Hub : Genes

EFR3B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0407	0.0200	0.00710	-0.002	0.001	0.000	0.003	-0.001	7.6e-01	2.5e-01	3.6e-01	9.7e-02	6.6e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.0732	0.0275	0.00059	0.026	0.033	0.022	0.033	0.021	2.4e-04	3.6e-05	7.2e-04	3.5e-05	8.1e-04
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0319	0.0161	0.00130	0.048	0.015	0.036	NA	0.041	3.6e-06	7.2e-03	6.3e-05	NA	1.9e-05
4	TCGA	Pancreatic Adenocarcinoma	0.2570	0.1220	0.00880	0.014	0.001	0.041	NA	0.050	8.0e-02	2.7e-01	7.9e-03	NA	3.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.9	3.0	7.1	0.1	-2.7	-0.1	-2.2
Bipolar Disorder or Schizophrenia	0.7	1.7	2.9	-0.9	0.7	1.6	-1.7
Depressed Affect (Nagel 2018)	0.6	1.2	4.1	-0.4	-0.4	-2.0	0.6
Depression (Nagel 2018)	0.3	0.5	1.2	0.5	-0.5	-1.1	-0.6
Intelligence (Savage-Jansen 2018)	1.5	4.6	11.2	-1.7	-1.4	-3.3	1.6
Neuroticism (Nagel 2018)	0.4	1.0	3.3	0.5	1.8	0.6	-0.0
Schizophrenia (2018)	1.9	3.9	9.1	-1.3	3.0	2.2	-0.4
Schizophrenia vs Biploar Disorder	3.5	4.6	13.7	-0.4	3.7	1.8	1.1
Worry (Nagel 2018)	2.7	5.7	9.6	2.2	2.8	3.1	-0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.5	-0.4	0.6	-0.1
Alzheimer’s Disease (in father)	2.4	2.6	7.8	0.2	2.8	0.2	1.6
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	-0.8	0.9	0.7	0.5
Crohns Disease (2017)	3.6	7.8	15.5	-3.2	-1.6	-3.9	1.8
Irritable Bowel Disease (IBD)	2.7	6.4	11.5	-3.3	-1.1	-3.4	1.5
Ulcerative Colitis (UC)	0.7	1.3	3.3	-1.8	-0.1	-1.3	0.5
Major Depression (MDD)	1.6	2.0	4.5	0.9	-0.6	-2.1	1.5
Reaction Time	1.0	1.9	7.7	0.1	0.0	2.8	0.2
Verbal and Numeric Reasoning (VNR)	1.6	3.9	12.2	-0.8	-1.3	-3.5	1.1
Breast Cancer	4.0	9.5	24.3	-2.4	-1.4	-4.9	2.5
Ovarian Cancer	1.3	1.7	4.6	2.1	-1.0	0.1	-1.1
Prostate Cancer	0.3	0.4	0.8	-0.9	-0.8	0.3	-0.2
Age at First Birth	0.7	1.0	2.9	0.4	1.7	0.4	0.8
Bipolar Disorder (2011)	1.5	1.4	4.3	-0.2	-1.1	-0.1	-2.1
Body Mass Index (BMI) (2010)	3.3	4.5	8.3	-2.9	-0.5	-2.9	1.1
Coronary Artery Disease (CAD)	0.7	0.8	1.6	0.6	-0.0	-1.3	1.2
Crohns Disease (2012)	1.8	2.8	6.0	-2.5	-1.0	-1.9	0.8
Mean Putamen Volume	0.2	0.2	0.3	0.4	-0.5	0.2	-0.5
Fasting Glucose	3.2	3.9	9.8	1.4	3.1	1.4	1.4
HbA1C	0.5	0.5	1.1	-1.1	-0.7	-0.4	0.5
HDL Cholesterol	0.6	1.1	3.2	0.6	-0.1	1.8	-0.8
LDL Cholesterol	0.6	1.0	1.8	0.1	1.1	-1.3	1.1
Lupus	0.4	0.7	1.1	0.9	0.2	-0.8	-1.1
Neuroticism (2016)	1.7	2.4	4.0	1.9	1.2	2.0	-0.6
Primary Biliary Cirrhosis	2.5	3.6	8.7	-0.3	-2.3	-3.0	0.6
Rheumatoid Arthritis	1.2	1.6	3.8	-0.2	0.1	-1.6	1.9
Schizophrenia (2014)	1.5	3.3	4.8	-1.6	2.2	2.1	-1.0
Triglycerides	0.3	0.5	1.4	0.7	-0.2	1.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	0.1	-0.9	0.1	-0.1
