Hub : Genes

AJUBA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Liver 0.423 0.127 0.00460 0.003 NA -0.009 NA -0.002 0.25000 NA 0.670 NA 3.6e-01
2 GTEx Skin Sun Exposed Lower leg 0.121 0.040 0.00067 0.039 NA 0.013 NA 0.049 0.00034 NA 0.029 NA 6.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.0 0.0 0.1 0.1
Bipolar Disorder or Schizophrenia 1.8 4.3 4.3 2.1 -2.1
Depressed Affect (Nagel 2018) 0.4 0.8 1.5 1.2 -0.0
Depression (Nagel 2018) 0.6 0.9 1.3 0.7 1.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.1 -0.6 1.8
Neuroticism (Nagel 2018) 0.5 1.1 2.0 1.4 -0.4
Schizophrenia (2018) 3.4 7.1 7.3 2.6 -2.7
Schizophrenia vs Biploar Disorder 3.1 4.0 6.2 1.4 -2.5
Worry (Nagel 2018) 1.7 3.7 5.2 1.4 -2.3
Alzheimer’s Disease (in mother) 0.7 0.8 1.4 -0.4 -1.2
Alzheimer’s Disease (in father) 0.7 0.8 0.9 0.9 -0.8
Alzheimer’s Disease (including proxy) 0.4 0.6 1.2 -0.1 -1.1
Crohns Disease (2017) 0.1 0.2 0.3 0.2 0.6
Irritable Bowel Disease (IBD) 0.2 0.6 0.7 0.8 -0.7
Ulcerative Colitis (UC) 0.9 1.7 2.3 1.1 -1.5
Major Depression (MDD) 3.3 4.0 7.9 0.1 2.8
Reaction Time 0.4 0.8 1.4 0.3 -1.2
Verbal and Numeric Reasoning (VNR) 2.0 4.8 5.9 -2.4 1.9
Breast Cancer 1.5 3.5 5.2 -2.3 1.3
Ovarian Cancer 0.3 0.4 0.5 0.5 -0.7
Prostate Cancer 2.8 4.0 7.3 0.8 -2.7
Age at First Birth 1.1 1.6 1.9 -1.1 1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 -0.2 -0.6
Coronary Artery Disease (CAD) 0.6 0.7 1.3 0.4 1.1
Crohns Disease (2012) 5.1 8.2 8.8 -3.0 2.8
Mean Putamen Volume 0.2 0.3 0.4 -0.6 0.4
Fasting Glucose 0.2 0.3 0.5 -0.7 -0.0
HbA1C 0.4 0.4 0.5 0.5 0.7
HDL Cholesterol 0.2 0.3 0.5 0.1 -0.7
LDL Cholesterol 0.2 0.4 0.7 0.2 0.9
Lupus 1.0 1.5 2.4 -0.7 1.6
Neuroticism (2016) 0.4 0.6 1.1 1.0 0.4
Primary Biliary Cirrhosis 4.2 6.0 7.5 -2.7 2.1
Rheumatoid Arthritis 4.4 6.0 8.9 1.8 -3.0
Schizophrenia (2014) 1.0 2.2 3.3 1.1 -1.8
Triglycerides 0.5 0.8 1.6 1.3 -0.3
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.4 0.3
Ulcerative Colitis 0.2 0.3 0.5 -0.7 0.4
Blood Eosinophil Count 3.0 23.3 37.4 -3.0 6.1
Blood Platelet Count 0.2 2.4 4.8 2.2 -0.1
Blood Red Count 0.7 6.6 7.6 -2.4 2.8
Blood White Count 0.5 3.7 4.4 1.8 -2.1
Heel T-Score 0.4 3.2 3.9 -2.0 1.6
BMI 0.2 1.1 2.0 -1.4 0.3
Height 0.6 12.2 24.2 -4.9 0.3
Waist Hip Ratio (WHR) 0.5 2.3 3.8 2.0 -0.9
Systolic Blood Pressure 3.6 17.8 30.0 2.4 -5.5
Smoking Status 0.0 0.1 0.1 -0.4 0.2
Allergy or Eczema 0.1 0.2 0.3 -0.5 0.3
Cardiovascular Disease 0.1 0.4 0.7 0.9 0.3
Hypothyroidism (self reported) 0.1 0.2 0.3 -0.4 0.6
Respiratory disease 0.3 0.6 0.9 -0.5 1.0
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.3 0.3
Lung FEV1/FVC ratio 5.2 26.5 50.5 -1.6 7.1
Lung FVC 0.4 1.9 2.9 -0.9 1.7
Neuroticism 0.6 1.5 2.1 1.5 -0.9
Chronotype (morning person) 0.6 1.4 2.3 -0.7 1.5
Hair Pigment 0.0 0.1 0.2 0.4 0.2
Tanning 0.0 0.1 0.2 0.4 0.1
Hand grip strength (left) 0.6 1.5 2.4 -1.5 0.7
Number of treatments/medications taken 0.2 0.4 0.8 -0.1 0.9
