Hub : Genes

MAP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1850 0.0640 8.8e-11 0.150 NA 0.158 NA 0.161 2.4e-11 NA 6.5e-12 NA 4.2e-12
2 GTEx Esophagus Mucosa 0.0500 0.0280 2.0e-03 0.040 NA 0.001 NA 0.018 1.0e-03 NA 2.8e-01 NA 2.3e-02
3 GTEx Skin Sun Exposed Lower leg 0.0360 0.0170 8.4e-04 0.037 NA 0.042 NA 0.031 4.3e-04 NA 2.0e-04 NA 1.3e-03
4 GTEx Testis 0.1610 0.0830 1.9e-03 0.017 NA 0.035 NA 0.014 5.6e-02 NA 1.1e-02 NA 7.4e-02
5 GTEx Thyroid 0.0690 0.0290 5.0e-05 0.046 NA 0.033 NA 0.047 1.9e-04 NA 1.4e-03 NA 1.6e-04
6 TCGA Breast Invasive Carcinoma 0.0255 0.0171 8.4e-04 0.004 0.013 0.013 NA 0.008 4.2e-02 9.0e-04 8.9e-04 NA 6.1e-03
7 TCGA Colon Adenocarcinoma 0.0610 0.0400 1.0e-03 0.048 0.048 0.041 NA 0.043 9.3e-04 8.8e-04 1.9e-03 NA 1.6e-03
8 TCGA Lung Adenocarcinoma 0.0271 0.0154 2.8e-05 0.037 0.040 0.038 NA 0.038 3.4e-05 1.6e-05 2.4e-05 NA 2.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.0 1.6 3.8 -1.5 1.0 -1.9 0.1 -0.8 -1.8 -0.5 -1.3
Bipolar Disorder or Schizophrenia 0.9 2.2 7.2 0.8 2.7 -0.2 0.4 -2.4 -0.6 1.5 1.0
Depressed Affect (Nagel 2018) 1.2 2.6 5.0 -2.1 -0.0 -2.2 -0.6 0.4 -1.8 -1.9 -2.0
Depression (Nagel 2018) 1.1 1.6 6.2 -1.3 1.2 -1.1 -0.3 -0.7 -2.5 -0.7 -1.2
Intelligence (Savage-Jansen 2018) 1.1 3.4 8.9 2.2 0.9 2.2 1.1 -0.9 0.5 3.0 2.3
Neuroticism (Nagel 2018) 0.2 0.5 1.7 -0.3 1.3 -0.5 -0.9 -1.1 -0.3 -0.1 -0.2
Schizophrenia (2018) 1.8 3.8 6.8 2.2 2.6 1.3 0.3 -2.5 0.6 2.4 2.3
Schizophrenia vs Biploar Disorder 2.6 3.5 6.8 2.2 1.4 2.6 -0.2 -1.7 1.2 2.1 2.2
Worry (Nagel 2018) 1.7 3.5 8.7 1.6 2.9 1.2 -0.1 -2.8 1.1 1.8 1.7
Alzheimer’s Disease (in mother) 1.5 1.8 3.7 1.1 1.9 0.6 1.0 -1.8 0.8 1.5 1.3
Alzheimer’s Disease (in father) 0.1 0.1 0.4 0.1 0.4 -0.6 -0.1 -0.2 -0.2 -0.1 -0.1
Alzheimer’s Disease (including proxy) 1.6 2.3 4.2 1.6 2.0 0.6 1.1 -2.0 0.6 1.7 1.5
Crohns Disease (2017) 0.3 0.6 2.1 -0.4 -0.9 -1.4 -0.1 0.6 -1.0 0.0 -0.3
Irritable Bowel Disease (IBD) 0.3 0.7 2.2 -0.4 -0.6 -1.5 -0.8 0.4 -1.4 0.2 -0.3
Ulcerative Colitis (UC) 0.2 0.4 1.1 -0.1 -0.2 -1.0 -1.1 0.2 -1.0 0.3 -0.1
Major Depression (MDD) 0.4 0.5 1.8 -0.1 1.4 -0.4 -0.6 -1.2 -0.3 0.1 -0.0
Reaction Time 1.5 2.9 7.9 1.8 1.0 2.8 1.5 -1.4 1.2 1.6 1.8
Verbal and Numeric Reasoning (VNR) 1.9 4.5 10.0 2.7 1.7 2.3 0.4 -1.5 0.8 3.2 2.7
Breast Cancer 0.6 1.5 3.7 1.2 -0.9 0.5 1.9 0.9 1.9 1.1 0.9
Ovarian Cancer 1.2 1.7 5.0 1.3 0.6 2.2 1.2 -0.5 1.3 1.0 1.3
Prostate Cancer 3.2 4.5 10.4 1.6 3.2 2.1 0.3 -3.2 1.6 1.8 1.7
Age at First Birth 6.6 9.5 16.8 3.7 0.9 3.9 2.6 -1.2 2.8 4.1 3.8
Bipolar Disorder (2011) 0.2 0.2 0.5 -0.2 0.3 -0.7 0.7 -0.1 -0.4 0.0 -0.3
Body Mass Index (BMI) (2010) 2.4 3.3 4.9 -1.8 -1.2 -2.2 -1.8 1.5 -2.1 -1.8 -1.9
Coronary Artery Disease (CAD) 2.8 3.4 7.2 1.6 2.6 1.4 0.4 -2.7 1.8 1.5 1.7
Crohns Disease (2012) 0.5 0.8 2.7 -0.8 -0.7 -1.6 -0.3 0.4 -1.4 -0.2 -0.7
Mean Putamen Volume 1.3 1.5 3.8 -1.0 -1.8 -0.7 0.9 1.9 -0.6 -1.0 -1.1
Fasting Glucose 3.3 4.0 7.0 2.6 1.8 1.3 1.0 -1.9 2.4 2.0 2.3
HbA1C 1.5 1.7 3.9 1.8 0.3 1.5 -0.7 -0.4 -0.1 2.0 1.9
HDL Cholesterol 0.8 1.4 3.9 -0.1 -1.7 -1.1 2.0 1.5 0.7 -0.1 -0.2
LDL Cholesterol 0.3 0.4 0.7 0.7 0.7 0.8 0.3 -0.5 0.6 0.6 0.7
Lupus 0.1 0.2 1.1 0.0 -0.5 1.1 -0.2 0.5 0.1 0.1 0.2
Neuroticism (2016) 0.4 0.6 3.2 0.4 0.0 -0.7 1.8 -0.4 1.0 0.1 0.2
Primary Biliary Cirrhosis 1.7 2.4 3.4 -1.8 -1.4 -0.4 -1.7 1.5 -1.5 -1.8 -1.7
Rheumatoid Arthritis 0.1 0.2 0.8 0.0 -0.9 0.2 0.3 0.9 -0.1 0.0 -0.0
Schizophrenia (2014) 1.3 2.9 5.2 1.8 2.3 1.3 -0.1 -2.2 0.3 2.1 1.9
