Best TWAS P=5.45e-16 · Best GWAS P=3.52e-16 conditioned to 0.0472
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | ADAMTS8 | 0.12 | 0.09 | lasso | 5 | 0.08 | 4.0e-10 | -5.6 | -5.3 | 1.3e-07 | 0.44 | 1 | 0.00 | FALSE |
| 2 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADAMTS8 | 0.06 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | -8.2 | 8.1 | 5.4e-16 | -0.90 | 0 | 0.98 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAMTS8 | 0.04 | 0.03 | enet | 8 | 0.03 | 8.5e-05 | -8.2 | 6.8 | 1.5e-11 | -0.82 | 0 | 0.96 | FALSE |