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chr15:90,712,555-92,135,418

Best TWAS P=2.73e-34 · Best GWAS P=2.48e-27 conditioned to 0.79

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	-7.7	7.7	1.4e-14	0.61	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	FES	0.21	0.09	lasso	5	0.05	1.3e-03	10.8	-10.5	1.5e-25	-0.95	0.00	0.99	FALSE
3	GTEx	Artery Tibial	FES	0.16	0.04	lasso	5	0.05	4.8e-05	9.4	-10.9	1.9e-27	-0.86	0.01	0.99	FALSE
4	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	10.8	-11.6	5.0e-31	-0.90	0.00	1.00	FALSE
5	GTEx	Lung	FES	0.24	0.07	lasso	6	0.05	5.1e-05	9.4	-10.8	2.7e-27	-0.88	0.01	0.99	FALSE
6	GTEx	Skin Sun Exposed Lower leg	FES	0.09	0.04	lasso	5	0.04	1.4e-04	10.8	-10.2	3.3e-24	-0.87	0.00	0.98	FALSE
7	GTEx	Thyroid	FES	0.33	0.19	lasso	6	0.18	4.3e-14	10.1	-10.1	7.4e-24	-0.94	0.01	0.99	FALSE
8	METSIM	Adipose	FES	0.08	0.06	lasso	3	0.05	6.8e-08	9.4	-9.4	4.9e-21	-0.88	0.17	0.83	FALSE
9	YFS	Blood	FES	0.31	0.11	enet	77	0.22	1.2e-68	10.8	-9.5	2.6e-21	-0.59	0.00	1.00	FALSE
10	YFS	Blood	FURIN	0.11	0.03	enet	37	0.06	8.3e-19	-7.7	-7.2	7.3e-13	-0.46	0.68	0.32	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	10.4	-10.6	4.0e-26	-0.72	0.02	0.96	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HDDC3	0.05	0.03	blup	59	0.03	1.3e-03	-4.0	-5.9	2.9e-09	-0.31	0.03	0.09	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	10.8	-12.2	2.7e-34	-0.88	0.00	1.00	TRUE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FES	0.06	0.02	blup	46	0.02	2.4e-02	10.8	-9.6	7.5e-22	-0.81	0.00	0.90	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	FES	0.08	0.07	blup	46	0.06	3.4e-04	9.7	-10.4	4.1e-25	-0.84	0.05	0.86	FALSE
16	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	10.4	-10.0	1.2e-23	-0.80	0.01	0.80	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	10.4	-10.9	7.9e-28	-0.76	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	10.4	-10.2	3.2e-24	-0.70	0.15	0.85	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	10.8	-11.4	3.3e-30	-0.92	0.00	0.99	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	10.8	-10.7	1.4e-26	-0.92	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FES	0.13	0.16	lasso	2	0.14	6.1e-10	10.8	-10.6	4.9e-26	-0.96	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	10.8	-11.4	3.0e-30	-0.91	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	10.4	-9.5	2.7e-21	-0.73	0.01	0.52	FALSE
24	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FES	0.32	0.26	lasso	2	0.25	2.0e-09	10.8	-10.9	1.5e-27	-1.00	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	10.8	-11.7	1.0e-31	-0.97	0.00	1.00	FALSE