Triglycerides 0.3 0.5 0.8 0.9 -0.7 0.9 -0.3 0.5 0.8 0.7 0.8
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.2 1.3 1.6 1.8 0.4 -2.0 1.4 1.5 1.5
Ulcerative Colitis 0.6 0.9 4.1 -0.2 0.4 -0.6 -2.0 -0.4 -1.5 0.3 -0.2
Blood Eosinophil Count 0.2 1.7 6.7 -1.1 -1.0 -0.2 -1.0 1.3 -2.6 -0.9 -1.1
Blood Platelet Count 0.3 3.5 11.2 -0.7 -2.6 -3.4 -0.7 2.4 0.3 -1.4 -1.1
Blood Red Count 1.7 16.9 23.5 4.6 4.3 4.8 1.0 -4.2 2.7 4.8 4.8
Blood White Count 1.1 8.1 22.3 2.6 3.0 4.7 1.4 -3.3 1.3 2.2 2.8
Heel T-Score 0.5 3.8 10.0 2.2 0.9 3.2 -1.8 -0.8 -0.7 2.2 2.3
BMI 4.5 26.1 46.1 -6.4 -1.7 -6.8 -3.6 2.2 -3.8 -6.6 -6.5
Height 0.6 10.6 26.3 3.3 -2.8 5.1 1.3 2.3 0.2 4.1 4.0
Waist Hip Ratio (WHR) 0.3 1.5 4.2 0.6 -1.0 1.7 -2.0 0.9 -1.6 0.4 0.6
Systolic Blood Pressure 11.0 55.1 85.7 7.8 8.8 6.9 3.6 -9.3 6.2 7.7 7.6
Smoking Status 4.7 11.3 20.4 -4.4 -1.5 -4.5 -1.1 1.8 -2.2 -4.5 -4.4
Allergy or Eczema 0.5 1.3 3.1 -0.2 -1.7 -1.7 0.3 1.8 -0.9 -0.1 -0.6
Cardiovascular Disease 8.0 26.4 51.0 5.2 6.3 4.1 2.0 -7.1 4.5 5.2 5.1
Hypothyroidism (self reported) 2.7 6.1 17.4 2.1 4.2 0.6 0.8 -4.0 0.9 2.3 2.0
Respiratory disease 3.5 7.8 13.3 -3.3 -2.5 -3.6 -0.6 2.4 -0.9 -3.7 -3.4
Type 2 Diabetes (T2D) (2018) 1.0 1.9 6.2 0.6 2.5 0.9 -0.9 -2.5 -0.1 0.6 0.7
Lung FEV1/FVC ratio 0.3 1.3 5.8 -0.9 -0.5 1.4 -1.1 0.7 -2.4 0.0 -0.4
Lung FVC 0.5 2.4 7.2 1.7 0.4 2.7 -0.4 -0.3 -0.1 2.3 1.9
Neuroticism 0.8 2.0 4.3 1.1 2.0 0.7 -0.4 -2.1 1.8 1.0 1.2
Chronotype (morning person) 2.0 4.5 7.8 2.4 1.9 2.8 1.2 -2.0 1.9 2.2 2.4
Hair Pigment 0.3 7.9 10.8 -2.9 -2.9 -2.3 -2.6 3.3 -2.4 -3.2 -2.7
Tanning 0.0 0.2 0.6 0.0 0.7 0.5 0.5 -0.7 -0.4 0.1 0.0
Hand grip strength (left) 0.1 0.3 0.7 -0.8 0.3 -0.1 0.8 0.0 -0.5 -0.6 -0.7
Number of treatments/medications taken 2.6 4.6 9.9 2.1 2.7 0.8 -0.2 -3.1 2.8 1.8 1.9
Average weekly spirits intake 4.4 5.5 10.1 -1.9 -3.0 -2.5 -0.3 3.2 0.8 -3.0 -2.3
Sensitivity / hurt feelings 0.2 0.4 1.2 -0.0 -0.7 -0.8 -1.1 0.5 0.6 -0.2 -0.1
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.3 -0.5 1.1 -0.2 -0.3 -0.8 -1.1 -0.2 -0.5
Hearing difficulty/problems: Yes 3.1 4.8 6.1 -2.3 -2.3 -2.0 -1.4 2.1 -2.5 -2.3 -2.5
Relative age of first facial hair 0.4 0.8 1.3 1.0 1.0 0.6 1.0 -1.0 0.4 1.1 0.9
Other serious medical condition/disability diagnosed by doctor 4.0 5.2 9.3 2.7 2.3 1.8 0.8 -2.4 1.4 3.0 2.8
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.9 -0.1 -0.1 -0.2 -1.0 -0.1 -0.7 -0.0 0.0
Ever had hysterectomy (womb removed) 0.8 0.9 2.4 -0.6 -0.1 -1.3 0.6 -0.4 1.6 -1.1 -0.7
Systolic blood pressure, automated reading 5.2 15.0 29.2 4.1 5.1 2.6 1.5 -5.4 3.4 3.7 3.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.4 0.5 0.2 0.3 -0.6 0.3 0.1 0.3
Angina 0.3 0.4 0.9 -0.1 0.5 -0.8 -1.0 -0.6 0.8 -0.6 -0.2
Medication for hormone replacement therapy 0.2 0.2 0.4 0.4 0.5 0.4 -0.6 -0.4 0.4 0.3 0.4
Vitamin and mineral supplements 2.3 3.1 6.9 1.9 1.2 2.6 1.1 -1.3 1.5 1.8 2.0
Supplements: Zinc 0.4 0.4 0.9 0.6 0.9 0.0 -0.8 -0.8 0.9 0.2 0.5
Medication: Co-codamol 1.1 1.3 2.6 -1.3 0.5 -1.4 -1.6 -0.6 -0.3 -1.2 -1.3
Medication: Metformin 2.3 3.2 6.1 2.5 0.6 1.6 -0.9 -1.0 2.1 2.1 2.4
Diabetes (father) 0.7 0.9 2.0 0.7 1.4 0.5 -0.2 -1.4 0.9 0.7 0.8
Diabetes (mother) 2.4 3.1 5.2 1.8 2.0 1.7 0.7 -2.3 1.7 1.5 1.8
Severe depression (siblings) 1.1 1.2 2.9 1.1 1.6 0.3 -0.1 -1.7 0.8 1.1 1.0
Pack years adult smoking proportion 2.3 3.6 7.5 1.3 2.7 1.5 2.0 -2.3 2.2 1.0 1.4
Impedance of leg (right) 1.7 8.1 15.5 3.8 -0.1 3.9 2.0 -0.4 1.8 3.6 3.8