Average weekly spirits intake 0.0 0.1 0.1 -0.2 0.3
Sensitivity / hurt feelings 0.3 0.5 0.9 0.3 1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.4 0.6 -0.4
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.5 0.2
Relative age of first facial hair 0.6 1.2 2.4 -0.1 1.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 0.9 0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 -0.2 0.3
Ever had hysterectomy (womb removed) 1.4 1.6 2.7 -0.7 1.6
Systolic blood pressure, automated reading 5.2 15.1 27.9 1.5 -5.3
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 2.2 1.5 -1.4
Angina 2.8 3.7 7.4 0.2 2.7
Medication for hormone replacement therapy 0.3 0.4 0.4 -0.6 0.6
Vitamin and mineral supplements 0.0 0.0 0.1 0.3 0.1
Supplements: Zinc 0.6 0.7 1.0 1.0 -0.6
Medication: Co-codamol 0.7 0.8 1.3 0.5 -1.1
Medication: Metformin 0.9 1.2 1.3 1.2 -1.1
Diabetes (father) 0.3 0.3 0.5 0.7 0.4
Diabetes (mother) 1.0 1.3 2.0 1.4 -0.8
Severe depression (siblings) 0.9 1.0 1.8 0.5 1.3
Pack years adult smoking proportion 0.4 0.6 1.1 -0.2 -1.0
Impedance of leg (right) 0.2 0.9 1.9 0.1 1.4
Leg fat-free mass (left) 0.3 1.4 2.1 -1.4 -0.9
Trunk fat percentage 0.3 1.4 1.7 -1.0 -1.3
Hand grip strength (right) 0.4 1.0 1.5 -1.2 0.7
Townsend deprivation index at recruitment 3.6 5.1 5.4 2.3 -2.2
Current tobacco smoking 1.5 2.5 3.3 1.8 -1.3
Average weekly fortified wine intake 1.8 2.1 2.2 -1.5 1.4
Maternal smoking around birth 1.6 2.3 2.5 1.6 -1.4
Fed-up feelings 0.3 0.6 1.0 1.0 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.6 0.5 0.7
Relative age voice broke 2.0 3.1 3.2 -1.7 1.8
Taking other prescription medications 1.3 2.1 3.8 0.5 2.0
Age when periods started (menarche) 4.2 10.1 14.0 -2.5 3.7
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 1.3 -1.1 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 -0.3 0.8
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.7 -0.4 -1.3
Qualifications: CSEs or equivalent 2.4 3.2 4.0 1.6 -2.0
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.0 0.5
High blood pressure 1.2 3.3 3.4 1.8 -1.8
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.3 0.1
Multivitamins +/- minerals 0.7 0.9 1.5 0.6 -1.2
Stomach or abdominal pain in last month 0.1 0.1 0.1 -0.1 -0.4
Supplements: Glucosamine 0.9 1.1 1.7 -1.3 0.8
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.4 -1.2 0.7
Medication: Atenolol 0.1 0.2 0.2 0.4 -0.4
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.6 -0.2
Sitting height 0.1 1.0 2.0 -1.4 -0.1
Chronic bronchitis/emphysema (father) 0.1 0.2 0.3 0.6 -0.1
High blood pressure (mother) 1.1 1.5 1.9 1.1 -1.4
Body mass index (BMI) 0.2 1.0 1.7 -0.6 -1.3
Impedance of leg (left) 0.1 0.4 0.8 0.0 0.9
Leg predicted mass (left) 0.3 1.5 2.1 -1.4 -0.9
Trunk fat mass 0.4 1.7 2.4 -1.5 -1.0
Waist circumference 0.4 1.6 3.1 -0.2 -1.8
Number of incorrect matches in round 0.5 0.8 1.3 -1.1 0.5
