Hub : Genes

EFR3B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0407 0.0200 0.00710 -0.002 0.001 0.000 0.003 -0.001 7.6e-01 2.5e-01 3.6e-01 9.7e-02 6.6e-01
2 ROSMAP Brain Pre-frontal Cortex 0.0732 0.0275 0.00059 0.026 0.033 0.022 0.033 0.021 2.4e-04 3.6e-05 7.2e-04 3.5e-05 8.1e-04
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0319 0.0161 0.00130 0.048 0.015 0.036 NA 0.041 3.6e-06 7.2e-03 6.3e-05 NA 1.9e-05
4 TCGA Pancreatic Adenocarcinoma 0.2570 0.1220 0.00880 0.014 0.001 0.041 NA 0.050 8.0e-02 2.7e-01 7.9e-03 NA 3.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.9 3.0 7.1 0.1 -2.7 -0.1 -2.2
Bipolar Disorder or Schizophrenia 0.7 1.7 2.9 -0.9 0.7 1.6 -1.7
Depressed Affect (Nagel 2018) 0.6 1.2 4.1 -0.4 -0.4 -2.0 0.6
Depression (Nagel 2018) 0.3 0.5 1.2 0.5 -0.5 -1.1 -0.6
Intelligence (Savage-Jansen 2018) 1.5 4.6 11.2 -1.7 -1.4 -3.3 1.6
Neuroticism (Nagel 2018) 0.4 1.0 3.3 0.5 1.8 0.6 -0.0
Schizophrenia (2018) 1.9 3.9 9.1 -1.3 3.0 2.2 -0.4
Schizophrenia vs Biploar Disorder 3.5 4.6 13.7 -0.4 3.7 1.8 1.1
Worry (Nagel 2018) 2.7 5.7 9.6 2.2 2.8 3.1 -0.7
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 -0.5 -0.4 0.6 -0.1
Alzheimer’s Disease (in father) 2.4 2.6 7.8 0.2 2.8 0.2 1.6
Alzheimer’s Disease (including proxy) 0.4 0.6 0.9 -0.8 0.9 0.7 0.5
Crohns Disease (2017) 3.6 7.8 15.5 -3.2 -1.6 -3.9 1.8
Irritable Bowel Disease (IBD) 2.7 6.4 11.5 -3.3 -1.1 -3.4 1.5
Ulcerative Colitis (UC) 0.7 1.3 3.3 -1.8 -0.1 -1.3 0.5
Major Depression (MDD) 1.6 2.0 4.5 0.9 -0.6 -2.1 1.5
Reaction Time 1.0 1.9 7.7 0.1 0.0 2.8 0.2
Verbal and Numeric Reasoning (VNR) 1.6 3.9 12.2 -0.8 -1.3 -3.5 1.1
Breast Cancer 4.0 9.5 24.3 -2.4 -1.4 -4.9 2.5
Ovarian Cancer 1.3 1.7 4.6 2.1 -1.0 0.1 -1.1
Prostate Cancer 0.3 0.4 0.8 -0.9 -0.8 0.3 -0.2
Age at First Birth 0.7 1.0 2.9 0.4 1.7 0.4 0.8
Bipolar Disorder (2011) 1.5 1.4 4.3 -0.2 -1.1 -0.1 -2.1
Body Mass Index (BMI) (2010) 3.3 4.5 8.3 -2.9 -0.5 -2.9 1.1
Coronary Artery Disease (CAD) 0.7 0.8 1.6 0.6 -0.0 -1.3 1.2
Crohns Disease (2012) 1.8 2.8 6.0 -2.5 -1.0 -1.9 0.8
Mean Putamen Volume 0.2 0.2 0.3 0.4 -0.5 0.2 -0.5
Fasting Glucose 3.2 3.9 9.8 1.4 3.1 1.4 1.4
HbA1C 0.5 0.5 1.1 -1.1 -0.7 -0.4 0.5
HDL Cholesterol 0.6 1.1 3.2 0.6 -0.1 1.8 -0.8
LDL Cholesterol 0.6 1.0 1.8 0.1 1.1 -1.3 1.1
Lupus 0.4 0.7 1.1 0.9 0.2 -0.8 -1.1
Neuroticism (2016) 1.7 2.4 4.0 1.9 1.2 2.0 -0.6
Primary Biliary Cirrhosis 2.5 3.6 8.7 -0.3 -2.3 -3.0 0.6
Rheumatoid Arthritis 1.2 1.6 3.8 -0.2 0.1 -1.6 1.9
Schizophrenia (2014) 1.5 3.3 4.8 -1.6 2.2 2.1 -1.0
Triglycerides 0.3 0.5 1.4 0.7 -0.2 1.2 -0.3
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.8 0.1 -0.9 0.1 -0.1