Leg fat-free mass (left) 0.6 3.0 6.1 -2.5 -0.5 -1.8 -1.6 0.8 -1.5 -2.1 -2.2
Trunk fat percentage 1.7 6.8 12.1 -2.9 -1.8 -3.5 -2.3 2.1 -1.4 -3.2 -2.9
Hand grip strength (right) 0.1 0.2 0.5 -0.5 0.5 0.6 0.7 -0.2 0.1 -0.2 -0.3
Townsend deprivation index at recruitment 0.5 0.7 2.4 -0.5 1.6 -0.5 -0.3 -1.2 0.4 -0.8 -0.5
Current tobacco smoking 2.1 3.5 6.9 -2.5 -1.4 -1.8 -0.1 1.7 -1.2 -2.6 -2.4
Average weekly fortified wine intake 1.0 1.1 3.1 -0.7 -1.3 -1.7 0.4 1.1 0.0 -1.2 -1.0
Maternal smoking around birth 0.7 1.1 3.1 -0.8 -0.6 -0.1 -1.5 0.8 -1.8 -1.0 -0.7
Fed-up feelings 1.8 3.2 7.4 -2.6 -0.2 -1.8 -0.3 0.4 -0.9 -2.7 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.9 1.4 -1.0 1.1 -1.1 0.5 -0.8 -1.2 -0.7 -1.0
Relative age voice broke 0.4 0.6 2.5 0.4 0.8 -0.2 1.6 -0.7 -0.4 0.7 0.4
Taking other prescription medications 0.8 1.2 4.2 0.7 1.9 -0.0 -0.1 -2.0 0.5 0.9 0.6
Age when periods started (menarche) 1.2 3.0 4.4 1.4 1.9 2.0 1.4 -2.1 1.7 1.4 1.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 1.0 0.3 0.3 -0.6 0.1 -0.6 1.0 0.2 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.6 1.0 0.8 1.2 -0.2 -0.5 -0.4 1.1 1.0
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.6 -1.1 -0.1 -0.6 -0.8 0.2 -0.7 -1.3 -1.0
Qualifications: CSEs or equivalent 0.7 0.9 2.3 -0.9 1.5 -0.1 -0.6 -1.3 -1.1 -0.4 -0.8
Serious illness, injury or assault to yourself 1.1 1.4 5.6 -0.2 2.4 -0.1 0.2 -2.2 -0.4 0.3 -0.1
High blood pressure 5.8 16.3 37.3 4.0 5.4 2.1 1.3 -6.1 3.9 3.7 3.7
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.8 0.4 -1.4 -0.6 1.9 1.3 0.6 0.5 0.1
Multivitamins +/- minerals 1.3 1.7 3.0 -1.6 -0.6 -1.7 -0.6 0.9 -1.6 -1.2 -1.5
Stomach or abdominal pain in last month 0.2 0.3 1.2 0.4 0.6 0.3 0.4 -0.6 1.1 0.2 0.3
Supplements: Glucosamine 0.7 1.0 2.0 1.0 -0.7 1.0 1.4 0.8 0.6 1.1 1.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 -0.1 0.2 0.9 -0.8 0.2 -0.5 -0.1 0.1
Medication: Atenolol 3.1 3.9 10.4 1.8 2.8 1.5 -0.3 -3.2 1.4 1.4 1.8
Medication: Levothyroxine sodium 1.4 2.3 8.0 0.9 2.8 -0.2 0.5 -2.6 0.3 1.3 1.0
Sitting height 0.7 4.9 11.0 2.8 -0.0 3.3 0.6 -0.1 1.5 2.8 3.1
Chronic bronchitis/emphysema (father) 1.5 1.8 4.2 -1.4 -0.2 -1.2 -2.0 0.3 -1.0 -1.7 -1.4
High blood pressure (mother) 1.1 1.5 4.6 0.8 2.1 -0.2 -0.6 -2.1 -0.2 1.2 0.6
Body mass index (BMI) 4.0 17.1 32.1 -5.1 -0.9 -5.7 -3.8 1.4 -2.6 -5.3 -5.2
Impedance of leg (left) 1.4 7.0 14.4 3.5 -0.1 3.8 1.3 -0.3 1.7 3.4 3.5
Leg predicted mass (left) 0.6 3.0 6.2 -2.5 -0.4 -1.8 -1.6 0.8 -1.5 -2.1 -2.2
Trunk fat mass 1.6 6.9 11.3 -3.1 -1.6 -3.4 -2.6 1.9 -1.6 -3.2 -3.0
Waist circumference 1.9 7.0 11.4 -2.9 -1.0 -3.4 -3.4 1.2 -1.9 -3.1 -3.0
Number of incorrect matches in round 1.1 1.9 5.6 1.7 1.1 0.2 0.7 -1.3 2.4 1.1 1.4
Past tobacco smoking 6.2 11.5 20.2 4.1 2.1 4.5 1.9 -2.2 2.2 4.3 4.2
Alcohol usually taken with meals 1.5 2.4 5.5 1.9 0.7 2.0 0.3 -0.7 0.9 2.4 2.1
Nervous feelings 1.7 3.1 4.5 2.1 2.1 1.2 0.6 -2.1 1.1 2.1 2.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 4.3 0.1 2.1 0.9 0.2 -1.9 -0.4 0.3 0.2
Hearing difficulty/problems with background noise 1.5 2.3 3.5 -1.3 -1.9 -1.8 -0.7 1.7 -1.4 -1.5 -1.6
Hair/balding pattern: Pattern 2 0.9 1.2 1.7 -1.2 -0.6 -1.0 -1.3 0.7 -1.3 -1.2 -1.2
Had menopause 1.0 1.3 2.9 -0.9 -1.2 -1.3 -1.7 1.0 -0.8 -0.9 -0.9
Had other major operations 0.1 0.2 0.5 0.2 -0.2 -0.5 0.7 0.1 0.6 0.1 0.1
Forced vital capacity (FVC) 1.2 4.7 16.6 2.1 0.2 4.1 1.0 -0.2 0.9 2.8 2.6