Past tobacco smoking 0.3 0.6 0.7 0.6 -0.8
Alcohol usually taken with meals 5.3 8.5 12.5 -2.1 3.5
Nervous feelings 2.7 5.1 5.9 2.1 -2.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 0.3 0.8
Hearing difficulty/problems with background noise 0.2 0.3 0.4 0.5 0.6
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.2 0.5
Had menopause 0.2 0.2 0.3 0.3 -0.6
Had other major operations 1.6 1.9 2.9 -1.0 1.7
Forced vital capacity (FVC) 0.3 1.3 1.8 -1.3 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.7 0.1 -0.9
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.3 -0.6 -0.3
Qualifications: None of the above 0.9 1.9 3.0 0.9 -1.7
Financial difficulties in last 2 years 0.5 0.7 1.2 1.1 0.4
Mouth/teeth dental problems 1.9 2.9 5.7 0.0 2.4
Heart attack 0.2 0.2 0.5 0.0 0.7
Allergy 0.1 0.2 0.5 0.7 -0.0
Pain all over the body in last month 0.2 0.2 0.4 0.6 0.1
Diabetes (self-reported) 0.1 0.2 0.4 0.6 0.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 0.4 0.9
Medication: Ramipril 0.2 0.3 0.6 0.7 0.1
Medication: Simvastatin 0.6 0.9 1.0 -1.0 0.8
Fluid intelligence score 1.1 2.2 3.7 -1.9 0.9
Illnesses of siblings 0.3 0.5 0.7 -0.5 0.8
Neuroticism score 1.5 3.1 3.5 1.9 -1.6
Weight 0.5 2.2 3.5 -1.9 -1.0
Impedance of arm (right) 0.4 1.7 2.6 -0.9 1.6
Arm fat percentage (right) 0.1 0.6 1.1 -1.0 -0.2
Trunk fat-free mass 0.4 2.3 4.5 -2.1 0.1
Hip circumference 0.5 2.2 4.0 -2.0 -0.6
Time employed in main current job 2.1 2.4 4.5 2.1 -0.5
Alcohol intake versus 10 years previously 1.5 2.2 4.3 0.5 -2.1
Father’s age at death 2.1 2.8 5.6 -2.4 0.1
Worrier / anxious feelings 0.0 0.0 0.0 -0.0 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.5 0.7 -0.5
Falls in the last year 0.6 0.9 1.3 -0.6 1.1
Hair/balding pattern: Pattern 3 1.0 1.5 2.1 -1.5 0.9
Number of live births 5.6 7.9 14.8 -1.0 3.9
Forced expiratory volume in 1-second (FEV1) 2.0 6.8 10.0 -1.9 3.2
Pulse rate 0.1 0.1 0.2 -0.5 0.0
Happiness 0.7 0.8 1.6 0.1 -1.3
Noisy workplace 1.4 1.7 1.9 1.4 -1.2
Qualifications: A levels/AS levels or equivalent 1.7 3.7 6.9 -0.8 2.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.3 0.3 0.5
Mouth/teeth dental problems: Dentures 2.5 4.3 4.4 2.1 -2.0
Asthma 0.4 0.8 0.8 -0.9 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.4 -0.6 0.5
Medication: Cholesterol lowering 0.6 1.0 1.8 -0.4 1.3
Depression (self-reported) 0.3 0.4 0.4 0.6 0.6
Medication: Lansoprazole 0.8 0.9 1.8 1.4 -0.2
Prospective memory result 2.3 2.8 2.8 1.7 -1.7
Lung cancer (father) 0.2 0.2 0.2 -0.5 -0.5
Illnesses of mother 2.9 3.6 4.5 -1.7 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.3 8.2 -2.1 2.9
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 -1.1 0.3
Impedance of arm (left) 0.1 0.3 0.6 0.0 0.8
Arm fat mass (right) 0.3 1.1 1.7 -1.3 -0.7
Trunk predicted mass 0.3 2.0 4.0 -2.0 0.0
Standing height 0.5 5.2 10.0 -3.2 0.6
Length of working week for main job 0.1 0.1 0.1 -0.2 0.3
