Hub : Genes

GOPC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.12400 0.0310 4.7e-08 0.109 0.070 0.087 0.084 0.093 3.4e-13 6.9e-09 1.1e-10 1.8e-10 2.2e-11
2 GTEx Artery Aorta 0.10500 0.0360 3.6e-04 0.093 NA 0.118 NA 0.087 7.9e-06 NA 4.7e-07 NA 1.5e-05
3 GTEx Artery Tibial 0.10940 0.0344 9.2e-05 0.076 NA 0.089 NA 0.093 1.5e-06 NA 1.8e-07 NA 8.9e-08
4 GTEx Breast Mammary Tissue (Male) 0.04920 0.0745 3.0e-01 0.034 NA 0.054 NA 0.038 5.7e-02 NA 2.2e-02 NA 4.7e-02
5 GTEx Breast Mammary Tissue (Female) 0.00494 0.0379 4.6e-01 0.010 NA 0.019 NA 0.009 1.5e-01 NA 8.9e-02 NA 1.7e-01
6 GTEx Nerve Tibial 0.12340 0.0413 4.3e-04 0.058 NA 0.061 NA 0.020 6.3e-05 NA 3.7e-05 NA 1.3e-02
7 GTEx Thyroid 0.10900 0.0350 3.2e-05 0.015 NA 0.018 NA 0.009 2.2e-02 NA 1.6e-02 NA 6.0e-02
8 ROSMAP Brain Pre-frontal Cortex 0.12800 0.0275 4.7e-15 0.157 0.134 0.156 0.150 0.155 1.2e-19 7.1e-17 1.5e-19 8.8e-19 2.1e-19
9 TCGA Breast Invasive Carcinoma 0.01680 0.0086 9.5e-03 0.022 0.010 0.012 NA 0.016 2.2e-05 3.6e-03 1.3e-03 NA 2.1e-04
10 TCGA Thyroid Carcinoma 0.18500 0.0480 4.6e-12 0.124 0.121 0.109 NA 0.121 4.4e-12 9.1e-12 9.3e-11 NA 8.4e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 3.1 5.0 12.3 -2.2 2.4 2.3 1.7 0.0 1.6 2.4 -2.7 1.6 3.5
Bipolar Disorder or Schizophrenia 3.7 9.0 14.5 -2.5 3.4 3.0 3.4 0.0 3.5 3.8 -3.1 2.6 2.9
Depressed Affect (Nagel 2018) 0.8 1.7 3.9 -1.6 1.3 1.7 1.0 0.0 2.0 0.5 -1.6 1.3 0.7
Depression (Nagel 2018) 1.5 2.2 3.7 -1.4 1.9 1.7 1.9 0.0 1.7 1.0 -1.5 1.4 1.3
Intelligence (Savage-Jansen 2018) 0.5 1.5 6.9 0.2 -1.9 -0.8 -0.5 0.0 -1.4 -2.6 1.0 -1.0 0.2
Neuroticism (Nagel 2018) 0.7 1.6 3.8 -0.9 1.5 1.3 1.1 0.0 1.9 1.4 -1.2 1.2 1.3
Schizophrenia (2018) 2.3 4.8 10.0 -1.4 2.4 2.1 2.9 0.0 3.2 3.0 -1.8 2.1 0.8
Schizophrenia vs Biploar Disorder 1.3 1.7 8.6 0.8 -1.5 -0.7 -0.2 0.0 -0.3 -1.8 1.2 -0.6 -2.9
Worry (Nagel 2018) 0.2 0.3 1.5 -0.1 0.8 0.4 -0.5 0.0 0.3 0.5 -0.5 -0.0 1.2
Alzheimer’s Disease (in mother) 1.2 1.4 2.6 1.4 -1.2 -1.5 0.4 0.0 -1.3 -1.2 1.6 -0.4 -1.5
Alzheimer’s Disease (in father) 0.7 0.7 1.9 1.4 -0.1 -1.1 -0.7 0.0 -0.2 -0.5 1.0 -1.3 1.0
Alzheimer’s Disease (including proxy) 0.8 1.1 3.2 1.8 -0.5 -1.6 0.5 0.0 -0.9 -1.3 1.5 -0.3 -0.5
Crohns Disease (2017) 2.9 6.3 11.9 -2.7 2.7 2.9 0.2 0.0 2.8 2.9 -3.2 1.4 3.5
Irritable Bowel Disease (IBD) 2.2 5.3 15.6 -2.2 2.5 2.5 -0.7 0.0 1.9 2.7 -2.8 0.7 3.9
Ulcerative Colitis (UC) 1.3 2.3 8.4 -1.0 1.8 1.6 -0.6 0.0 0.9 2.0 -1.8 0.4 2.9
Major Depression (MDD) 1.8 2.1 5.6 -0.5 1.6 1.1 2.4 0.0 1.8 0.9 -1.3 2.2 1.2
Reaction Time 0.6 1.1 2.4 -0.8 1.4 0.8 1.6 0.0 1.1 0.7 -0.6 1.5 -1.1
Verbal and Numeric Reasoning (VNR) 0.9 2.1 7.3 0.5 -2.1 -1.1 -1.6 0.0 -1.3 -2.7 1.2 -1.5 -0.5
Breast Cancer 1.3 3.1 6.0 -1.9 1.2 2.4 2.0 0.0 2.4 0.9 -2.2 2.2 -0.0
Ovarian Cancer 0.8 1.0 3.0 -1.7 0.9 1.4 0.7 0.0 0.8 -0.0 -1.5 0.9 0.4
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.9 1.3 3.5 -1.1 0.7 1.5 1.9 0.0 1.5 1.3 -1.1 0.6 -0.1
Bipolar Disorder (2011) 1.6 1.5 3.3 -1.6 1.2 1.2 0.0 0.0 0.6 1.8 -1.3 1.1 1.7
Body Mass Index (BMI) (2010) 0.5 0.7 5.3 -0.3 0.7 0.2 0.6 0.0 0.1 0.2 -0.5 -0.2 2.3
Coronary Artery Disease (CAD) 0.5 0.6 1.4 -0.9 0.6 1.2 0.8 0.0 0.7 0.6 -1.0 0.7 0.4
Crohns Disease (2012) 4.0 6.4 12.6 -2.5 2.6 3.2 1.1 0.0 3.2 3.6 -3.1 2.2 1.6
Mean Putamen Volume 0.3 0.3 1.1 -0.1 -0.2 0.5 -1.0 0.0 -0.1 -0.8 -0.3 -0.4 0.8
Fasting Glucose 0.6 0.7 2.1 0.7 -0.7 -1.1 0.6 0.0 -0.8 -1.4 0.9 -0.5 -0.8
HbA1C 0.8 0.9 2.1 1.0 -0.9 -1.1 -0.7 0.0 -1.2 -0.8 1.0 -1.5 0.2
HDL Cholesterol 0.8 1.3 3.7 1.9 -1.1 -1.8 0.1 0.0 -0.4 -0.4 1.9 -0.7 -0.6
LDL Cholesterol 1.2 1.9 4.2 1.2 -1.6 -1.4 -1.9 0.0 -2.0 -0.8 1.3 -1.2 -1.2
Lupus 2.0 3.0 6.1 -1.1 2.1 1.2 2.5 0.0 1.8 2.0 -1.5 1.8 2.1
Neuroticism (2016) 2.3 3.3 6.9 0.4 2.6 0.8 2.0 0.0 2.6 2.2 -1.0 2.3 1.9
Primary Biliary Cirrhosis 0.9 1.3 6.6 -0.7 0.9 0.5 -0.4 0.0 1.1 1.5 -1.1 -0.5 2.6
