nerves’	0.3	0.5	1.3	-0.9	-1.1	-0.0	0.7	-0.2	0.6
Overall health rating	0.1	0.1	0.3	0.1	-0.4	-0.2	0.5	-0.1	-0.3
Chest pain or discomfort	1.1	1.5	5.6	-0.9	-0.8	2.4	-1.4	-0.3	-0.6
Had major operations	0.2	0.2	0.6	0.8	0.5	-0.1	0.5	-0.1	0.1
Age at last live birth	1.9	2.8	6.2	0.2	-0.4	-2.1	1.8	1.7	-2.5
Family relationship satisfaction	0.3	0.4	1.7	0.2	-0.5	0.5	1.3	0.3	0.3
Leg pain on walking	0.8	1.0	3.2	-0.5	0.7	0.7	-0.6	1.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.5	0.5	-0.4	-1.9	0.4	0.9	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.8	-0.7	-0.6	-0.9	0.6	1.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.1	0.6	-0.5	0.0	0.7	0.5
Medication: Aspirin	0.7	0.9	3.0	0.2	1.1	0.4	-1.1	1.7	0.3
Supplements: Vitamin C	1.5	1.8	4.4	1.1	0.8	-1.2	1.3	2.1	1.1
Knee pain experienced in last month	0.3	0.5	1.2	-0.2	-1.1	-1.0	0.6	0.6	0.2
Hypertension (Self-reported)	4.5	12.6	47.2	-0.4	2.5	3.7	-1.8	6.9	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.7	0.3	0.3	-0.0	-0.0	-1.9	0.1
Illnesses of father: Heart disease	0.9	1.2	4.2	-1.1	-0.7	0.5	-2.0	-0.5	-0.9
Illnesses of siblings: Diabetes	0.6	0.8	1.7	-1.3	-1.3	0.5	0.2	-0.1	-1.1
Smoking status: Previous	0.7	1.1	2.8	0.2	-0.9	-1.2	1.7	0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.8	-0.5	-1.4	-1.7	2.2	1.2	0.4
Whole body fat-free mass	0.9	4.9	8.7	-2.8	-3.0	-0.8	2.6	2.3	-0.4
Leg fat-free mass (right)	0.7	3.7	8.0	-2.7	-2.8	-0.3	2.0	1.3	-0.8
Arm fat percentage (left)	0.6	2.3	7.0	-0.4	-1.8	-0.8	1.4	-2.6	-1.0
Average weekly red wine intake	0.2	0.3	1.0	0.4	1.0	0.6	-0.2	-0.1	-0.3
Handedness (chirality/laterality): Left-handed	1.9	2.3	6.5	-0.8	-0.7	-2.5	1.3	-2.1	-0.2
Mood swings	0.6	1.0	1.9	-0.2	0.5	-1.4	1.1	-1.3	-1.0
Loneliness, isolation	1.3	1.7	3.6	-1.0	-1.4	-1.1	1.9	-1.1	-1.3
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.5	-0.5	0.5	-0.8	-0.4	-0.2
Ever had bowel cancer screening	0.4	0.5	2.1	0.5	0.4	0.3	-0.5	-1.4	0.5
Diabetes diagnosed by doctor	1.3	2.1	3.7	-0.1	0.8	1.8	-1.7	-1.5	1.9
Ever had stillbirth, spontaneous miscarriage or termination	6.3	6.8	26.6	-0.1	-2.3	-1.5	1.1	-2.2	-5.2
Friendships satisfaction	1.2	1.4	3.1	1.0	1.1	-1.0	1.8	0.1	-1.5
Qualifications: nursing, teaching	0.3	0.5	2.2	-0.1	0.3	0.5	0.4	-1.5	0.7
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.3	0.2	-0.2	-0.3	0.2	-0.7
Eye problems/disorders: Cataract	1.7	1.9	3.5	1.9	1.5	0.6	-1.8	-1.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-1.1	-0.7	0.8	0.0	0.3	0.7