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 6.8 2.2 0.8 2.6 0.5 -0.6 0.6 2.1 2.2
Ever unenthusiastic/disinterested for a whole week 3.4 4.2 7.7 -2.4 0.1 -2.8 -1.8 0.4 -2.5 -2.1 -2.5
Qualifications: None of the above 5.7 12.2 23.8 -4.4 -1.4 -4.7 -2.2 1.8 -1.8 -4.9 -4.4
Financial difficulties in last 2 years 0.8 1.0 1.7 -1.3 -0.4 -0.9 -1.2 0.7 -0.6 -1.2 -1.2
Mouth/teeth dental problems 3.8 5.9 9.4 2.6 2.6 3.1 1.3 -2.7 1.2 2.7 2.6
Heart attack 1.6 2.0 6.2 1.0 2.5 1.0 -0.0 -2.3 1.0 0.7 1.0
Allergy 2.2 5.1 11.0 1.9 3.3 2.7 -0.9 -3.1 0.3 1.9 2.2
Pain all over the body in last month 1.2 1.2 4.9 0.1 2.2 -0.4 -0.3 -2.1 0.7 0.1 0.1
Diabetes (self-reported) 0.4 0.7 1.0 0.8 0.9 0.4 -1.0 -1.0 0.8 0.6 0.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.3 0.9 -0.3 0.5 1.8 0.2 0.9 0.8 0.7
Medication: Ramipril 0.4 0.6 1.9 0.6 0.9 -0.2 0.3 -1.0 1.4 0.4 0.5
Medication: Simvastatin 1.5 2.2 5.1 1.3 1.7 0.8 0.2 -2.0 2.3 1.1 1.3
Fluid intelligence score 3.4 7.1 13.5 3.2 2.3 2.8 0.9 -2.2 1.9 3.7 3.3
Illnesses of siblings 3.6 5.0 17.4 -0.8 -4.2 0.2 1.7 4.0 1.2 -1.2 -0.7
Neuroticism score 0.1 0.3 0.8 0.2 0.9 -0.1 -0.5 -0.9 0.5 0.2 0.3
Weight 1.4 6.6 10.4 -3.2 -0.9 -3.2 -2.9 1.3 -1.8 -3.1 -3.1
Impedance of arm (right) 1.4 6.6 10.5 3.2 -1.5 3.0 2.9 1.1 1.2 3.0 3.2
Arm fat percentage (right) 3.0 11.7 22.4 -4.1 -1.3 -4.7 -2.6 1.8 -2.2 -4.4 -4.2
Trunk fat-free mass 0.2 1.1 2.7 -1.5 0.7 -0.5 -1.6 -0.4 -1.1 -0.8 -1.1
Hip circumference 1.6 6.8 15.8 -3.0 -1.0 -4.0 -2.7 1.2 -1.1 -3.0 -3.1
Time employed in main current job 0.5 0.6 2.6 0.6 0.5 0.2 1.6 -0.4 0.8 0.7 0.5
Alcohol intake versus 10 years previously 0.5 0.7 1.7 -0.9 0.5 -1.2 -1.3 -0.4 -0.7 -0.6 -0.8
Father’s age at death 0.4 0.5 2.2 -0.2 -1.5 0.2 -0.0 1.2 -0.1 0.3 0.1
Worrier / anxious feelings 2.9 5.4 10.8 2.1 3.3 2.7 -0.1 -3.2 0.4 2.4 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 -0.2 0.7 0.4 0.6 -0.7 0.2 -0.0 -0.2
Falls in the last year 3.7 5.0 8.0 -2.6 -1.1 -2.5 -1.7 1.3 -2.5 -2.7 -2.8
Hair/balding pattern: Pattern 3 0.2 0.3 1.9 -0.1 -0.1 0.5 1.4 0.2 -0.0 -0.0 -0.1
Number of live births 3.8 5.4 13.7 -2.6 -0.8 -2.0 -3.7 1.1 -1.6 -2.9 -2.5
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 15.1 1.6 0.1 3.9 0.3 -0.0 -0.1 2.6 2.2
Pulse rate 1.1 1.8 5.4 1.6 -0.1 2.3 -0.4 -0.0 0.4 1.7 1.8
Happiness 1.3 1.6 3.0 1.2 1.7 1.2 1.1 -1.5 -0.0 1.5 1.1
Noisy workplace 0.7 0.9 1.5 -1.2 -0.3 -1.1 -0.4 0.7 -1.0 -1.1 -1.2
Qualifications: A levels/AS levels or equivalent 3.5 7.8 19.6 3.5 1.3 2.8 2.3 -1.5 0.8 4.4 3.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.6 0.4 0.2 -0.3 1.9 -0.3 1.5 0.3 0.4
Mouth/teeth dental problems: Dentures 1.7 2.9 5.8 -1.9 -1.4 -1.9 -1.1 1.4 -0.8 -2.4 -2.0
Asthma 4.2 8.3 13.2 -3.3 -2.8 -3.6 -0.5 2.7 -1.2 -3.6 -3.6
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 3.7 -1.8 -0.7 -1.9 -1.8 0.8 0.1 -1.9 -1.7
Medication: Cholesterol lowering 1.9 2.9 6.2 1.7 2.2 1.1 -0.2 -2.5 1.6 1.7 1.7
Depression (self-reported) 1.2 1.4 5.3 -0.9 -1.1 -2.3 0.3 1.1 -0.4 -1.0 -1.2
Medication: Lansoprazole 4.3 4.9 10.0 2.3 2.4 3.2 0.8 -2.1 0.4 2.7 2.4
Prospective memory result 0.6 0.7 1.4 -0.8 -1.0 -0.4 0.2 1.1 -1.2 -0.9 -0.8
Lung cancer (father) 0.4 0.5 0.9 -0.8 -0.6 -0.9 0.8 0.5 -0.0 -0.9 -0.8
Illnesses of mother 2.3 2.9 5.1 -2.3 -1.6 -0.8 -0.0 2.0 -1.4 -2.1 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 9.5 1.0 -0.2 3.1 0.6 0.2 -0.5 1.8 1.5
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 0.7 -0.0 0.7 0.0 0.1 0.6 0.5 0.6