Rheumatoid Arthritis 1.6 2.2 4.1 1.9 -1.4 -1.7 -2.0 0.0 -1.4 -0.5 1.7 -2.0 0.3
Schizophrenia (2014) 1.2 2.7 6.2 -1.3 1.7 1.8 2.3 0.0 2.5 2.0 -1.4 1.2 0.7
Triglycerides 0.8 1.2 3.4 1.5 -0.5 -1.3 -1.8 0.0 -1.2 0.1 0.9 -1.3 0.9
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.9 0.5 -0.2 -1.0 0.7 0.0 -0.2 -0.3 0.6 -0.6 -0.5
Ulcerative Colitis 1.3 1.9 5.0 -1.3 1.6 1.5 -0.3 0.0 0.7 2.1 -1.7 0.4 2.2
Blood Eosinophil Count 0.0 0.2 1.3 -1.1 0.0 0.6 -0.1 0.0 -0.3 0.2 -0.5 -0.0 -0.0
Blood Platelet Count 0.4 4.1 7.7 -0.9 2.6 1.8 1.9 0.0 2.8 2.3 -1.8 2.1 2.3
Blood Red Count 0.7 6.6 22.3 1.6 -2.6 -2.5 -1.2 0.0 -2.4 -3.0 2.7 -2.1 -4.7
Blood White Count 0.1 0.4 2.0 0.8 -0.1 -0.8 -0.3 0.0 -0.4 -1.4 0.6 -0.7 -0.3
Heel T-Score 0.8 6.7 14.1 -3.2 2.2 3.8 2.2 0.0 3.5 0.9 -3.5 2.7 -0.5
BMI 0.3 2.0 5.3 -0.5 2.3 0.9 1.7 0.0 1.0 1.1 -1.6 1.5 2.0
Height 4.1 79.2 118.8 10.0 -9.6 -10.9 -6.7 0.0 -10.5 -9.9 10.8 -9.3 -5.0
Waist Hip Ratio (WHR) 2.4 10.9 19.7 4.2 -3.2 -4.4 -2.3 0.0 -3.5 -2.6 4.2 -4.4 -1.0
Systolic Blood Pressure 7.8 39.0 88.4 6.0 -6.4 -6.6 -5.7 0.0 -6.5 -9.4 6.6 -6.0 -5.1
Smoking Status 0.2 0.5 2.0 0.5 -0.7 -0.6 -0.4 0.0 -0.8 -1.4 0.5 -0.6 -0.2
Allergy or Eczema 0.8 2.0 8.8 -1.5 1.6 1.1 0.5 0.0 1.6 0.6 -1.4 0.2 3.0
Cardiovascular Disease 2.1 6.9 23.4 2.0 -2.5 -2.5 -3.0 0.0 -2.8 -4.8 2.2 -2.3 -1.5
Hypothyroidism (self reported) 0.4 0.8 3.2 -0.1 1.3 0.6 0.6 0.0 0.6 1.0 -0.9 0.7 1.8
Respiratory disease 0.6 1.3 3.3 -1.6 0.8 1.4 0.9 0.0 1.0 0.9 -1.3 0.3 1.8
Type 2 Diabetes (T2D) (2018) 2.9 5.4 9.6 2.6 -2.6 -2.7 -2.4 0.0 -3.1 -1.7 2.5 -3.0 -0.5
Lung FEV1/FVC ratio 2.3 11.8 35.0 2.2 -3.5 -2.8 -1.2 0.0 -3.8 -5.2 3.5 -1.8 -5.9
Lung FVC 0.0 0.2 0.9 0.9 -0.3 -0.1 0.4 0.0 -0.3 0.4 0.5 0.6 -0.5
Neuroticism 0.8 2.0 4.6 -1.4 1.9 1.6 1.4 0.0 2.1 0.5 -1.3 1.8 0.5
Chronotype (morning person) 2.1 4.8 9.7 2.1 -2.6 -2.4 -2.3 0.0 -1.0 -2.7 2.1 -1.8 -3.1
Hair Pigment 0.3 7.4 16.8 -0.6 3.7 1.6 4.1 0.0 2.7 2.9 -2.0 3.0 3.5
Tanning 0.1 1.2 3.1 1.1 -1.3 -1.3 -0.8 0.0 -0.7 -0.1 1.5 -1.0 -1.8
Hand grip strength (left) 0.3 0.9 1.7 1.2 -0.7 -1.2 -0.7 0.0 -0.8 -1.3 1.1 -1.2 -0.1
Number of treatments/medications taken 1.1 2.1 7.8 1.2 -0.9 -1.4 -1.7 0.0 -1.8 -2.8 1.0 -1.1 0.2
Average weekly spirits intake 0.5 0.6 1.8 0.5 -0.1 -0.8 0.1 0.0 -1.3 0.7 0.7 -0.9 1.2
Sensitivity / hurt feelings 0.2 0.4 0.8 0.7 0.9 -0.3 0.6 0.0 0.6 0.1 0.1 0.9 0.8
Frequency of depressed mood in last 2 weeks 1.8 2.5 6.0 -0.8 2.0 1.4 2.4 0.0 1.9 1.1 -1.2 2.4 0.8
Hearing difficulty/problems: Yes 0.3 0.5 1.2 0.7 -0.6 -0.7 0.7 0.0 -1.1 -1.0 0.8 -0.2 0.2
Relative age of first facial hair 0.2 0.4 1.1 -0.5 0.1 -0.0 1.1 0.0 1.0 -0.4 -0.4 1.0 -0.4
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 0.7 0.4 -0.2 -0.5 -0.5 0.0 -0.8 0.8 0.4 -0.8 0.7
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.4 0.3 1.8 0.5 1.3 0.0 1.1 1.5 -0.7 1.3 1.8
Ever had hysterectomy (womb removed) 0.3 0.3 0.7 -0.5 0.6 0.8 0.4 0.0 0.7 -0.2 -0.7 0.5 0.4
Systolic blood pressure, automated reading 9.7 28.2 59.1 5.1 -5.6 -5.7 -4.7 0.0 -6.1 -7.7 5.6 -5.4 -3.9
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 5.2 2.1 -2.0 -2.1 -1.6 0.0 -1.6 -1.7 2.3 -1.7 -1.6
Angina 0.8 1.0 4.0 0.6 -0.6 -1.1 -0.9 0.0 -0.7 -2.0 0.6 -0.8 1.3
Medication for hormone replacement therapy 3.5 3.9 7.7 -1.3 2.2 2.1 1.5 0.0 2.8 2.6 -1.9 1.8 2.0
Vitamin and mineral supplements 0.4 0.5 1.0 0.4 0.9 0.5 0.9 0.0 0.7 1.0 -0.4 1.0 0.5
Supplements: Zinc 2.2 2.4 4.8 1.3 -1.5 -2.0 -1.7 0.0 -1.6 -1.1 1.9 -2.2 -1.0
Medication: Co-codamol 0.7 0.8 2.5 0.1 1.0 0.5 1.6 0.0 0.7 1.3 -0.5 1.3 -0.3
Medication: Metformin 0.8 1.1 2.2 1.0 -1.1 -1.4 -1.0 0.0 -1.5 -1.0 1.1 -1.3 -0.0
Diabetes (father) 1.6 2.0 4.2 1.1 -1.9 -1.3 -1.6 0.0 -1.5 -1.2 1.5 -2.1 -0.7
Diabetes (mother) 2.3 2.9 5.9 2.4 -1.1 -2.1 -1.4 0.0 -2.3 -1.2 1.9 -2.2 0.8