Ulcerative Colitis	1.2	1.8	2.6	-1.4	1.1	-1.6	1.2
Blood Eosinophil Count	0.3	2.5	7.6	0.2	-1.4	-2.8	-0.5
Blood Platelet Count	0.3	3.8	6.4	1.2	1.3	-2.4	2.5
Blood Red Count	0.7	6.5	8.7	2.7	-2.9	-1.1	-3.0
Blood White Count	1.0	7.1	17.0	-2.2	-4.1	-2.0	-1.7
Heel T-Score	1.0	8.1	13.8	-2.5	3.7	-1.9	3.0
BMI	14.5	84.1	187.7	-11.4	-2.9	-13.7	3.3
Height	8.1	156.5	299.3	9.2	-7.1	17.3	-13.8
Waist Hip Ratio (WHR)	3.4	15.3	27.5	3.3	-3.2	3.5	-5.2
Systolic Blood Pressure	7.6	37.9	58.1	5.4	-5.1	6.2	-7.6
Smoking Status	1.7	4.0	12.8	-3.6	-0.4	-1.7	0.5
Allergy or Eczema	2.2	5.7	12.0	-3.5	3.0	1.2	0.1
Cardiovascular Disease	4.5	14.8	33.2	0.4	-5.8	-0.5	-5.0
Hypothyroidism (self reported)	0.6	1.4	2.9	-1.2	-1.7	-1.1	-0.4
Respiratory disease	0.2	0.5	1.6	0.0	1.3	0.0	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-0.2	-0.5	-0.9	-0.7
Lung FEV1/FVC ratio	1.7	8.5	22.3	-1.9	-0.8	-4.7	2.8
Lung FVC	1.4	7.3	14.5	-0.4	-3.8	1.2	-3.6
Neuroticism	0.4	0.9	2.8	0.3	0.3	-1.7	-0.7
Chronotype (morning person)	2.8	6.5	11.3	3.2	-0.7	3.4	-2.1
Hair Pigment	0.4	10.3	28.6	0.1	-1.0	-5.3	3.4
Tanning	1.3	15.7	44.2	4.2	-0.1	6.7	-0.8
Hand grip strength (left)	2.9	7.7	16.3	1.6	-1.4	4.0	-3.1
Number of treatments/medications taken	1.8	3.3	5.3	-1.8	-2.3	-0.2	-2.1
Average weekly spirits intake	1.8	2.2	4.5	-1.0	-2.1	-1.8	0.0
Sensitivity / hurt feelings	0.7	1.2	3.0	-0.3	0.6	-1.7	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	-0.6	-1.3	-0.3	-1.1
Hearing difficulty/problems: Yes	2.0	3.0	10.3	-3.2	1.1	-0.6	-0.5
Relative age of first facial hair	1.7	3.6	9.6	-0.3	1.6	-1.4	3.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.6	-0.8	0.2	-0.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.1	1.3	0.1	1.5	-1.4
Ever had hysterectomy (womb removed)	1.5	1.7	3.7	-0.7	-1.9	-0.2	-1.5
Systolic blood pressure, automated reading	4.5	13.2	27.0	2.1	-3.7	2.9	-5.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.3	-0.1	-0.2	-1.5	-0.6
Angina	2.5	3.2	4.9	-1.8	-2.2	-1.6	1.5
Medication for hormone replacement therapy	0.3	0.4	0.8	-0.6	0.9	0.5	0.1
Vitamin and mineral supplements	1.0	1.3	3.1	0.3	0.4	-1.8	1.4
Supplements: Zinc	0.1	0.1	0.2	-0.1	0.4	-0.0	0.2
Medication: Co-codamol	0.6	0.7	1.6	-1.3	-0.7	0.9	-0.1
Medication: Metformin	0.5	0.7	1.8	-0.7	0.1	-1.4	-0.5
Diabetes (father)	2.1	2.6	4.8	1.6	-1.6	2.2	-0.6
Diabetes (mother)	0.6	0.7	1.0	0.9	0.7	1.0	-0.7
Severe depression (siblings)	0.6	0.7	2.3	-1.5	-0.0	0.0	-0.6
Pack years adult smoking proportion	1.2	1.9	5.2	-2.3	-0.8	-1.3	0.2
Impedance of leg (right)	2.9	13.8	29.4	4.9	0.7	5.4	-1.3
Leg fat-free mass (left)	1.9	9.9	14.6	-3.2	-3.8	-2.4	-3.0
Trunk fat percentage	6.8	27.2	65.6	-5.7	-3.3	-8.1	0.2