Ulcerative Colitis 1.2 1.8 2.6 -1.4 1.1 -1.6 1.2
Blood Eosinophil Count 0.3 2.5 7.6 0.2 -1.4 -2.8 -0.5
Blood Platelet Count 0.3 3.8 6.4 1.2 1.3 -2.4 2.5
Blood Red Count 0.7 6.5 8.7 2.7 -2.9 -1.1 -3.0
Blood White Count 1.0 7.1 17.0 -2.2 -4.1 -2.0 -1.7
Heel T-Score 1.0 8.1 13.8 -2.5 3.7 -1.9 3.0
BMI 14.5 84.1 187.7 -11.4 -2.9 -13.7 3.3
Height 8.1 156.5 299.3 9.2 -7.1 17.3 -13.8
Waist Hip Ratio (WHR) 3.4 15.3 27.5 3.3 -3.2 3.5 -5.2
Systolic Blood Pressure 7.6 37.9 58.1 5.4 -5.1 6.2 -7.6
Smoking Status 1.7 4.0 12.8 -3.6 -0.4 -1.7 0.5
Allergy or Eczema 2.2 5.7 12.0 -3.5 3.0 1.2 0.1
Cardiovascular Disease 4.5 14.8 33.2 0.4 -5.8 -0.5 -5.0
Hypothyroidism (self reported) 0.6 1.4 2.9 -1.2 -1.7 -1.1 -0.4
Respiratory disease 0.2 0.5 1.6 0.0 1.3 0.0 0.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.9 -0.2 -0.5 -0.9 -0.7
Lung FEV1/FVC ratio 1.7 8.5 22.3 -1.9 -0.8 -4.7 2.8
Lung FVC 1.4 7.3 14.5 -0.4 -3.8 1.2 -3.6
Neuroticism 0.4 0.9 2.8 0.3 0.3 -1.7 -0.7
Chronotype (morning person) 2.8 6.5 11.3 3.2 -0.7 3.4 -2.1
Hair Pigment 0.4 10.3 28.6 0.1 -1.0 -5.3 3.4
Tanning 1.3 15.7 44.2 4.2 -0.1 6.7 -0.8
Hand grip strength (left) 2.9 7.7 16.3 1.6 -1.4 4.0 -3.1
Number of treatments/medications taken 1.8 3.3 5.3 -1.8 -2.3 -0.2 -2.1
Average weekly spirits intake 1.8 2.2 4.5 -1.0 -2.1 -1.8 0.0
Sensitivity / hurt feelings 0.7 1.2 3.0 -0.3 0.6 -1.7 1.1
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.7 -0.6 -1.3 -0.3 -1.1
Hearing difficulty/problems: Yes 2.0 3.0 10.3 -3.2 1.1 -0.6 -0.5
Relative age of first facial hair 1.7 3.6 9.6 -0.3 1.6 -1.4 3.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.6 -0.8 0.2 -0.1
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.1 1.3 0.1 1.5 -1.4
Ever had hysterectomy (womb removed) 1.5 1.7 3.7 -0.7 -1.9 -0.2 -1.5
Systolic blood pressure, automated reading 4.5 13.2 27.0 2.1 -3.7 2.9 -5.2
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.3 -0.1 -0.2 -1.5 -0.6
Angina 2.5 3.2 4.9 -1.8 -2.2 -1.6 1.5
Medication for hormone replacement therapy 0.3 0.4 0.8 -0.6 0.9 0.5 0.1
Vitamin and mineral supplements 1.0 1.3 3.1 0.3 0.4 -1.8 1.4
Supplements: Zinc 0.1 0.1 0.2 -0.1 0.4 -0.0 0.2
Medication: Co-codamol 0.6 0.7 1.6 -1.3 -0.7 0.9 -0.1
Medication: Metformin 0.5 0.7 1.8 -0.7 0.1 -1.4 -0.5
Diabetes (father) 2.1 2.6 4.8 1.6 -1.6 2.2 -0.6
Diabetes (mother) 0.6 0.7 1.0 0.9 0.7 1.0 -0.7
Severe depression (siblings) 0.6 0.7 2.3 -1.5 -0.0 0.0 -0.6
Pack years adult smoking proportion 1.2 1.9 5.2 -2.3 -0.8 -1.3 0.2
Impedance of leg (right) 2.9 13.8 29.4 4.9 0.7 5.4 -1.3
Leg fat-free mass (left) 1.9 9.9 14.6 -3.2 -3.8 -2.4 -3.0
Trunk fat percentage 6.8 27.2 65.6 -5.7 -3.3 -8.1 0.2
