Best TWAS P=6.84e-10 · Best GWAS P=1.6e-09 conditioned to 0.765
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | UBXN2A | 0.20 | 0.09 | lasso | 6 | 0.08 | 4.1e-05 | 4.9 | 5.2 | 2.0e-07 | 0.06 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Esophagus Muscularis | NCOA1 | 0.11 | 0.01 | enet | 9 | 0.01 | 5.8e-02 | -6.0 | -5.2 | 1.8e-07 | 0.83 | 0.01 | 0.88 | FALSE |
| 3 | GTEx | Lung | UBXN2A | 0.09 | 0.06 | enet | 7 | 0.07 | 6.1e-06 | 4.8 | 5.1 | 2.8e-07 | 0.03 | 0.04 | 0.95 | FALSE |
| 4 | GTEx | Muscle Skeletal | UBXN2A | 0.10 | 0.04 | lasso | 7 | 0.03 | 5.5e-04 | 4.9 | 5.2 | 1.7e-07 | 0.05 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Prostate | FAM228B | 0.16 | 0.02 | enet | 31 | 0.07 | 9.6e-03 | 5.0 | -5.9 | 3.5e-09 | 0.07 | 0.04 | 0.64 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | UBXN2A | 0.12 | 0.06 | enet | 33 | 0.12 | 6.8e-07 | 4.3 | 6.2 | 6.8e-10 | -0.12 | 0.04 | 0.94 | TRUE |
| 7 | GTEx | Stomach | UBXN2A | 0.13 | 0.14 | enet | 5 | 0.14 | 3.6e-07 | 4.9 | 5.2 | 2.2e-07 | 0.03 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | ADCY3 | 0.36 | 0.14 | enet | 7 | 0.13 | 8.9e-05 | -6.0 | 5.7 | 1.0e-08 | -0.90 | 0.00 | 0.96 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBXN2A | 0.03 | 0.02 | blup | 46 | 0.03 | 5.7e-04 | 4.8 | 5.3 | 9.8e-08 | 0.09 | 0.02 | 0.94 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EFR3B | 0.26 | 0.01 | lasso | 4 | 0.05 | 3.8e-03 | -6.0 | -5.2 | 2.0e-07 | 0.87 | 0.00 | 0.92 | FALSE |