Impedance of arm (left) 1.6 7.2 10.5 3.2 -2.0 3.0 3.2 1.5 1.5 3.0 3.2
Arm fat mass (right) 2.7 11.0 18.6 -4.1 -1.1 -4.3 -3.1 1.5 -2.2 -4.2 -4.1
Trunk predicted mass 0.2 1.0 2.8 -1.4 0.8 -0.4 -1.7 -0.5 -1.1 -0.7 -1.0
Standing height 0.9 8.6 22.0 3.4 -0.3 4.7 1.3 -0.0 1.3 4.0 3.9
Length of working week for main job 2.3 2.6 10.6 -1.4 -0.8 -1.2 -3.3 1.2 0.2 -1.6 -1.2
Exposure to tobacco smoke at home 3.3 3.7 6.2 1.9 2.5 1.9 0.9 -2.4 1.5 2.0 1.9
Breastfed as a baby 0.2 0.3 0.7 0.2 -0.6 -0.2 0.8 0.9 -0.1 0.3 0.3
Tense / ‘highly strung’ 3.7 6.1 7.7 2.7 2.6 2.0 1.9 -2.8 2.2 2.7 2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 5.5 -1.6 -0.1 -2.3 -0.8 0.0 -1.2 -1.6 -1.7
Hair/balding pattern: Pattern 4 0.4 0.9 2.8 -0.7 -0.1 -1.7 -1.6 0.0 -0.3 -0.9 -0.9
Birth weight of first child 2.5 4.5 9.5 -2.0 -2.9 -2.0 -1.1 3.1 -1.3 -2.0 -1.9
Peak expiratory flow (PEF) 0.9 2.0 4.3 1.0 1.6 2.1 0.2 -1.4 0.3 2.0 1.5
Pulse wave reflection index 2.6 3.2 6.6 -2.0 -0.0 -2.6 -1.9 0.2 -1.4 -2.2 -2.2
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.8 -1.2 -0.1 -2.2 -0.7 0.6 -1.4 -1.4 -1.5
Loud music exposure frequency 1.5 1.6 6.2 -1.2 1.0 -0.2 -1.8 -0.3 -2.5 -0.4 -0.9
Qualifications: O levels/GCSEs or equivalent 3.4 5.5 13.5 2.4 1.4 3.3 1.2 -1.5 -0.3 3.7 2.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.2 -0.8 -1.5 -1.1 -0.8 1.5 -0.7 -0.4 -0.8
Blood clot in the leg (DVT) 0.9 1.1 2.2 -1.5 -0.2 -1.1 -1.1 0.2 -0.7 -1.3 -1.4
Medication: Paracetamol 2.4 4.0 6.2 -2.4 -1.8 -1.6 -1.9 2.0 -1.0 -2.5 -2.3
Headache pain in last month 2.1 3.6 5.6 -2.1 -1.5 -1.4 -2.0 1.5 -2.4 -2.0 -2.0
Medication for cholesterol, blood pressure or diabetes 5.1 8.4 15.7 -3.0 -3.5 -2.0 -0.5 4.0 -3.0 -2.9 -2.9
Glaucoma (self-reported) 1.6 1.9 3.7 1.5 1.9 0.9 -0.4 -1.6 0.4 1.8 1.5
Gout (self-reported) 0.8 1.2 2.5 0.9 1.1 1.6 -0.1 -1.4 0.6 1.1 1.1
Hypothyroidism/myxoedema (self-reported) 2.0 3.9 12.3 1.4 3.5 0.1 -0.3 -3.3 0.2 1.9 1.5
Medication: Amlodipine 1.9 2.6 4.8 2.0 2.1 0.5 -0.1 -2.2 1.1 1.7 1.8
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 -1.1 0.4 -0.8 0.1 -0.2 -0.6 -1.0 -1.1
Birth weight 2.3 4.9 8.8 -3.0 -2.1 -2.1 -0.7 2.0 -1.4 -2.6 -2.8
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.5 -0.6 -0.4 -0.3 -0.7 -0.1 -0.3 -0.7 -0.6
High blood pressure (siblings) 1.8 2.7 9.3 0.8 3.0 -0.4 -1.0 -3.0 -0.4 0.9 0.5
Forced vital capacity (FVC), Best measure 0.9 3.4 12.5 1.7 -0.5 3.5 1.3 0.3 0.4 2.3 2.1
Body fat percentage 2.2 8.6 16.1 -3.4 -1.5 -4.0 -2.7 1.9 -1.7 -3.7 -3.5
Leg fat percentage (right) 2.5 9.0 17.5 -3.4 -0.6 -4.2 -3.4 1.0 -1.8 -3.8 -3.6
Arm fat-free mass (right) 0.4 2.2 4.6 -2.1 0.1 -1.0 -2.1 0.1 -1.4 -1.6 -1.7
Exposure to tobacco smoke outside home 0.9 1.2 3.3 0.5 1.8 1.2 -0.4 -1.8 -0.0 0.8 0.6
Comparative body size at age 10 7.6 20.9 31.6 -5.4 -3.8 -5.5 -2.0 4.2 -3.2 -5.6 -5.5
Number of full brothers 1.1 1.4 2.6 -1.4 -0.4 -1.6 -0.9 0.3 -1.3 -1.4 -1.4
Worry too long after embarrassment 0.3 0.5 1.4 0.7 -0.5 0.8 -1.2 0.2 0.6 0.6 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.9 -0.4 -0.8 -0.7 0.6 0.8 -1.0 -0.4 -0.5
Wheeze or whistling in the chest in last year 6.9 12.3 20.9 -3.9 -2.9 -4.6 -1.8 3.0 -2.1 -4.3 -4.3
Number of children fathered 0.1 0.1 0.3 -0.2 0.2 0.5 0.5 -0.1 0.2 -0.1 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 0.0 0.7 0.4 -0.9 -0.5 -0.9 0.4 0.2
Age at first live birth 4.7 8.4 17.9 3.3 -0.6 3.2 4.2 -0.1 2.1 3.6 3.2