Hand grip strength (right)	2.9	7.9	17.5	0.8	-1.5	4.2	-3.3
Townsend deprivation index at recruitment	1.0	1.4	2.7	-0.8	-1.4	-0.6	-1.6
Current tobacco smoking	0.7	1.1	2.3	-1.5	-1.1	-0.8	-0.4
Average weekly fortified wine intake	0.9	1.1	2.1	0.3	1.4	-0.3	1.4
Maternal smoking around birth	0.3	0.4	1.2	0.6	1.1	-0.4	-0.3
Fed-up feelings	0.9	1.6	3.7	-1.9	0.6	-1.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	0.3	-0.5	-0.3	-1.1
Relative age voice broke	0.8	1.2	3.1	-0.2	1.1	-0.6	1.8
Taking other prescription medications	0.2	0.3	1.0	-0.5	-1.0	-0.0	-0.2
Age when periods started (menarche)	1.0	2.3	7.1	1.3	0.4	2.7	-0.4
Bilateral oophorectomy (both ovaries removed)	2.4	2.7	6.6	-0.1	-2.6	0.3	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.7	-1.9	1.3	-0.5	1.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	0.1	0.4	-0.9	0.5
Qualifications: CSEs or equivalent	0.7	1.0	1.1	-0.9	-1.1	-1.0	1.0
Serious illness, injury or assault to yourself	0.4	0.4	1.6	-0.4	-0.0	0.0	1.3
High blood pressure	6.8	18.8	36.0	1.9	-6.0	-0.2	-6.0
Hayfever, allergic rhinitis or eczema	2.2	4.9	11.6	-2.5	3.4	1.3	0.2
Multivitamins +/- minerals	0.8	1.0	3.1	0.6	0.4	1.8	-0.8
Stomach or abdominal pain in last month	0.5	0.6	2.1	-1.5	0.3	0.1	-0.1
Supplements: Glucosamine	0.9	1.2	2.2	-0.6	-1.5	0.2	-1.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.2	0.2	0.5	0.5
Medication: Atenolol	4.7	5.9	13.0	-0.3	-3.6	-1.8	-2.7
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.3	-0.2	0.8	0.4
Sitting height	5.2	37.0	94.7	5.9	1.3	9.7	-4.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	0.4	0.3	-0.8	-0.3
High blood pressure (mother)	4.3	6.1	14.9	-0.4	-3.9	-0.1	-3.0
Body mass index (BMI)	13.2	56.0	134.6	-8.6	-3.5	-11.6	2.0
Impedance of leg (left)	3.1	14.8	33.5	4.8	0.9	5.8	-1.4
Leg predicted mass (left)	1.9	9.9	14.5	-3.3	-3.8	-2.4	-2.9
Trunk fat mass	5.9	25.4	52.7	-5.6	-4.1	-7.3	-1.0
Waist circumference	7.1	26.2	50.1	-5.5	-4.7	-7.1	-1.4
Number of incorrect matches in round	2.9	4.8	11.9	1.7	1.0	3.5	-1.8
Past tobacco smoking	2.7	4.9	12.4	3.5	1.0	2.5	0.6
Alcohol usually taken with meals	0.3	0.4	1.1	0.7	0.2	1.1	-0.3
Nervous feelings	2.6	4.9	11.8	1.0	3.4	2.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.3	0.2	-1.8	1.2	-1.2
Hearing difficulty/problems with background noise	2.4	3.8	5.8	-2.4	1.9	1.7	-1.7
Hair/balding pattern: Pattern 2	1.5	2.0	5.2	-0.0	-2.3	-1.5	0.6
Had menopause	1.2	1.4	2.4	1.3	-0.6	1.6	-1.1
Had other major operations	0.9	1.1	2.0	-1.4	-1.0	-1.0	-0.8
Forced vital capacity (FVC)	5.5	21.1	32.8	3.2	-3.2	5.7	-5.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.7	-1.6	-0.6	-0.2	0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.9	-1.7	0.5	-1.1	0.8