Hand grip strength (right) 2.9 7.9 17.5 0.8 -1.5 4.2 -3.3
Townsend deprivation index at recruitment 1.0 1.4 2.7 -0.8 -1.4 -0.6 -1.6
Current tobacco smoking 0.7 1.1 2.3 -1.5 -1.1 -0.8 -0.4
Average weekly fortified wine intake 0.9 1.1 2.1 0.3 1.4 -0.3 1.4
Maternal smoking around birth 0.3 0.4 1.2 0.6 1.1 -0.4 -0.3
Fed-up feelings 0.9 1.6 3.7 -1.9 0.6 -1.5 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.3 0.3 -0.5 -0.3 -1.1
Relative age voice broke 0.8 1.2 3.1 -0.2 1.1 -0.6 1.8
Taking other prescription medications 0.2 0.3 1.0 -0.5 -1.0 -0.0 -0.2
Age when periods started (menarche) 1.0 2.3 7.1 1.3 0.4 2.7 -0.4
Bilateral oophorectomy (both ovaries removed) 2.4 2.7 6.6 -0.1 -2.6 0.3 -2.0
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 3.7 -1.9 1.3 -0.5 1.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 0.1 0.4 -0.9 0.5
Qualifications: CSEs or equivalent 0.7 1.0 1.1 -0.9 -1.1 -1.0 1.0
Serious illness, injury or assault to yourself 0.4 0.4 1.6 -0.4 -0.0 0.0 1.3
High blood pressure 6.8 18.8 36.0 1.9 -6.0 -0.2 -6.0
Hayfever, allergic rhinitis or eczema 2.2 4.9 11.6 -2.5 3.4 1.3 0.2
Multivitamins +/- minerals 0.8 1.0 3.1 0.6 0.4 1.8 -0.8
Stomach or abdominal pain in last month 0.5 0.6 2.1 -1.5 0.3 0.1 -0.1
Supplements: Glucosamine 0.9 1.2 2.2 -0.6 -1.5 0.2 -1.4
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 0.2 0.2 0.5 0.5
Medication: Atenolol 4.7 5.9 13.0 -0.3 -3.6 -1.8 -2.7
Medication: Levothyroxine sodium 0.1 0.2 0.6 -0.3 -0.2 0.8 0.4
Sitting height 5.2 37.0 94.7 5.9 1.3 9.7 -4.0
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 0.4 0.3 -0.8 -0.3
High blood pressure (mother) 4.3 6.1 14.9 -0.4 -3.9 -0.1 -3.0
Body mass index (BMI) 13.2 56.0 134.6 -8.6 -3.5 -11.6 2.0
Impedance of leg (left) 3.1 14.8 33.5 4.8 0.9 5.8 -1.4
Leg predicted mass (left) 1.9 9.9 14.5 -3.3 -3.8 -2.4 -2.9
Trunk fat mass 5.9 25.4 52.7 -5.6 -4.1 -7.3 -1.0
Waist circumference 7.1 26.2 50.1 -5.5 -4.7 -7.1 -1.4
Number of incorrect matches in round 2.9 4.8 11.9 1.7 1.0 3.5 -1.8
Past tobacco smoking 2.7 4.9 12.4 3.5 1.0 2.5 0.6
Alcohol usually taken with meals 0.3 0.4 1.1 0.7 0.2 1.1 -0.3
Nervous feelings 2.6 4.9 11.8 1.0 3.4 2.6 0.2
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.3 0.2 -1.8 1.2 -1.2
Hearing difficulty/problems with background noise 2.4 3.8 5.8 -2.4 1.9 1.7 -1.7
Hair/balding pattern: Pattern 2 1.5 2.0 5.2 -0.0 -2.3 -1.5 0.6
Had menopause 1.2 1.4 2.4 1.3 -0.6 1.6 -1.1
Had other major operations 0.9 1.1 2.0 -1.4 -1.0 -1.0 -0.8
Forced vital capacity (FVC) 5.5 21.1 32.8 3.2 -3.2 5.7 -5.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.7 -1.6 -0.6 -0.2 0.8
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.9 -1.7 0.5 -1.1 0.8