Pulse wave peak to peak time 0.1 0.1 0.2 -0.4 0.1 -0.3 0.2 -0.2 -0.5 -0.1 -0.3
Health satisfaction 0.3 0.4 0.9 -0.5 0.8 -0.9 -0.3 -0.7 0.5 -0.8 -0.6
Shortness of breath walking on level ground 3.7 4.4 9.4 -2.8 -1.2 -1.8 -1.2 1.5 -1.4 -3.1 -2.8
Qualifications: College or University degree 5.7 17.9 38.4 5.0 2.8 5.6 1.8 -3.0 0.6 6.2 5.3
Eye problems/disorders: None of the above 0.4 0.4 0.9 -0.6 -1.0 -0.3 0.2 1.0 -0.5 -0.6 -0.5
Mouth/teeth dental problems: Loose teeth 1.4 1.7 3.1 -1.4 -1.1 -1.4 -1.8 1.1 -0.8 -1.3 -1.4
Emphysema/chronic bronchitis 4.0 4.5 10.2 -1.9 -3.2 -2.1 0.4 2.8 0.3 -2.4 -2.0
Medication for pain relief, constipation, heartburn 1.7 2.9 9.4 1.7 0.5 1.7 3.1 -0.5 -0.4 2.2 1.6
Neck or shoulder pain in last month 1.1 1.6 5.6 -1.3 -0.6 -0.6 -2.4 0.6 -1.1 -1.4 -1.3
Medication: Blood pressure 8.9 15.7 25.3 4.3 4.6 3.4 0.8 -5.0 3.7 4.3 4.2
Angina (self-reported) 0.3 0.3 0.9 0.2 0.5 -0.5 -0.8 -0.7 0.9 -0.3 -0.0
Migraine (self-reported) 6.1 7.5 13.5 -3.0 -1.9 -2.1 -3.4 2.5 -3.7 -2.1 -2.7
Medication: Ibuprofen 2.1 2.5 6.3 -1.9 -0.6 -2.5 -1.2 0.7 0.5 -2.0 -1.8
Medication: Allopurinol 2.4 3.2 5.1 1.8 1.9 2.3 -0.5 -2.1 0.5 2.2 2.0
Medication: Omeprazole 1.0 1.2 3.0 -1.4 -0.0 -1.3 -0.9 0.2 0.1 -1.7 -1.5
Medication: Seretide 50 evohaler 2.9 3.3 6.5 -2.4 -0.3 -2.4 -0.6 0.7 -1.1 -2.6 -2.5
Mean time to correctly identify matches 2.6 5.0 11.2 2.5 1.1 3.3 1.7 -1.5 1.9 2.3 2.6
Heart disease (mother) 1.0 1.2 2.6 1.6 0.8 0.6 0.0 -1.0 1.4 1.1 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 2.7 -1.2 -1.2 -1.5 -1.6 1.3 -0.3 -1.4 -1.3
Whole body fat mass 2.0 8.3 13.3 -3.5 -1.2 -3.6 -3.0 1.6 -1.8 -3.6 -3.4
Leg fat mass (right) 2.8 10.8 17.1 -4.0 -0.9 -4.1 -3.6 1.3 -2.2 -4.1 -4.0
Arm predicted mass (right) 0.4 1.9 4.1 -2.0 0.4 -1.0 -1.9 -0.1 -0.9 -1.6 -1.6
Pulse rate, automated reading 3.5 11.2 22.1 4.4 1.3 4.4 1.0 -1.7 2.6 4.1 4.7
Alcohol intake frequency. 0.2 0.6 1.9 -0.3 1.4 -0.7 -0.5 -1.0 -0.5 -0.5 -0.4
Comparative height size at age 10 0.2 1.0 3.4 0.6 -1.4 1.9 0.2 1.3 0.2 0.5 0.8
Number of full sisters 4.5 5.5 10.0 -2.6 0.5 -2.5 -2.9 0.3 -3.2 -2.4 -2.6
Suffer from ‘nerves’ 0.6 1.0 1.6 1.2 1.1 -0.0 0.4 -0.9 1.3 1.0 1.2
Overall health rating 1.2 2.7 4.7 -2.2 0.3 -1.6 -2.0 -0.2 -1.2 -2.0 -2.1
Chest pain or discomfort 0.1 0.1 0.1 0.3 -0.2 0.3 0.4 -0.0 0.3 0.3 0.3
Had major operations 1.6 1.8 7.0 0.2 2.6 -0.1 -0.1 -2.6 0.9 0.2 0.1
Age at last live birth 2.3 3.3 6.0 2.1 -0.8 2.2 2.3 0.3 0.8 2.4 2.1
Family relationship satisfaction 0.2 0.3 1.2 0.1 0.8 0.0 1.1 -0.5 -0.2 0.1 -0.0
Leg pain on walking 1.1 1.3 2.4 -1.6 -0.7 -0.4 -0.6 1.0 -1.2 -1.5 -1.5
Qualifications: NVQ or HND or HNC or equivalent 3.9 4.7 9.0 -3.0 -0.4 -2.2 -0.8 0.9 -2.3 -2.9 -2.9
Commuting to job workplace: Car/motor vehicle 4.2 4.9 10.3 -1.7 -3.2 -1.9 -2.2 3.2 -0.3 -2.0 -1.8
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.5 -0.3 -1.9 -0.7 0.0 1.8 -0.5 -0.6 -0.5
Medication: Aspirin 5.5 7.3 11.6 3.1 2.5 2.1 0.3 -3.1 3.4 2.7 3.0
Supplements: Vitamin C 1.0 1.2 3.6 -0.7 -1.2 -0.5 -1.9 1.1 -0.7 -1.1 -0.8
Knee pain experienced in last month 4.1 6.4 9.6 -3.0 -1.3 -2.3 -2.6 1.3 -2.9 -3.1 -3.1
Hypertension (Self-reported) 7.0 19.5 41.5 4.5 5.7 2.6 1.3 -6.4 4.2 4.2 4.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.4 -1.1 -0.9 -0.8 -0.4 0.9 -0.6 -1.1 -1.2
Illnesses of father: Heart disease 1.7 2.3 3.4 1.6 1.4 0.7 1.8 -1.9 1.7 1.5 1.5
Illnesses of siblings: Diabetes 0.5 0.6 2.1 0.2 1.4 0.1 -0.0 -1.4 0.6 0.1 0.3