Exposure to tobacco smoke at home 1.6 1.7 2.5 1.6 -1.0
Breastfed as a baby 1.9 2.3 4.0 -0.8 2.0
Tense / ‘highly strung’ 0.8 1.3 2.0 1.4 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 3.9 -0.5 2.0
Hair/balding pattern: Pattern 4 1.3 3.0 4.0 -1.4 2.0
Birth weight of first child 0.0 0.1 0.1 -0.3 0.2
Peak expiratory flow (PEF) 3.6 8.3 14.2 -1.5 3.8
Pulse wave reflection index 1.1 1.3 1.3 -1.1 1.1
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.7 -0.8 0.0
Loud music exposure frequency 6.6 7.2 7.3 2.7 -2.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.1 0.8 1.4
Mouth/teeth dental problems: Bleeding gums 2.4 3.1 6.2 -2.5 0.0
Blood clot in the leg (DVT) 0.4 0.5 0.6 -0.7 -0.7
Medication: Paracetamol 1.4 2.3 4.4 2.1 0.5
Headache pain in last month 0.1 0.2 0.4 0.1 0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.6 -0.3 -0.7
Glaucoma (self-reported) 1.1 1.3 1.7 1.3 -1.0
Gout (self-reported) 0.4 0.5 0.9 0.4 1.0
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 -0.3 0.3
Medication: Amlodipine 0.0 0.0 0.0 0.1 -0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 0.4 0.3
Birth weight 2.2 4.8 9.5 -0.3 -3.1
Chronic bronchitis/emphysema (mother) 0.6 0.8 1.2 1.1 -0.5
High blood pressure (siblings) 0.1 0.2 0.3 -0.0 -0.6
Forced vital capacity (FVC), Best measure 0.6 2.2 3.3 -1.8 1.1
Body fat percentage 0.3 1.1 1.5 -0.9 -1.2
Leg fat percentage (right) 0.0 0.1 0.2 -0.1 -0.5
Arm fat-free mass (right) 0.3 1.3 1.4 -1.2 -1.1
Exposure to tobacco smoke outside home 0.7 0.9 1.4 -0.6 -1.2
Comparative body size at age 10 0.5 1.4 2.7 -1.6 0.3
Number of full brothers 0.2 0.2 0.4 0.2 0.6
Worry too long after embarrassment 0.2 0.3 0.4 0.4 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.9 -0.4 1.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 -0.6 -0.4
Number of children fathered 0.7 0.8 1.5 -0.3 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 1.4 -0.9 1.2
Age at first live birth 3.2 5.7 9.0 -3.0 1.6
Pulse wave peak to peak time 0.4 0.5 0.9 1.0 -0.2
Health satisfaction 1.3 1.7 3.0 0.6 -1.7
Shortness of breath walking on level ground 1.9 2.3 4.4 -2.1 0.4
Qualifications: College or University degree 4.4 13.8 26.0 -1.3 5.1
Eye problems/disorders: None of the above 2.1 2.4 3.0 -1.7 1.4
Mouth/teeth dental problems: Loose teeth 1.8 2.1 4.2 0.0 -2.0
Emphysema/chronic bronchitis 0.9 1.0 1.6 0.7 -1.3
Medication for pain relief, constipation, heartburn 0.9 1.6 1.8 -1.2 -1.3
Neck or shoulder pain in last month 1.2 1.7 2.6 1.6 -0.9
Medication: Blood pressure 0.2 0.4 0.7 0.8 0.2
Angina (self-reported) 2.8 3.6 7.3 -0.1 2.7
Migraine (self-reported) 2.1 2.6 3.5 -1.3 1.9
Medication: Ibuprofen 0.2 0.2 0.4 0.1 -0.6
Medication: Allopurinol 0.1 0.2 0.4 0.2 0.6
Medication: Omeprazole 0.4 0.5 0.7 0.8 0.6
Medication: Seretide 50 evohaler 0.6 0.7 1.3 0.1 -1.2
Mean time to correctly identify matches 0.2 0.4 0.8 -0.1 -0.9