Qualifications: None of the above 0.2 0.3 1.1 -1.1 -0.1 -0.5 -0.1
Financial difficulties in last 2 years 0.2 0.3 0.8 -0.9 -0.4 0.2 -0.3
Mouth/teeth dental problems 1.0 1.5 3.7 1.0 -0.9 1.9 0.5
Heart attack 1.5 2.0 2.7 -1.5 -1.4 -1.0 1.7
Allergy 1.1 2.6 7.7 0.8 -2.8 -1.4 -0.2
Pain all over the body in last month 1.3 1.4 3.7 -0.7 -0.4 1.1 -1.9
Diabetes (self-reported) 0.3 0.5 1.5 -0.5 0.5 -1.2 -0.1
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 2.1 0.3 1.5 1.2 -1.3
Medication: Ramipril 4.4 5.6 11.2 -0.1 -3.3 -1.4 -3.1
Medication: Simvastatin 0.3 0.5 0.7 0.5 -0.6 -0.7 -0.8
Fluid intelligence score 1.7 3.6 8.8 0.0 1.2 -3.0 2.0
Illnesses of siblings 1.6 2.3 4.8 1.1 1.8 0.0 2.2
Neuroticism score 0.3 0.7 1.9 -0.3 0.9 -1.4 -0.1
Weight 4.5 22.2 30.3 -5.0 -5.2 -5.5 -2.6
Impedance of arm (right) 1.4 6.4 13.0 3.1 1.4 3.6 -0.8
Arm fat percentage (right) 13.6 53.7 132.2 -8.3 -3.2 -11.5 1.7
Trunk fat-free mass 2.6 15.0 31.4 -1.0 -5.2 0.9 -5.6
Hip circumference 6.5 27.9 54.2 -7.0 -2.9 -7.4 0.6
Time employed in main current job 3.7 4.2 8.4 2.9 -0.1 2.9 -0.4
Alcohol intake versus 10 years previously 0.7 1.0 2.7 -0.6 -0.2 1.6 -1.0
Father’s age at death 0.4 0.5 1.7 -0.2 0.4 1.3 0.3
Worrier / anxious feelings 3.1 5.8 10.5 1.6 3.2 3.2 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.8 -1.9 -0.5 -1.0 -1.0
Falls in the last year 0.2 0.3 0.9 0.1 0.3 0.4 -0.9
Hair/balding pattern: Pattern 3 2.3 3.4 6.6 0.5 1.6 2.6 -2.0
Number of live births 0.7 1.0 2.8 0.3 -1.7 -0.1 -1.0
Forced expiratory volume in 1-second (FEV1) 3.4 11.5 16.7 2.6 -2.9 3.7 -4.1
Pulse rate 0.6 1.0 2.8 0.2 1.1 -0.2 -1.7
Happiness 1.2 1.5 2.1 -1.5 -0.7 1.3 -1.2
Noisy workplace 0.4 0.5 1.6 0.2 0.5 1.3 0.1
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.1 1.5 0.1 1.3 -1.2
Serious illness, injury or assault of a close relative in last 2 years 3.0 3.5 7.2 -2.7 1.5 -0.9 2.0
Mouth/teeth dental problems: Dentures 1.0 1.8 6.3 0.2 0.7 -2.5 0.6
Asthma 0.1 0.2 0.4 0.6 -0.5 -0.4 0.0
Medication: Ibuprofen (e.g. Nurofen) 3.6 4.5 11.2 -0.4 -2.5 0.9 -3.3
Medication: Cholesterol lowering 0.1 0.2 0.4 -0.5 -0.1 -0.6 -0.3
Depression (self-reported) 0.3 0.3 0.7 0.8 -0.7 0.0 -0.2
Medication: Lansoprazole 0.6 0.7 1.8 -0.1 -0.5 -0.9 1.3
Prospective memory result 0.6 0.8 2.4 -0.1 -0.9 1.5 -0.1
Lung cancer (father) 0.9 1.1 3.6 0.5 -1.9 0.5 -0.4
Illnesses of mother 4.1 5.1 11.0 0.7 3.3 -0.5 2.9
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 9.8 12.4 2.5 -3.5 3.0 -3.5
Pulse wave Arterial Stiffness index 1.3 1.5 4.3 -0.9 -2.1 -0.3 -1.0
Impedance of arm (left) 1.2 5.4 11.2 3.1 0.9 3.4 -0.5
