Best TWAS P=1.69e-13 · Best GWAS P=1.19e-13 conditioned to 4.45e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRIG2 | 0.05 | 0.01 | bslmm | 358 | 0.03 | 1.0e-04 | -2.9 | 5.7 | 1.0e-08 | 0.00 | 0.08 | 0.49 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | 6.9 | 7.1 | 1.2e-12 | -0.25 | 0.08 | 0.92 | FALSE |
| 3 | GTEx | Artery Aorta | WNT2B | 0.15 | 0.01 | enet | 7 | 0.01 | 1.0e-01 | -6.0 | -5.9 | 3.8e-09 | 0.41 | 0.15 | 0.40 | FALSE |
| 4 | GTEx | Brain Cortex | WNT2B | 0.36 | 0.19 | lasso | 5 | 0.23 | 5.5e-07 | 6.7 | 6.0 | 2.0e-09 | -0.14 | 0.12 | 0.85 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | WNT2B | 0.29 | 0.28 | lasso | 3 | 0.29 | 2.6e-08 | 6.8 | 6.3 | 3.6e-10 | -0.20 | 0.12 | 0.87 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | WNT2B | 0.18 | 0.07 | lasso | 6 | 0.05 | 2.3e-02 | -5.9 | -5.5 | 4.5e-08 | 0.45 | 0.08 | 0.06 | FALSE |
| 7 | GTEx | Esophagus Muscularis | SLC16A1 | 0.11 | 0.03 | lasso | 4 | 0.04 | 2.9e-03 | 5.2 | -6.4 | 1.6e-10 | -0.14 | 0.13 | 0.73 | FALSE |
| 8 | GTEx | Heart Left Ventricle | SLC16A1 | 0.08 | 0.05 | lasso | 3 | 0.03 | 7.3e-03 | -6.9 | -6.2 | 7.0e-10 | -0.05 | 0.06 | 0.67 | FALSE |
| 9 | GTEx | Muscle Skeletal | WNT2B | 0.06 | 0.02 | lasso | 7 | 0.03 | 9.4e-04 | -5.9 | -5.5 | 3.5e-08 | 0.51 | 0.54 | 0.05 | FALSE |
| 10 | GTEx | Nerve Tibial | RP4-671G15.2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.9e-05 | -5.4 | 5.7 | 1.6e-08 | -0.40 | 0.90 | 0.05 | FALSE |
| 11 | GTEx | Pituitary | ST7L | 0.31 | 0.18 | lasso | 7 | 0.18 | 3.0e-05 | 4.5 | 5.9 | 3.4e-09 | -0.23 | 0.14 | 0.71 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | SLC16A1 | 0.12 | 0.00 | lasso | 5 | 0.04 | 5.0e-03 | 6.7 | -5.4 | 5.8e-08 | 0.23 | 0.06 | 0.70 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | MOV10 | 0.05 | 0.02 | lasso | 5 | 0.02 | 1.1e-02 | 6.7 | 6.8 | 7.4e-12 | -0.32 | 0.14 | 0.57 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | RHOC | 0.07 | 0.02 | lasso | 3 | 0.02 | 1.5e-02 | -5.8 | -5.7 | 1.2e-08 | 0.40 | 0.24 | 0.56 | FALSE |
| 15 | GTEx | Spleen | SLC16A1 | 0.16 | 0.08 | lasso | 5 | 0.07 | 8.3e-03 | -6.9 | -7.1 | 1.6e-12 | -0.10 | 0.06 | 0.50 | TRUE |
| 16 | METSIM | Adipose | SLC16A1 | 0.10 | 0.10 | lasso | 5 | 0.10 | 2.5e-14 | -6.7 | 6.8 | 8.3e-12 | 0.02 | 0.03 | 0.97 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | CAPZA1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.1e-07 | -5.8 | -5.7 | 1.2e-08 | 0.40 | 0.98 | 0.02 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | WNT2B | 0.34 | 0.40 | enet | 30 | 0.42 | 1.5e-59 | 6.7 | 6.5 | 7.6e-11 | -0.15 | 0.11 | 0.89 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC16A1 | 0.06 | 0.01 | blup | 38 | 0.02 | 1.4e-03 | -2.7 | 6.2 | 4.5e-10 | 0.04 | 0.01 | 0.68 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC16A1 | 0.15 | 0.05 | blup | 38 | 0.05 | 2.4e-04 | -7.1 | 5.5 | 4.7e-08 | 0.06 | 0.00 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 4.7e-04 | -6.0 | -7.4 | 1.7e-13 | 0.45 | 0.05 | 0.13 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC16A1 | 0.09 | 0.11 | lasso | 2 | 0.11 | 3.0e-11 | -6.9 | 7.0 | 3.1e-12 | 0.05 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | MOV10 | 0.06 | 0.06 | lasso | 7 | 0.05 | 9.4e-06 | 4.6 | 5.8 | 5.6e-09 | -0.20 | 0.01 | 0.99 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 1.4e-04 | -6.1 | -7.2 | 4.5e-13 | 0.49 | 0.20 | 0.22 | FALSE |