Severe depression (siblings) 1.1 1.2 2.4 -1.3 1.1 0.9 -1.6 0.0 0.9 1.4 -1.2 0.6 1.1
Pack years adult smoking proportion 3.1 4.8 10.3 2.1 -1.9 -2.7 -2.7 0.0 -2.5 -1.6 2.4 -3.2 0.8
Impedance of leg (right) 0.1 0.3 1.1 0.7 0.3 -0.2 -0.4 0.0 -0.5 1.0 0.5 0.0 -0.9
Leg fat-free mass (left) 1.1 5.7 10.8 2.7 -2.3 -3.1 -1.7 0.0 -2.9 -3.3 2.6 -2.4 0.3
Trunk fat percentage 0.2 0.7 1.7 1.1 0.5 -1.2 0.1 0.0 -1.3 -1.3 0.6 -0.1 0.2
Hand grip strength (right) 0.3 0.8 1.6 1.1 -0.5 -1.3 -0.7 0.0 -1.0 -1.2 1.1 -0.9 -0.2
Townsend deprivation index at recruitment 0.2 0.2 1.4 0.0 -0.4 0.0 0.2 0.0 -0.8 -1.2 0.1 0.2 -0.4
Current tobacco smoking 0.2 0.3 1.6 0.1 -0.7 -0.4 -0.2 0.0 -0.5 -1.3 0.6 -0.3 -0.2
Average weekly fortified wine intake 1.9 2.2 6.0 0.6 -2.1 -1.5 -1.3 0.0 -2.4 -0.9 1.5 -2.0 -0.6
Maternal smoking around birth 0.8 1.1 4.4 0.2 -1.1 -1.0 -1.3 0.0 -2.1 -1.0 0.6 -1.0 -0.6
Fed-up feelings 1.1 1.9 4.2 -0.7 1.6 1.3 2.0 0.0 2.0 0.9 -1.3 1.8 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.3 -0.8 1.8 1.0 1.3 0.0 1.1 0.8 -1.1 1.2 1.8
Relative age voice broke 0.2 0.4 1.8 0.1 -0.2 0.2 1.3 0.0 0.3 0.3 -0.2 1.2 0.0
Taking other prescription medications 0.8 1.3 4.3 1.0 -0.9 -1.4 -0.9 0.0 -2.1 -1.1 1.1 -1.2 0.3
Age when periods started (menarche) 1.2 2.9 7.6 0.8 -2.8 -1.3 -1.3 0.0 -2.1 -2.5 1.4 -1.6 -1.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.2 0.3 0.3 0.7 0.0 0.1 -0.2 0.2 0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 7.2 -2.0 1.9 2.7 1.7 0.0 2.3 1.8 -2.7 2.6 0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.3 -0.3 -1.2 -0.3 -1.1 0.0 0.0 -0.6 0.4 -0.9 -0.1
Qualifications: CSEs or equivalent 0.0 0.1 0.2 0.1 0.2 0.1 -0.2 0.0 -0.3 0.3 -0.1 -0.2 0.4
Serious illness, injury or assault to yourself 0.3 0.4 1.1 0.6 -0.6 -1.0 -1.0 0.0 -0.8 -0.0 0.7 -0.6 0.1
High blood pressure 4.0 11.2 27.7 2.9 -3.2 -3.6 -2.7 0.0 -4.2 -5.3 3.3 -2.9 -3.0
Hayfever, allergic rhinitis or eczema 0.9 2.0 5.1 -1.7 1.6 1.5 0.7 0.0 1.7 0.7 -1.6 1.0 2.3
Multivitamins +/- minerals 0.4 0.5 1.7 -1.0 -0.5 -0.0 -1.3 0.0 -0.8 -0.3 0.0 -1.0 -0.1
Stomach or abdominal pain in last month 3.3 4.1 6.4 -1.7 2.3 1.8 2.4 0.0 2.4 2.5 -2.2 2.5 1.0
Supplements: Glucosamine 0.2 0.2 0.8 -0.2 0.3 0.5 0.2 0.0 0.6 0.9 -0.4 0.0 0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 0.9 -0.6 -1.1 -0.9 0.0 -0.8 0.5 0.8 -1.1 0.4
Medication: Atenolol 0.4 0.6 1.9 -0.4 1.3 0.4 0.0 0.0 0.2 0.3 -0.8 0.9 1.4
Medication: Levothyroxine sodium 0.2 0.3 0.7 0.6 -0.3 -0.6 -0.6 0.0 -0.8 -0.2 0.4 -0.5 0.8
Sitting height 2.8 19.7 46.1 4.2 -4.8 -4.9 -3.9 0.0 -4.6 -6.8 4.8 -4.7 -2.1
Chronic bronchitis/emphysema (father) 0.5 0.5 2.9 -0.7 0.7 0.6 -0.4 0.0 0.0 -0.2 -0.9 0.1 1.7
High blood pressure (mother) 1.9 2.6 7.7 1.1 -1.8 -1.6 -2.8 0.0 -1.4 -1.4 1.3 -2.4 -0.5
Body mass index (BMI) 0.1 0.6 3.1 -0.4 1.1 0.3 0.8 0.0 -0.0 0.1 -0.9 0.5 1.8
Impedance of leg (left) 0.1 0.4 2.4 0.1 1.1 0.4 0.1 0.0 0.5 1.6 -0.2 0.5 -0.5
Leg predicted mass (left) 1.1 5.7 10.6 2.7 -2.3 -3.0 -1.8 0.0 -2.9 -3.3 2.6 -2.4 0.3
Trunk fat mass 0.5 2.0 4.3 2.1 -0.4 -2.1 -0.4 0.0 -2.1 -1.9 1.4 -0.9 0.3
Waist circumference 0.6 2.4 4.7 2.1 -0.9 -2.2 -0.7 0.0 -2.0 -1.7 1.5 -1.8 1.1
Number of incorrect matches in round 0.1 0.2 0.8 0.6 -0.4 -0.2 0.3 0.0 -0.0 0.9 0.3 -0.3 -0.5
Past tobacco smoking 0.8 1.5 2.5 -1.4 1.5 1.6 0.9 0.0 1.4 1.4 -1.1 1.4 -0.4
Alcohol usually taken with meals 0.2 0.3 1.5 -0.3 0.1 0.2 0.5 0.0 0.9 0.6 -0.0 0.4 -1.2
Nervous feelings 0.2 0.3 1.9 0.6 0.6 -0.4 -1.4 0.0 0.2 -0.0 0.0 0.2 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 3.1 0.6 0.7 -0.2 1.8 0.0 0.8 -1.0 0.4 0.9 -0.6
Hearing difficulty/problems with background noise 0.7 1.1 3.1 -0.5 1.3 0.8 1.8 0.0 1.0 0.6 -0.8 0.7 1.7
Hair/balding pattern: Pattern 2 1.9 2.4 4.3 -1.1 1.5 1.6 1.3 0.0 1.4 1.7 -2.1 1.6 2.1
Had menopause 0.1 0.1 0.6 -0.3 -0.0 -0.0 -0.8 0.0 -0.0 -0.8 -0.1 -0.3 0.2