Qualifications: None of the above	0.2	0.3	1.1	-1.1	-0.1	-0.5	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.9	-0.4	0.2	-0.3
Mouth/teeth dental problems	1.0	1.5	3.7	1.0	-0.9	1.9	0.5
Heart attack	1.5	2.0	2.7	-1.5	-1.4	-1.0	1.7
Allergy	1.1	2.6	7.7	0.8	-2.8	-1.4	-0.2
Pain all over the body in last month	1.3	1.4	3.7	-0.7	-0.4	1.1	-1.9
Diabetes (self-reported)	0.3	0.5	1.5	-0.5	0.5	-1.2	-0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.1	0.3	1.5	1.2	-1.3
Medication: Ramipril	4.4	5.6	11.2	-0.1	-3.3	-1.4	-3.1
Medication: Simvastatin	0.3	0.5	0.7	0.5	-0.6	-0.7	-0.8
Fluid intelligence score	1.7	3.6	8.8	0.0	1.2	-3.0	2.0
Illnesses of siblings	1.6	2.3	4.8	1.1	1.8	0.0	2.2
Neuroticism score	0.3	0.7	1.9	-0.3	0.9	-1.4	-0.1
Weight	4.5	22.2	30.3	-5.0	-5.2	-5.5	-2.6
Impedance of arm (right)	1.4	6.4	13.0	3.1	1.4	3.6	-0.8
Arm fat percentage (right)	13.6	53.7	132.2	-8.3	-3.2	-11.5	1.7
Trunk fat-free mass	2.6	15.0	31.4	-1.0	-5.2	0.9	-5.6
Hip circumference	6.5	27.9	54.2	-7.0	-2.9	-7.4	0.6
Time employed in main current job	3.7	4.2	8.4	2.9	-0.1	2.9	-0.4
Alcohol intake versus 10 years previously	0.7	1.0	2.7	-0.6	-0.2	1.6	-1.0
Father’s age at death	0.4	0.5	1.7	-0.2	0.4	1.3	0.3
Worrier / anxious feelings	3.1	5.8	10.5	1.6	3.2	3.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.8	-1.9	-0.5	-1.0	-1.0
Falls in the last year	0.2	0.3	0.9	0.1	0.3	0.4	-0.9
Hair/balding pattern: Pattern 3	2.3	3.4	6.6	0.5	1.6	2.6	-2.0
Number of live births	0.7	1.0	2.8	0.3	-1.7	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1)	3.4	11.5	16.7	2.6	-2.9	3.7	-4.1
Pulse rate	0.6	1.0	2.8	0.2	1.1	-0.2	-1.7
Happiness	1.2	1.5	2.1	-1.5	-0.7	1.3	-1.2
Noisy workplace	0.4	0.5	1.6	0.2	0.5	1.3	0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.1	1.5	0.1	1.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	7.2	-2.7	1.5	-0.9	2.0
Mouth/teeth dental problems: Dentures	1.0	1.8	6.3	0.2	0.7	-2.5	0.6
Asthma	0.1	0.2	0.4	0.6	-0.5	-0.4	0.0
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.5	11.2	-0.4	-2.5	0.9	-3.3
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.5	-0.1	-0.6	-0.3
Depression (self-reported)	0.3	0.3	0.7	0.8	-0.7	0.0	-0.2
Medication: Lansoprazole	0.6	0.7	1.8	-0.1	-0.5	-0.9	1.3
Prospective memory result	0.6	0.8	2.4	-0.1	-0.9	1.5	-0.1
Lung cancer (father)	0.9	1.1	3.6	0.5	-1.9	0.5	-0.4
Illnesses of mother	4.1	5.1	11.0	0.7	3.3	-0.5	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.8	12.4	2.5	-3.5	3.0	-3.5
Pulse wave Arterial Stiffness index	1.3	1.5	4.3	-0.9	-2.1	-0.3	-1.0
Impedance of arm (left)	1.2	5.4	11.2	3.1	0.9	3.4	-0.5