Medication for cholesterol	2.2	3.4	10.7	1.2	-0.7	-1.5	2.1	-3.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	-0.2	1.0	1.0	-0.5	1.1	0.4
Back pain experienced in last month	1.6	2.3	7.7	-2.8	-2.4	0.3	0.1	0.0	0.6
Mineral and other dietary supplements	0.8	1.0	5.1	0.0	0.2	-0.4	0.7	-0.6	-2.2
Breast cancer (self-reported)	0.6	0.7	1.7	1.1	1.3	0.6	0.2	0.3	-0.9
Asthma (self-reported)	1.8	3.6	6.4	-0.1	-2.0	-2.4	2.5	-0.8	-2.2
Osteoporosis (self-reported)	0.2	0.2	0.7	0.5	-0.5	-0.2	0.8	0.3	-0.3
Osteoarthritis (self-reported)	1.1	1.4	4.3	1.4	-0.4	-0.1	-0.9	2.1	-1.2
Medication: Aspirin	1.0	1.3	3.6	0.6	1.4	0.6	-1.3	1.9	-0.2
Medication: Gliclazide	0.3	0.3	0.7	0.6	0.8	0.3	-0.0	0.7	-0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	4.3	1.1	1.2	0.5	0.5	-2.1	1.1
Smoking status: Current	0.6	0.9	2.2	-1.4	-1.5	-0.7	0.7	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.7	-1.2	-0.9	0.9	-1.3	-0.9	1.1
Whole body water mass	0.9	5.1	8.8	-2.9	-3.0	-0.8	2.7	2.3	-0.2
Leg predicted mass (right)	0.7	3.8	8.3	-2.7	-2.9	-0.4	2.0	1.4	-0.9
Arm fat mass (left)	0.7	2.7	5.3	-1.2	-2.3	-1.1	2.2	-1.6	-1.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	0.1	-0.9	-0.1	-0.1	0.8	0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.2	0.2	-0.0	1.1	-0.4	1.1	-0.1
Miserableness	1.3	2.3	5.6	-2.4	-1.4	0.7	-1.4	-1.9	-0.2
Guilty feelings	1.4	2.2	4.5	-2.1	-1.4	0.8	0.9	-2.0	1.1
Wears glasses or contact lenses	0.8	0.9	2.8	1.7	0.4	0.1	-0.6	-0.1	1.5
Ever taken oral contraceptive pill	1.9	2.1	3.0	-1.7	-1.7	-1.1	0.4	-1.6	-1.7
Hearing aid user	0.6	0.6	2.9	0.1	0.0	0.8	-0.3	0.3	1.7
Mother’s age at death	0.4	0.4	1.1	0.3	1.0	0.5	-0.5	0.4	-0.9
Financial situation satisfaction	0.3	0.3	0.9	0.2	0.3	-0.4	0.3	1.0	0.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	5.6	-0.5	0.5	1.4	-2.4	0.5	0.8
Commuting to job workplace: Public transport	0.6	0.7	1.5	-0.7	-0.4	-0.3	1.2	-1.2	-0.8
Eye problems/disorders: Glaucoma	0.9	1.1	3.8	0.1	-1.3	0.7	-2.0	-0.3	0.7
Medication: Blood pressure	4.6	8.8	29.7	-0.1	2.6	2.7	-1.9	5.5	2.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	3.0	-0.5	-0.8	-0.9	0.2	1.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	0.3	-0.3	-0.1	-0.1	0.9	1.3
High cholesterol (Self-reported)	0.2	0.4	1.6	0.3	-0.0	-1.3	0.3	0.6	-0.1
Medication: Bendroflumethiazide	2.7	4.2	23.8	-0.5	0.5	-0.6	0.5	4.9	0.3
Medication: Paracetamol	1.6	2.4	7.5	-2.7	-2.1	-0.5	-1.3	-0.6	-0.6