Had other major operations 0.2 0.2 1.2 -0.7 -0.3 0.5 1.1 0.0 0.3 -0.2 -0.4 0.1 0.4
Forced vital capacity (FVC) 1.5 5.8 10.1 2.9 -2.4 -2.9 -1.9 0.0 -2.3 -3.1 3.2 -1.9 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.2 -1.5 1.5 2.0 1.7 0.0 1.5 1.4 -2.0 1.7 0.5
Ever unenthusiastic/disinterested for a whole week 2.6 3.1 5.3 -0.9 2.2 1.8 2.2 0.0 1.9 1.7 -1.8 2.3 1.7
Qualifications: None of the above 0.2 0.4 1.3 -1.1 0.1 0.4 -0.9 0.0 -0.4 -0.8 -0.9 0.1 0.4
Financial difficulties in last 2 years 0.5 0.7 1.8 -0.6 1.2 0.7 1.1 0.0 0.6 0.5 -0.8 0.6 1.3
Mouth/teeth dental problems 1.3 2.0 5.4 1.9 -1.2 -1.4 0.9 0.0 -1.5 -0.8 2.0 -0.2 -2.3
Heart attack 1.8 2.3 4.0 -1.0 1.9 1.6 1.4 0.0 1.9 -0.4 -1.7 2.0 1.7
Allergy 0.3 0.8 2.0 1.4 -0.8 -1.1 -0.1 0.0 -0.9 0.2 1.1 -0.3 -1.4
Pain all over the body in last month 0.1 0.1 0.5 -0.3 0.3 0.1 0.2 0.0 -0.2 0.7 -0.4 -0.1 0.6
Diabetes (self-reported) 1.5 2.3 4.2 1.6 -2.1 -1.8 -0.8 0.0 -1.9 -1.7 1.6 -1.4 -1.1
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 3.7 -0.8 -0.3 0.1 -1.1 0.0 -0.5 -1.4 -0.2 -1.1 1.9
Medication: Ramipril 4.1 5.3 17.7 1.6 -2.3 -2.2 -1.3 0.0 -1.9 -4.2 2.5 -2.0 -2.7
Medication: Simvastatin 2.2 3.2 8.2 1.1 -1.8 -1.8 -2.2 0.0 -1.9 -2.9 1.6 -1.4 -1.7
Fluid intelligence score 1.1 2.2 5.6 0.8 -2.1 -1.4 -1.7 0.0 -1.0 -2.4 1.3 -1.9 -0.3
Illnesses of siblings 0.5 0.7 4.9 0.2 0.8 -0.2 0.7 0.0 1.0 2.2 0.4 0.3 -0.2
Neuroticism score 0.6 1.2 3.5 -0.7 1.4 1.0 1.3 0.0 1.9 0.7 -0.8 1.6 0.2
Weight 0.9 4.3 7.8 2.6 -1.6 -2.8 -1.1 0.0 -2.8 -2.8 2.2 -2.0 0.4
Impedance of arm (right) 0.9 4.1 8.4 2.3 -1.8 -1.9 -1.5 0.0 -2.0 -2.5 2.5 -1.3 -2.9
Arm fat percentage (right) 0.1 0.6 1.6 1.1 0.2 -0.9 0.0 0.0 -1.2 -1.3 0.5 -0.1 0.4
Trunk fat-free mass 1.8 10.2 17.1 3.8 -3.4 -4.1 -2.6 0.0 -3.8 -3.3 3.7 -3.6 0.4
Hip circumference 0.2 0.9 3.5 1.0 -0.1 -1.1 -0.4 0.0 -1.4 -1.9 0.5 -0.5 0.9
Time employed in main current job 1.0 1.2 5.0 -0.1 -1.4 -0.2 -0.2 0.0 -0.3 -1.9 0.3 -0.9 -2.2
Alcohol intake versus 10 years previously 1.1 1.7 3.1 -1.4 1.8 1.2 1.1 0.0 1.6 1.4 -1.3 0.9 1.5
Father’s age at death 0.4 0.6 3.6 0.4 0.6 0.2 1.9 0.0 0.6 0.8 -0.1 0.9 0.0
Worrier / anxious feelings 0.4 0.8 1.7 -1.0 1.3 0.8 0.5 0.0 1.3 0.4 -0.9 0.9 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 2.3 -1.1 1.1 1.4 1.3 0.0 1.4 0.2 -1.2 1.3 1.5
Falls in the last year 1.0 1.4 3.1 1.5 -1.0 -1.7 -0.9 0.0 -1.8 -0.9 1.2 -1.3 0.2
Hair/balding pattern: Pattern 3 0.7 1.1 4.6 -0.0 -0.6 -0.5 0.1 0.0 -0.9 -2.0 0.9 -0.3 -2.1
Number of live births 0.2 0.3 2.3 -0.2 0.1 0.2 -0.2 0.0 0.0 0.2 -0.7 -0.4 1.5
Forced expiratory volume in 1-second (FEV1) 2.8 9.5 18.7 3.3 -2.9 -3.4 -2.0 0.0 -3.0 -4.3 3.9 -2.1 -3.5
Pulse rate 0.9 1.5 6.5 0.2 -1.5 -0.9 -1.6 0.0 -0.5 -1.1 0.8 -0.7 -2.5
Happiness 4.0 4.9 10.4 -3.0 1.6 3.2 2.6 0.0 2.3 0.0 -2.6 2.8 -0.2
Noisy workplace 0.2 0.2 0.9 -0.5 -0.1 0.2 0.5 0.0 0.4 0.9 -0.3 -0.2 0.8
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.0 -0.5 -1.1 0.3 -1.4 0.0 -0.5 -0.7 -0.1 -1.1 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 3.0 -0.4 1.0 0.9 0.5 0.0 1.7 1.7 -1.0 1.3 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 1.7 -0.3 0.2 -0.6 -1.3 0.0 -0.2 -0.2 -0.1 -0.6 1.0
Asthma 1.0 1.9 3.7 -1.9 0.9 1.8 1.7 0.0 1.4 0.5 -1.9 0.9 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.5 1.6 -0.2 -0.9 -0.3 0.0 -0.5 -0.3 0.7 -0.3 0.9
Medication: Cholesterol lowering 1.5 2.3 7.2 0.6 -1.4 -1.2 -2.7 0.0 -1.6 -2.2 1.1 -1.3 -1.4
Depression (self-reported) 0.2 0.3 0.8 0.7 0.5 -0.4 0.3 0.0 0.9 0.1 0.2 0.4 0.7
Medication: Lansoprazole 0.5 0.5 1.9 -0.4 0.5 0.6 1.0 0.0 0.7 -0.8 -0.7 1.4 0.1
Prospective memory result 0.9 1.1 1.9 -1.4 1.0 1.2 0.6 0.0 1.4 1.1 -1.3 1.2 -0.1
Lung cancer (father) 2.4 2.8 9.1 0.7 -2.0 -1.6 -1.2 0.0 -3.0 -0.9 1.7 -2.3 -0.7
Illnesses of mother 3.2 3.9 6.1 -2.0 2.5 2.3 2.4 0.0 2.2 1.8 -2.1 2.1 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.8 13.8 2.7 -2.4 -3.0 -1.6 0.0 -2.5 -3.7 3.3 -1.5 -3.2
