Best TWAS P=7.05e-14 · Best GWAS P=3.34e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | 5.8 | 5.8 | 7.5e-09 | -0.76 | 0.82 | 0.18 | FALSE |
| 2 | GTEx | Muscle Skeletal | RP11-436D10.3 | 0.08 | 0.04 | enet | 13 | 0.06 | 3.2e-06 | -7.3 | 7.3 | 3.8e-13 | -0.87 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | NRBF2 | 0.06 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -7.1 | 7.2 | 5.7e-13 | -0.68 | 0.06 | 0.31 | FALSE |
| 4 | GTEx | Testis | ADO | 0.21 | 0.23 | lasso | 7 | 0.22 | 6.6e-10 | 5.8 | -5.8 | 5.7e-09 | 0.74 | 0.73 | 0.27 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ADO | 0.06 | 0.04 | lasso | 2 | 0.06 | 3.1e-08 | -7.3 | 6.6 | 4.8e-11 | -0.89 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADO | 0.03 | 0.02 | blup | 53 | 0.03 | 1.8e-06 | 3.9 | 5.9 | 3.9e-09 | -0.73 | 0.06 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADO | 0.10 | 0.03 | enet | 6 | 0.06 | 4.6e-07 | 5.2 | 6.5 | 6.5e-11 | -0.79 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADO | 0.14 | 0.05 | blup | 53 | 0.05 | 3.8e-06 | -7.1 | 6.9 | 5.0e-12 | -0.85 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADO | 0.06 | 0.04 | blup | 55 | 0.01 | 1.4e-01 | -7.3 | 6.8 | 1.2e-11 | -0.84 | 0.00 | 0.86 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ADO | 0.12 | 0.10 | lasso | 5 | 0.09 | 5.2e-09 | -7.3 | 7.5 | 7.1e-14 | -0.97 | 0.00 | 1.00 | TRUE |