Arm fat mass (right)	9.9	40.8	92.5	-7.2	-4.3	-9.6	-0.2
Trunk predicted mass	2.7	15.5	32.7	-1.1	-5.2	1.0	-5.7
Standing height	7.8	77.8	146.4	6.9	-4.3	12.1	-10.0
Length of working week for main job	0.4	0.4	1.0	1.0	0.3	-0.6	-0.5
Exposure to tobacco smoke at home	1.1	1.3	3.6	0.6	-0.3	1.9	-0.9
Breastfed as a baby	1.4	1.8	4.9	0.9	-0.9	2.2	-0.8
Tense / ‘highly strung’	1.3	2.2	4.6	1.2	0.4	2.2	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	0.2	0.4	-1.2	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	-0.4	0.5	-1.2	0.2
Birth weight of first child	1.8	3.3	8.9	0.9	-0.6	3.0	-1.8
Peak expiratory flow (PEF)	1.1	2.6	4.4	1.5	-0.7	1.8	-2.1
Pulse wave reflection index	0.5	0.6	1.6	-0.6	-1.3	0.5	-0.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.6	-0.4	-0.1	1.6	0.3
Loud music exposure frequency	1.3	1.4	4.5	0.4	1.0	2.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.5	0.6	-1.2	0.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.5	-0.5	0.2	-1.6	0.3
Blood clot in the leg (DVT)	0.9	1.2	3.6	0.9	0.3	0.3	1.9
Medication: Paracetamol	0.9	1.4	2.6	-1.4	-1.0	0.5	-1.6
Headache pain in last month	0.3	0.5	1.1	-0.5	0.2	0.8	-1.0
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	5.7	0.9	2.4	0.3	2.2
Glaucoma (self-reported)	0.5	0.6	1.5	-0.9	0.1	-1.2	-0.3
Gout (self-reported)	1.3	1.8	6.1	-2.5	0.7	0.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.8	-1.7	-1.1	-0.3	0.4
Medication: Amlodipine	2.0	2.8	6.7	0.4	-1.9	-0.7	-2.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.7	0.8	-0.9	0.1	-0.7
Birth weight	1.0	2.2	4.5	1.6	-0.8	-1.0	-2.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.9	-0.6	0.4	0.1	-2.0
High blood pressure (siblings)	3.6	5.2	10.3	-0.4	-3.2	0.5	-3.2
Forced vital capacity (FVC), Best measure	5.1	18.7	27.4	3.0	-3.8	4.9	-5.2
Body fat percentage	9.8	38.8	95.6	-6.9	-3.3	-9.8	1.2
Leg fat percentage (right)	11.8	42.7	104.0	-7.2	-3.2	-10.2	2.0
Arm fat-free mass (right)	2.1	10.7	19.4	-2.1	-4.4	-0.2	-4.4
Exposure to tobacco smoke outside home	2.2	3.0	8.0	-1.1	-1.6	-2.8	0.2
Comparative body size at age 10	39.4	108.8	292.4	-9.5	-4.9	-17.1	5.3
Number of full brothers	1.4	1.7	4.0	-1.6	2.0	0.2	-0.4
Worry too long after embarrassment	0.8	1.4	3.7	0.4	1.9	-0.8	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.4	1.1	1.6	0.2	0.6
Wheeze or whistling in the chest in last year	1.1	1.9	3.6	-1.7	-1.0	-0.3	-1.9
Number of children fathered	1.4	1.6	4.4	1.4	-2.1	0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.9	12.2	1.4	-0.6	3.5	-0.9
Age at first live birth	1.1	1.9	4.6	0.0	2.1	1.7	0.4
Pulse wave peak to peak time	1.3	1.6	3.4	1.3	1.8	1.1	0.3
Health satisfaction	0.1	0.1	0.3	-0.5	-0.0	-0.0	0.6