Arm fat mass (right) 9.9 40.8 92.5 -7.2 -4.3 -9.6 -0.2
Trunk predicted mass 2.7 15.5 32.7 -1.1 -5.2 1.0 -5.7
Standing height 7.8 77.8 146.4 6.9 -4.3 12.1 -10.0
Length of working week for main job 0.4 0.4 1.0 1.0 0.3 -0.6 -0.5
Exposure to tobacco smoke at home 1.1 1.3 3.6 0.6 -0.3 1.9 -0.9
Breastfed as a baby 1.4 1.8 4.9 0.9 -0.9 2.2 -0.8
Tense / ‘highly strung’ 1.3 2.2 4.6 1.2 0.4 2.2 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.4 0.2 0.4 -1.2 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.6 -0.4 0.5 -1.2 0.2
Birth weight of first child 1.8 3.3 8.9 0.9 -0.6 3.0 -1.8
Peak expiratory flow (PEF) 1.1 2.6 4.4 1.5 -0.7 1.8 -2.1
Pulse wave reflection index 0.5 0.6 1.6 -0.6 -1.3 0.5 -0.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.6 -0.4 -0.1 1.6 0.3
Loud music exposure frequency 1.3 1.4 4.5 0.4 1.0 2.1 -0.5
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.5 0.6 -1.2 0.6 -1.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.5 -0.5 0.2 -1.6 0.3
Blood clot in the leg (DVT) 0.9 1.2 3.6 0.9 0.3 0.3 1.9
Medication: Paracetamol 0.9 1.4 2.6 -1.4 -1.0 0.5 -1.6
Headache pain in last month 0.3 0.5 1.1 -0.5 0.2 0.8 -1.0
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 5.7 0.9 2.4 0.3 2.2
Glaucoma (self-reported) 0.5 0.6 1.5 -0.9 0.1 -1.2 -0.3
Gout (self-reported) 1.3 1.8 6.1 -2.5 0.7 0.3 0.7
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 2.8 -1.7 -1.1 -0.3 0.4
Medication: Amlodipine 2.0 2.8 6.7 0.4 -1.9 -0.7 -2.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.7 0.8 -0.9 0.1 -0.7
Birth weight 1.0 2.2 4.5 1.6 -0.8 -1.0 -2.1
Chronic bronchitis/emphysema (mother) 1.0 1.1 3.9 -0.6 0.4 0.1 -2.0
High blood pressure (siblings) 3.6 5.2 10.3 -0.4 -3.2 0.5 -3.2
Forced vital capacity (FVC), Best measure 5.1 18.7 27.4 3.0 -3.8 4.9 -5.2
Body fat percentage 9.8 38.8 95.6 -6.9 -3.3 -9.8 1.2
Leg fat percentage (right) 11.8 42.7 104.0 -7.2 -3.2 -10.2 2.0
Arm fat-free mass (right) 2.1 10.7 19.4 -2.1 -4.4 -0.2 -4.4
Exposure to tobacco smoke outside home 2.2 3.0 8.0 -1.1 -1.6 -2.8 0.2
Comparative body size at age 10 39.4 108.8 292.4 -9.5 -4.9 -17.1 5.3
Number of full brothers 1.4 1.7 4.0 -1.6 2.0 0.2 -0.4
Worry too long after embarrassment 0.8 1.4 3.7 0.4 1.9 -0.8 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.4 1.1 1.6 0.2 0.6
Wheeze or whistling in the chest in last year 1.1 1.9 3.6 -1.7 -1.0 -0.3 -1.9
Number of children fathered 1.4 1.6 4.4 1.4 -2.1 0.3 0.1
Reason for reducing amount of alcohol drunk: Health precaution 3.3 3.9 12.2 1.4 -0.6 3.5 -0.9
Age at first live birth 1.1 1.9 4.6 0.0 2.1 1.7 0.4
Pulse wave peak to peak time 1.3 1.6 3.4 1.3 1.8 1.1 0.3
Health satisfaction 0.1 0.1 0.3 -0.5 -0.0 -0.0 0.6