Smoking status: Previous 3.3 5.0 9.9 -2.6 -1.5 -3.2 -1.4 1.3 -1.3 -2.8 -2.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.2 0.8 0.0 1.8 0.7 0.2 -0.5 1.3 1.1
Whole body fat-free mass 0.4 2.1 4.4 -2.1 0.2 -1.2 -1.9 0.1 -1.4 -1.5 -1.7
Leg fat-free mass (right) 0.6 3.1 6.5 -2.5 -0.4 -1.7 -1.9 0.8 -1.5 -2.0 -2.2
Arm fat percentage (left) 2.8 11.0 21.1 -4.0 -1.7 -4.6 -2.3 2.1 -1.9 -4.3 -4.1
Average weekly red wine intake 1.9 2.8 5.3 2.2 -0.0 2.1 1.1 -0.0 1.6 2.2 2.3
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.3 1.2 1.5 0.8 0.5 -1.5 0.3 1.3 1.1
Mood swings 0.8 1.4 2.8 -1.2 1.4 -1.3 -0.7 -0.9 -1.7 -0.8 -1.1
Loneliness, isolation 0.3 0.4 1.6 -0.3 1.3 -0.3 0.2 -1.0 0.4 -0.3 -0.3
Long-standing illness, disability or infirmity 0.3 0.5 1.6 -0.4 0.7 -1.3 -0.4 -1.0 0.6 -0.4 -0.5
Ever had bowel cancer screening 0.1 0.1 0.5 0.1 -0.3 0.0 0.7 -0.0 0.2 0.2 0.2
Diabetes diagnosed by doctor 0.6 0.9 2.0 0.8 1.4 0.5 -1.1 -1.4 0.5 0.7 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.4 -0.8 -2.1 -1.4 -0.2 1.8 -1.0 -0.9 -0.9
Friendships satisfaction 0.9 1.1 5.2 0.6 0.9 0.8 2.3 -0.6 0.2 0.9 0.5
Qualifications: nursing, teaching 2.2 3.4 8.4 2.7 0.8 1.1 1.7 -0.8 0.5 2.9 2.5
Commuting to job workplace: Walk 2.0 2.2 4.1 1.2 2.0 1.0 1.9 -2.0 0.6 1.3 1.2
Eye problems/disorders: Cataract 0.6 0.7 1.2 1.1 0.9 0.0 -0.2 -1.0 0.9 0.9 0.9
Mouth/teeth dental problems: Mouth ulcers 2.3 3.6 6.8 -1.9 -2.2 -2.6 -1.4 2.2 -1.3 -1.6 -1.8
Medication for cholesterol 2.8 4.3 9.1 -2.1 -2.6 -0.8 -1.3 3.0 -2.2 -1.8 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 4.5 -1.3 -0.0 -2.1 -2.1 0.2 -0.2 -2.1 -1.5
Back pain experienced in last month 4.3 6.2 9.9 -3.0 -2.6 -2.7 -0.8 2.4 -1.2 -3.1 -3.1
Mineral and other dietary supplements 0.4 0.6 1.4 -0.9 -0.5 -0.5 0.6 0.2 1.0 -1.2 -0.7
Breast cancer (self-reported) 0.1 0.1 0.4 -0.2 -0.1 0.1 -0.6 0.0 0.3 -0.2 -0.0
Asthma (self-reported) 4.4 8.7 13.4 -3.3 -3.1 -3.7 -0.6 2.9 -1.1 -3.6 -3.5
Osteoporosis (self-reported) 1.8 2.3 6.5 1.5 0.9 0.7 2.5 -1.3 1.2 1.7 1.4
Osteoarthritis (self-reported) 1.0 1.3 4.8 -0.3 0.7 -0.1 -2.2 -0.4 -2.1 0.1 -0.3
Medication: Aspirin 4.4 5.8 11.6 2.7 2.3 1.6 0.4 -2.9 3.4 2.2 2.6
Medication: Gliclazide 0.7 0.8 1.8 1.2 0.6 0.7 0.5 -0.7 0.5 1.4 1.2
Illnesses of father: None of the above (group 1) 4.0 4.9 8.4 -2.2 -2.5 -1.9 -1.6 2.9 -2.4 -2.0 -2.0
Smoking status: Current 2.4 3.8 7.1 -2.7 -1.2 -1.8 -0.3 1.6 -1.6 -2.6 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.2 0.4 -0.2 1.5 -0.1 0.3 -1.0 0.9 0.6
Whole body water mass 0.4 2.1 4.6 -2.1 0.3 -1.1 -1.9 0.1 -1.4 -1.6 -1.7
Leg predicted mass (right) 0.6 3.3 6.7 -2.6 -0.4 -1.7 -1.9 0.8 -1.5 -2.1 -2.2
Arm fat mass (left) 2.6 10.8 17.8 -4.1 -1.3 -4.2 -2.9 1.7 -2.2 -4.2 -4.1
Number of self-reported non-cancer illnesses 2.7 4.7 9.6 1.9 2.5 0.5 2.2 -3.1 2.4 2.0 1.8
Average weekly champagne plus white wine intake 0.1 0.1 0.4 0.2 -0.5 0.0 -0.1 0.7 -0.2 0.2 0.1
Miserableness 1.4 2.3 4.3 -2.1 0.6 -2.0 -0.7 -0.1 -1.1 -2.1 -2.0
Guilty feelings 2.6 3.9 6.2 -2.5 -1.9 -2.1 -1.1 1.7 -1.3 -2.3 -2.4
Wears glasses or contact lenses 0.3 0.4 0.7 0.6 0.7 0.1 -0.5 -0.8 0.6 0.7 0.7
Ever taken oral contraceptive pill 0.8 0.9 1.6 0.9 1.1 0.5 0.3 -1.1 1.2 0.9 0.9
Hearing aid user 0.7 0.8 1.6 -1.0 -0.6 -0.5 -1.3 0.7 -1.1 -0.6 -1.0
Mother’s age at death 0.6 0.7 1.6 1.1 -0.5 1.2 0.5 0.3 0.2 1.3 1.1
Financial situation satisfaction 0.3 0.4 1.3 0.5 -0.3 0.5 0.6 0.6 1.1 0.3 0.4
