Hub : Genes

GTF2B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0107 0.0060 0.0097 0.005 0.008 0.008 0.008 0.010 0.0082 0.00086 0.00081 0.00093 0.00023
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0422 0.0281 0.0055 0.014 0.010 0.001 NA 0.007 0.0093 0.02200 0.24000 NA 0.05300

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.6 2.5 5.0 -0.3 -2.2
Bipolar Disorder or Schizophrenia 0.5 1.1 2.1 -0.3 -1.5
Depressed Affect (Nagel 2018) 0.3 0.7 1.4 0.2 -1.2
Depression (Nagel 2018) 0.1 0.2 0.3 -0.3 -0.6
Intelligence (Savage-Jansen 2018) 3.1 9.6 18.3 -4.3 -0.9
Neuroticism (Nagel 2018) 0.4 0.9 1.6 1.3 -0.5
Schizophrenia (2018) 0.0 0.0 0.0 -0.2 -0.1
Schizophrenia vs Biploar Disorder 2.0 2.6 2.8 1.7 1.6
Worry (Nagel 2018) 3.0 6.3 10.6 3.3 1.4
Alzheimer’s Disease (in mother) 0.3 0.3 0.5 -0.4 -0.7
Alzheimer’s Disease (in father) 3.1 3.3 3.6 -1.9 -1.7
Alzheimer’s Disease (including proxy) 1.9 2.8 3.1 -1.8 -1.6
Crohns Disease (2017) 1.0 2.3 2.3 1.5 -1.5
Irritable Bowel Disease (IBD) 0.8 1.9 3.0 1.7 -0.8
Ulcerative Colitis (UC) 0.4 0.7 1.3 1.1 -0.4
Major Depression (MDD) 1.4 1.8 2.7 -1.6 -0.9
Reaction Time 0.1 0.1 0.1 0.4 0.4
Verbal and Numeric Reasoning (VNR) 1.0 2.5 4.8 -2.2 0.3
Breast Cancer 2.5 6.1 12.2 3.5 -0.3
Ovarian Cancer 0.6 0.8 1.6 -0.0 1.3
Prostate Cancer 0.2 0.3 0.5 0.3 -0.7
Age at First Birth 1.3 1.9 3.7 -1.9 0.3
Bipolar Disorder (2011) 1.1 1.0 1.7 0.6 -1.3
Body Mass Index (BMI) (2010) 0.9 1.2 1.4 1.0 -1.2
Coronary Artery Disease (CAD) 2.6 3.1 4.8 2.2 1.2
Crohns Disease (2012) 0.6 0.9 1.7 0.4 -1.3
Mean Putamen Volume 0.0 0.0 0.0 -0.1 0.1
Fasting Glucose 0.9 1.1 2.0 1.4 0.3
HbA1C 0.1 0.1 0.2 0.5 -0.2
HDL Cholesterol 0.3 0.4 0.8 0.1 -0.9
LDL Cholesterol 1.3 2.0 2.7 -1.6 -1.2
Lupus 0.0 0.0 0.0 -0.1 0.1
Neuroticism (2016) 1.8 2.6 3.3 1.8 -1.4
Primary Biliary Cirrhosis 0.0 0.1 0.1 -0.0 0.4
Rheumatoid Arthritis 1.0 1.4 2.1 1.5 0.8
Schizophrenia (2014) 0.2 0.5 0.7 0.8 0.5
Triglycerides 0.0 0.0 0.1 0.2 -0.1
Type 2 Diabetes (T2D) (2012) 1.2 1.3 2.1 1.5 0.7
Ulcerative Colitis 0.3 0.4 0.8 0.1 -0.9
Blood Eosinophil Count 0.2 1.7 2.7 1.6 -0.9
Blood Platelet Count 1.0 11.1 21.3 4.6 0.9
Blood Red Count 3.7 36.0 68.7 8.3 1.8
Blood White Count 1.3 9.4 17.4 4.2 1.2
Heel T-Score 4.7 37.4 66.1 8.1 2.9
BMI 1.2 7.1 14.1 3.8 0.3
Height 5.0 96.8 185.0 -13.6 -2.9
Waist Hip Ratio (WHR) 2.9 13.0 17.1 -4.1 -3.0
Systolic Blood Pressure 12.8 64.0 82.1 9.1 6.8
Smoking Status 0.2 0.6 1.1 -0.2 -1.1
Allergy or Eczema 1.4 3.8 5.1 2.2 1.6
Cardiovascular Disease 10.0 33.0 36.0 6.0 5.5
Hypothyroidism (self reported) 0.0 0.0 0.0 0.1 0.0
Respiratory disease 0.6 1.3 2.2 -1.5 0.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 1.9 1.4 0.8
Lung FEV1/FVC ratio 1.6 8.0 8.5 2.9 2.8
Lung FVC 0.3 1.3 2.6 0.2 1.6
Neuroticism 0.8 2.0 3.8 1.9 0.5
Chronotype (morning person) 2.9 6.7 7.7 2.8 -2.4
Hair Pigment 0.2 5.5 10.8 3.3 -0.5
Tanning 0.1 1.2 1.9 0.7 1.4
Hand grip strength (left) 1.5 4.1 8.0 -2.8 0.4
