Best TWAS P=1.57e-12 · Best GWAS P=2.97e-11 conditioned to 0.692
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ITGB5 | 0.34 | 0.28 | lasso | 4 | 0.32 | 4.4e-26 | -6.6 | -7.1 | 1.6e-12 | 0.92 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ITGB5 | 0.30 | 0.17 | lasso | 4 | 0.19 | 2.0e-07 | 4.7 | -6.5 | 6.7e-11 | 0.77 | 0.04 | 0.94 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ITGB5 | 0.37 | 0.13 | lasso | 4 | 0.22 | 1.5e-13 | 6.2 | -6.5 | 7.4e-11 | 0.74 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Nerve Tibial | ITGB5 | 0.10 | 0.01 | lasso | 4 | 0.03 | 2.3e-03 | -6.6 | -5.9 | 3.1e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 5 | METSIM | Adipose | ITGB5 | 0.05 | 0.04 | lasso | 3 | 0.04 | 2.2e-06 | -6.6 | 6.5 | 7.3e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ITGB5 | 0.05 | 0.00 | blup | 116 | 0.01 | 2.4e-02 | 2.4 | -5.3 | 1.4e-07 | 0.41 | 0.03 | 0.09 | FALSE |