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chr1:88,453,303-90,145,331

Best TWAS P=4.81e-11 · Best GWAS P=7.98e-11 conditioned to 0.0373

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	YFS	Blood	GTF2B	0.01	0.00	lasso	3	0.01	2.3e-04	6.5	6.6	4.8e-11	0.80	0.03	0.90	TRUE
6	GTEx	Brain Cerebellar Hemisphere	CCBL2	0.31	0.18	lasso	5	0.23	1.7e-06	6.4	-6.4	1.2e-10	-0.89	0.03	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	PKN2	0.09	0.04	enet	8	0.05	1.2e-03	6.4	6.1	1.2e-09	0.74	0.10	0.80	FALSE
15	GTEx	Pituitary	CCBL2	0.45	0.30	lasso	2	0.26	2.7e-07	6.4	-6.0	1.8e-09	-0.80	0.04	0.95	FALSE
14	GTEx	Pancreas	CCBL2	0.26	0.21	lasso	4	0.23	5.3e-10	6.4	-5.8	6.4e-09	-0.73	0.01	0.99	FALSE
18	METSIM	Adipose	CCBL2	0.27	0.14	lasso	6	0.18	6.4e-27	4.7	-5.8	7.2e-09	-0.77	0.25	0.75	FALSE
11	GTEx	Colon Transverse	CCBL2	0.30	0.19	lasso	8	0.26	1.2e-12	4.7	-5.8	8.3e-09	-0.76	0.11	0.89	FALSE
17	GTEx	Thyroid	CCBL2	0.22	0.15	enet	22	0.22	9.8e-17	6.4	-5.7	9.4e-09	-0.71	0.03	0.97	FALSE
16	GTEx	Stomach	CCBL2	0.16	0.08	lasso	4	0.15	9.0e-08	4.7	-5.6	1.7e-08	-0.81	0.10	0.89	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	CCBL2	0.38	0.44	enet	20	0.32	2.1e-09	5.0	-5.5	4.2e-08	-0.80	0.18	0.82	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	CCBL2	0.43	0.56	enet	31	0.56	1.1e-87	4.7	-5.5	4.3e-08	-0.76	0.99	0.01	FALSE
7	GTEx	Brain Cortex	CCBL2	0.59	0.39	enet	13	0.37	3.0e-11	6.4	-5.4	5.4e-08	-0.76	0.06	0.94	FALSE
12	GTEx	Esophagus Muscularis	CCBL2	0.25	0.29	enet	18	0.28	1.6e-17	4.7	-5.4	5.5e-08	-0.74	0.71	0.29	FALSE
5	GTEx	Artery Tibial	CCBL2	0.30	0.24	lasso	8	0.29	4.9e-23	4.7	-5.3	8.8e-08	-0.73	0.48	0.52	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCBL2	0.58	0.68	lasso	7	0.69	1.4e-117	4.7	-5.3	9.3e-08	-0.73	0.99	0.01	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	CCBL2	0.36	0.32	enet	37	0.33	6.4e-11	4.7	-5.2	1.8e-07	-0.68	0.02	0.98	FALSE
13	GTEx	Nerve Tibial	CCBL2	0.42	0.33	enet	38	0.38	3.4e-28	4.7	-5.2	1.9e-07	-0.71	0.99	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	CCBL2	0.21	0.10	enet	7	0.15	5.2e-08	4.7	-5.2	2.3e-07	-0.71	0.14	0.86	FALSE
8	GTEx	Brain Frontal Cortex BA9	CCBL2	0.47	0.38	enet	25	0.48	1.5e-14	4.7	-5.1	2.8e-07	-0.78	0.11	0.89	FALSE
10	GTEx	Cells Transformed fibroblasts	CCBL2	0.65	0.61	enet	32	0.67	6.1e-67	4.7	-5.1	2.9e-07	-0.69	0.99	0.01	FALSE
2	GTEx	Adipose Subcutaneous	CCBL2	0.26	0.21	enet	15	0.23	1.2e-18	4.7	-5.1	3.1e-07	-0.67	0.99	0.01	FALSE