Tinnitus: Yes, now most or all of the time 0.6 0.8 1.8 -0.4 1.1 0.8 -1.2 -0.8 -1.3 0.2 -0.1
Commuting to job workplace: Public transport 4.8 5.8 8.7 2.5 2.9 2.3 1.6 -2.9 1.0 2.7 2.6
Eye problems/disorders: Glaucoma 1.3 1.5 2.3 1.3 1.5 0.8 -0.8 -1.4 0.8 1.4 1.3
Medication: Blood pressure 3.6 6.9 18.7 2.4 3.9 0.5 1.1 -4.3 2.5 2.0 2.0
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.9 -1.2 -0.9 -0.4 -1.0 0.5 -1.7 -0.8 -1.1
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.5 0.6 1.4 0.3 -1.6 -1.1 -1.4 0.9 0.4
High cholesterol (Self-reported) 0.5 0.8 1.8 0.9 0.6 0.5 0.9 -1.1 1.4 0.8 0.9
Medication: Bendroflumethiazide 2.5 3.8 8.8 1.9 2.7 0.7 0.2 -3.0 2.3 1.5 1.7
Medication: Paracetamol 1.5 2.2 4.7 -2.0 -1.1 -1.4 -1.3 1.1 -0.2 -2.2 -1.8
Medication: Lisinopril 8.5 11.0 21.3 3.1 4.2 3.0 0.8 -4.6 3.2 3.2 3.1
Medication: Atorvastatin 1.3 1.6 3.9 1.7 0.4 0.5 0.5 -0.9 2.0 1.3 1.6
Illnesses of father: High blood pressure 3.4 4.2 7.2 2.0 2.3 2.7 1.0 -2.4 1.0 2.3 2.1
Alcohol drinker status: Never 0.3 0.4 0.9 -0.1 -0.8 -0.9 -0.1 0.6 -1.0 -0.5 -0.3
Ever smoked 6.3 11.0 19.0 -4.0 -2.5 -4.4 -1.4 2.8 -1.4 -4.3 -4.1
Basal metabolic rate 0.6 3.2 6.4 -2.5 -0.1 -1.7 -2.2 0.5 -1.6 -2.0 -2.2
Leg fat percentage (left) 2.9 10.4 19.0 -3.7 -0.7 -4.4 -3.7 1.2 -1.9 -4.0 -3.9
Arm fat-free mass (left) 0.6 2.9 6.7 -2.3 0.9 -1.2 -2.6 -0.5 -1.6 -1.8 -1.9
Number of operations (self-reported) 0.7 1.0 2.5 -1.2 0.6 -1.6 0.2 -0.4 -0.1 -1.4 -1.4
Average weekly beer plus cider intake 1.1 1.6 3.1 -1.6 -0.2 -1.0 -1.7 0.3 -1.8 -1.2 -1.3
Irritability 1.8 3.0 5.2 1.9 1.6 1.3 -0.0 -1.6 2.3 2.1 2.0
Risk taking 1.4 2.0 4.5 -1.4 -1.2 -0.5 -2.1 1.3 -1.8 -1.3 -1.2
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.7 -0.9 -0.8 -1.1 0.0 1.0 -1.3 -0.8 -0.8
Fractured/broken bones in last 5 years 0.3 0.3 0.9 0.1 0.7 -0.2 0.8 -0.8 1.0 0.0 -0.0
Age started oral contraceptive pill 0.3 0.3 1.7 0.2 0.1 -0.1 -0.7 -0.2 -1.3 0.5 0.3
Diastolic blood pressure, automated reading 7.2 22.4 41.6 4.8 6.3 4.2 1.1 -6.5 3.2 4.8 4.7
Ever depressed for a whole week 2.6 3.3 8.1 -2.0 0.7 -2.9 -1.7 -0.8 -1.3 -2.0 -2.1
Unable to work because of sickness or disability 2.2 2.8 5.9 -2.3 -0.3 -2.1 -0.7 0.2 -1.0 -2.4 -2.3
Commuting to job workplace: Cycle 1.1 1.4 2.9 1.1 -0.6 1.7 1.6 0.3 1.0 1.1 1.2
Myopia 0.5 0.8 2.4 -0.2 1.2 -0.5 1.6 -1.3 -0.2 0.4 -0.1
Vascular/heart problems diagnosed by doctor 6.3 17.2 41.1 -3.9 -5.8 -2.2 -0.9 6.4 -3.8 -3.7 -3.7
Cholesterol lowering medication 1.6 2.4 6.3 1.9 0.8 0.9 1.0 -1.4 2.5 1.3 1.8
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 4.0 -1.9 -0.1 -1.6 -1.1 0.4 -0.6 -2.0 -1.9
Pain experienced in last month 2.1 3.6 6.3 2.4 0.4 2.2 1.9 -0.4 1.2 2.5 2.5
Supplements: Calcium 1.5 1.6 2.4 -1.5 -1.2 -1.5 -0.7 1.2 -1.1 -1.3 -1.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 -0.3 -0.4 0.3 0.2 0.8 -0.8 0.2 -0.0
Heart attack/myocardial infarction (self-reported) 1.5 2.0 6.2 1.0 2.5 1.0 -0.1 -2.3 1.0 0.7 1.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.5 -1.2 0.3 -0.8 -0.8 -0.3 -0.4 -1.1 -1.2
Heart disease (siblings) 2.0 2.5 6.7 0.1 2.6 -0.0 -2.5 -2.3 -1.3 0.5 0.2
Alcohol drinker status: Previous 0.5 0.6 1.4 -0.4 0.7 -0.4 -1.2 -0.7 0.9 -1.1 -0.5
Pack years of smoking 2.6 3.9 7.8 1.5 2.8 1.6 1.6 -2.5 2.3 1.2 1.6
Impedance of whole body 1.6 8.3 14.4 3.7 -1.3 3.8 2.6 0.9 1.8 3.5 3.7
Leg fat mass (left) 2.8 11.1 17.3 -4.1 -0.9 -4.2 -3.7 1.4 -2.2 -4.2 -4.0
Arm predicted mass (left) 0.6 3.1 6.2 -2.4 0.4 -1.3 -2.5 -0.1 -1.8 -1.9 -2.0