Shortness of breath walking on level ground 0.2 0.2 0.7 -0.8 -0.3 -0.2 -0.0
Qualifications: College or University degree 0.7 2.3 3.1 1.5 1.8 1.8 -0.6
Eye problems/disorders: None of the above 1.0 1.1 4.0 -0.1 0.2 2.0 0.7
Mouth/teeth dental problems: Loose teeth 4.3 5.0 13.5 -2.3 0.8 -3.7 1.0
Emphysema/chronic bronchitis 1.1 1.2 3.2 -1.3 0.1 1.8 -0.1
Medication for pain relief, constipation, heartburn 2.0 3.5 6.0 1.5 2.5 -0.3 2.4
Neck or shoulder pain in last month 0.5 0.6 1.9 -0.1 0.3 -0.8 1.4
Medication: Blood pressure 4.9 8.6 22.2 0.2 -4.7 -0.5 -3.4
Angina (self-reported) 2.6 3.4 3.8 -1.7 -1.8 -1.9 1.9
Migraine (self-reported) 0.3 0.4 0.9 -1.0 -0.1 -0.7 0.4
Medication: Ibuprofen 3.0 3.5 8.1 -0.7 -2.3 0.7 -2.8
Medication: Allopurinol 0.6 0.8 3.2 -1.8 0.2 0.1 0.2
Medication: Omeprazole 1.8 2.2 3.3 1.6 -1.5 0.8 -1.8
Medication: Seretide 50 evohaler 0.1 0.2 0.3 0.5 -0.5 -0.4 0.2
Mean time to correctly identify matches 0.8 1.5 4.3 1.0 0.7 2.1 0.4
Heart disease (mother) 3.5 4.3 14.2 -1.2 -3.8 -0.2 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.0 2.4 4.4 2.1 1.7 1.5 -0.2
Whole body fat mass 7.6 31.8 68.7 -6.5 -4.0 -8.3 -0.5
Leg fat mass (right) 9.3 36.0 78.3 -7.1 -3.8 -8.8 0.4
Arm predicted mass (right) 2.2 11.3 21.5 -2.0 -4.6 -0.5 -4.4
Pulse rate, automated reading 0.3 1.1 3.8 0.3 0.7 -0.0 -2.0
Alcohol intake frequency. 0.7 1.7 5.2 -0.6 -0.2 -2.3 1.1
Comparative height size at age 10 7.2 39.8 63.2 5.5 -3.5 7.3 -8.0
Number of full sisters 1.4 1.7 6.6 -2.6 -0.3 0.0 0.2
Suffer from ‘nerves’ 1.3 2.1 3.0 1.7 0.9 1.6 -1.4
Overall health rating 1.2 2.7 7.1 -2.7 -0.9 -0.2 -1.7
Chest pain or discomfort 0.6 0.8 2.9 -1.7 -0.0 0.4 0.5
Had major operations 0.2 0.2 0.7 -0.8 0.3 -0.1 0.2
Age at last live birth 1.4 2.1 5.5 -0.2 1.4 2.4 -0.8
Family relationship satisfaction 1.1 1.4 4.2 0.7 0.8 2.0 -0.4
Leg pain on walking 1.3 1.6 4.1 -2.0 -0.9 -0.8 1.0
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 5.8 2.4 0.1 -0.0 1.1
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.6 -0.5 -1.6 -0.9 0.2
Illness, injury, bereavement, stress in last 2 years 2.5 3.0 7.1 2.7 -0.4 0.9 -2.0
Medication: Aspirin 0.4 0.6 1.9 -0.4 -1.4 -0.5 0.2
Supplements: Vitamin C 0.1 0.2 0.3 0.0 -0.2 0.6 -0.5
Knee pain experienced in last month 0.8 1.2 2.4 -1.6 -1.1 -0.9 -0.7
Hypertension (Self-reported) 7.2 19.9 39.9 1.8 -6.3 -0.1 -6.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.4 -1.8 -1.4 -0.9 -0.1
Illnesses of father: Heart disease 1.0 1.4 1.8 -1.2 -1.0 -1.2 1.3
Illnesses of siblings: Diabetes 0.4 0.5 1.6 1.3 0.1 0.6 -0.0
Smoking status: Previous 2.3 3.5 7.2 -2.6 -0.3 -2.7 0.1
