[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr3:47,204,518-50,085,153

Best TWAS P=3.24e-10 · Best GWAS P=1.12e-08 conditioned to 0.378

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ZNF589 0.15 0.14 bslmm 254 0.16 1.3e-19 -4.7 -5.2 2.2e-07 0.89 0.45 0.54 FALSE
2 GTEx Adrenal Gland NME6 0.12 0.07 lasso 9 0.08 6.1e-04 -5.7 5.6 2.3e-08 -0.97 0.04 0.89 FALSE
3 GTEx Brain Cerebellum GPX1 0.31 0.09 enet 19 0.23 2.0e-07 -4.3 5.3 1.2e-07 -0.16 0.09 0.81 FALSE
4 GTEx Brain Frontal Cortex BA9 GPX1 0.16 0.06 lasso 6 0.15 7.9e-05 4.2 5.7 9.1e-09 -0.12 0.07 0.55 TRUE
5 GTEx Breast Mammary Tissue NME6 0.11 0.08 enet 21 0.12 5.6e-07 -4.9 5.2 2.0e-07 -0.70 0.25 0.61 FALSE
6 GTEx Breast Mammary Tissue FCF1P2 0.07 0.04 lasso 7 0.02 5.1e-02 -5.7 5.7 1.2e-08 -1.00 0.01 0.96 FALSE
7 GTEx Breast Mammary Tissue (Female) ZNF589 0.29 0.21 lasso 8 0.20 1.3e-06 -4.7 -5.2 2.2e-07 0.91 0.11 0.87 FALSE
8 GTEx Breast Mammary Tissue (Female) NME6 0.05 -0.01 lasso 2 0.03 3.5e-02 -4.9 6.3 3.2e-10 -0.70 0.04 0.22 TRUE
9 GTEx Breast Mammary Tissue (Female) ARIH2 0.06 0.00 lasso 2 -0.01 5.9e-01 -4.6 -5.2 1.6e-07 0.10 0.02 0.06 FALSE
10 GTEx Esophagus Mucosa MAP4 0.05 0.04 lasso 4 0.02 2.3e-02 -4.8 5.1 3.0e-07 -0.91 0.07 0.85 FALSE
11 GTEx Esophagus Muscularis GPX1 0.13 0.05 lasso 14 0.06 1.1e-04 -4.1 5.2 2.5e-07 -0.17 0.08 0.82 FALSE
12 GTEx Liver MRPS18AP1 0.19 0.01 enet 22 0.02 9.0e-02 -4.9 -5.2 2.3e-07 0.85 0.09 0.69 FALSE
13 GTEx Lung GPX1 0.04 0.02 enet 13 0.04 5.7e-04 -4.6 5.7 1.0e-08 -0.17 0.06 0.49 FALSE
14 GTEx Ovary MRPS18AP1 0.53 0.33 lasso 8 0.43 7.8e-12 -4.7 -5.2 1.9e-07 0.94 0.05 0.95 FALSE
15 GTEx Pituitary SLC26A6 0.16 0.18 lasso 8 0.14 2.0e-04 -5.5 -5.6 2.2e-08 0.98 0.02 0.85 FALSE
16 GTEx Prostate CDC25A 0.18 0.14 lasso 4 0.16 7.9e-05 -5.5 -5.4 8.7e-08 0.95 0.03 0.92 FALSE
17 GTEx Prostate MRPS18AP1 0.29 0.32 lasso 5 0.36 6.8e-10 -4.7 -5.1 2.9e-07 0.91 0.05 0.95 FALSE
18 GTEx Skin Sun Exposed Lower leg NME6 0.16 0.17 lasso 11 0.20 1.5e-16 -4.8 5.1 3.1e-07 -0.88 0.32 0.67 FALSE
19 GTEx Stomach FCF1P2 0.12 0.05 enet 5 0.03 1.3e-02 -5.7 5.5 2.9e-08 -0.96 0.03 0.89 FALSE
20 GTEx Thyroid MAP4 0.07 0.05 lasso 12 0.05 1.6e-04 -5.5 -5.4 6.4e-08 0.96 0.03 0.97 FALSE
21 NTR Blood ZNF589 0.02 0.02 lasso 8 0.02 2.8e-06 -5.7 -5.5 3.8e-08 0.97 0.01 0.99 FALSE
22 The Cancer Genome Atlas Bladder Urothelial Carcinoma NME6 0.08 0.06 blup 33 0.07 1.7e-06 -4.8 5.1 2.8e-07 -0.85 0.02 0.97 FALSE
23 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CDC25A 0.05 0.04 blup 19 0.04 3.7e-03 -4.7 -5.3 1.2e-07 0.94 0.01 0.78 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma CDC25A 0.02 0.00 blup 20 0.01 5.0e-02 -5.5 -5.5 4.8e-08 0.97 0.01 0.65 FALSE