Best TWAS P=3.65e-08 · Best GWAS P=1.47e-06 conditioned to 0.634
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EDEM3 | 0.11 | 0.08 | lasso | 14 | 0.11 | 2.3e-13 | 4.7 | -5.3 | 8.9e-08 | -0.79 | 0.03 | 0.95 | FALSE |
| 2 | GTEx | Artery Tibial | EDEM3 | 0.23 | 0.16 | enet | 24 | 0.19 | 1.7e-14 | 4.5 | -5.5 | 3.7e-08 | -0.82 | 0.04 | 0.94 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EDEM3 | 0.05 | 0.06 | enet | 7 | 0.08 | 8.7e-10 | 4.6 | -5.2 | 2.0e-07 | -0.82 | 0.03 | 0.95 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | EDEM3 | 0.04 | 0.04 | blup | 66 | 0.04 | 2.0e-05 | 4.7 | -5.2 | 2.1e-07 | -0.90 | 0.02 | 0.96 | FALSE |