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.8	-0.3	-0.2	-0.0
Qualifications: College or University degree	0.7	2.3	3.1	1.5	1.8	1.8	-0.6
Eye problems/disorders: None of the above	1.0	1.1	4.0	-0.1	0.2	2.0	0.7
Mouth/teeth dental problems: Loose teeth	4.3	5.0	13.5	-2.3	0.8	-3.7	1.0
Emphysema/chronic bronchitis	1.1	1.2	3.2	-1.3	0.1	1.8	-0.1
Medication for pain relief, constipation, heartburn	2.0	3.5	6.0	1.5	2.5	-0.3	2.4
Neck or shoulder pain in last month	0.5	0.6	1.9	-0.1	0.3	-0.8	1.4
Medication: Blood pressure	4.9	8.6	22.2	0.2	-4.7	-0.5	-3.4
Angina (self-reported)	2.6	3.4	3.8	-1.7	-1.8	-1.9	1.9
Migraine (self-reported)	0.3	0.4	0.9	-1.0	-0.1	-0.7	0.4
Medication: Ibuprofen	3.0	3.5	8.1	-0.7	-2.3	0.7	-2.8
Medication: Allopurinol	0.6	0.8	3.2	-1.8	0.2	0.1	0.2
Medication: Omeprazole	1.8	2.2	3.3	1.6	-1.5	0.8	-1.8
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.5	-0.5	-0.4	0.2
Mean time to correctly identify matches	0.8	1.5	4.3	1.0	0.7	2.1	0.4
Heart disease (mother)	3.5	4.3	14.2	-1.2	-3.8	-0.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.4	2.1	1.7	1.5	-0.2
Whole body fat mass	7.6	31.8	68.7	-6.5	-4.0	-8.3	-0.5
Leg fat mass (right)	9.3	36.0	78.3	-7.1	-3.8	-8.8	0.4
Arm predicted mass (right)	2.2	11.3	21.5	-2.0	-4.6	-0.5	-4.4
Pulse rate, automated reading	0.3	1.1	3.8	0.3	0.7	-0.0	-2.0
Alcohol intake frequency.	0.7	1.7	5.2	-0.6	-0.2	-2.3	1.1
Comparative height size at age 10	7.2	39.8	63.2	5.5	-3.5	7.3	-8.0
Number of full sisters	1.4	1.7	6.6	-2.6	-0.3	0.0	0.2
Suffer from ‘nerves’	1.3	2.1	3.0	1.7	0.9	1.6	-1.4
Overall health rating	1.2	2.7	7.1	-2.7	-0.9	-0.2	-1.7
Chest pain or discomfort	0.6	0.8	2.9	-1.7	-0.0	0.4	0.5
Had major operations	0.2	0.2	0.7	-0.8	0.3	-0.1	0.2
Age at last live birth	1.4	2.1	5.5	-0.2	1.4	2.4	-0.8
Family relationship satisfaction	1.1	1.4	4.2	0.7	0.8	2.0	-0.4
Leg pain on walking	1.3	1.6	4.1	-2.0	-0.9	-0.8	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.8	2.4	0.1	-0.0	1.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.6	-0.5	-1.6	-0.9	0.2
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	7.1	2.7	-0.4	0.9	-2.0
Medication: Aspirin	0.4	0.6	1.9	-0.4	-1.4	-0.5	0.2
Supplements: Vitamin C	0.1	0.2	0.3	0.0	-0.2	0.6	-0.5
Knee pain experienced in last month	0.8	1.2	2.4	-1.6	-1.1	-0.9	-0.7
Hypertension (Self-reported)	7.2	19.9	39.9	1.8	-6.3	-0.1	-6.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.4	-1.8	-1.4	-0.9	-0.1
Illnesses of father: Heart disease	1.0	1.4	1.8	-1.2	-1.0	-1.2	1.3
Illnesses of siblings: Diabetes	0.4	0.5	1.6	1.3	0.1	0.6	-0.0
Smoking status: Previous	2.3	3.5	7.2	-2.6	-0.3	-2.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.1	10.8	3.1	-0.8	3.3	-2.8