Number of treatments/medications taken 2.2 3.9 6.3 2.5 1.2
Average weekly spirits intake 0.1 0.1 0.1 0.1 0.4
Sensitivity / hurt feelings 1.9 3.2 4.6 -2.1 -1.4
Frequency of depressed mood in last 2 weeks 2.1 2.9 5.8 0.0 -2.4
Hearing difficulty/problems: Yes 0.1 0.2 0.2 0.3 -0.5
Relative age of first facial hair 0.7 1.4 1.8 -1.0 -1.3
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 0.1 -0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.6 0.2 -0.7
Ever had hysterectomy (womb removed) 1.4 1.6 2.9 -0.6 -1.7
Systolic blood pressure, automated reading 9.0 26.1 43.3 6.6 3.0
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.3 -0.1
Angina 2.4 3.1 4.9 2.2 1.2
Medication for hormone replacement therapy 0.8 0.8 1.5 -0.4 -1.2
Vitamin and mineral supplements 0.8 1.1 2.0 1.4 -0.5
Supplements: Zinc 0.6 0.6 1.2 -0.0 1.1
Medication: Co-codamol 0.5 0.6 1.1 -0.2 1.1
Medication: Metformin 0.8 1.1 2.2 1.5 -0.0
Diabetes (father) 0.3 0.4 0.6 0.8 0.4
Diabetes (mother) 0.2 0.2 0.2 0.4 -0.5
Severe depression (siblings) 0.3 0.4 0.4 -0.7 -0.6
Pack years adult smoking proportion 1.0 1.5 2.5 -1.6 -0.7
Impedance of leg (right) 0.0 0.1 0.1 0.3 -0.3
Leg fat-free mass (left) 0.4 2.0 3.9 -2.0 0.0
Trunk fat percentage 0.4 1.6 3.0 1.7 -0.4
Hand grip strength (right) 1.7 4.5 8.9 -3.0 -0.2
Townsend deprivation index at recruitment 1.5 2.1 2.8 -1.2 -1.7
Current tobacco smoking 0.1 0.2 0.3 -0.4 -0.5
Average weekly fortified wine intake 0.1 0.1 0.3 0.5 0.0
Maternal smoking around birth 0.1 0.1 0.2 -0.5 -0.1
Fed-up feelings 0.2 0.4 0.8 -0.2 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 3.1 -1.8 -1.6
Relative age voice broke 2.2 3.3 4.1 -2.0 -1.6
Taking other prescription medications 0.2 0.3 0.3 0.5 0.6
Age when periods started (menarche) 0.9 2.2 4.0 -0.6 2.0
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 1.1 -0.9 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 3.4 7.8 10.3 3.2 2.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.6 -0.8 0.6
Qualifications: CSEs or equivalent 2.6 3.4 6.5 2.6 0.5
Serious illness, injury or assault to yourself 2.1 2.5 4.4 -0.8 -2.1
High blood pressure 11.6 32.3 41.1 6.4 4.8
Hayfever, allergic rhinitis or eczema 1.0 2.2 3.3 1.8 1.1
Multivitamins +/- minerals 1.2 1.5 1.9 -1.1 1.4
Stomach or abdominal pain in last month 3.4 4.2 5.1 -1.8 -2.3
Supplements: Glucosamine 0.0 0.0 0.0 0.1 0.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 0.8 0.9 -0.8
Medication: Atenolol 5.0 6.3 11.8 3.4 0.8
Medication: Levothyroxine sodium 0.2 0.3 0.5 0.3 -0.7
Sitting height 4.0 28.5 53.0 -7.3 -2.0
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.5 -0.1
High blood pressure (mother) 7.3 10.3 12.1 2.9 3.5
Body mass index (BMI) 2.1 8.8 16.7 4.1 0.9
Impedance of leg (left) 0.1 0.3 0.5 -0.1 -0.7
Leg predicted mass (left) 0.4 2.0 4.0 -2.0 0.0
Trunk fat mass 0.1 0.4 0.8 0.9 -0.3
Waist circumference 0.0 0.2 0.3 0.1 -0.5
