Best TWAS P=1.5e-11 · Best GWAS P=2.75e-21 conditioned to 1.55e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NSUN6 | 0.10 | 0.09 | lasso | 3 | 0.09 | 4.5e-11 | -4.8 | 5.2 | 1.7e-07 | -0.20 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | NSUN6 | 0.24 | 0.23 | lasso | 6 | 0.22 | 2.8e-12 | -4.8 | 5.6 | 2.5e-08 | -0.20 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | NSUN6 | 0.18 | 0.11 | lasso | 8 | 0.10 | 4.9e-08 | -4.8 | 6.7 | 1.7e-11 | -0.21 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | RP11-499P20.2 | 0.38 | -0.01 | enet | 32 | 0.01 | 1.6e-01 | 2.1 | 5.8 | 5.3e-09 | -0.18 | 0.11 | 0.06 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | NSUN6 | 0.22 | 0.03 | lasso | 7 | 0.03 | 3.1e-02 | -4.7 | 5.8 | 6.2e-09 | -0.17 | 0.20 | 0.11 | FALSE |
| 6 | GTEx | Nerve Tibial | NSUN6 | 0.37 | 0.35 | enet | 36 | 0.36 | 1.7e-26 | -4.8 | 5.2 | 2.1e-07 | -0.15 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | NSUN6 | 0.14 | 0.10 | enet | 32 | 0.09 | 1.0e-05 | -4.7 | 5.3 | 1.1e-07 | -0.24 | 0.83 | 0.02 | FALSE |
| 8 | GTEx | Whole Blood | NSUN6 | 0.06 | 0.04 | lasso | 2 | 0.04 | 2.4e-04 | -4.8 | 5.6 | 2.6e-08 | -0.20 | 0.60 | 0.05 | FALSE |
| 9 | YFS | Blood | NSUN6 | 0.07 | 0.07 | enet | 21 | 0.08 | 2.8e-25 | -4.8 | 5.2 | 2.6e-07 | -0.19 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | NSUN6 | 0.08 | 0.01 | blup | 119 | 0.05 | 5.6e-04 | -4.8 | 5.8 | 5.6e-09 | -0.32 | 0.08 | 0.34 | TRUE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CACNB2 | 0.05 | 0.05 | enet | 4 | 0.04 | 8.8e-06 | 5.9 | 6.8 | 1.5e-11 | -0.10 | 0.99 | 0.00 | TRUE |