Forced expiratory volume in 1-second (FEV1), predicted 3.4 7.1 10.8 3.1 -0.8 3.3 -2.8
Whole body fat-free mass 2.1 12.1 22.1 -2.1 -4.7 -0.3 -4.7
Leg fat-free mass (right) 1.6 8.6 12.6 -3.0 -3.5 -1.8 -3.1
Arm fat percentage (left) 14.0 55.9 139.2 -8.3 -3.3 -11.8 2.0
Average weekly red wine intake 1.7 2.5 7.3 -0.7 -2.7 -1.1 -1.1
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.6 0.8 1.3 -0.2 0.9
Mood swings 0.3 0.6 1.7 0.1 -0.0 -1.3 0.7
Loneliness, isolation 0.8 1.1 2.9 -0.9 -0.6 -1.7 0.7
Long-standing illness, disability or infirmity 1.3 1.9 7.4 -2.7 -0.4 -0.3 0.0
Ever had bowel cancer screening 1.2 1.4 2.9 1.7 0.9 1.1 -0.9
Diabetes diagnosed by doctor 0.4 0.7 2.6 -0.5 0.0 -1.6 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 5.2 -2.3 0.7 1.0 -1.1
Friendships satisfaction 0.8 1.0 2.5 -0.7 0.7 1.6 0.6
Qualifications: nursing, teaching 0.3 0.5 1.8 0.2 0.2 0.1 1.3
Commuting to job workplace: Walk 1.0 1.1 2.9 0.8 1.7 0.8 -0.1
Eye problems/disorders: Cataract 0.4 0.4 1.1 0.6 0.3 -0.0 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 3.7 -0.2 -0.5 0.5 -1.9
Medication for cholesterol 1.8 2.8 6.7 -0.2 2.6 0.9 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 0.4 0.7 -0.3 -0.7
Back pain experienced in last month 0.2 0.3 0.6 -0.8 -0.0 0.5 -0.3
Mineral and other dietary supplements 0.6 0.7 1.8 -0.2 0.4 -1.0 1.4
Breast cancer (self-reported) 1.3 1.6 4.2 -0.4 0.9 2.1 -1.1
Asthma (self-reported) 0.1 0.2 0.5 0.7 -0.2 -0.7 0.1
Osteoporosis (self-reported) 1.9 2.4 6.9 0.2 -2.6 -0.3 -1.6
Osteoarthritis (self-reported) 2.1 2.7 6.2 -2.5 -1.2 -1.6 0.7
Medication: Aspirin 0.5 0.7 2.8 0.0 -1.7 0.0 0.0
Medication: Gliclazide 0.9 1.0 3.1 -0.2 -1.8 -0.3 -1.0
Illnesses of father: None of the above (group 1) 1.2 1.5 3.6 -0.6 1.9 -0.6 1.3
Smoking status: Current 0.5 0.8 1.9 -1.4 -1.1 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 3.8 -0.3 -2.0 -0.2 -1.5
Whole body water mass 2.2 12.5 22.9 -2.1 -4.8 -0.3 -4.8
Leg predicted mass (right) 1.6 8.4 12.7 -2.9 -3.6 -1.7 -3.1
Arm fat mass (left) 10.2 41.8 92.2 -7.4 -4.5 -9.6 -0.1
Number of self-reported non-cancer illnesses 1.3 2.3 5.2 -0.1 -2.3 0.2 -2.0
Average weekly champagne plus white wine intake 0.6 0.8 1.6 -0.3 1.2 1.3 -0.3
Miserableness 1.4 2.5 5.1 -2.3 -0.8 -2.0 -0.4
Guilty feelings 1.2 1.7 3.6 -1.5 0.9 -1.9 -0.4
Wears glasses or contact lenses 1.1 1.3 3.0 -0.2 -1.0 1.0 -1.7
Ever taken oral contraceptive pill 0.6 0.6 1.2 -1.1 0.9 0.2 -0.7
Hearing aid user 2.2 2.5 5.4 -2.1 -0.3 -2.3 -0.1
Mother’s age at death 0.7 0.8 2.3 -0.6 1.5 0.2 0.8
Financial situation satisfaction 0.4 0.5 1.3 -0.7 0.2 1.1 -0.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 -1.0 -0.5 -1.1 0.2