Medication: Lisinopril	1.2	1.5	3.0	0.5	1.6	1.4	-1.1	1.7	0.4
Medication: Atorvastatin	0.3	0.4	1.6	1.2	1.0	-0.1	-0.1	0.1	0.1
Illnesses of father: High blood pressure	1.4	1.7	4.1	-1.4	-0.3	0.7	-2.0	1.9	-0.6
Alcohol drinker status: Never	0.8	1.0	2.0	-0.6	-1.4	-1.1	-0.7	-0.7	-1.1
Ever smoked	0.5	0.9	3.8	-0.2	-0.6	-0.6	1.0	0.1	-2.0
Basal metabolic rate	0.8	4.4	8.2	-2.7	-2.9	-0.9	2.7	1.7	-0.5
Leg fat percentage (left)	0.4	1.5	4.0	-0.6	-1.8	-0.6	0.9	-2.0	-0.2
Arm fat-free mass (left)	0.9	4.6	8.6	-2.5	-2.8	-0.8	2.9	2.0	-0.4
Number of operations (self-reported)	0.3	0.4	1.9	0.6	-0.1	-0.0	0.3	1.4	0.3
Average weekly beer plus cider intake	1.4	2.0	7.9	1.2	0.5	-0.7	0.1	-1.3	-2.8
Irritability	0.8	1.3	3.6	-0.1	-1.3	-1.4	0.2	0.8	-1.9
Risk taking	1.1	1.7	4.1	0.3	-0.3	-1.4	1.9	0.6	-2.0
Ever had prostate specific antigen (PSA) test	1.7	1.9	6.5	-1.4	-1.0	1.4	-0.2	-2.5	-0.1
Fractured/broken bones in last 5 years	0.5	0.7	3.0	0.2	-0.7	-0.3	1.7	-0.8	0.1
Age started oral contraceptive pill	1.0	1.2	2.9	1.5	0.9	1.0	-0.8	-0.1	1.7
Diastolic blood pressure, automated reading	4.2	12.9	42.6	1.5	2.5	4.4	-2.6	6.5	0.5
Ever depressed for a whole week	1.4	1.7	3.7	1.1	1.7	-0.4	-0.1	1.5	-1.9
Unable to work because of sickness or disability	3.3	4.2	7.3	-2.0	-2.7	-2.5	2.5	0.4	-1.1
Commuting to job workplace: Cycle	0.7	0.8	3.0	1.7	1.0	-0.1	0.5	-0.6	-0.4
Myopia	0.4	0.5	1.2	0.4	1.0	0.0	-1.1	-0.8	-0.3
Vascular/heart problems diagnosed by doctor	4.5	12.3	42.6	-0.4	-3.5	-3.5	1.7	-6.5	-1.9
Cholesterol lowering medication	1.1	1.6	4.4	-0.3	1.3	1.3	-2.1	1.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.5	1.6	-0.6	-0.5	0.9	-1.3	-0.4	0.4
Pain experienced in last month	1.7	2.8	8.1	2.8	2.4	-0.2	0.5	0.6	-1.5
Supplements: Calcium	2.3	2.5	8.9	0.8	1.1	1.3	-1.6	-0.0	3.0
Basal cell carcinoma (self-reported)	0.5	0.6	2.2	0.3	0.2	-0.9	1.5	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	1.9	2.5	5.5	0.4	2.0	2.3	-1.5	1.5	0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.0	0.5	0.3	1.6	-1.7	0.7	-1.2
Heart disease (siblings)	0.9	1.1	4.2	-0.6	0.1	-0.0	-1.4	2.0	-0.1
Alcohol drinker status: Previous	0.3	0.3	0.8	0.1	0.2	0.7	-0.1	-0.7	-0.9
Pack years of smoking	0.4	0.6	1.3	-0.9	-0.6	-1.1	-0.3	-0.7	-0.7
Impedance of whole body	0.6	3.0	9.0	3.0	2.2	-0.7	-0.4	-1.3	-1.2
Leg fat mass (left)	0.6	2.5	6.7	-1.4	-2.6	-1.1	1.8	-1.3	-0.7
Arm predicted mass (left)	0.9	4.8	8.6	-2.7	-2.9	-0.7	2.7	2.3	-0.3