Whole body fat-free mass	2.1	12.1	22.1	-2.1	-4.7	-0.3	-4.7
Leg fat-free mass (right)	1.6	8.6	12.6	-3.0	-3.5	-1.8	-3.1
Arm fat percentage (left)	14.0	55.9	139.2	-8.3	-3.3	-11.8	2.0
Average weekly red wine intake	1.7	2.5	7.3	-0.7	-2.7	-1.1	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.6	0.8	1.3	-0.2	0.9
Mood swings	0.3	0.6	1.7	0.1	-0.0	-1.3	0.7
Loneliness, isolation	0.8	1.1	2.9	-0.9	-0.6	-1.7	0.7
Long-standing illness, disability or infirmity	1.3	1.9	7.4	-2.7	-0.4	-0.3	0.0
Ever had bowel cancer screening	1.2	1.4	2.9	1.7	0.9	1.1	-0.9
Diabetes diagnosed by doctor	0.4	0.7	2.6	-0.5	0.0	-1.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	5.2	-2.3	0.7	1.0	-1.1
Friendships satisfaction	0.8	1.0	2.5	-0.7	0.7	1.6	0.6
Qualifications: nursing, teaching	0.3	0.5	1.8	0.2	0.2	0.1	1.3
Commuting to job workplace: Walk	1.0	1.1	2.9	0.8	1.7	0.8	-0.1
Eye problems/disorders: Cataract	0.4	0.4	1.1	0.6	0.3	-0.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.7	-0.2	-0.5	0.5	-1.9
Medication for cholesterol	1.8	2.8	6.7	-0.2	2.6	0.9	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.4	0.7	-0.3	-0.7
Back pain experienced in last month	0.2	0.3	0.6	-0.8	-0.0	0.5	-0.3
Mineral and other dietary supplements	0.6	0.7	1.8	-0.2	0.4	-1.0	1.4
Breast cancer (self-reported)	1.3	1.6	4.2	-0.4	0.9	2.1	-1.1
Asthma (self-reported)	0.1	0.2	0.5	0.7	-0.2	-0.7	0.1
Osteoporosis (self-reported)	1.9	2.4	6.9	0.2	-2.6	-0.3	-1.6
Osteoarthritis (self-reported)	2.1	2.7	6.2	-2.5	-1.2	-1.6	0.7
Medication: Aspirin	0.5	0.7	2.8	0.0	-1.7	0.0	0.0
Medication: Gliclazide	0.9	1.0	3.1	-0.2	-1.8	-0.3	-1.0
Illnesses of father: None of the above (group 1)	1.2	1.5	3.6	-0.6	1.9	-0.6	1.3
Smoking status: Current	0.5	0.8	1.9	-1.4	-1.1	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.8	-0.3	-2.0	-0.2	-1.5
Whole body water mass	2.2	12.5	22.9	-2.1	-4.8	-0.3	-4.8
Leg predicted mass (right)	1.6	8.4	12.7	-2.9	-3.6	-1.7	-3.1
Arm fat mass (left)	10.2	41.8	92.2	-7.4	-4.5	-9.6	-0.1
Number of self-reported non-cancer illnesses	1.3	2.3	5.2	-0.1	-2.3	0.2	-2.0
Average weekly champagne plus white wine intake	0.6	0.8	1.6	-0.3	1.2	1.3	-0.3
Miserableness	1.4	2.5	5.1	-2.3	-0.8	-2.0	-0.4
Guilty feelings	1.2	1.7	3.6	-1.5	0.9	-1.9	-0.4
Wears glasses or contact lenses	1.1	1.3	3.0	-0.2	-1.0	1.0	-1.7
Ever taken oral contraceptive pill	0.6	0.6	1.2	-1.1	0.9	0.2	-0.7
Hearing aid user	2.2	2.5	5.4	-2.1	-0.3	-2.3	-0.1
Mother’s age at death	0.7	0.8	2.3	-0.6	1.5	0.2	0.8
Financial situation satisfaction	0.4	0.5	1.3	-0.7	0.2	1.1	-0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-1.0	-0.5	-1.1	0.2
