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chr14:22,670,975-24,147,787

Best TWAS P=1.96e-11 · Best GWAS P=6.07e-11 conditioned to 3.44e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HAUS4	0.20	0.25	lasso	7	0.25	1.2e-29	5.0	5.2	1.6e-07	0.01	0.90	0.10	FALSE
2	GTEx	Adipose Visceral Omentum	HAUS4	0.29	0.17	lasso	14	0.21	5.2e-11	5.3	5.5	3.9e-08	0.03	0.78	0.22	FALSE
3	GTEx	Adrenal Gland	HAUS4	0.35	0.22	enet	11	0.21	3.5e-08	5.1	5.5	3.0e-08	0.03	0.76	0.21	FALSE
4	GTEx	Artery Aorta	HAUS4	0.35	0.26	enet	14	0.32	6.1e-18	5.0	5.5	3.9e-08	0.02	0.80	0.20	FALSE
5	GTEx	Artery Aorta	RP11-298I3.1	0.18	0.07	enet	12	0.08	2.6e-05	5.2	-5.3	1.2e-07	-0.03	0.71	0.21	FALSE
6	GTEx	Artery Coronary	HAUS4	0.36	0.25	lasso	5	0.22	8.6e-08	5.0	5.3	1.1e-07	0.03	0.82	0.16	FALSE
7	GTEx	Brain Cerebellum	HAUS4	0.36	0.27	enet	6	0.32	2.6e-10	5.3	5.5	4.4e-08	0.03	0.64	0.36	FALSE
8	GTEx	Brain Cerebellum	RBM23	0.31	0.18	lasso	4	0.22	3.4e-07	5.5	-5.7	1.5e-08	-0.03	0.56	0.29	FALSE
9	GTEx	Brain Frontal Cortex BA9	HAUS4	0.26	0.07	lasso	6	0.04	3.7e-02	5.5	5.7	1.6e-08	0.01	0.15	0.08	FALSE
10	GTEx	Brain Hypothalamus	RBM23	0.30	0.06	lasso	5	0.15	2.2e-04	4.7	-5.6	2.8e-08	-0.05	0.12	0.11	FALSE
11	GTEx	Brain Putamen basal ganglia	HAUS4	0.29	0.00	enet	4	-0.01	6.3e-01	5.3	5.4	7.6e-08	0.03	0.12	0.08	FALSE
12	GTEx	Breast Mammary Tissue	HAUS4	0.35	0.26	enet	21	0.23	4.6e-12	5.0	5.7	1.3e-08	-0.04	0.86	0.14	FALSE
13	GTEx	Colon Sigmoid	RBM23	0.49	0.14	lasso	6	0.06	2.8e-03	5.3	-5.4	5.1e-08	-0.02	0.20	0.09	FALSE
14	GTEx	Colon Transverse	HAUS4	0.30	0.28	enet	8	0.27	3.2e-13	5.3	5.5	3.4e-08	0.03	0.74	0.26	FALSE
15	GTEx	Colon Transverse	RBM23	0.31	0.05	lasso	4	0.10	2.0e-05	4.7	-5.2	1.5e-07	0.23	0.16	0.07	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	HAUS4	0.37	0.24	enet	22	0.24	3.7e-09	5.0	6.1	8.8e-10	-0.19	0.76	0.22	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	RBM23	0.28	0.00	enet	32	0.04	1.7e-02	2.2	-6.7	2.0e-11	0.32	0.05	0.41	TRUE
18	GTEx	Esophagus Mucosa	HAUS4	0.33	0.26	enet	17	0.28	7.4e-19	5.2	5.2	2.5e-07	0.03	0.82	0.18	FALSE
19	GTEx	Heart Left Ventricle	HAUS4	0.17	0.13	lasso	2	0.12	5.0e-07	5.0	-5.1	2.7e-07	0.00	0.64	0.16	FALSE
20	GTEx	Lung	HAUS4	0.30	0.26	enet	26	0.29	1.9e-22	5.3	5.3	1.4e-07	0.03	0.76	0.24	FALSE
21	GTEx	Muscle Skeletal	HAUS4	0.09	0.08	lasso	4	0.06	1.4e-06	5.5	5.7	1.1e-08	0.03	0.48	0.52	FALSE
22	GTEx	Nerve Tibial	HAUS4	0.36	0.29	enet	38	0.33	8.2e-24	5.3	5.2	2.3e-07	0.02	0.74	0.26	FALSE
23	GTEx	Ovary	HAUS4	0.32	0.10	enet	16	0.09	2.6e-03	5.0	5.5	4.8e-08	0.00	0.22	0.10	FALSE
24	GTEx	Pancreas	RBM23	0.20	0.10	enet	7	0.03	1.7e-02	5.2	-5.3	1.2e-07	-0.05	0.26	0.09	FALSE
25	GTEx	Skin Sun Exposed Lower leg	HAUS4	0.31	0.25	enet	25	0.32	2.5e-27	5.0	5.4	7.5e-08	-0.03	0.78	0.22	FALSE
26	GTEx	Skin Sun Exposed Lower leg	AJUBA	0.12	0.04	lasso	4	0.05	6.8e-05	5.0	-5.3	1.3e-07	-0.04	0.58	0.28	FALSE
27	GTEx	Stomach	HAUS4	0.29	0.20	enet	13	0.20	6.0e-10	5.3	5.4	8.7e-08	0.04	0.80	0.20	FALSE
28	GTEx	Stomach	RP11-298I3.1	0.29	0.16	lasso	9	0.14	2.4e-07	5.2	-5.1	3.0e-07	-0.04	0.82	0.18	FALSE
29	GTEx	Vagina	HAUS4	0.37	0.18	enet	12	0.16	1.8e-04	5.2	5.3	1.1e-07	0.03	0.32	0.13	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HAUS4	0.09	0.04	lasso	5	0.04	5.1e-04	5.3	5.3	1.5e-07	0.02	0.02	0.95	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAUS4	0.03	0.06	blup	41	0.06	1.1e-12	5.3	5.4	7.1e-08	0.03	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	HAUS4	0.21	0.23	blup	40	0.28	4.5e-09	5.3	5.4	5.7e-08	0.03	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAUS4	0.03	0.05	blup	41	0.04	8.4e-06	5.0	5.3	9.9e-08	0.03	0.03	0.96	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	HAUS4	0.11	0.20	lasso	7	0.22	5.5e-24	5.0	5.4	7.3e-08	0.01	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HAUS4	0.09	0.07	blup	41	0.08	8.0e-06	5.2	5.2	1.9e-07	0.03	0.03	0.96	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HAUS4	0.12	0.19	lasso	4	0.21	4.8e-09	5.1	5.2	2.2e-07	0.02	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HAUS4	0.12	0.15	lasso	4	0.15	1.3e-06	5.3	5.3	1.2e-07	0.03	0.02	0.97	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	HAUS4	0.12	0.15	blup	40	0.19	1.2e-19	5.0	5.3	1.4e-07	0.03	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAUS4	0.07	0.06	blup	40	0.08	1.3e-05	5.3	5.4	5.8e-08	0.03	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Skin Cutaneous Melanoma	HAUS4	0.13	0.15	lasso	8	0.17	2.8e-05	5.0	5.6	2.8e-08	0.03	0.02	0.94	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HAUS4	0.12	0.07	blup	39	0.10	3.0e-04	5.0	5.4	7.4e-08	0.03	0.03	0.93	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	HAUS4	0.15	0.22	lasso	5	0.23	2.4e-22	5.3	5.6	2.6e-08	0.03	0.02	0.98	FALSE