Number of incorrect matches in round 1.4 2.2 4.2 2.0 -0.5
Past tobacco smoking 0.6 1.0 2.1 -0.0 1.4
Alcohol usually taken with meals 0.4 0.7 1.1 1.1 0.6
Nervous feelings 1.1 2.1 4.1 2.0 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 1.8 0.9 -1.4
Hearing difficulty/problems with background noise 1.5 2.3 3.0 -1.3 -1.7
Hair/balding pattern: Pattern 2 2.4 3.0 6.0 -2.5 0.2
Had menopause 1.1 1.4 1.8 -1.3 -1.0
Had other major operations 1.2 1.4 2.7 -0.4 -1.6
Forced vital capacity (FVC) 1.8 6.9 13.6 -3.7 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 3.2 7.3 10.8 3.3 1.9
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.2 -1.5 -0.7
Qualifications: None of the above 2.4 5.2 10.0 3.2 0.6
Financial difficulties in last 2 years 0.2 0.2 0.2 -0.5 0.4
Mouth/teeth dental problems 0.8 1.2 1.9 0.7 1.4
Heart attack 1.3 1.7 3.3 1.8 -0.2
Allergy 0.4 1.0 1.6 -1.3 -0.6
Pain all over the body in last month 0.5 0.6 1.1 0.2 1.1
Diabetes (self-reported) 0.3 0.5 1.1 -0.1 -1.0
Hayfever/allergic rhinitis (self-reported) 1.5 1.9 2.4 1.2 1.5
Medication: Ramipril 4.6 5.9 10.6 3.2 1.1
Medication: Simvastatin 1.1 1.7 2.2 1.5 1.1
Fluid intelligence score 2.4 4.9 9.4 -3.1 -0.6
Illnesses of siblings 4.4 6.2 11.5 -3.4 -0.9
Neuroticism score 0.6 1.2 1.7 1.3 -0.8
Weight 0.0 0.1 0.1 -0.4 0.1
Impedance of arm (right) 1.2 5.7 8.6 -2.9 -1.6
Arm fat percentage (right) 1.4 5.6 11.2 3.3 0.2
Trunk fat-free mass 0.5 2.7 5.0 -2.2 0.6
Hip circumference 0.1 0.6 1.2 1.1 -0.1
Time employed in main current job 1.7 1.9 3.1 0.8 1.8
Alcohol intake versus 10 years previously 2.6 3.8 5.6 2.4 1.4
Father’s age at death 0.2 0.3 0.4 -0.3 0.6
Worrier / anxious feelings 1.1 2.0 3.8 1.9 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.7 0.2 -0.8
Falls in the last year 0.2 0.2 0.3 0.6 -0.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 0.4 0.2
Number of live births 1.1 1.5 2.7 -0.6 -1.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 2.4 -1.6 0.8
Pulse rate 0.1 0.1 0.2 -0.1 0.4
Happiness 0.9 1.1 2.1 -1.5 -0.1
Noisy workplace 3.9 4.8 8.3 2.9 -1.1
Qualifications: A levels/AS levels or equivalent 1.8 4.0 4.8 -2.2 1.8
Serious illness, injury or assault of a close relative in last 2 years 2.9 3.3 5.7 2.4 1.0
Mouth/teeth dental problems: Dentures 0.6 1.0 1.1 0.9 -1.0
Asthma 0.5 0.9 1.5 -1.2 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 -0.2 0.7
Medication: Cholesterol lowering 2.2 3.4 3.5 1.9 1.8
Depression (self-reported) 0.1 0.2 0.3 -0.6 -0.1
Medication: Lansoprazole 1.6 1.8 1.8 1.4 1.3
Prospective memory result 6.8 8.4 11.8 3.4 2.2
Lung cancer (father) 0.1 0.1 0.1 -0.4 0.3
Illnesses of mother 4.2 5.2 5.6 -2.4 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 3.8 -2.0 1.4
Pulse wave Arterial Stiffness index 0.3 0.3 0.3 -0.6 -0.6
Impedance of arm (left) 1.7 8.1 13.3 -3.6 -1.7
Arm fat mass (right) 0.7 2.8 5.6 2.4 0.2
Trunk predicted mass 0.4 2.5 4.6 -2.1 0.6
Standing height 4.7 46.4 89.3 -9.4 -1.9