Pulse wave Arterial Stiffness index 0.7 0.8 1.2 -0.9 0.9 1.0 0.5 0.0 0.8 -1.1 -1.1 1.0 0.9
Impedance of arm (left) 0.5 2.4 7.6 1.8 -1.1 -1.3 -0.9 0.0 -1.1 -2.1 1.8 -0.5 -2.8
Arm fat mass (right) 0.4 1.6 3.4 1.8 -0.4 -1.8 -0.7 0.0 -1.8 -1.7 1.1 -1.0 0.8
Trunk predicted mass 1.7 9.5 15.9 3.6 -3.3 -4.0 -2.5 0.0 -3.7 -3.3 3.5 -3.5 0.4
Standing height 3.6 35.3 55.4 7.0 -6.2 -7.4 -4.7 0.0 -6.7 -6.7 7.4 -6.1 -2.9
Length of working week for main job 0.1 0.1 0.2 0.1 0.5 0.2 0.4 0.0 -0.4 0.4 -0.2 0.1 0.4
Exposure to tobacco smoke at home 0.8 0.9 1.8 -1.1 1.3 1.1 0.4 0.0 1.0 1.4 -1.0 0.8 0.4
Breastfed as a baby 0.2 0.3 1.2 -0.5 -0.1 0.6 0.6 0.0 1.1 0.0 -0.2 0.4 -0.5
Tense / ‘highly strung’ 0.5 0.9 2.0 -0.3 1.3 0.4 1.4 0.0 1.3 1.2 -0.6 1.2 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.5 0.0 1.4 0.5 0.7 0.0 1.6 -0.2 -0.9 1.6 1.5
Hair/balding pattern: Pattern 4 0.1 0.4 1.4 0.8 0.2 -0.5 0.8 0.0 0.2 1.2 0.6 0.4 0.0
Birth weight of first child 0.4 0.8 5.2 -0.3 0.6 0.7 0.5 0.0 0.5 2.3 -0.7 0.5 0.6
Peak expiratory flow (PEF) 1.9 4.5 12.2 2.2 -1.5 -2.3 -1.9 0.0 -1.7 -3.5 2.5 -1.0 -2.6
Pulse wave reflection index 2.5 3.1 4.9 -1.8 2.0 2.2 1.8 0.0 2.1 0.4 -2.1 2.0 1.5
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.3 -1.8 1.3 1.3 0.8 0.0 0.3 1.4 -1.3 0.7 1.1
Loud music exposure frequency 0.3 0.3 1.2 0.4 -0.3 -0.7 0.7 0.0 -0.5 -0.5 0.7 0.1 -1.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 3.7 0.7 -1.9 -0.8 -1.1 0.0 -1.0 -0.7 1.1 -1.6 -0.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.9 -1.7 0.4 1.2 -0.8 0.0 0.7 -0.3 -1.4 -0.4 1.5
Blood clot in the leg (DVT) 1.2 1.6 4.8 0.4 -1.0 -1.2 -1.6 0.0 -1.7 -2.2 0.9 -1.1 -1.1
Medication: Paracetamol 0.3 0.6 2.8 0.5 0.4 -0.6 -0.6 0.0 -1.2 -0.7 -0.1 -0.2 1.7
Headache pain in last month 1.0 1.7 3.4 -1.1 1.8 1.2 1.8 0.0 1.4 0.8 -1.5 1.6 0.7
Medication for cholesterol, blood pressure or diabetes 2.9 4.8 10.9 -1.2 2.3 1.9 2.8 0.0 2.5 3.3 -1.8 2.1 2.2
Glaucoma (self-reported) 0.4 0.5 1.3 0.0 1.0 0.2 -0.0 0.0 1.1 -0.0 -0.6 1.1 0.9
Gout (self-reported) 1.3 1.8 3.6 -0.8 1.7 1.6 0.9 0.0 1.8 1.0 -1.7 1.9 0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.3 1.1 -0.2 -1.0 -0.8 0.0 -0.9 -0.3 0.7 -0.9 1.1
Medication: Amlodipine 1.9 2.7 4.7 1.6 -1.6 -1.7 -2.0 0.0 -2.1 -2.2 1.6 -1.3 -1.0
Medication: Ventolin 100micrograms inhaler 2.1 2.7 8.2 -2.2 1.5 1.5 1.3 0.0 1.1 1.4 -1.9 0.9 2.9
Birth weight 0.3 0.7 2.6 -0.2 0.8 0.2 0.5 0.0 1.2 1.6 -0.5 0.9 0.8
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.4 -1.2 -0.1 0.7 -0.6 0.0 -0.8 -0.1 -0.9 0.7 -0.3
High blood pressure (siblings) 1.2 1.8 7.6 0.8 -1.5 -0.7 -0.9 0.0 -1.9 -2.8 0.6 -0.7 -1.2
Forced vital capacity (FVC), Best measure 1.4 5.0 8.9 2.5 -2.2 -2.7 -1.9 0.0 -2.1 -3.0 2.9 -1.7 -1.8
Body fat percentage 0.1 0.4 1.1 0.6 1.1 -0.5 0.6 0.0 -0.7 -0.5 -0.1 0.5 0.7
Leg fat percentage (right) 0.3 0.9 2.9 -0.3 1.7 0.5 1.1 0.0 0.1 0.9 -1.0 1.2 1.3
Arm fat-free mass (right) 0.5 2.6 4.7 1.6 -1.5 -2.2 -1.3 0.0 -2.0 -1.7 1.4 -1.9 1.4
Exposure to tobacco smoke outside home 0.6 0.8 2.1 -1.4 1.2 1.1 -0.1 0.0 0.4 1.4 -1.1 0.4 0.5
Comparative body size at age 10 0.6 1.6 4.1 -1.1 1.4 1.1 1.6 0.0 0.9 2.0 -1.0 1.0 1.6
Number of full brothers 0.5 0.6 1.8 1.3 -0.7 -0.9 0.1 0.0 -0.4 -1.1 1.0 -0.1 -0.9
Worry too long after embarrassment 0.9 1.5 3.9 -1.4 1.1 1.5 0.9 0.0 2.0 1.1 -1.2 1.6 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.6 0.3 1.1 0.8 1.2 0.0 1.6 0.5 -0.6 1.0 0.6
Wheeze or whistling in the chest in last year 0.7 1.2 8.0 -0.9 0.2 0.5 -0.2 0.0 0.2 0.4 -0.9 -1.2 2.8
Number of children fathered 0.7 0.8 2.0 0.7 -0.8 -1.1 1.3 0.0 -0.6 -0.5 1.1 -0.1 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 4.5 2.0 -1.6 -1.5 -0.8 0.0 -1.7 -0.6 1.5 -0.9 -2.1