Commuting to job workplace: Public transport 2.3 2.8 7.5 -1.6 2.7 0.6 0.8
Eye problems/disorders: Glaucoma 0.2 0.2 0.6 -0.5 0.0 -0.8 -0.3
Medication: Blood pressure 4.7 9.0 17.1 1.6 -4.0 0.2 -4.1
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.6 -0.0 -1.6 0.6 -1.1
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.6 1.0 -0.2 1.3 -0.3
High cholesterol (Self-reported) 0.1 0.1 0.3 -0.1 0.2 -0.5 -0.4
Medication: Bendroflumethiazide 5.3 8.0 19.8 0.4 -3.4 -0.8 -4.5
Medication: Paracetamol 1.4 2.2 4.1 -2.0 -1.2 0.6 -1.7
Medication: Lisinopril 3.6 4.7 11.3 1.4 -3.4 0.1 -2.3
Medication: Atorvastatin 0.6 0.7 1.0 -1.0 0.4 -0.9 0.8
Illnesses of father: High blood pressure 9.2 11.3 24.4 0.8 -4.0 2.1 -4.9
Alcohol drinker status: Never 1.7 2.0 5.8 -0.5 1.1 -0.9 2.4
Ever smoked 2.5 4.5 12.7 -3.6 -1.2 -1.2 -1.5
Basal metabolic rate 2.4 13.5 25.1 -2.8 -5.0 -1.7 -4.3
Leg fat percentage (left) 11.6 41.9 102.0 -7.2 -3.1 -10.1 2.0
Arm fat-free mass (left) 2.7 13.4 23.9 -2.6 -4.8 -0.6 -4.9
Number of operations (self-reported) 3.6 5.4 10.8 -2.0 -3.3 -1.1 -2.4
Average weekly beer plus cider intake 0.3 0.5 1.6 -1.2 0.1 0.5 -0.2
Irritability 0.4 0.6 1.9 -1.4 0.5 -0.6 -0.2
Risk taking 0.4 0.6 1.4 1.0 0.1 -1.2 0.1
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.6 0.6 1.3 1.2 0.7
Fractured/broken bones in last 5 years 0.4 0.5 1.0 0.0 -0.3 0.8 -1.0
Age started oral contraceptive pill 0.6 0.7 1.7 -0.1 1.3 -0.2 1.0
Diastolic blood pressure, automated reading 2.6 8.2 17.9 0.5 -3.5 1.6 -4.2
Ever depressed for a whole week 0.9 1.1 2.2 -1.5 0.5 -1.2 0.5
Unable to work because of sickness or disability 0.8 1.1 1.7 -0.9 -1.0 -1.3 -0.9
Commuting to job workplace: Cycle 1.4 1.7 2.5 1.2 1.4 -1.6 0.9
Myopia 2.6 3.7 10.8 1.1 -0.8 3.3 -1.5
Vascular/heart problems diagnosed by doctor 5.3 14.4 32.2 -1.1 5.7 0.5 4.9
Cholesterol lowering medication 0.9 1.3 2.5 0.8 -1.6 -0.1 -1.5
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 5.0 1.4 -1.1 1.2 -2.2
Pain experienced in last month 0.2 0.3 1.1 1.1 0.0 0.1 -0.1
Supplements: Calcium 0.8 0.8 1.9 0.6 1.4 0.9 -0.6
Basal cell carcinoma (self-reported) 0.7 0.9 2.8 -0.3 0.7 1.7 -0.2
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.0 -1.4 -1.4 -0.9 1.7
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 2.5 1.4 0.3 0.6 1.6
Heart disease (siblings) 0.8 1.0 1.5 -1.2 0.9 -1.0 0.9
Alcohol drinker status: Previous 1.2 1.4 4.8 0.2 -0.8 -2.2 0.2
Pack years of smoking 1.1 1.6 4.3 -2.1 -0.5 -1.3 0.4
Impedance of whole body 2.5 13.0 27.5 4.6 1.6 5.2 -0.7
Leg fat mass (left) 9.0 35.3 76.4 -7.1 -3.7 -8.7 0.4
Arm predicted mass (left) 2.8 14.2 26.8 -2.2 -5.0 -0.4 -5.2