Length of working week for main job 0.1 0.1 0.2 -0.0 -0.4
Exposure to tobacco smoke at home 2.4 2.7 5.2 -2.3 -0.5
Breastfed as a baby 2.2 2.7 5.3 0.4 -2.3
Tense / ‘highly strung’ 2.9 4.8 6.3 2.5 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 2.1 -1.4 -1.2
Hair/balding pattern: Pattern 4 1.9 4.6 9.2 3.0 0.2
Birth weight of first child 6.4 11.7 20.6 -4.5 -1.6
Peak expiratory flow (PEF) 0.1 0.2 0.4 -0.6 0.1
Pulse wave reflection index 1.8 2.2 4.3 2.1 -0.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 0.9 0.9 -0.7
Loud music exposure frequency 0.2 0.3 0.4 -0.4 -0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.0 -1.0 0.8
Mouth/teeth dental problems: Bleeding gums 0.0 0.1 0.1 -0.2 0.3
Blood clot in the leg (DVT) 0.0 0.0 0.1 -0.3 -0.1
Medication: Paracetamol 0.7 1.1 2.0 1.4 0.4
Headache pain in last month 1.3 2.2 3.7 -1.9 -0.8
Medication for cholesterol, blood pressure or diabetes 5.7 9.4 11.4 -3.4 -2.7
Glaucoma (self-reported) 1.1 1.3 2.6 0.1 1.6
Gout (self-reported) 1.0 1.4 2.8 -0.1 -1.7
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 0.5 0.1
Medication: Amlodipine 0.7 1.0 1.7 1.3 -0.5
Medication: Ventolin 100micrograms inhaler 2.6 3.3 6.6 0.2 2.6
Birth weight 2.1 4.6 9.1 -3.0 -0.4
Chronic bronchitis/emphysema (mother) 1.4 1.6 1.9 1.2 1.4
High blood pressure (siblings) 1.7 2.5 4.2 2.1 0.9
Forced vital capacity (FVC), Best measure 1.9 7.0 13.8 -3.7 0.4
Body fat percentage 1.0 4.0 8.0 2.8 -0.0
Leg fat percentage (right) 3.9 14.0 27.5 5.2 0.7
Arm fat-free mass (right) 0.2 1.0 1.4 -1.2 0.7
Exposure to tobacco smoke outside home 0.2 0.3 0.4 -0.6 -0.5
Comparative body size at age 10 0.2 0.5 0.9 0.2 1.0
Number of full brothers 0.6 0.7 1.2 -0.5 -1.1
Worry too long after embarrassment 0.4 0.7 0.8 -0.9 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 3.5 4.5 8.8 -0.4 -3.0
Wheeze or whistling in the chest in last year 1.1 2.0 3.3 -1.8 -0.8
Number of children fathered 4.6 5.2 5.8 2.4 2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.2 -1.1 -0.6
Age at first live birth 1.8 3.2 5.4 -2.3 0.9
Pulse wave peak to peak time 0.2 0.2 0.4 -0.2 0.6
Health satisfaction 0.7 0.9 1.2 1.1 -0.7
Shortness of breath walking on level ground 1.1 1.3 2.6 0.1 -1.6
Qualifications: College or University degree 3.7 11.7 22.8 -4.8 -0.8
Eye problems/disorders: None of the above 0.2 0.2 0.3 0.4 0.5
Mouth/teeth dental problems: Loose teeth 1.9 2.2 4.4 -2.1 -0.2
Emphysema/chronic bronchitis 0.6 0.6 1.0 -0.5 -1.0
Medication for pain relief, constipation, heartburn 0.9 1.6 2.6 -1.6 -0.7
Neck or shoulder pain in last month 0.9 1.3 2.2 0.6 -1.5
Medication: Blood pressure 6.6 11.6 16.0 4.0 2.7
Angina (self-reported) 2.2 2.9 4.8 2.2 1.0
Migraine (self-reported) 0.7 0.9 1.2 -1.1 -0.7
Medication: Ibuprofen 0.1 0.2 0.2 0.4 0.4
Medication: Allopurinol 0.3 0.4 0.8 0.0 -0.9
Medication: Omeprazole 0.1 0.1 0.2 0.2 -0.5
Medication: Seretide 50 evohaler 0.4 0.5 0.8 -0.9 0.5