Age at first live birth 1.4 2.4 7.0 -1.2 1.5 1.6 1.8 0.0 2.6 1.7 -1.3 1.7 0.5
Pulse wave peak to peak time 1.4 1.6 2.8 1.6 -1.4 -1.6 -0.9 0.0 -1.4 0.5 1.7 -1.5 -1.1
Health satisfaction 1.0 1.3 3.2 0.8 -1.5 -0.9 -1.3 0.0 -1.8 -1.4 0.8 -1.4 -0.0
Shortness of breath walking on level ground 1.5 1.8 3.5 -1.9 1.6 1.4 1.1 0.0 0.4 1.1 -1.7 1.3 1.6
Qualifications: College or University degree 1.4 4.4 11.0 -1.9 1.6 2.3 1.7 0.0 2.1 2.6 -2.2 1.6 3.3
Eye problems/disorders: None of the above 1.1 1.3 5.8 -1.2 0.5 1.5 -0.5 0.0 0.3 0.2 -1.6 -0.2 2.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 0.1 -0.8 -0.3 -0.9 0.0 -0.9 -0.9 0.3 -0.7 -0.3
Emphysema/chronic bronchitis 1.8 2.0 3.3 1.5 -1.7 -1.8 -1.6 0.0 -1.2 -1.3 1.8 -1.5 -1.0
Medication for pain relief, constipation, heartburn 0.2 0.3 2.0 -0.5 -0.2 0.3 -0.0 0.0 0.5 1.4 0.0 -0.6 -0.2
Neck or shoulder pain in last month 0.9 1.2 6.7 -0.3 1.3 0.5 -0.8 0.0 0.4 1.1 -1.1 0.4 2.6
Medication: Blood pressure 2.3 4.1 8.9 1.5 -1.7 -2.1 -2.2 0.0 -2.5 -3.0 1.8 -2.0 -1.9
Angina (self-reported) 0.9 1.2 3.2 0.6 -0.6 -1.1 -1.4 0.0 -0.8 -1.8 0.5 -1.0 1.7
Migraine (self-reported) 0.6 0.7 2.7 -0.4 1.1 0.4 0.1 0.0 -0.1 1.1 -0.8 0.9 1.6
Medication: Ibuprofen 0.5 0.5 1.8 1.3 -0.4 -0.8 -0.6 0.0 -0.8 -0.2 0.7 -0.6 1.0
Medication: Allopurinol 1.6 2.1 4.2 -1.0 2.0 1.6 0.8 0.0 1.1 2.1 -1.7 1.6 1.2
Medication: Omeprazole 1.3 1.6 3.9 -1.7 1.1 1.3 -0.4 0.0 1.0 0.9 -1.8 1.0 2.0
Medication: Seretide 50 evohaler 0.3 0.3 1.2 0.4 0.0 -0.8 -0.4 0.0 -1.1 -0.5 0.6 -0.1 0.4
Mean time to correctly identify matches 0.5 1.0 2.2 -0.8 1.2 0.8 1.3 0.0 1.1 0.4 -0.7 1.5 -1.3
Heart disease (mother) 0.6 0.7 2.8 -0.8 0.4 0.8 0.8 0.0 0.8 0.7 -1.0 1.7 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.9 -0.8 0.6 0.6 0.2 0.0 0.8 -0.8 -0.7 1.4 -0.9
Whole body fat mass 0.3 1.1 2.6 1.6 0.1 -1.6 -0.2 0.0 -1.6 -1.4 0.9 -0.6 0.8
Leg fat mass (right) 0.1 0.4 2.1 0.7 0.8 -0.6 0.2 0.0 -0.8 -0.3 -0.0 0.2 1.5
Arm predicted mass (right) 0.5 2.4 4.3 1.6 -1.3 -2.1 -1.2 0.0 -1.9 -1.8 1.4 -1.8 1.4
Pulse rate, automated reading 1.0 3.2 7.4 2.7 -1.5 -2.5 -0.7 0.0 -1.3 -1.1 2.1 -0.8 -2.6
Alcohol intake frequency. 1.2 2.7 6.0 -1.1 2.3 1.2 0.1 0.0 2.1 2.4 -1.6 1.0 2.3
Comparative height size at age 10 3.5 19.3 34.7 5.9 -4.2 -5.9 -3.1 0.0 -4.8 -3.7 5.9 -4.4 -2.2
Number of full sisters 0.7 0.8 1.6 0.8 -1.0 -0.6 -1.0 0.0 -1.3 -1.2 0.7 -1.3 -0.7
Suffer from ‘nerves’ 0.4 0.7 1.7 -0.5 1.3 0.8 -0.2 0.0 0.9 0.6 -1.0 1.2 0.7
Overall health rating 0.1 0.3 2.0 -0.3 0.3 0.3 0.4 0.0 -0.0 0.0 -0.5 -0.1 1.4
Chest pain or discomfort 1.8 2.7 10.4 -1.0 1.7 1.4 0.7 0.0 1.7 1.7 -1.7 0.9 3.2
Had major operations 1.6 1.9 5.2 1.3 -1.3 -1.5 -2.3 0.0 -1.5 -0.6 1.2 -1.9 0.3
Age at last live birth 0.4 0.6 2.0 -0.4 0.6 0.5 1.0 0.0 1.3 1.4 -0.5 0.5 0.3
Family relationship satisfaction 0.4 0.5 1.6 -1.3 -0.2 1.3 0.6 0.0 0.3 -0.3 -0.9 0.5 -0.4
Leg pain on walking 0.7 0.9 3.7 -1.3 0.5 0.9 0.1 0.0 0.3 0.6 -1.2 0.2 1.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.6 -0.6 -0.1 0.5 -1.2 0.0 -0.1 0.4 -0.4 0.2 -1.3
Commuting to job workplace: Car/motor vehicle 2.9 3.4 7.9 -1.3 2.4 1.8 0.6 0.0 2.5 2.8 -2.0 1.3 1.7
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 3.3 0.5 -0.9 -1.2 -0.8 0.0 -1.2 -1.8 1.2 -1.4 -1.3
Medication: Aspirin 3.0 3.9 17.7 0.8 -2.2 -1.2 -1.8 0.0 -1.7 -4.2 1.1 -1.4 -2.2
Supplements: Vitamin C 0.2 0.2 0.5 0.7 -0.3 -0.7 0.6 0.0 -0.2 0.5 0.5 -0.3 -0.4
Knee pain experienced in last month 0.1 0.1 0.5 -0.3 0.4 0.0 0.7 0.0 -0.1 0.3 -0.2 0.1 0.6
Hypertension (Self-reported) 3.9 10.7 27.1 3.1 -3.0 -3.6 -2.8 0.0 -4.0 -5.2 3.2 -2.9 -2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.7 -0.5 -0.7 -0.2 -0.6 0.0 -1.3 -0.7 -0.1 -0.4 -0.3
Illnesses of father: Heart disease 1.0 1.4 3.1 -1.8 1.5 1.4 0.6 0.0 1.6 0.3 -1.4 1.0 0.8
Illnesses of siblings: Diabetes 0.7 0.8 2.4 -1.6 0.5 1.2 0.1 0.0 -0.2 0.0 -1.5 0.6 1.2