Commuting to job workplace: Public transport	2.3	2.8	7.5	-1.6	2.7	0.6	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.5	0.0	-0.8	-0.3
Medication: Blood pressure	4.7	9.0	17.1	1.6	-4.0	0.2	-4.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.6	-0.0	-1.6	0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	1.0	-0.2	1.3	-0.3
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.1	0.2	-0.5	-0.4
Medication: Bendroflumethiazide	5.3	8.0	19.8	0.4	-3.4	-0.8	-4.5
Medication: Paracetamol	1.4	2.2	4.1	-2.0	-1.2	0.6	-1.7
Medication: Lisinopril	3.6	4.7	11.3	1.4	-3.4	0.1	-2.3
Medication: Atorvastatin	0.6	0.7	1.0	-1.0	0.4	-0.9	0.8
Illnesses of father: High blood pressure	9.2	11.3	24.4	0.8	-4.0	2.1	-4.9
Alcohol drinker status: Never	1.7	2.0	5.8	-0.5	1.1	-0.9	2.4
Ever smoked	2.5	4.5	12.7	-3.6	-1.2	-1.2	-1.5
Basal metabolic rate	2.4	13.5	25.1	-2.8	-5.0	-1.7	-4.3
Leg fat percentage (left)	11.6	41.9	102.0	-7.2	-3.1	-10.1	2.0
Arm fat-free mass (left)	2.7	13.4	23.9	-2.6	-4.8	-0.6	-4.9
Number of operations (self-reported)	3.6	5.4	10.8	-2.0	-3.3	-1.1	-2.4
Average weekly beer plus cider intake	0.3	0.5	1.6	-1.2	0.1	0.5	-0.2
Irritability	0.4	0.6	1.9	-1.4	0.5	-0.6	-0.2
Risk taking	0.4	0.6	1.4	1.0	0.1	-1.2	0.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.6	0.6	1.3	1.2	0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.0	0.0	-0.3	0.8	-1.0
Age started oral contraceptive pill	0.6	0.7	1.7	-0.1	1.3	-0.2	1.0
Diastolic blood pressure, automated reading	2.6	8.2	17.9	0.5	-3.5	1.6	-4.2
Ever depressed for a whole week	0.9	1.1	2.2	-1.5	0.5	-1.2	0.5
Unable to work because of sickness or disability	0.8	1.1	1.7	-0.9	-1.0	-1.3	-0.9
Commuting to job workplace: Cycle	1.4	1.7	2.5	1.2	1.4	-1.6	0.9
Myopia	2.6	3.7	10.8	1.1	-0.8	3.3	-1.5
Vascular/heart problems diagnosed by doctor	5.3	14.4	32.2	-1.1	5.7	0.5	4.9
Cholesterol lowering medication	0.9	1.3	2.5	0.8	-1.6	-0.1	-1.5
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	5.0	1.4	-1.1	1.2	-2.2
Pain experienced in last month	0.2	0.3	1.1	1.1	0.0	0.1	-0.1
Supplements: Calcium	0.8	0.8	1.9	0.6	1.4	0.9	-0.6
Basal cell carcinoma (self-reported)	0.7	0.9	2.8	-0.3	0.7	1.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.0	-1.4	-1.4	-0.9	1.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.5	1.4	0.3	0.6	1.6
Heart disease (siblings)	0.8	1.0	1.5	-1.2	0.9	-1.0	0.9
Alcohol drinker status: Previous	1.2	1.4	4.8	0.2	-0.8	-2.2	0.2
Pack years of smoking	1.1	1.6	4.3	-2.1	-0.5	-1.3	0.4
Impedance of whole body	2.5	13.0	27.5	4.6	1.6	5.2	-0.7
Leg fat mass (left)	9.0	35.3	76.4	-7.1	-3.7	-8.7	0.4
Arm predicted mass (left)	2.8	14.2	26.8	-2.2	-5.0	-0.4	-5.2