Mean time to correctly identify matches 0.1 0.1 0.2 -0.1 0.5
Heart disease (mother) 0.4 0.5 0.9 0.9 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.1 0.4
Whole body fat mass 0.3 1.1 2.2 1.5 -0.2
Leg fat mass (right) 1.3 5.2 9.9 3.1 0.7
Arm predicted mass (right) 0.2 0.8 1.2 -1.1 0.6
Pulse rate, automated reading 0.0 0.1 0.1 0.2 0.2
Alcohol intake frequency. 0.4 0.9 1.6 -0.5 1.3
Comparative height size at age 10 2.1 11.6 21.8 -4.7 -1.1
Number of full sisters 0.1 0.1 0.1 -0.4 -0.2
Suffer from ‘nerves’ 0.5 0.8 1.4 0.4 -1.2
Overall health rating 0.0 0.1 0.1 0.3 -0.3
Chest pain or discomfort 0.6 0.9 1.3 0.7 -1.2
Had major operations 0.6 0.7 1.0 -0.6 -1.0
Age at last live birth 2.0 2.8 5.7 -2.4 0.1
Family relationship satisfaction 0.3 0.4 0.7 -0.8 0.1
Leg pain on walking 0.0 0.0 0.0 0.0 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 0.0 -0.6
Commuting to job workplace: Car/motor vehicle 3.8 4.4 5.3 2.3 1.9
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 1.8 -1.3 -0.3
Medication: Aspirin 2.6 3.5 5.0 2.2 1.4
Supplements: Vitamin C 0.1 0.1 0.1 -0.2 -0.3
Knee pain experienced in last month 1.1 1.7 2.9 1.7 -0.7
Hypertension (Self-reported) 10.6 29.6 37.3 6.1 4.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.0 0.2
Illnesses of father: Heart disease 0.6 0.9 1.7 1.3 0.3
Illnesses of siblings: Diabetes 4.2 5.1 7.4 2.7 1.7
Smoking status: Previous 1.0 1.5 2.9 0.3 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 3.6 7.4 14.5 -3.8 0.6
Whole body fat-free mass 0.5 2.8 5.5 -2.3 0.3
Leg fat-free mass (right) 0.6 3.4 6.8 -2.6 -0.3
Arm fat percentage (left) 1.2 4.7 9.3 3.0 0.2
Average weekly red wine intake 0.6 0.8 1.3 -1.1 0.6
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.4 -0.1
Mood swings 0.7 1.2 2.5 1.6 0.2
Loneliness, isolation 2.3 3.1 4.7 -2.2 -1.3
Long-standing illness, disability or infirmity 0.5 0.8 1.6 0.2 -1.3
Ever had bowel cancer screening 2.4 2.8 4.9 -0.8 -2.2
Diabetes diagnosed by doctor 0.2 0.3 0.6 0.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.3 0.6 0.5
Friendships satisfaction 0.0 0.1 0.1 0.3 0.1
Qualifications: nursing, teaching 0.4 0.6 1.3 -1.1 0.1
Commuting to job workplace: Walk 2.0 2.2 3.3 -1.0 -1.8
Eye problems/disorders: Cataract 0.6 0.7 1.0 -1.0 0.6
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.9 -1.4 -0.9
Medication for cholesterol 4.2 6.4 12.3 -3.5 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.1 -0.1 -1.0
Back pain experienced in last month 0.2 0.3 0.3 -0.5 0.5
Mineral and other dietary supplements 1.9 2.5 5.1 2.2 0.1
Breast cancer (self-reported) 1.5 1.7 2.6 -1.6 -1.0
Asthma (self-reported) 0.4 0.8 1.5 -1.2 0.4
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.5 -0.1
Osteoarthritis (self-reported) 1.2 1.6 3.1 0.2 -1.8
Medication: Aspirin 2.6 3.4 4.7 2.2 1.5
Medication: Gliclazide 2.4 2.7 5.3 2.3 -0.3
Illnesses of father: None of the above (group 1) 0.2 0.3 0.6 -0.8 -0.0