Smoking status: Previous 0.8 1.2 2.0 1.4 -0.9 -1.4 -1.0 0.0 -0.9 -1.2 1.1 -1.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 3.0 6.1 11.5 3.1 -2.2 -3.4 -2.6 0.0 -2.6 -2.4 3.1 -2.3 -1.0
Whole body fat-free mass 1.3 7.3 12.3 3.1 -2.8 -3.5 -2.1 0.0 -3.3 -3.1 3.0 -3.0 0.7
Leg fat-free mass (right) 1.0 5.6 11.7 2.6 -2.3 -3.0 -1.8 0.0 -2.7 -3.4 2.5 -2.5 0.4
Arm fat percentage (left) 0.1 0.3 0.6 0.6 0.7 -0.3 0.5 0.0 -0.5 -0.8 -0.2 0.6 0.7
Average weekly red wine intake 0.2 0.4 1.0 -0.6 -0.5 1.0 0.7 0.0 -0.5 0.2 -0.6 0.5 -0.7
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.8 -1.6 1.6 1.2 0.6 0.0 1.2 1.3 -1.5 1.0 2.0
Mood swings 0.6 1.1 2.9 -0.3 1.3 0.8 1.6 0.0 1.7 0.5 -0.7 1.7 0.2
Loneliness, isolation 0.6 0.8 1.8 -1.3 0.8 1.3 -0.2 0.0 1.1 0.1 -1.0 1.1 0.2
Long-standing illness, disability or infirmity 0.3 0.5 3.1 -0.1 0.1 -0.1 -0.6 0.0 -0.9 -0.0 -0.2 -0.7 1.8
Ever had bowel cancer screening 2.4 2.8 4.4 -1.9 2.1 2.0 1.2 0.0 1.9 1.5 -2.1 1.8 0.8
Diabetes diagnosed by doctor 1.9 3.2 5.8 1.9 -2.2 -2.0 -1.8 0.0 -2.4 -1.7 1.9 -1.9 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.2 -0.6 1.0 0.6 1.5 0.0 0.9 1.1 -0.4 0.5 -0.0
Friendships satisfaction 0.6 0.8 2.3 -1.5 0.3 1.5 -0.1 0.0 0.7 0.1 -1.3 0.1 0.9
Qualifications: nursing, teaching 0.9 1.4 2.8 -0.8 1.1 1.4 1.5 0.0 1.4 1.5 -0.9 1.7 0.2
Commuting to job workplace: Walk 5.1 5.5 9.2 2.6 -2.4 -3.0 -2.4 0.0 -2.4 -2.2 2.8 -2.7 -1.2
Eye problems/disorders: Cataract 0.9 1.1 2.9 -1.0 0.7 0.6 1.7 0.0 0.9 1.0 -0.5 1.5 -1.4
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 6.3 -0.9 2.0 0.8 1.2 0.0 1.4 2.5 -1.2 1.3 1.8
Medication for cholesterol 0.3 0.4 2.8 -0.1 0.2 -0.0 -0.8 0.0 -0.3 1.7 -0.1 -0.1 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 6.3 -0.5 1.0 0.6 -0.7 0.0 0.0 0.7 -1.0 0.1 2.5
Back pain experienced in last month 0.8 1.1 3.0 -1.7 0.7 1.4 0.6 0.0 0.7 0.1 -1.6 0.9 1.4
Mineral and other dietary supplements 0.8 1.0 4.6 2.1 -0.4 -1.6 0.2 0.0 -0.2 -0.6 1.6 -0.4 0.0
Breast cancer (self-reported) 0.3 0.4 1.1 -0.6 0.5 0.5 0.4 0.0 0.4 -0.5 -0.5 1.1 1.0
Asthma (self-reported) 0.8 1.6 3.5 -1.9 0.7 1.7 1.5 0.0 1.1 0.1 -1.7 0.8 1.4
Osteoporosis (self-reported) 0.4 0.5 1.6 -1.3 0.7 0.9 0.6 0.0 0.9 0.6 -0.8 0.2 0.5
Osteoarthritis (self-reported) 0.4 0.6 2.8 1.7 -0.3 -1.0 -0.3 0.0 -0.8 -0.3 0.8 -0.1 0.3
Medication: Aspirin 2.6 3.4 13.8 0.9 -2.0 -1.3 -1.8 0.0 -1.7 -3.7 1.1 -1.5 -1.9
Medication: Gliclazide 0.3 0.3 1.1 0.2 -1.0 -0.2 -0.0 0.0 -0.8 -0.2 0.5 -0.4 -0.9
Illnesses of father: None of the above (group 1) 1.0 1.3 2.5 1.3 -1.2 -1.3 -0.7 0.0 -1.6 0.4 1.5 -1.0 -1.2
Smoking status: Current 0.2 0.3 1.6 -0.1 -0.7 -0.3 -0.1 0.0 -0.4 -1.2 0.4 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 5.8 0.2 -0.2 -0.3 0.6 0.0 -0.3 -0.9 0.7 0.9 -2.4
Whole body water mass 1.3 7.3 12.4 3.1 -2.8 -3.5 -2.1 0.0 -3.3 -3.2 3.0 -3.0 0.6
Leg predicted mass (right) 1.1 5.8 12.4 2.6 -2.4 -3.1 -1.8 0.0 -2.8 -3.5 2.6 -2.5 0.3
Arm fat mass (left) 0.3 1.0 2.4 1.4 -0.2 -1.4 -0.5 0.0 -1.4 -1.6 0.8 -0.6 0.8
Number of self-reported non-cancer illnesses 1.1 1.9 5.2 1.4 -1.0 -1.5 -1.4 0.0 -2.3 -1.8 1.2 -1.4 -0.1
Average weekly champagne plus white wine intake 0.3 0.4 2.7 0.3 0.7 -0.1 0.4 0.0 -0.0 0.7 -0.0 0.4 1.6
Miserableness 1.3 2.3 6.4 -1.7 1.6 1.8 1.3 0.0 2.5 1.0 -1.7 1.5 0.6
Guilty feelings 0.6 0.9 2.9 -0.5 1.0 0.5 1.3 0.0 1.1 1.7 -0.4 1.2 -0.5
Wears glasses or contact lenses 0.6 0.7 2.2 0.9 -0.6 -1.1 -0.4 0.0 -1.5 -1.0 0.8 -0.8 0.3
Ever taken oral contraceptive pill 0.2 0.2 0.8 0.8 -0.0 -0.2 -0.4 0.0 0.7 0.5 0.1 0.0 0.9
Hearing aid user 0.8 0.9 3.4 1.8 -0.3 -1.4 0.2 0.0 -1.1 0.1 1.2 -0.7 0.5
Mother’s age at death 1.4 1.8 3.6 -1.1 1.8 1.4 0.9 0.0 1.9 1.1 -1.4 0.9 1.7
Financial situation satisfaction 0.1 0.2 0.5 0.3 -0.6 -0.1 -0.0 0.0 -0.1 -0.7 0.3 -0.3 -0.7
