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chr3:47,204,518-50,085,153

Best TWAS P=3.24e-10 · Best GWAS P=1.12e-08 conditioned to 0.378

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ZNF589	0.15	0.14	bslmm	254	0.16	1.3e-19	-4.7	-5.2	2.2e-07	0.89	0.45	0.54	FALSE
2	GTEx	Adrenal Gland	NME6	0.12	0.07	lasso	9	0.08	6.1e-04	-5.7	5.6	2.3e-08	-0.97	0.04	0.89	FALSE
3	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	-4.3	5.3	1.2e-07	-0.16	0.09	0.81	FALSE
4	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	4.2	5.7	9.1e-09	-0.12	0.07	0.55	TRUE
5	GTEx	Breast Mammary Tissue	NME6	0.11	0.08	enet	21	0.12	5.6e-07	-4.9	5.2	2.0e-07	-0.70	0.25	0.61	FALSE
6	GTEx	Breast Mammary Tissue	FCF1P2	0.07	0.04	lasso	7	0.02	5.1e-02	-5.7	5.7	1.2e-08	-1.00	0.01	0.96	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ZNF589	0.29	0.21	lasso	8	0.20	1.3e-06	-4.7	-5.2	2.2e-07	0.91	0.11	0.87	FALSE
8	GTEx	Breast Mammary Tissue (Female)	NME6	0.05	-0.01	lasso	2	0.03	3.5e-02	-4.9	6.3	3.2e-10	-0.70	0.04	0.22	TRUE
9	GTEx	Breast Mammary Tissue (Female)	ARIH2	0.06	0.00	lasso	2	-0.01	5.9e-01	-4.6	-5.2	1.6e-07	0.10	0.02	0.06	FALSE
10	GTEx	Esophagus Mucosa	MAP4	0.05	0.04	lasso	4	0.02	2.3e-02	-4.8	5.1	3.0e-07	-0.91	0.07	0.85	FALSE
11	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	-4.1	5.2	2.5e-07	-0.17	0.08	0.82	FALSE
12	GTEx	Liver	MRPS18AP1	0.19	0.01	enet	22	0.02	9.0e-02	-4.9	-5.2	2.3e-07	0.85	0.09	0.69	FALSE
13	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	-4.6	5.7	1.0e-08	-0.17	0.06	0.49	FALSE
14	GTEx	Ovary	MRPS18AP1	0.53	0.33	lasso	8	0.43	7.8e-12	-4.7	-5.2	1.9e-07	0.94	0.05	0.95	FALSE
15	GTEx	Pituitary	SLC26A6	0.16	0.18	lasso	8	0.14	2.0e-04	-5.5	-5.6	2.2e-08	0.98	0.02	0.85	FALSE
16	GTEx	Prostate	CDC25A	0.18	0.14	lasso	4	0.16	7.9e-05	-5.5	-5.4	8.7e-08	0.95	0.03	0.92	FALSE
17	GTEx	Prostate	MRPS18AP1	0.29	0.32	lasso	5	0.36	6.8e-10	-4.7	-5.1	2.9e-07	0.91	0.05	0.95	FALSE
18	GTEx	Skin Sun Exposed Lower leg	NME6	0.16	0.17	lasso	11	0.20	1.5e-16	-4.8	5.1	3.1e-07	-0.88	0.32	0.67	FALSE
19	GTEx	Stomach	FCF1P2	0.12	0.05	enet	5	0.03	1.3e-02	-5.7	5.5	2.9e-08	-0.96	0.03	0.89	FALSE
20	GTEx	Thyroid	MAP4	0.07	0.05	lasso	12	0.05	1.6e-04	-5.5	-5.4	6.4e-08	0.96	0.03	0.97	FALSE
21	NTR	Blood	ZNF589	0.02	0.02	lasso	8	0.02	2.8e-06	-5.7	-5.5	3.8e-08	0.97	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NME6	0.08	0.06	blup	33	0.07	1.7e-06	-4.8	5.1	2.8e-07	-0.85	0.02	0.97	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC25A	0.05	0.04	blup	19	0.04	3.7e-03	-4.7	-5.3	1.2e-07	0.94	0.01	0.78	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC25A	0.02	0.00	blup	20	0.01	5.0e-02	-5.5	-5.5	4.8e-08	0.97	0.01	0.65	FALSE