Heart disease (mother) 0.1 0.1 0.2 0.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.1 0.1 0.2 -0.3
Whole body fat mass 0.3 1.3 1.5 -1.2 -1.0
Leg fat mass (right) 0.2 0.8 0.8 -0.9 -0.9
Arm predicted mass (right) 0.2 1.2 1.3 -1.0 -1.2
Pulse rate, automated reading 1.0 3.1 5.3 1.0 -2.3
Alcohol intake frequency. 1.3 3.0 4.4 1.2 -2.1
Comparative height size at age 10 1.2 6.8 13.4 -0.3 -3.7
Number of full sisters 0.2 0.3 0.6 0.7 -0.1
Suffer from ‘nerves’ 3.5 5.4 5.8 2.4 -2.3
Overall health rating 1.2 2.6 3.5 1.3 -1.9
Chest pain or discomfort 0.0 0.0 0.0 -0.2 0.1
Had major operations 0.2 0.2 0.4 0.7 0.1
Age at last live birth 4.9 7.2 9.1 -3.0 2.3
Family relationship satisfaction 0.2 0.2 0.4 0.1 -0.6
Leg pain on walking 0.9 1.1 1.5 0.8 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.1 1.0 -1.0
Commuting to job workplace: Car/motor vehicle 1.7 2.0 2.3 -1.5 1.3
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.7 -1.3 -0.1
Medication: Aspirin 0.5 0.6 0.9 0.5 1.0
Supplements: Vitamin C 0.1 0.1 0.3 -0.1 -0.5
Knee pain experienced in last month 0.0 0.0 0.1 -0.2 -0.1
Hypertension (Self-reported) 1.0 2.7 2.9 1.6 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 2.3 0.2 1.5
Illnesses of father: Heart disease 0.3 0.4 0.6 -0.6 0.7
Illnesses of siblings: Diabetes 1.8 2.3 4.1 2.0 -0.7
Smoking status: Previous 1.1 1.6 2.8 -1.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.4 -1.2 0.1
Whole body fat-free mass 0.3 1.7 3.1 -1.8 -0.5
Leg fat-free mass (right) 0.3 1.6 2.2 -1.5 -1.0
Arm fat percentage (left) 0.1 0.5 0.6 -0.6 -0.8
Average weekly red wine intake 2.2 3.3 6.3 -0.5 2.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.8 0.9 -0.6
Mood swings 1.4 2.5 3.6 1.9 -1.2
Loneliness, isolation 0.5 0.7 1.1 1.0 -0.7
Long-standing illness, disability or infirmity 0.6 1.0 1.8 1.3 -0.3
Ever had bowel cancer screening 0.0 0.0 0.0 0.1 -0.2
Diabetes diagnosed by doctor 0.3 0.4 0.7 0.9 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.2 2.7 -1.6 1.3
Friendships satisfaction 0.4 0.5 0.5 -0.7 -0.7
Qualifications: nursing, teaching 4.7 7.3 14.1 -0.6 3.8
Commuting to job workplace: Walk 0.6 0.7 1.4 1.2 0.1
Eye problems/disorders: Cataract 0.4 0.5 0.9 -0.2 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.3 -0.7
Medication for cholesterol 0.6 0.8 1.6 -0.2 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.3 -1.5 0.2
Back pain experienced in last month 2.3 3.4 3.7 1.8 -1.9
Mineral and other dietary supplements 0.4 0.5 0.5 0.7 -0.7
Breast cancer (self-reported) 0.0 0.0 0.1 -0.3 -0.1
Asthma (self-reported) 0.5 1.0 1.1 -1.1 0.9
Osteoporosis (self-reported) 1.1 1.3 2.3 1.5 0.6
Osteoarthritis (self-reported) 0.7 0.9 1.7 0.2 -1.3
Medication: Aspirin 0.6 0.8 1.6 0.3 1.3
Medication: Gliclazide 0.5 0.6 1.2 1.1 0.0
Illnesses of father: None of the above (group 1) 0.3 0.4 0.7 -0.8 -0.1
Smoking status: Current 2.0 3.2 4.1 2.0 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.7 -0.6 1.3