Tinnitus: Yes, now most or all of the time 1.0 1.2 2.9 1.7 -1.0 -1.4 0.4 0.0 -1.7 -0.4 1.4 -0.7 -0.7
Commuting to job workplace: Public transport 2.1 2.5 7.5 0.6 -2.0 -1.1 -0.5 0.0 -1.6 -2.7 1.5 -1.1 -2.5
Eye problems/disorders: Glaucoma 0.6 0.7 2.1 -0.2 1.2 0.2 0.7 0.0 1.4 0.2 -0.6 1.5 0.5
Medication: Blood pressure 1.7 3.3 14.7 1.2 -1.8 -1.4 -1.3 0.0 -1.8 -3.8 1.4 -1.1 -1.9
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.1 0.3 -0.3 -0.7 -1.0 0.0 -1.1 -0.3 0.6 -1.0 0.9
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.0 -1.4 -0.1 1.1 -0.4 0.0 -0.2 0.1 -1.0 0.0 -0.5
High cholesterol (Self-reported) 2.7 4.7 7.8 2.4 -2.1 -2.5 -2.8 0.0 -2.5 -2.4 2.2 -2.2 -1.1
Medication: Bendroflumethiazide 3.5 5.4 8.4 2.2 -2.9 -2.2 -2.2 0.0 -2.9 -2.9 2.3 -2.1 -2.2
Medication: Paracetamol 0.4 0.6 3.1 0.5 0.3 -0.2 -0.3 0.0 -1.4 -0.7 -0.2 -0.0 1.8
Medication: Lisinopril 0.6 0.8 3.8 0.6 0.2 -0.9 -1.9 0.0 -0.3 -0.8 0.2 -1.0 1.2
Medication: Atorvastatin 0.4 0.5 2.7 -0.4 -1.0 0.2 0.2 0.0 -0.1 -1.6 0.2 0.0 -0.9
Illnesses of father: High blood pressure 0.3 0.3 0.9 -0.9 0.2 0.3 -0.3 0.0 0.4 -0.9 -0.5 0.4 -0.9
Alcohol drinker status: Never 1.0 1.2 2.2 -1.4 1.0 1.5 0.2 0.0 1.2 1.2 -1.5 0.9 0.8
Ever smoked 0.3 0.5 1.5 0.6 -1.2 -0.8 0.2 0.0 -0.6 -0.8 0.6 -0.6 0.4
Basal metabolic rate 1.2 6.7 11.6 3.0 -2.5 -3.4 -2.0 0.0 -3.2 -3.1 2.9 -2.8 0.6
Leg fat percentage (left) 0.4 1.6 4.3 -0.7 2.1 0.9 1.4 0.0 0.7 1.0 -1.5 1.4 1.5
Arm fat-free mass (left) 0.9 4.3 7.9 2.2 -1.9 -2.8 -1.6 0.0 -2.6 -2.2 2.2 -2.5 1.1
Number of operations (self-reported) 1.8 2.7 4.5 1.6 -1.7 -1.9 -2.1 0.0 -1.4 -2.1 1.6 -2.1 -0.3
Average weekly beer plus cider intake 0.4 0.6 1.2 0.6 -0.6 -1.1 -0.8 0.0 -1.1 -1.0 0.9 -0.8 -0.2
Irritability 0.8 1.4 6.9 0.0 0.8 0.7 2.6 0.0 1.5 -0.3 -0.4 1.7 -0.1
Risk taking 1.9 2.7 5.2 -1.6 1.9 1.7 1.3 0.0 2.1 2.3 -1.7 1.9 1.0
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.9 -0.3 -1.3 -0.5 -0.6 0.0 -1.1 -0.7 0.5 -1.1 -1.4
Fractured/broken bones in last 5 years 1.4 1.8 4.3 0.8 -1.8 -1.3 -0.5 0.0 -2.1 -1.4 1.5 -1.3 -1.4
Age started oral contraceptive pill 0.4 0.5 2.7 1.6 -0.2 -0.8 -0.1 0.0 0.1 -0.8 0.8 -0.3 0.6
Diastolic blood pressure, automated reading 1.2 3.8 16.1 1.5 -1.9 -1.4 -1.5 0.0 -1.9 -4.0 1.4 -1.1 -2.2
Ever depressed for a whole week 0.8 1.0 2.4 -1.2 1.0 1.4 -0.6 0.0 0.7 0.6 -1.5 0.8 1.1
Unable to work because of sickness or disability 0.3 0.4 1.6 0.3 0.9 -0.2 -0.3 0.0 0.1 0.9 -0.3 0.0 1.3
Commuting to job workplace: Cycle 0.7 0.8 2.2 0.7 -0.9 -0.7 -1.3 0.0 -0.5 -1.5 0.8 -0.4 -1.2
Myopia 0.5 0.7 1.8 -0.6 -1.1 0.2 -1.2 0.0 -0.9 -1.0 -0.1 -1.3 0.3
Vascular/heart problems diagnosed by doctor 3.5 9.4 27.6 -2.6 3.0 3.1 2.4 0.0 3.6 5.3 -2.9 2.5 2.8
Cholesterol lowering medication 0.2 0.3 1.4 0.3 -0.8 -0.3 -0.1 0.0 -0.4 -1.2 0.2 -0.6 0.2
Medication: Omeprazole (e.g. Zanprol) 2.6 3.2 6.1 -2.2 2.0 1.9 0.6 0.0 1.5 1.5 -2.5 1.7 2.3
Pain experienced in last month 0.3 0.6 2.7 0.7 -0.9 -0.5 0.3 0.0 -0.0 -0.1 1.0 -0.4 -1.6
Supplements: Calcium 0.1 0.1 0.5 -0.3 0.2 -0.4 0.5 0.0 -0.7 -0.6 -0.0 -0.0 0.1
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 0.4 -0.2 -0.5 1.1 0.0 -0.6 0.4 0.4 0.1 0.3
Heart attack/myocardial infarction (self-reported) 1.7 2.2 3.7 -1.1 1.8 1.6 1.2 0.0 1.9 -0.1 -1.8 1.9 1.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 3.2 0.0 -0.5 -0.7 -1.1 0.0 -1.0 -1.8 0.4 -0.6 -0.7
Heart disease (siblings) 0.4 0.5 0.9 0.9 -0.7 -0.8 -1.0 0.0 -0.6 -0.9 0.2 -0.7 0.8
Alcohol drinker status: Previous 0.4 0.5 2.1 1.4 0.2 -1.1 0.6 0.0 0.0 0.0 1.0 -0.4 -0.2
Pack years of smoking 2.9 4.3 8.9 1.9 -1.7 -2.5 -2.9 0.0 -2.4 -1.2 2.1 -3.0 1.0
Impedance of whole body 0.1 0.6 3.3 0.9 -0.0 -0.5 -0.6 0.0 -0.4 -0.4 0.8 -0.0 -1.8
Leg fat mass (left) 0.1 0.5 3.0 0.6 1.1 -0.5 0.3 0.0 -0.4 -0.2 -0.3 0.3 1.7
Arm predicted mass (left) 0.9 4.4 7.9 2.2 -2.0 -2.8 -1.6 0.0 -2.6 -2.3 2.1 -2.5 1.1