Smoking status: Current 0.1 0.2 0.3 -0.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 -0.1 1.1
Whole body water mass 0.4 2.5 4.9 -2.2 0.4
Leg predicted mass (right) 0.6 3.4 6.7 -2.6 -0.3
Arm fat mass (left) 0.6 2.3 4.6 2.1 0.2
Number of self-reported non-cancer illnesses 6.4 11.1 13.5 3.0 3.7
Average weekly champagne plus white wine intake 0.2 0.2 0.4 -0.6 -0.3
Miserableness 1.6 2.8 4.8 -0.8 -2.2
Guilty feelings 0.7 1.0 2.0 -0.0 -1.4
Wears glasses or contact lenses 0.5 0.5 0.9 -0.4 -0.9
Ever taken oral contraceptive pill 2.2 2.5 3.7 -1.9 -1.1
Hearing aid user 1.3 1.5 2.2 0.8 1.5
Mother’s age at death 0.4 0.5 0.7 0.9 0.5
Financial situation satisfaction 0.0 0.0 0.1 0.1 -0.3
Tinnitus: Yes, now most or all of the time 1.0 1.1 1.3 1.1 -1.0
Commuting to job workplace: Public transport 0.8 1.0 1.8 -0.5 -1.3
Eye problems/disorders: Glaucoma 1.8 2.2 3.1 1.1 1.8
Medication: Blood pressure 10.4 19.8 33.3 5.8 2.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.1 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.5 -1.2 -0.1
High cholesterol (Self-reported) 2.1 3.6 4.9 2.2 1.6
Medication: Bendroflumethiazide 4.8 7.2 10.1 3.2 2.1
Medication: Paracetamol 1.3 2.0 3.7 1.9 0.5
Medication: Lisinopril 1.1 1.4 2.1 1.5 0.8
Medication: Atorvastatin 1.3 1.7 2.7 1.6 0.8
Illnesses of father: High blood pressure 2.8 3.4 3.6 1.9 1.8
Alcohol drinker status: Never 0.8 0.9 1.1 1.1 0.8
Ever smoked 0.6 1.1 2.1 -0.3 -1.5
Basal metabolic rate 0.3 1.6 3.1 -1.8 0.3
Leg fat percentage (left) 3.3 11.9 23.5 4.8 0.4
Arm fat-free mass (left) 0.1 0.3 0.4 -0.7 0.3
Number of operations (self-reported) 0.5 0.7 1.0 -0.7 -1.0
Average weekly beer plus cider intake 0.2 0.2 0.4 -0.4 0.6
Irritability 1.7 2.8 5.1 2.3 -0.7
Risk taking 0.6 0.8 1.7 -1.3 0.1
Ever had prostate specific antigen (PSA) test 2.7 3.1 5.8 -0.6 -2.4
Fractured/broken bones in last 5 years 0.2 0.2 0.5 0.1 -0.7
Age started oral contraceptive pill 0.8 1.0 1.8 -1.3 -0.4
Diastolic blood pressure, automated reading 3.6 11.0 15.7 4.0 2.5
Ever depressed for a whole week 1.6 1.9 2.1 -1.3 -1.4
Unable to work because of sickness or disability 1.0 1.3 1.3 1.1 -1.1
Commuting to job workplace: Cycle 1.6 1.9 3.1 -1.8 -0.9
Myopia 0.2 0.2 0.5 -0.7 -0.0
Vascular/heart problems diagnosed by doctor 13.1 35.8 48.9 -7.0 -4.8
Cholesterol lowering medication 0.2 0.3 0.4 0.7 0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.6 -0.8 -0.7
Pain experienced in last month 0.2 0.3 0.6 -0.3 0.8
Supplements: Calcium 3.6 4.0 8.0 -2.8 0.2
Basal cell carcinoma (self-reported) 1.1 1.4 1.5 -1.2 -1.1
Heart attack/myocardial infarction (self-reported) 1.6 2.1 4.2 2.0 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.4 -0.4 -0.6
Heart disease (siblings) 3.6 4.4 8.1 2.9 -0.8
Alcohol drinker status: Previous 1.3 1.5 2.7 -1.6 -0.5
Pack years of smoking 0.7 1.0 1.3 -1.1 -0.9
Impedance of whole body 0.7 3.7 5.1 -2.3 -1.5
Leg fat mass (left) 1.1 4.5 8.6 2.9 0.6
Arm predicted mass (left) 0.0 0.2 0.2 -0.5 0.4