Whole body water mass 0.3 1.8 3.3 -1.8 -0.6
Leg predicted mass (right) 0.3 1.7 2.4 -1.5 -1.0
Arm fat mass (left) 0.3 1.0 1.6 -1.2 -0.7
Number of self-reported non-cancer illnesses 1.9 3.2 5.3 -1.1 2.3
Average weekly champagne plus white wine intake 0.8 1.1 2.1 -0.2 1.4
Miserableness 0.1 0.2 0.3 0.5 0.2
Guilty feelings 0.6 0.9 1.3 0.7 1.2
Wears glasses or contact lenses 2.2 2.5 4.2 -0.9 2.1
Ever taken oral contraceptive pill 0.4 0.5 0.7 0.8 0.5
Hearing aid user 1.8 2.1 2.9 -1.7 1.1
Mother’s age at death 1.8 2.3 3.7 -1.9 0.9
Financial situation satisfaction 2.1 2.6 4.6 2.1 -0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.6 0.2 -0.8
Commuting to job workplace: Public transport 2.4 2.9 4.6 1.1 -2.2
Eye problems/disorders: Glaucoma 0.2 0.3 0.4 0.3 -0.7
Medication: Blood pressure 1.4 2.6 5.1 -0.1 -2.3
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.2 0.6 -1.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.2 0.9
High cholesterol (Self-reported) 0.2 0.3 0.5 0.3 0.7
Medication: Bendroflumethiazide 1.4 2.1 4.1 0.4 -2.0
Medication: Paracetamol 2.2 3.4 6.9 2.6 0.1
Medication: Lisinopril 1.3 1.6 2.9 0.7 -1.7
Medication: Atorvastatin 0.6 0.8 1.0 0.7 1.0
Illnesses of father: High blood pressure 1.2 1.5 2.7 0.6 -1.6
Alcohol drinker status: Never 0.4 0.5 1.0 0.1 -1.0
Ever smoked 0.7 1.2 2.3 -0.4 1.5
Basal metabolic rate 0.4 2.0 3.5 -1.9 -0.7
Leg fat percentage (left) 0.1 0.5 0.9 0.0 -1.0
Arm fat-free mass (left) 0.4 2.1 3.9 -2.0 -0.7
Number of operations (self-reported) 4.6 6.9 11.3 -1.6 3.4
Average weekly beer plus cider intake 8.4 12.1 16.4 2.8 -4.0
Irritability 0.9 1.4 2.0 0.9 -1.4
Risk taking 1.1 1.7 3.2 -0.4 1.8
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.7 -0.3 1.3
Fractured/broken bones in last 5 years 0.6 0.8 0.9 -0.8 1.0
Age started oral contraceptive pill 0.7 0.9 1.0 -1.0 0.9
Diastolic blood pressure, automated reading 3.9 12.2 24.1 0.6 -4.9
Ever depressed for a whole week 0.9 1.1 1.2 -1.0 1.1
Unable to work because of sickness or disability 2.5 3.3 3.9 2.0 -1.6
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.2 0.4
Myopia 0.1 0.2 0.3 -0.2 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.4 -1.5 0.7
Cholesterol lowering medication 0.0 0.1 0.1 0.1 0.4
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 2.7 1.6 0.3
Pain experienced in last month 2.1 3.5 4.8 -2.2 1.5
Supplements: Calcium 0.0 0.0 0.0 -0.1 -0.1
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 -1.0 0.5
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 -0.1 0.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 0.8 -0.8 -0.9
Heart disease (siblings) 0.1 0.1 0.1 0.2 -0.3
Alcohol drinker status: Previous 1.9 2.1 4.3 2.1 -0.1
Pack years of smoking 0.2 0.3 0.5 -0.3 -0.7
Impedance of whole body 0.1 0.4 0.7 0.1 0.8
Leg fat mass (left) 0.3 1.0 1.2 -0.9 -1.1
Arm predicted mass (left) 0.4 1.9 3.2 -1.8 -0.8